diff --git a/.github/workflows/build_python_3.yml b/.github/workflows/build_python_3.yml
index a20779fbe81..f03c3c1bdcd 100644
--- a/.github/workflows/build_python_3.yml
+++ b/.github/workflows/build_python_3.yml
@@ -47,6 +47,7 @@ jobs:
     runs-on: ${{ matrix.os }}
     name: Build ${{ matrix.only }}
     strategy:
+      fail-fast: false
       matrix:
         include: ${{ fromJson(needs.build-wheels-matrix.outputs.include) }}
 
diff --git a/tests/smoke_test.py b/tests/smoke_test.py
index 24017c0df81..56a2ab3a9c0 100644
--- a/tests/smoke_test.py
+++ b/tests/smoke_test.py
@@ -1,13 +1,13 @@
 import copy
 import os
-from platform import system
+import platform
 import subprocess
 import sys
 import textwrap
 
 
 def mac_supported_iast_version():
-    if system() == "Darwin":
+    if platform.system() == "Darwin":
         # TODO: MacOS 10.9 or lower has a old GCC version but cibuildwheel has a GCC old version in newest mac versions
         # mac_version = [int(i) for i in mac_ver()[0].split(".")]
         # mac_version > [10, 9]
@@ -45,7 +45,7 @@ def emit(self, record):
 
 if __name__ == "__main__":
     # ASM IAST smoke test
-    if sys.version_info >= (3, 6, 0) and system() != "Windows" and mac_supported_iast_version():
+    if sys.version_info >= (3, 6, 0) and platform.system() != "Windows" and mac_supported_iast_version():
         print("Running native IAST module load test...")
         test_code = textwrap.dedent(test_native_load_code)
         cmd = [sys.executable, "-c", test_code]
@@ -67,7 +67,7 @@ def emit(self, record):
             os.environ = orig_env
 
     # ASM WAF smoke test
-    if system() != "Linux" or sys.maxsize > 2**32:
+    if platform.system() != "Linux" or sys.maxsize > 2**32:
         import ddtrace.appsec._ddwaf
         import ddtrace.bootstrap.sitecustomize as module
 
@@ -80,3 +80,35 @@ def emit(self, record):
     else:
         # Skip the test for 32-bit Linux systems
         print("Skipping test, 32-bit DDWAF not ready yet")
+
+    # Profiling smoke test
+    print("Running profiling smoke test...")
+    profiling_cmd = [sys.executable, "-c", "import ddtrace.profiling.auto"]
+    if sys.version_info >= (3, 13, 0):
+        print("Skipping profiling smoke test for Python 3.13+ as it's not supported yet")
+    elif (
+        # echion doesn't work on Windows
+        platform.system() == "Windows"
+        # libdatadog x86_64-apple-darwin has not yet been integrated to dd-trace-py
+        or (platform.system() == "Darwin" and platform.machine() == "x86_64")
+        # echion only works with 3.8+
+        or sys.version_info < (3, 8, 0)
+        # echion crashes on musl linux with Python 3.12 for both x86_64 and
+        # aarch64
+        or (platform.system() == "Linux" and sys.version_info[:2] == (3, 12) and platform.libc_ver()[0] != "glibc")
+    ):
+        orig_env = os.environ.copy()
+        copied_env = copy.deepcopy(orig_env)
+        copied_env["DD_PROFILING_STACK_V2_ENABLED"] = "False"
+        if platform.system() == "Windows":
+            # Memory profiler crashes on Windows
+            copied_env["DD_PROFILING_MEMORY_ENABLED"] = "False"
+        result = subprocess.run(profiling_cmd, env=copied_env, capture_output=True, text=True)
+        assert result.returncode == 0, "Failed with DD_PROFILING_STACK_V2_ENABLED=0: %s, %s" % (
+            result.stdout,
+            result.stderr,
+        )
+    else:
+        result = subprocess.run(profiling_cmd, capture_output=True, text=True)
+        assert result.returncode == 0, "Failed: %s, %s" % (result.stdout, result.stderr)
+    print("Profiling smoke test completed successfully")