diff --git a/.changeset/neat-hounds-repeat.md b/.changeset/neat-hounds-repeat.md
new file mode 100644
index 0000000000..fd2e2fd284
--- /dev/null
+++ b/.changeset/neat-hounds-repeat.md
@@ -0,0 +1,5 @@
+---
+'react-select': patch
+---
+
+Fix re-focus of component in Firefox if being disabled while focused
diff --git a/packages/react-select/src/Select.tsx b/packages/react-select/src/Select.tsx
index 361226a011..699f6119ce 100644
--- a/packages/react-select/src/Select.tsx
+++ b/packages/react-select/src/Select.tsx
@@ -730,6 +730,15 @@ export default class Select<
       // ensure select state gets blurred in case Select is programmatically disabled while focused
       // eslint-disable-next-line react/no-did-update-set-state
       this.setState({ isFocused: false }, this.onMenuClose);
+    } else if (
+      !isFocused &&
+      !isDisabled &&
+      prevProps.isDisabled &&
+      this.inputRef === document.activeElement
+    ) {
+      // ensure select state gets focused in case Select is programatically re-enabled while focused (Firefox)
+      // eslint-disable-next-line react/no-did-update-set-state
+      this.setState({ isFocused: true });
     }
 
     // scroll the focused option into view if necessary