diff --git a/scripts/.env.template b/scripts/.env.template
index 4e274092e..dc225ff0e 100644
--- a/scripts/.env.template
+++ b/scripts/.env.template
@@ -7,7 +7,8 @@ RS_HOME="/path/to/prime-reportstream"
 RS_LCL_API_URL="http://localhost:7071"
 RS_STG_API_URL="https://staging.prime.cdc.gov:443"
 RS_PRD_API_URL="https://prime.cdc.gov:443"
-TI_LCL_API_URL="http://host.docker.internal:8080"
+TI_LCL_API_URL="http://localhost:8080"
+TI_LCL_API_URL_RS_CONFIG="http://host.docker.internal:8080"
 TI_STG_API_URL="https://cdcti-stg-api.azurewebsites.net:443"
 TI_PRD_API_URL="https://cdcti-prd-api.azurewebsites.net:443"
 
diff --git a/scripts/README.md b/scripts/README.md
index 554dd3434..0f9fee201 100644
--- a/scripts/README.md
+++ b/scripts/README.md
@@ -1,8 +1,34 @@
-# Scripts
+- [Setup](#setup)
+- [Available Scripts](#available-scripts)
+  - [submit.sh](#submitsh)
+    - [Requirements](#requirements)
+    - [Usage](#usage)
+  - [rs.sh](#rssh)
+    - [Requirements](#requirements-1)
+    - [Usage](#usage-1)
+    - [Examples](#examples)
+  - [ti.sh](#tish)
+    - [Requirements](#requirements-2)
+    - [Usage](#usage-2)
+    - [Examples](#examples-1)
+  - [ucsd.sh](#ucsdsh)
+    - [Requirements](#requirements-3)
+    - [Before running the script](#before-running-the-script)
+    - [Usage](#usage-3)
+  - [setup/update-examples-snapshots.sh](#setupupdate-examples-snapshotssh)
+    - [Requirements](#requirements-4)
+    - [Usage](#usage-4)
+  - [setup/setup-reportstream.sh](#setupsetup-reportstreamsh)
+    - [Requirements](#requirements-5)
+    - [Usage](#usage-5)
+  - [lib/common.sh](#libcommonsh)
+    - [lib/submission-utils.sh](#libsubmission-utilssh)
+- [Resources](#resources)
 
 ## Setup
-
-Follow the instructions below to load the environments variables required for these scripts
+The steps to set up TT and RS locally are in [setup locally section in the main README.md ](../README.md#setup-with-reportstream).
+Follow the instructions below to load the environments variables required for these scripts.
+ReportStream and Trusted Intermediary must be running locally before running any scripts.
 
 1. Copy `.env.template` to `.env`
     ```
@@ -209,7 +235,7 @@ Sends all the HL7 files with `_0_initial_message.hl7` suffix in the `/examples`
 
 ### setup/setup-reportstream.sh
 
-Setup script for ReportStream
+Setup script for ReportStream.
 
 #### Requirements
 
diff --git a/scripts/setup/setup-reportstream.sh b/scripts/setup/setup-reportstream.sh
index cdf85353f..6e6f1a71b 100755
--- a/scripts/setup/setup-reportstream.sh
+++ b/scripts/setup/setup-reportstream.sh
@@ -16,6 +16,17 @@ echo "Resetting the database and loading the baseline settings..."
 ./gradlew reloadTables
 ./gradlew reloadSettings
 
+# If either TI or RS are not running in docker, then use a gradle hosted URL
+local_ti_docker_image_name=$(docker ps --filter "name=trusted-intermediary-router-1" | grep trusted-intermediary-router-1)
+local_rs_docker_image_name=$(docker ps --filter "name=prime-router-prime_dev-1" | grep prime-router-prime_dev-1)
+if [[ -z $local_ti_docker_image_name || -z $local_rs_docker_image_name ]]; then
+  ti_api_url=${TI_LCL_API_URL}
+  echo "No docker instances detected, ReportStream transport will use ${TI_LCL_API_URL}..."
+else
+  ti_api_url=${TI_LCL_API_URL_RS_CONFIG}
+  echo "Docker instances detected, ReportStream transport will use ${TI_LCL_API_URL_RS_CONFIG}..."
+fi
+
 # Need to CD to prime-router to run the prime CLI
 cd "prime-router" || exit
 
@@ -41,8 +52,8 @@ yq eval '.[0].receivers[] |= (
 )' -i "settings/STLTs/Flexion/flexion.yml"
 
 echo "Updating local URL and host in transport settings..."
-sed -i '' "s|__TI_API_URL__|${TI_LCL_API_URL}|g" "settings/STLTs/Flexion/flexion.yml"
-sed -i '' "s|__TI_API_HOST__|$(extract_host_from_url "${TI_LCL_API_URL}")|g" "settings/STLTs/Flexion/flexion.yml"
+sed -i '' "s|__TI_API_URL__|${ti_api_url}|g" "settings/STLTs/Flexion/flexion.yml"
+sed -i '' "s|__TI_API_HOST__|$(extract_host_from_url "${ti_api_url}")|g" "settings/STLTs/Flexion/flexion.yml"
 
 echo "Updating transport settings in partner org files..."
 for file in "settings/STLTs/CA/ucsd.yml" "settings/STLTs/LA/la-ochsner.yml" "settings/STLTs/LA/la-phl.yml"; do