diff --git a/src/Auditor.jl b/src/Auditor.jl
index 0b47187ae..35b2aa8ea 100644
--- a/src/Auditor.jl
+++ b/src/Auditor.jl
@@ -135,9 +135,13 @@ function audit(prefix::Prefix, src_name::AbstractString = "";
     shlib_files = filter(f -> startswith(f, prefix.path) && valid_library_path(f, platform), collapse_symlinks(bin_files))
 
     for f in shlib_files
-        # Inspect all shared library files for our platform (but only if we're
-        # running native, don't try to load library files from other platforms)
-        if platforms_match(platform, HostPlatform())
+        # Always include microarchitecture in the host platform: we don't want to try and
+        # dlopen a library built for an incompatible microarchitecture.
+        hp = augment_microarchitecture!(HostPlatform())
+        set_compare_strategy!(hp, "march", march_comparison_strategy)
+        # Inspect all shared library files for our platform (but only if we're running
+        # native, don't try to load library files from other platforms or incompatible ISAs)
+        if platforms_match(platform, hp)
             if verbose
                 @info("Checking shared library $(relpath(f, prefix.path))")
             end
diff --git a/src/auditor/instruction_set.jl b/src/auditor/instruction_set.jl
index 07beb52c4..7070c627a 100644
--- a/src/auditor/instruction_set.jl
+++ b/src/auditor/instruction_set.jl
@@ -1,4 +1,6 @@
 using JSON
+using Base.BinaryPlatforms: arch_march_isa_mapping, set_compare_strategy!
+using Base.BinaryPlatforms.CPUID
 
 ## We start with definitions of instruction mnemonics, broken down by category:
 const instruction_categories = JSON.parsefile(joinpath(@__DIR__, "instructions.json");
@@ -168,3 +170,34 @@ function analyze_instruction_set(oh::ObjectHandle, platform::AbstractPlatform; v
     # Otherwise, return `min_march` and let 'em know!
     return min_march
 end
+
+function augment_microarchitecture!(platform::Platform)
+    haskey(platform, "march") && return platform
+
+    host_arch = arch(HostPlatform())
+    host_isas = arch_march_isa_mapping[host_arch]
+    idx = findlast(((name, isa),) -> isa <= CPUID.cpu_isa(), host_isas)
+    platform["march"] = first(host_isas[idx])
+    return platform
+end
+
+function march_comparison_strategy(a::String, b::String, a_requested::Bool, b_requested::Bool)
+    function get_arch_isa(isa_name::String)
+        for (arch, isas) in arch_march_isa_mapping
+            for (name, isa) in isas
+                name == isa_name && return arch, isa
+            end
+        end
+        return nothing, nothing
+    end
+
+    a_arch, a_isa = get_arch_isa(a)
+    b_arch, b_isa = get_arch_isa(b)
+    if any(isnothing, (a_arch, b_arch)) || a_arch != b_arch
+        # Architectures are definitely not compatible, exit early
+        return false
+    end
+
+    # ISA `a` is compatible with ISA `b` only if it's a subset of `b`
+    return a_isa ≤ b_isa
+end