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Welcome to the MicroED wiki!

Data collection, transfer and processing scripts and documentations are in our repository.

設備: Our equipments

• Talos Arctica (200 kV)
• Ceta
• Automated data collection with SerialEM

利用方法: How to use our facility

以下のどちらかの窓口から相談・申請してください。

• MicroED 共同利用研究課題 2024 年度, 2023 年度
• 創薬等先端技術支援基盤プラットフォーム BINDS

従来の X 線結晶回折法では解けない試料(1 um 以下のナノ結晶や混合物)を優先しています。結晶が十分に大きいと判断した時は、放射光 X 線を紹介することがあります。また、試料の性状や実験目的によっては、HRTEM や STEM など実空間でのイメージングを推奨することがあります(我々の装置では不可能)。

We prioritize samples that are not amenable to X-ray crystallography, e.g. nano-crystals smaller than 1 um and/or mixtures. When the sample turns out to be large enough, we might refer it to synchrotron X-ray beamlines. Depending on the sample and the goal of the experiment, we might recommend real-space methods such as HRTEM and STEM at other facilities.

成果: Publications & Presentations

• 中根 崇智, "High multiplicity MicroED with high-throughput measurements", 第 2 回アグロデザイン学術セミナー 基調講演, 2022 年 12 月 26 日 講演ビデオ
• Sasaki, Nakane et al. Microcrystal Electron Diffraction (MicroED) Structure Determination of a Mechanochemically Synthesized Co-crystal not Affordable from Solution Crystallization, CrystEngComm, 2023
• Gogoi, Sasaki et al. Structure elucidation of olanzapine molecular salts by combining mechanochemistry and MicroED, Cryst. Growth Des., 2023

公開データ: Public datasets

From our Talos Arctica/Ceta:

• XRD-00126 (MicroED datasets of olanzapinium succinate and two impurities)
• XRD-00125 (MicroED dataset of olanzapinium oxalate)
• XRD-00124 (MicroED dataset of clathrate-II ice (?) and hexagonal ice)
• XRD-00109 (MicroED dataset of solid-state synthesized 2:1 co-crystals of 2-aminopyridine and succinic acid)
• XRD-00103 (MicroED dataset of Biotin)
• XRD-00102 (MicroED dataset of Histidine)
• XRD-00101 (MicroED dataset of Sodium Glutamate Monohydrate (Ajinomoto))
  See also a companion dataset by X-ray: XRD-00094 (Sodium Glutamate Monohydrate ("Ajinomoto") from a Rigaku HyPix 6000 detector)
• XRD-00100 (MicroED dataset of Sucrose)
• XRD-00099 (MicroED dataset of Ribitol)
• XRD-00098 (MicroED dataset of Trehalose)

From other scopes (data processing collaboration):

• XRD-00141 (MicroED dataset of histidine collected with Direct Electron Apollo)
• XRD-00140 (MicroED dataset of sodium glutamate collected with Direct Electron Apollo)