diff --git a/ddtrace/appsec/_iast/_ast/ast_patching.py b/ddtrace/appsec/_iast/_ast/ast_patching.py
index 7e2258bd556..4c9f0dccaec 100644
--- a/ddtrace/appsec/_iast/_ast/ast_patching.py
+++ b/ddtrace/appsec/_iast/_ast/ast_patching.py
@@ -27,6 +27,46 @@
 # Prefixes for modules where IAST patching is allowed
 IAST_ALLOWLIST: Tuple[Text, ...] = ("tests.appsec.iast.",)
 IAST_DENYLIST: Tuple[Text, ...] = (
+    "altgraph.",
+    "dipy.",
+    "black.",
+    "mypy.",
+    "mypy_extensions.",
+    "autopep8.",
+    "pycodestyle.",
+    "pydicom.",
+    "pyinstaller.",
+    "pystray.",
+    "contourpy.",
+    "cx_logging.",
+    "dateutil.",
+    "pytz.",
+    "wcwidth.",
+    "win32ctypes.",
+    "xlib.",
+    "cycler.",
+    "cython.",
+    "dnspython.",
+    "elasticdeform." "numpy.",
+    "matplotlib.",
+    "skbase.",
+    "scipy.",
+    "networkx.",
+    "imageio.",
+    "fonttools.",
+    "nibabel.",
+    "nilearn.",
+    "gprof2dot.",
+    "h5py.",
+    "kiwisolver.",
+    "pandas.",
+    "pdf2image.",
+    "pefile.",
+    "pil.",
+    "threadpoolctl.",
+    "tifffile.",
+    "tqdm.",
+    "trx.",
     "flask.",
     "werkzeug.",
     "aiohttp._helpers.",
@@ -110,6 +150,7 @@
     "difflib.",
     "dill.info.",
     "dill.settings.",
+    "silk.",  # django-silk package
     "django.apps.config.",
     "django.apps.registry.",
     "django.conf.",
diff --git a/releasenotes/notes/denylist-extend-more-f0d96917c50d43cf.yaml b/releasenotes/notes/denylist-extend-more-f0d96917c50d43cf.yaml
new file mode 100644
index 00000000000..b0c378dadaa
--- /dev/null
+++ b/releasenotes/notes/denylist-extend-more-f0d96917c50d43cf.yaml
@@ -0,0 +1,4 @@
+---
+fixes:
+  - |
+    Add more modules to the IAST patching denylist to improve startup time