diff --git a/src/ontology/efo-edit.owl b/src/ontology/efo-edit.owl
index f00c09e7..1802d697 100644
--- a/src/ontology/efo-edit.owl
+++ b/src/ontology/efo-edit.owl
@@ -16874,6 +16874,7 @@ Declaration(Class(efo:EFO_0022487))
 Declaration(Class(efo:EFO_0022488))
 Declaration(Class(efo:EFO_0022489))
 Declaration(Class(efo:EFO_0022490))
+Declaration(Class(efo:EFO_0022491))
 Declaration(Class(efo:EFO_0030000))
 Declaration(Class(efo:EFO_0030001))
 Declaration(Class(efo:EFO_0030002))
@@ -202402,6 +202403,14 @@ AnnotationAssertion(dc:date efo:EFO_0022490 "2024-01-10T09:12:40Z"^^xsd:dateTime
 AnnotationAssertion(rdfs:label efo:EFO_0022490 "ScaleBio single cell RNA sequencing"@en)
 SubClassOf(efo:EFO_0022490 efo:EFO_0010183)
 
+# Class: efo:EFO_0022491 (Paired-Tag)
+
+AnnotationAssertion(Annotation(efo:definition_citation "PMID:33589836") obo:IAO_0000115 efo:EFO_0022491 "An ultra-high throughput method, Paired-Tag, for joint profiling of histone modifications and transcriptome in single cells to produce cell-type-resolved maps of chromatin state and transcriptome in complex tissues.")
+AnnotationAssertion(dc:creator efo:EFO_0022491 "Zoe May Pendlington")
+AnnotationAssertion(dc:date efo:EFO_0022491 "2024-01-11T09:07:31Z"^^xsd:dateTime)
+AnnotationAssertion(rdfs:label efo:EFO_0022491 "Paired-Tag"@en)
+SubClassOf(efo:EFO_0022491 efo:EFO_0002692)
+
 # Class: efo:EFO_0030000 (STARmap)
 
 AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:29930089") Annotation(oboInOwl:hasDbXref "https://orcid.org/0000-0002-3090-9894") obo:IAO_0000115 efo:EFO_0030000 "STARmap is an image-based technology for 3D intact-tissue RNA sequencing, which integrates hydrogel-tissue chemistry, targeted signal amplification, and in situ sequencing.")