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Rosetta_Gemme_data.csv
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Rosetta_Gemme_data.csv
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"position","wt_aa","sub_aa","variant","SE_interaction","epsilon_interaction","score_interaction","SE_abundance","epsilon_abundance","score_abundance","Rosetta_ddG","Gemme_ddE"
487,"Arg","Ala","p.Arg487Ala",0.0392609677224898,4.25007251614318e-17,0.0572811074241342,0.128536304223601,5.55111512312578e-17,0.168416191414784,-0.142413793103452,-0.387193646064477
487,"Arg","Asn","p.Arg487Asn",0.0722634642627461,1.73472347597681e-18,0.134634577855336,0.0917933356141628,0,0.0549230670749455,-0.185977011494272,-0.415010635833368
487,"Arg","Asp","p.Arg487Asp",0.0635020480734873,0,1.38985584366257,0.06306805770788,0,0.0201992306580759,-0.172873563218406,-0.325726570236632
487,"Arg","Cys","p.Arg487Cys",0.0376797909503523,9.13028778016384e-11,0.164925236703885,0.0646364523075652,0,0.117268240839925,0.793908045977003,-0.651346195092343
487,"Arg","Gln","p.Arg487Gln",0.0769641129987146,3.46944695195361e-18,0.0951209545667661,0.0956471795708567,0,0.00356017780957388,0.419540229885016,-0.159922637402002
487,"Arg","Glu","p.Arg487Glu",0.0732902585330903,0,1.11238867539248,0.124349308655125,0,-0.123884574832501,0.0289655172413739,-0.337892092387305
487,"Arg","Gly","p.Arg487Gly",0.0522358749409357,0,0.0334427778730099,0.0309694227724043,2.23952800748606e-15,-0.0212394847752372,-0.818045977011516,-0.228404200001296
487,"Arg","His","p.Arg487His",0.0601624110244422,0,0.0872294917875745,0.038376125759815,0,0.066355477512627,-0.477701149425308,-0.375376473195105
487,"Arg","Ile","p.Arg487Ile",0.0852098461579008,0,0.051476696392627,0.0253289650012564,7.01047249548545e-08,0.0460848638638574,-0.048160919540241,-0.665913311274971
487,"Arg","Leu","p.Arg487Leu",0.0242817985723487,1.00886885526658e-36,0.118968588409485,0.0449356279524792,0,0.156327313898652,-0.882298850574705,-0.500493373690533
487,"Arg","Lys","p.Arg487Lys",0.0569792509023765,0,-0.0252476232888601,0.0259384403795155,3.30838731844169e-10,-0.0071652028380306,0.305287356321833,-0.135682109639963
487,"Arg","Met","p.Arg487Met",0.0723794085488715,0,0.213167989470171,0.105190493009181,1.38777878078145e-17,0.165003480757814,-0.00298850574713417,-0.665913311274971
487,"Arg","Phe","p.Arg487Phe",0.0675063361732876,5.20417042793042e-18,0.314173377016912,0.0622070438704795,0,0.0268497151675188,0.624022988505757,-0.875009779062989
487,"Arg","Pro","p.Arg487Pro",0.040597837857121,7.05598773853566e-16,0.0923086960662714,0.0309106039228311,1.17111181863194e-14,0.0200747974731999,-0.943563218390838,-0.450116210075699
487,"Arg","Ser","p.Arg487Ser",0.082446300587823,0,0.2237874271907,0.154573426298392,0,0.184305635898993,-0.541264367816099,-0.424108203563263
487,"Arg","Thr","p.Arg487Thr",0.0415680076330171,1.26218480112072e-14,0.047601505427076,0.0213849180562828,1.38568950648907e-25,0.18233726340933,-0.178390804597717,-0.394542907691134
487,"Arg","Trp","p.Arg487Trp",0.0710252671489679,0,0.561798092855025,0.0774016316033205,0,-0.0750409639409299,0.641379310344819,-0.875009779062989
487,"Arg","Tyr","p.Arg487Tyr",0.0502045621194943,0,0.226004628359886,0.0638595202308832,0,-0.0628746290474834,1.0242528735632,-0.875009779062989
487,"Arg","Val","p.Arg487Val",0.0252427956160908,2.0117043632789e-37,0.114252572742787,0.0731370515712565,0,0.124888870517656,0.446321839080438,-0.448548265441746
488,"Lys","Ala","p.Lys488Ala",0.027383274017709,6.73441761228337e-16,0.112117237836419,0.0808426023186959,6.93889390390723e-18,-0.0603892684698574,0.142068965517227,-1.04819449237813
488,"Lys","Arg","p.Lys488Arg",0.02610922019237,2.89000874079941e-19,0.0732441994543358,0.0289794629550882,3.87606613472258e-14,-0.0782795533419899,0.258505747126466,-0.997922590910983
488,"Lys","Asn","p.Lys488Asn",0.0330398696615946,6.16126838133904e-10,0.221000094607809,0.0911867080707688,0,-0.00282666697763317,0.17356321839083,-1.1074587195211
488,"Lys","Asp","p.Lys488Asp",0.0971194114730179,0,0.388409028312076,0.0711734193610443,0,-0.0697519769722029,-0.153563218390806,-1.1943260754094
488,"Lys","Cys","p.Lys488Cys",0.0512616843065068,0,0.142548376238495,0.116161348625202,0,0.161144013992072,1.21827586206898,-1.73029935800584
488,"Lys","Gln","p.Lys488Gln",0.0839781947469562,0,0.143670550622568,0.132987840313183,0,0.0937614013337903,0.539999999999984,-0.150458306536263
488,"Lys","Glu","p.Lys488Glu",0.0223214207795543,1.07577692528678e-25,0.173099054366207,0.0822895813425276,0,-0.0139343785144729,-0.141609195402295,-0.31473917250596
488,"Lys","Gly","p.Lys488Gly",0.0495927896091624,0,0.121484020950919,0.0325338004478482,0,-0.0241284253215291,0.566666666666674,-1.19780235418849
488,"Lys","His","p.Lys488His",0.0853887427319913,0,0.0847924688005332,0.165708514615682,0,0.131663003674966,-0.269195402298836,-1.20518831359374
488,"Lys","Ile","p.Lys488Ile",0.0352144464478739,2.2848064586134e-13,0.232438974587789,0.072439828556014,0,-0.0282638776592204,0.629425287356361,-1.56618525709381
488,"Lys","Leu","p.Lys488Leu",0.0866139938296917,0,0.188508126229308,0.0718442288565874,0,-0.0219603817217963,0.0258620689655068,-1.26355897825604
488,"Lys","Met","p.Lys488Met",0.0935473276673248,0,0.189440418715411,0.0425558933567727,0,-0.0130898506278481,0.269310344827569,-1.42518963854983
488,"Lys","Phe","p.Lys488Phe",0.089727502077678,3.46944695195361e-18,0.24436981315369,0.089124599839438,2.08166817117217e-17,0.0509332143393286,0.580000000000006,-2.52720310607995
488,"Lys","Pro","p.Lys488Pro",0.0444015128979687,5.64912699951847e-15,0.153014987302964,0.063744903531927,6.93889390390723e-18,-0.0928127916012839,1.45885057471267,-1.37916873001143
488,"Lys","Ser","p.Lys488Ser",0.0583047475206037,0,0.215273397370454,0.0460850439225117,3.46944695195361e-18,0.0773051260729487,-0.1906896551724,-0.368203876750295
488,"Lys","Thr","p.Lys488Thr",0.0426898576137198,8.67361737988404e-19,0.169451729958345,0.0372779186331827,8.67361737988404e-19,0.073488499433044,0.2067816091954,-0.96422973765842
488,"Lys","Trp","p.Lys488Trp",0.0358787180935049,1.81712284108571e-16,0.231670221671606,0.0320324410884631,1.73472347597681e-18,0.0592393368527933,-0.171724137930999,-2.52720310607995
488,"Lys","Tyr","p.Lys488Tyr",0.0549567054785374,0,0.216189460434214,0.0663405126856775,6.93889390390723e-18,-0.0526612973651666,0.552528735632186,-2.52720310607995
488,"Lys","Val","p.Lys488Val",0.0484943126553462,0,0.133323542689624,0.112490562475609,2.77555756156289e-17,0.0194574782824101,0.71528735632186,-1.04521753569165
489,"Glu","Ala","p.Glu489Ala",0.0626834976741386,0,0.0176190068063558,0.0639082384321191,6.93889390390723e-18,-0.0688489641872949,1.57586206896542,-1.41200770430633
489,"Glu","Arg","p.Glu489Arg",0.0289285097967348,9.40282575769509e-17,0.0555987217906392,0.11365460921193,0,-0.660942446897279,1.42517241379296,-2.15480441607239
489,"Glu","Asn","p.Glu489Asn",0.0618644342475385,0,0.0468671434093378,0.0496853000345402,3.46944695195361e-18,-0.0296443918121024,0.846551724137827,-0.894010449675246
489,"Glu","Asp","p.Glu489Asp",0.056342601054415,0,0.107541342584165,0.116973694801631,0,0.151377054518777,0.18482758620676,-0.292768890974782
489,"Glu","Cys","p.Glu489Cys",0.0438504067867081,0,0.101776104866048,0.019964378975847,1.19744493512762e-26,-0.0902341448770122,2.13965517241369,-1.79099097596667
489,"Glu","Gln","p.Glu489Gln",0.0644230025201412,1.73472347597681e-18,0.0962214939211267,0.0634678754593593,1.38777878078145e-17,-0.257333260634727,0.29827586206889,-0.784440322278764
489,"Glu","Gly","p.Glu489Gly",0.0232555981958753,4.2752833071293e-117,-0.0527266146076777,0.077483712405151,0,-0.0351148625108565,1.96103448275851,-0.855988687905039
489,"Glu","His","p.Glu489His",0.0744905339079393,5.20417042793042e-18,0.153322807933512,0.0393944885398925,8.67361737988404e-19,-0.187893930892098,0.105172413792969,-1.44602594856161
489,"Glu","Ile","p.Glu489Ile",0.0685838790701105,0,0.138219922481033,0.0259786576396176,2.45958522819556e-09,-0.0405999133759235,1.56827586206889,-2.40314572392582
489,"Glu","Leu","p.Glu489Leu",0.055576521294123,0,0.135586312508931,0.199541221760975,1.38777878078145e-16,-0.0399340230784633,0.836896551724028,-2.40314572392582
489,"Glu","Lys","p.Glu489Lys",0.0974913003388493,3.46944695195361e-18,0.0367729631734792,0.115506952288024,0,-0.553178430773075,1.33172413793091,-1.62831503228322
489,"Glu","Met","p.Glu489Met",0.0421448455892941,1.30104260698261e-18,0.0936665228777307,0.0206781313030806,2.77250927171482e-08,-0.0730423603268861,1.25999999999992,-2.40314572392582
489,"Glu","Phe","p.Glu489Phe",0.0273113396334635,3.20298896231997e-09,0.200699523182732,0.0606379507667875,0,0.0083428258006262,1.02448275862061,-2.40314572392582
489,"Glu","Pro","p.Glu489Pro",0.0638103479371401,0,0.15428341393414,0.0233435991077281,3.90192835613107e-07,-0.10949711818838,3.68862068965506,-1.59675641392724
489,"Glu","Ser","p.Glu489Ser",0.0383851258265303,2.16840434497101e-18,0.0690499406712358,0.137620015319339,0,-0.00966580194093354,1.20896551724125,-0.923717844142197
489,"Glu","Thr","p.Glu489Thr",0.0260591256644683,5.92109134849442e-17,0.100746638757393,0.0396901782870981,0,-0.159349513573605,0.992068965517147,-1.03301222032463
489,"Glu","Trp","p.Glu489Trp",0.0327564600010379,1.64002925823192e-14,0.391968164594933,0.0682101125339939,0,-0.135556682138371,0.90574712643669,-2.40314572392582
489,"Glu","Tyr","p.Glu489Tyr",0.0429160635441927,0,0.243764742472016,0.0733548460296796,1.04083408558608e-17,0.054226024008865,1.16827586206886,-2.40314572392582
489,"Glu","Val","p.Glu489Val",0.0685551778792855,0,0.0951138221277114,0.10430871811178,0,-0.178781540854138,1.48551724137923,-2.40314572392582
490,"Met","Ala","p.Met490Ala",0.0605252114280266,0,0.0600709926230539,0.0267119692131272,2.57507589906601e-11,-0.233814341672135,1.50988505747131,-1.5579903151689
490,"Met","Arg","p.Met490Arg",0.034821524405052,4.9439619065339e-17,0.00171719143584785,0.0330379985716957,3.03576608295941e-18,-0.346184933066997,1.07977011494256,-2.38540285669979
490,"Met","Asn","p.Met490Asn",0.0787139646722892,1.73472347597681e-18,0.122719885900213,0.0505563472490382,0,-0.144407453721125,1.20770114942532,-1.48662262202387
490,"Met","Asp","p.Met490Asp",0.0647080004554232,3.46944695195361e-18,0.0379737377127739,0.0387010184945373,0,-0.204968775906497,2.07149425287363,-2.32283340491129
490,"Met","Cys","p.Met490Cys",0.0712671679640425,0,0.104381346313164,0.0535632683955403,5.20417042793042e-18,-0.00423964148599514,1.59103448275866,-2.20914098859776
490,"Met","Gln","p.Met490Gln",0.0446360500995873,4.00009886325492e-14,-0.028468429491702,0.0649302616136577,0,0.136297239489747,1.17712643678166,-2.32283340491129
490,"Met","Glu","p.Met490Glu",0.0466894602460148,0,0.0880735324463795,0.0780514918857006,0,-0.0926766129806125,1.46287356321843,-1.5106474017526
490,"Met","Gly","p.Met490Gly",0.0662432556287382,0,0.0965373331036179,0.0496609595164593,5.20417042793042e-18,-0.317249633084549,2.07689655172419,-1.94587826034466
490,"Met","His","p.Met490His",0.0698840329972959,0,0.0599634613555554,0.0515404246648433,0,-0.292113282026863,0.857356321839113,-2.32283340491129
490,"Met","Ile","p.Met490Ile",0.0474788679728277,0,0.123118285676336,0.0855555109262759,1.38777878078145e-17,-0.0255480347994919,0.71678160919544,-0.967923366752664
490,"Met","Leu","p.Met490Leu",0.0959212839120048,0,0.06536538765415,0.131525732870803,2.77555756156289e-17,-0.140956434838932,-0.188045977011464,-0.320224048551107
490,"Met","Lys","p.Met490Lys",0.0271792029508187,1.55488445031426e-19,-0.00814388694856599,0.0616655538900537,0,-0.382586458164279,1.17275862068968,-1.44518059135129
490,"Met","Phe","p.Met490Phe",0.0886826273324749,0,0.142182688913659,0.0816184394346392,0,-0.0326352820936298,-0.261724137930987,-2.96847826498682
490,"Met","Pro","p.Met490Pro",0.0310426235627637,6.74451454328156e-06,0.0779824529699681,0.0486171395622974,3.46944695195361e-18,-0.240264896158356,6.90229885057476,-2.96847826498682
490,"Met","Ser","p.Met490Ser",0.0355902590163492,5.82327752208026e-10,0.0883669770264933,0.0879318201937263,0,-0.0434048205057678,1.87505747126438,-1.35819701343618
490,"Met","Thr","p.Met490Thr",0.0276166247244701,8.30620917767097e-36,-0.0490246503843276,0.0291515961475503,1.89700382138835e-12,-0.176861263980875,1.140459770115,-1.09306973172189
490,"Met","Trp","p.Met490Trp",0.0568667377316657,0,0.190758591931668,0.0183807935076013,8.47856058071339e-24,0.0145441799730238,-0.857931034482726,-2.96847826498682
490,"Met","Tyr","p.Met490Tyr",0.0992261924165456,3.46944695195361e-18,0.205506793384071,0.0559538466977066,9.6904191254632e-08,0.0674348794851525,-0.091149425287344,-2.96847826498682
490,"Met","Val","p.Met490Val",0.0231324692004182,5.48046558283842e-27,0.0203937849647956,0.0729360277866628,6.93889390390723e-18,-0.111894352132184,1.10172413793109,-0.742017749892515
491,"Thr","Ala","p.Thr491Ala",0.0568856607813157,3.46944695195361e-18,0.0391532324606532,0.0700111954069932,0,-0.233108086483327,1.43356321839093,-0.904764153667086
491,"Thr","Arg","p.Thr491Arg",0.0490419050342128,3.46944695195361e-18,0.13494031287552,0.13080270469616,0,-0.678683180553214,3.58804597701159,-1.89331289805307
491,"Thr","Asn","p.Thr491Asn",0.0569157113310897,0,0.0349224389976735,0.106372825554167,0,-0.219918637621963,1.99678160919551,-1.55251127572087
491,"Thr","Asp","p.Thr491Asp",0.0552644004395973,0,0.120749855809196,0.0621763150371914,0,-0.285654303197356,4.22252873563227,-1.55438417547968
491,"Thr","Cys","p.Thr491Cys",0.0663764067053752,0,0.20748939146785,0.0293113446879691,8.85153564934485e-06,-0.628694291809541,1.24459770114953,-2.1871102491184
491,"Thr","Gln","p.Thr491Gln",0.106735106962192,0,0.0746753197157919,0.0792357778755574,0,-0.379716871823225,3.43022988505758,-2.59009239236761
491,"Thr","Glu","p.Thr491Glu",0.0698252561350434,5.20417042793042e-18,0.0996409320771324,0.0353318870587322,2.16840434497101e-17,-0.180533252688373,5.10057471264378,-2.59009239236761
491,"Thr","Gly","p.Thr491Gly",0.0291685249651693,2.10430088175356e-55,0.112641943447382,0.109292848902938,1.38777878078145e-17,-0.311972268929785,2.2513793103449,-3.61433325669572
491,"Thr","His","p.Thr491His",0.0813615859347622,3.46944695195361e-18,0.181917896904882,0.069498109064181,0,-0.423391314857082,6.10310344827596,-2.59009239236761
491,"Thr","Ile","p.Thr491Ile",0.034171384826302,5.7218942467617e-18,0.216361789769314,0.0939641537704359,6.93889390390723e-18,-0.364943547204126,2.27678160919553,-3.37734623566227
491,"Thr","Leu","p.Thr491Leu",0.0261952362464501,2.57659659118172e-10,0.135151741774787,0.056482712170746,0,-0.523477860517099,1.85827586206909,-3.37734623566227
491,"Thr","Lys","p.Thr491Lys",0.0694034994950169,5.20417042793042e-18,0.0718311898560602,0.0418446832756848,1.71763495475808e-07,-0.659180430163777,4.03436781609205,-1.64676867231512
491,"Thr","Met","p.Thr491Met",0.0544574346052455,8.67361737988404e-19,0.183733107058747,0.028971518338947,1.07794906744909e-05,-0.459961940068693,3.38873563218401,-3.37734623566227
491,"Thr","Phe","p.Thr491Phe",0.0965622823406427,0,0.221890403006803,0.0325293853780244,6.76471852477958e-06,-0.512635144210557,9.67448275862078,-3.61433325669572
491,"Thr","Pro","p.Thr491Pro",0.0769473343768688,0,0.0727346098949546,0.0769251888169374,1.38777878078145e-17,-0.24452577933019,7.30770114942539,-3.61433325669572
491,"Thr","Ser","p.Thr491Ser",0.0463341922144089,5.20417042793042e-18,0.101673587520597,0.0309256934756234,1.84696085249415e-07,-0.238400009557367,1.30390804597712,-1.18021754312673
491,"Thr","Trp","p.Thr491Trp",0.0649617402778745,0,0.405948041804559,0.0516467657880195,3.46944695195361e-18,-0.364503776245011,11.7790804597703,-3.61433325669572
491,"Thr","Tyr","p.Thr491Tyr",0.0580280111778155,0,0.30375060400573,0.102185246325337,0,-0.448343888960579,5.51275862068976,-3.61433325669572
491,"Thr","Val","p.Thr491Val",0.0602033606847128,0,0.102964248886274,0.0559983026743795,3.46944695195361e-18,-0.305585630562876,0.668390804597838,-3.37734623566227
492,"Ala","Arg","p.Ala492Arg",0.0743278124548018,0,0.134948085959013,0.0659516340027383,0,-0.630312611500347,3.32494252873565,-2.68630354062968
492,"Ala","Asn","p.Ala492Asn",0.118228268102049,1.38777878078145e-17,0.14707500582091,0.0553170064038017,3.46944695195361e-18,-0.263279079980094,1.85505747126438,-1.39050432675123
492,"Ala","Asp","p.Ala492Asp",0.0755312492083056,3.46944695195361e-18,0.0861341218927852,0.0249336736601361,9.05901648663193e-23,-0.305279515449543,2.98022988505748,-1.49342118765254
492,"Ala","Cys","p.Ala492Cys",0.100615811842209,6.93889390390723e-18,0.206014664699361,0.128122079797183,1.38777878078145e-17,-0.0492779370258351,1.27264367816093,-2.08923722539359
492,"Ala","Gln","p.Ala492Gln",0.0374651548377978,2.24584172681899e-16,0.0680419994462543,0.107299765428942,1.38777878078145e-17,-0.458115259475102,5.05114942528735,-2.37986467666523
492,"Ala","Glu","p.Ala492Glu",0.0877460827666607,0,0.0944978006386328,0.0300849671204758,1.58234250305454e-07,-0.298222236637276,6.70655172413793,-1.43177924325131
492,"Ala","Gly","p.Ala492Gly",0.0512157653943936,1.73472347597681e-18,0.154680798133458,0.0817393663000484,0,-0.177106414333112,1.63367816091954,-3.40391708758769
492,"Ala","His","p.Ala492His",0.0436830898221644,1.57896569083493e-12,0.166862892566702,0.0662708327121354,3.46944695195361e-18,-0.351838220921608,1.38908045977012,-2.37986467666523
492,"Ala","Ile","p.Ala492Ile",0.0777561775647509,0,0.133182654106973,0.0570569921851503,0,-0.363087272929704,3.50321839080461,-1.58630461685267
492,"Ala","Leu","p.Ala492Leu",0.0279855837551493,9.7516213406189e-11,0.154078935639881,0.0269935211143629,6.98848163476715e-15,-0.421729090819523,4.58735632183909,-1.86332263872286
492,"Ala","Lys","p.Ala492Lys",0.070718164816926,0,0.072674353625305,0.0871715496324891,6.93889390390723e-18,-0.533550508316189,3.98103448275862,-1.69515410308413
492,"Ala","Met","p.Ala492Met",0.0347513203192742,7.72341493821105e-06,0.160147537785233,0.038587489284963,5.75509255534064e-07,-0.319757281360583,8.64344827586208,-2.54200096373535
492,"Ala","Phe","p.Ala492Phe",0.086874826482561,1.38777878078145e-17,0.354780669472617,0.0539758055043527,1.73472347597681e-17,-0.506710910165675,1.34310344827586,-3.40391708758769
492,"Ala","Pro","p.Ala492Pro",0.049765128013091,0,0.111749180367567,0.106312591098586,0,-0.448420187031328,5.17528735632185,-2.77101782038356
492,"Ala","Ser","p.Ala492Ser",0.120557048223955,0,0.113390914966962,0.0817462801327936,6.93889390390723e-18,-0.315574766963487,1.10057471264368,-1.28158743781068
492,"Ala","Thr","p.Ala492Thr",0.0798687609299364,3.46944695195361e-18,0.11558875901957,0.0450309292601901,0,-0.330696574657838,2.03321839080461,-1.11068770372328
492,"Ala","Trp","p.Ala492Trp",0.125043198782095,0,0.37443225494224,0.149073029466587,5.55111512312578e-17,-0.165435465655708,0.420574712643664,-3.40391708758769
492,"Ala","Tyr","p.Ala492Tyr",0.0394311504969485,3.71833596898852e-12,0.270286854403459,0.031124173586661,1.60573470928764e-32,-0.509488658047088,1.47206896551724,-3.40391708758769
492,"Ala","Val","p.Ala492Val",0.0453178600635783,3.87897179654484e-14,0.0379324489021446,0.0401643399324699,2.38871422642006e-15,-0.192570799020449,2.95413793103449,-1.58982863828354
493,"Ala","Arg","p.Ala493Arg",0.0318035937072298,3.17353717594017e-18,0.156566148432394,0.0588886144229567,0,-0.411474967108302,7.01781609195406,-3.86249506153067
493,"Ala","Asn","p.Ala493Asn",0.103670299766309,3.46944695195361e-18,0.0845783719237058,0.053587343628802,0,-0.198148286404399,2.0957471264368,-2.36645428409128
493,"Ala","Asp","p.Ala493Asp",0.0586183114572013,0,0.147189382906512,0.0547313888423461,1.73472347597681e-18,-0.20673113446573,2.36241379310346,-2.60530519398794
493,"Ala","Cys","p.Ala493Cys",0.0850982820357933,0,0.0646762976360805,0.0848667389219433,2.08166817117217e-17,0.0244351607858004,1.77781609195406,-2.30321452236057
493,"Ala","Gln","p.Ala493Gln",0.0473315403061752,1.14491749414469e-16,0.160398474409364,0.0995587257194313,1.38777878078145e-17,-0.354704350946278,2.40080459770117,-3.07138435246076
493,"Ala","Glu","p.Ala493Glu",0.0633161327733609,1.73472347597681e-18,0.0907566112863696,0.0287307940598137,7.68612604118424e-15,-0.0473163439602526,4.25425287356324,-2.55299897237285
493,"Ala","Gly","p.Ala493Gly",0.0488038158829502,0,0.16614913928216,0.0219403278132793,6.08617628972477e-06,-0.115190981245894,1.87942528735636,-3.86249506153067
493,"Ala","His","p.Ala493His",0.0906949105275416,3.46944695195361e-18,0.101951611425451,0.107893564700077,1.38777878078145e-17,-0.218042723650649,5.57873563218394,-3.07138435246076
493,"Ala","Ile","p.Ala493Ile",0.092681125378501,0,0.129939489652056,0.0537212174799696,0,-0.261762666315688,6.19655172413794,-3.11379213444884
493,"Ala","Leu","p.Ala493Leu",0.0866597975054849,0,0.122423184693485,0.0270803546442286,8.31901255724997e-07,-0.157540936687297,5.67816091954027,-2.6589192467312
493,"Ala","Lys","p.Ala493Lys",0.0345906780511724,2.70551097839424e-93,0.0407003672099618,0.0506865812597417,1.21430643318376e-17,-0.486233242768288,7.21310344827588,-3.86249506153067
493,"Ala","Met","p.Ala493Met",0.0571664334653575,0,0.126756191117435,0.0296992938260395,5.69880004459341e-10,-0.383354522361831,3.04701149425293,-3.11379213444884
493,"Ala","Phe","p.Ala493Phe",0.0345051462301734,8.08235210697642e-17,0.338982331999433,0.0980955871125736,0,-0.288584490227327,7.42735632183912,-3.86249506153067
493,"Ala","Pro","p.Ala493Pro",0.0341643006771626,4.11130495555992e-25,0.145673593826963,0.0582550573163467,3.46944695195361e-18,-0.326728482979079,4.62126436781611,-2.61986519504047
493,"Ala","Ser","p.Ala493Ser",0.0327238190860393,2.48119131792878e-14,0.101593044948615,0.0679067185906902,3.46944695195361e-18,-0.149382893970616,1.59781609195406,-1.21055268834871
493,"Ala","Thr","p.Ala493Thr",0.0474518504549559,2.16840434497101e-18,0.0462007028277325,0.108789805637895,4.16333634234434e-17,-0.294240183282565,2.47977011494256,-1.73734462799174
493,"Ala","Trp","p.Ala493Trp",0.0513161663401201,8.76902717106276e-16,0.437979843213218,0.0677472054233216,1.04083408558608e-17,-0.365076356472303,8.23793103448279,-3.86249506153067
493,"Ala","Tyr","p.Ala493Tyr",0.0347904066955905,1.37118868760864e-31,0.259295164424239,0.0463332713869975,6.93889390390723e-18,-0.247850462120863,7.44517241379315,-3.86249506153067
493,"Ala","Val","p.Ala493Val",0.0251837454538669,1.1004286342642e-11,0.00556835580426992,0.124731586908139,0,-0.15523493565475,3.6040229885058,-2.5078784890934
494,"Cys","Ala","p.Cys494Ala",0.0785781283699601,0,0.0631382144638244,0.0456498504581627,1.73472347597681e-18,-0.0581294911798558,-0.283333333333246,-0.534637363874675
494,"Cys","Arg","p.Cys494Arg",0.028655161683219,2.25260437704798e-06,-0.00280150274607229,0.0748424158113587,0,-0.113857301410745,-0.730804597701065,-2.10072870226172
494,"Cys","Asn","p.Cys494Asn",0.079323230716455,0,0.0129021063372237,0.0609869386642016,0,0.135996734971317,-1.70563218390796,-1.42283190877144
494,"Cys","Asp","p.Cys494Asp",0.0541366665044413,2.60208521396521e-18,0.0451193126444936,0.0197971752915175,1.30637958660662e-08,-0.0136841984148825,-0.212873563218323,-2.15309694680944
494,"Cys","Gln","p.Cys494Gln",0.08515018444981,0,0.0961276952013197,0.0310895635541315,1.13112210570199e-13,-0.0105205054864918,-0.881954022988428,-2.11569759697226
494,"Cys","Glu","p.Cys494Glu",0.0978951042426773,0,0.014373651045145,0.032718546197404,0,0.045481841595962,-0.292413793103329,-1.8994595088593
494,"Cys","Gly","p.Cys494Gly",0.0587053251798668,0,-0.0386429869316115,0.0889347342843514,0,0.0381300164238137,-1.04195402298843,-3.41696560788576
494,"Cys","His","p.Cys494His",0.0822282504479321,6.93889390390723e-18,0.0356931769061569,0.0505753660307839,1.73472347597681e-18,-0.197266799624128,-0.926206896551645,-2.52601709172313
494,"Cys","Ile","p.Cys494Ile",0.0285019570022184,4.51893548498828e-11,0.12251171136297,0.0270644445229367,3.91545166318424e-07,-0.236462063361316,1.88977011494264,-1.29055321405318
494,"Cys","Leu","p.Cys494Leu",0.0807774476125515,3.46944695195361e-18,0.0952768009618316,0.0561997052166351,3.46944695195361e-18,-0.00637948860029137,-0.8032183908045,-2.28718381761015
494,"Cys","Lys","p.Cys494Lys",0.0729775539713411,3.46944695195361e-18,0.0747092459861904,0.0486500576803345,3.46944695195361e-18,-0.0363600630906284,-0.806321839080393,-2.22517746446146
494,"Cys","Met","p.Cys494Met",0.0679634407232106,3.46944695195361e-18,0.0491833561513815,0.0728442497648453,0,0.0750365352926659,-0.844712643678075,-2.28718381761015
494,"Cys","Phe","p.Cys494Phe",0.0938217273948362,0,-0.00204780153939872,0.104684249230953,1.38777878078145e-17,-0.208557105486893,-0.662758620689559,-2.17268932468699
494,"Cys","Pro","p.Cys494Pro",0.0296993663525555,3.4966515439974e-184,0.108794234987616,0.0479935071109889,0,-0.262308351429925,4.87931034482767,-2.13788846722377
494,"Cys","Ser","p.Cys494Ser",0.067650046395203,1.73472347597681e-18,0.121501978579379,0.0374623692082337,0,-0.0839348338074871,0.00965517241390454,-0.511919886141603
494,"Cys","Thr","p.Cys494Thr",0.088229662004133,3.46944695195361e-18,0.0366106108953818,0.0375579185722848,6.36643515683488e-16,-0.185540572364777,1.11908045977021,-1.33148656300254
494,"Cys","Trp","p.Cys494Trp",0.0549643739150231,0,0.139006922588559,0.0445660546447797,0,-0.14329393289197,-2.2535632183907,-2.88746053469494
494,"Cys","Tyr","p.Cys494Tyr",0.0822234067952473,3.46944695195361e-18,0.0980883047810996,0.0348441907164303,0,-0.0792355879635568,-0.670804597701072,-2.44068674629754
494,"Cys","Val","p.Cys494Val",0.10735464494489,6.93889390390723e-18,0.10252093217384,0.0700674583611061,0,-0.13163913785947,0.270344827586296,-1.28875097942127
495,"Thr","Ala","p.Thr495Ala",0.0442420269882407,0,0.0821111061713674,0.10554485880721,0,-0.0414966968231676,1.33241379310346,-0.393592718507165
495,"Thr","Arg","p.Thr495Arg",0.0254240428062365,2.57973600183395e-13,0.0296119535226391,0.0752568488097635,0,-0.0205262931328247,-0.797586206896508,-1.07443611654984
495,"Thr","Asn","p.Thr495Asn",0.044516390417802,4.77048955893622e-18,0.104048872441291,0.0519836377239647,0,-0.0407377791638756,1.16793103448274,-0.827254240388203
495,"Thr","Asp","p.Thr495Asp",0.0801545520761413,0,0.14397515153542,0.0499462074519372,0,-0.167447954234194,1.46793103448278,-0.994111787745693
495,"Thr","Cys","p.Thr495Cys",0.0775063864002355,0,0.0954209523321812,0.0406687369692903,0,-0.109580055595444,0.916206896551698,-0.165392661864171
495,"Thr","Gln","p.Thr495Gln",0.0752424570931,1.73472347597681e-18,0.047709845903814,0.0368609114863966,0,-0.0928318138266069,0.134137931034525,-0.619439862146344
495,"Thr","Glu","p.Thr495Glu",0.024182996039936,6.21875298342999e-17,0.0360273510892072,0.0804153461481213,1.38777878078145e-17,-0.0818993782195534,0.331724137931031,-1.11567892510335
495,"Thr","Gly","p.Thr495Gly",0.0773794286937662,3.46944695195361e-18,0.0666722310803825,0.0566712907178279,0,-0.22171089338548,2.2441379310345,-1.56726912892993
495,"Thr","His","p.Thr495His",0.0371925039684292,5.39195424420491e-15,0.0944101126040257,0.07375796360301,6.93889390390723e-18,-0.0597584767482628,0.584482758620668,-1.54375877867511
495,"Thr","Ile","p.Thr495Ile",0.0444498512921542,4.77048955893622e-18,0.0104781137844864,0.0481829564435745,0,0.0472643324869123,-0.427931034482754,-1.02950161675457
495,"Thr","Leu","p.Thr495Leu",0.0418965662800963,0,-0.0395897712767622,0.0699527493608159,6.93889390390723e-18,0.089766073778211,-0.379310344827555,-0.56295617575651
495,"Thr","Lys","p.Thr495Lys",0.0727462163321232,1.73472347597681e-18,0.00171391643900464,0.066619509313831,0,-0.117646004798295,0.382413793103422,-0.667077988735154
495,"Thr","Met","p.Thr495Met",0.0868914182351308,0,0.0665605135586462,0.0957133817020921,0,0.0811914202101513,0.447586206896552,-1.24086455422551
495,"Thr","Phe","p.Thr495Phe",0.0944314778224782,0,0.0923738505210591,0.0503231770334385,0,0.03061078484205,0.762068965517254,-2.28404896305599
495,"Thr","Pro","p.Thr495Pro",0.0447001067409929,7.48099499014998e-15,0.0699881473926403,0.0716087893205568,0,-0.582796494680082,5.0003448275862,-1.67251105061012
495,"Thr","Ser","p.Thr495Ser",0.103238843321593,0,0.100520473654116,0.0995217420204476,0,-0.178406477972789,1.71758620689655,-0.265565353315406
495,"Thr","Trp","p.Thr495Trp",0.0382250658321975,8.67361737988404e-19,0.185375050220535,0.0468592637091582,0,-0.263079256463688,-0.253103448275836,-2.28404896305599
495,"Thr","Tyr","p.Thr495Tyr",0.0861177254227607,0,0.206601290291583,0.0793036379012241,0,-0.275788487913328,0.837931034482781,-2.28404896305599
495,"Thr","Val","p.Thr495Val",0.0836374338819227,3.46944695195361e-18,0.00156830164131597,0.101562658998796,0,0.0710838341050626,-0.444482758620685,-0.635661914069669
496,"Pro","Ala","p.Pro496Ala",0.0654993186658691,1.73472347597681e-18,0.0551670594695487,0.0298690288752206,2.82022669106929e-15,-0.217295787350044,0.0358620689655317,-1.65299695465329
496,"Pro","Arg","p.Pro496Arg",0.0801704197117574,3.46944695195361e-18,0.0228571824575893,0.0576396266390282,0,-0.46040345296241,-0.0468965517241266,-1.71801781797159
496,"Pro","Asn","p.Pro496Asn",0.0498794974179539,0,0.13555868452692,0.0785994311635435,0,-0.136597766611909,0.107241379310318,-1.38314702575826
496,"Pro","Asp","p.Pro496Asp",0.0390030260792245,0,0.104968890202653,0.0764012430004179,0,-0.0845385947890771,0.176206896551713,-1.42389202753508
496,"Pro","Cys","p.Pro496Cys",0.0703007406257908,0,0.269579802323854,0.0659083258435711,0,-0.158802038647663,0.455862068965479,-2.70224829454762
496,"Pro","Gln","p.Pro496Gln",0.0674070905831978,5.20417042793042e-18,-0.000537007836779118,0.0683656958767421,0,-0.160204133401305,0.200344827586174,-1.52442004883172
496,"Pro","Glu","p.Pro496Glu",0.0690350810408216,5.20417042793042e-18,0.0897454565449539,0.0423812734916251,3.46944695195361e-18,0.0693200321449606,-0.461724137931093,-1.40329890908298
496,"Pro","Gly","p.Pro496Gly",0.0386227452630447,4.33680868994202e-19,0.100131956520548,0.0824693214627349,0,-0.361135168161581,0.688965517241396,-2.3521723571737
496,"Pro","His","p.Pro496His",0.0903425676033514,0,0.18188850252423,0.0705982601796051,0,-0.287071465004329,-0.436206896551759,-1.62689659305726
496,"Pro","Ile","p.Pro496Ile",0.04168097778977,3.03576608295941e-18,0.177329343342133,0.115124265772205,0,0.0228716379281787,-0.319310344827641,-3.25263791331923
496,"Pro","Leu","p.Pro496Leu",0.0496011129954429,0,0.133733381337088,0.0726879769146968,0,-0.164814554079634,-0.649655172413798,-1.96709699897186
496,"Pro","Lys","p.Pro496Lys",0.0578885887244545,1.73472347597681e-18,0.129994999167039,0.0511891172807021,1.19574489199081e-14,-0.927609300342501,-0.161379310344853,-1.75987870319477
496,"Pro","Met","p.Pro496Met",0.087956135232574,3.46944695195361e-18,0.113223602530449,0.0840693585250681,1.38777878078145e-17,-0.20180991641194,-0.35862068965516,-3.25263791331923
496,"Pro","Phe","p.Pro496Phe",0.0434244086218871,0,0.145585094603558,0.0652931645863371,1.04083408558608e-17,-0.0698547001006112,-0.810919540229892,-2.40143894463287
496,"Pro","Ser","p.Pro496Ser",0.0453090015785433,0,0.090601503104307,0.0428004482152577,5.20417042793042e-18,-0.235125441003787,-0.00413793103454172,-1.5968456119095
496,"Pro","Thr","p.Pro496Thr",0.0723811906650254,1.73472347597681e-18,0.0590330439945016,0.044753487260985,0,-0.137752396324436,-0.242758620689638,-1.24613421813446
496,"Pro","Trp","p.Pro496Trp",0.0794794230009206,0,0.257150216582415,0.0337631562660436,0,-0.202302289201585,-0.916666666666682,-3.19477745564607
496,"Pro","Tyr","p.Pro496Tyr",0.0750717275707764,3.46944695195361e-18,0.141534289577166,0.0554909800608068,0,-0.332391987113362,-0.774482758620722,-2.26205109184008
496,"Pro","Val","p.Pro496Val",0.0694356133086956,0,0.120819234431514,0.064001518408264,6.93889390390723e-18,-0.0759368216586467,-0.36551724137937,-2.57207978948119
497,"Arg","Ala","p.Arg497Ala",0.0822581073319605,0,0.124887825952097,0.029389889483995,4.33680868994202e-19,-0.141398449634816,1.44724137931039,-1.47517945368921
497,"Arg","Asn","p.Arg497Asn",0.048792147516976,0,0.101769678027718,0.0223831129352748,5.74500374978238e-31,-0.120740703555518,1.74310344827588,-1.03865193734344
497,"Arg","Asp","p.Arg497Asp",0.0624771232656842,1.73472347597681e-18,0.241181150213418,0.0444185607645877,0,-0.19395293318315,2.9020689655173,-1.23383444027296
497,"Arg","Cys","p.Arg497Cys",0.0262034901482756,2.18110843608669e-07,0.228258962096544,0.0857438518215664,0,-0.212248458548483,1.53068965517244,-2.01515055826512
497,"Arg","Gln","p.Arg497Gln",0.0358853248632545,6.44252446529991e-14,0.160273675673245,0.0491959423653829,6.93889390390723e-18,-0.175855206711925,1.14758620689654,-0.950727604199666
497,"Arg","Glu","p.Arg497Glu",0.0698991712670504,0,0.14024701408065,0.0305034653017446,1.30104260698261e-18,-0.0620952807906608,2.44206896551728,-1.0396081995082
497,"Arg","Gly","p.Arg497Gly",0.0201064626728072,3.20759404456118e-09,0.0446695325958123,0.0533912757777924,3.46944695195361e-18,-0.190142343184231,2.8548275862069,-1.43432543787371
497,"Arg","His","p.Arg497His",0.100155969217567,0,0.139672532298509,0.0511817936469471,5.20417042793042e-18,-0.148579716434637,0.682758620689662,-1.26501907046522
497,"Arg","Ile","p.Arg497Ile",0.0709125753705475,1.73472347597681e-18,0.225115839696068,0.095416810617357,2.77555756156289e-17,-0.0663994196549093,0.0637931034483355,-1.2936635161808
497,"Arg","Leu","p.Arg497Leu",0.068825614552581,0,0.279995737371636,0.0500025246967809,1.73472347597681e-18,0.0125024650731365,0.10655172413792,-1.42760206300005
497,"Arg","Lys","p.Arg497Lys",0.0321333146488332,3.09905974047071e-08,0.0811387797216243,0.0446158450318112,1.73472347597681e-18,-0.23703999456176,0.551724137931082,-0.1816743716833
497,"Arg","Met","p.Arg497Met",0.0781868925429902,0,0.237671743057317,0.033847570265361,1.73472347597681e-18,-0.0351999891263904,0.558965517241412,-2.01515055826512
497,"Arg","Phe","p.Arg497Phe",0.0633691183719855,0,0.206440277323128,0.0661670476566203,0,-0.012395803182573,0.458965517241424,-1.1631228321375
497,"Arg","Pro","p.Arg497Pro",0.0770381905108217,3.46944695195361e-18,0.205000600143239,0.0456105585254807,5.20417042793042e-18,-0.123853094895279,6.42620689655171,-1.3709706833632
497,"Arg","Ser","p.Arg497Ser",0.0741518496433881,0,0.145997453987147,0.0557599366202808,3.46944695195361e-18,-0.0940656919678713,2.17620689655178,-1.36741767799261
497,"Arg","Thr","p.Arg497Thr",0.0714773563045142,0,0.198226561934808,0.0454210312194381,0,-0.0812088173185762,1.41103448275865,-1.2608333510618
497,"Arg","Trp","p.Arg497Trp",0.0211145838225926,4.96399869198218e-08,0.440777125550701,0.0458775602588372,0,0.0248929952468424,-0.570689655172404,-1.98777262827144
497,"Arg","Tyr","p.Arg497Tyr",0.0653459344062996,0,0.23214075409928,0.0775978842958282,0,-0.0819596956773402,0.213448275862118,-1.98777262827144
497,"Arg","Val","p.Arg497Val",0.0365057783623497,6.04076250826369e-14,0.188081714786212,0.0789697032722007,0,0.00202470461778376,0.149655172413782,-1.33799697915009
498,"Arg","Ala","p.Arg498Ala",0.065424656468221,0,0.0487438646565583,0.0390576951641431,8.67361737988404e-19,0.136331195673907,1.39965517241378,-2.82437477716373
498,"Arg","Asn","p.Arg498Asn",0.0563643628406968,0,0.0268467074256525,0.0258290458565956,1.03267873852869e-11,0.00883569201681367,0.993103448275821,-3.01069848836202
498,"Arg","Asp","p.Arg498Asp",0.0871390964070233,6.93889390390723e-18,0.201087154940691,0.0284692493786996,0,-0.031075844831429,0.901724137931038,-2.52108548470948
498,"Arg","Cys","p.Arg498Cys",0.0235478163733723,4.67345849871997e-31,0.0725639716942955,0.060055581590151,0,0.087027293081927,1.80620689655174,-3.41811885561459
498,"Arg","Gln","p.Arg498Gln",0.101519587436394,6.93889390390723e-18,0.141706678722911,0.0261199225423731,2.40174307578967e-06,0.031148700202983,0.826896551724107,-1.81424672741944
498,"Arg","Glu","p.Arg498Glu",0.0440874888149339,0,0.0627097996448335,0.0232513420942407,3.0967286933207e-08,0.0344579093190497,0.694137931034455,-2.28339109745742
498,"Arg","Gly","p.Arg498Gly",0.0514251775787657,8.67361737988404e-19,0.0632108489372483,0.0399691169187773,0,0.000419968583341906,2.2434482758621,-2.85227221430647
498,"Arg","His","p.Arg498His",0.0421027424770149,0,0.132925797717656,0.030599245458814,1.30104260698261e-18,0.199657893029596,0.585862068965541,-2.4013530043441
498,"Arg","Ile","p.Arg498Ile",0.0494608978393448,0,0.178523373993135,0.108856845013834,2.77555756156289e-17,0.126531885244809,0.531379310344807,-2.71567832062249
498,"Arg","Leu","p.Arg498Leu",0.0319090125801328,2.92821322744885e-15,0.104229346740541,0.0576739222310935,0,0.0557321941871576,0.139310344827585,-2.44477643641649
498,"Arg","Lys","p.Arg498Lys",0.0713142731485973,1.73472347597681e-18,0.00301969155709166,0.0694155898430481,0,-0.0875117166334349,0.488620689655144,-0.893919309745187
498,"Arg","Met","p.Arg498Met",0.103338694628916,1.04083408558608e-17,0.203470091046227,0.105719831572135,2.77555756156289e-17,-0.017854728964023,0.779655172413782,-2.38805954825159
498,"Arg","Phe","p.Arg498Phe",0.0484430265457125,1.73472347597681e-18,0.172601807496278,0.0787542703919155,1.38777878078145e-17,0.058150113223077,0.0475862068965241,-2.21959124299739
498,"Arg","Pro","p.Arg498Pro",0.0642696120343388,3.46944695195361e-18,0.0827564342333998,0.0683890822653377,0,-0.301108740113961,3.03724137931034,-2.79756823581383
498,"Arg","Ser","p.Arg498Ser",0.0276868226566797,2.29165679904705e-98,0.0960728896913784,0.103407139024327,0,0.10371262021989,1.26517241379306,-3.41811885561459
498,"Arg","Thr","p.Arg498Thr",0.0466040509536462,8.67361737988404e-19,0.142959161008589,0.0879545683067281,0,0.166743895926302,0.525172413793073,-2.7313311776254
498,"Arg","Trp","p.Arg498Trp",0.0554366314969076,0,0.248680959551655,0.0442281500075246,1.73472347597681e-18,0.0171899883249158,-0.75586206896552,-2.13828321759674
498,"Arg","Tyr","p.Arg498Tyr",0.0398687902878317,1.12757025938492e-16,0.197390498657963,0.10473400944336,1.38777878078145e-17,0.0290162794785151,-0.00137931034487337,-2.15671453820524
498,"Arg","Val","p.Arg498Val",0.0257362370358997,6.25819265229443e-24,0.0773343398849378,0.0855184400418079,6.93889390390723e-18,0.0995827219169564,0.492413793103408,-2.62362724187221
499,"Arg","Ala","p.Arg499Ala",0.0562853856103426,0,0.0962838271699007,0.0964218085485387,0,-0.303476012994879,2.22632183908037,-2.02792919224638
499,"Arg","Asn","p.Arg499Asn",0.0763436895879044,0,0.0763551622190901,0.0609970199882654,3.46944695195361e-18,-0.189195383238304,2.37896551724126,-1.74169810920961
499,"Arg","Asp","p.Arg499Asp",0.104707268731645,0,0.202192841699201,0.03557544966727,8.67361737988404e-19,-0.235497729848129,2.14459770114931,-1.90293100362418
499,"Arg","Cys","p.Arg499Cys",0.0379633362108571,4.33680868994202e-18,0.225637101133399,0.0629480967340513,0,-0.222026045444528,2.25988505747117,-2.72352813047673
499,"Arg","Gln","p.Arg499Gln",0.0601825391175505,0,0.130457560948661,0.100288877175041,0,-0.2206294336237,1.75172413793093,-1.92769860303183
499,"Arg","Glu","p.Arg499Glu",0.0458880073682038,8.67361737988404e-19,0.18020924480823,0.0983497077106363,4.16333634234434e-17,-0.286853023466533,2.45701149425277,-1.71619082520958
499,"Arg","Gly","p.Arg499Gly",0.0210142454381088,1.66822291428698e-17,0.0610120059230555,0.0259825321602133,6.59890978665922e-14,-0.296323285264754,3.17137931034476,-2.88679451555098
499,"Arg","His","p.Arg499His",0.0693604072780282,1.73472347597681e-18,0.194440663194771,0.0465404812947914,1.73472347597681e-18,-0.130306238904205,2.14862068965504,-1.57956938674958
499,"Arg","Ile","p.Arg499Ile",0.0498811089579732,0,0.206405974970935,0.0872574818647243,6.93889390390723e-18,-0.134464900259388,1.59701149425274,-1.84570695893966
499,"Arg","Leu","p.Arg499Leu",0.0664262114732602,0,0.339882071597476,0.0212400087283432,3.37554861696072e-45,-0.271834386016654,1.37114942528724,-2.13714582425579
499,"Arg","Lys","p.Arg499Lys",0.0932340960110901,0,0.0391126252453584,0.0737072830690483,0,-0.221803968721628,2.40999999999991,-1.23118459461024
499,"Arg","Met","p.Arg499Met",0.0532018486635329,0,0.180811550445807,0.062764172452967,1.38777878078145e-17,-0.324241674333063,1.72287356321832,-2.78306367399712
499,"Arg","Phe","p.Arg499Phe",0.092058016987942,0,0.411812070262694,0.0263775812802605,1.82694571276842e-14,-0.212122154892146,1.6160919540229,-3.16422146970975
499,"Arg","Pro","p.Arg499Pro",0.0607308272125316,1.73472347597681e-18,0.124306355714918,0.112939168105321,1.38777878078145e-17,-0.337648206647654,7.05482758620679,-2.82559474519948
499,"Arg","Ser","p.Arg499Ser",0.0823662143186099,0,0.141544475571988,0.0315546702014962,0,-0.0998037322056055,2.60080459770104,-1.92556399345109
499,"Arg","Thr","p.Arg499Thr",0.0798410724978818,6.93889390390723e-18,0.066851431331801,0.0477366999297925,0,-0.231454847490724,1.73367816091945,-1.93865159932456
499,"Arg","Trp","p.Arg499Trp",0.0734268120118256,3.46944695195361e-18,0.357037936936256,0.0737828246191256,0,-0.0825344460758159,0.817586206896428,-3.7950475088157
499,"Arg","Tyr","p.Arg499Tyr",0.0511138694359711,0,0.397137899130587,0.0670661100650037,0,-0.195243323833632,1.33080459770107,-3.7950475088157
499,"Arg","Val","p.Arg499Val",0.0464752073603398,1.73472347597681e-18,0.208783309222313,0.0604321583172274,0,-0.177081562352838,1.715172413793,-1.57726960536837
500,"Ile","Ala","p.Ile500Ala",0.0675977067089601,0,-0.0263345610774916,0.0866340073037815,1.38777878078145e-17,-0.0333102497323336,0.367241379310364,-0.344277144552945
500,"Ile","Arg","p.Ile500Arg",0.0486808736775576,0,0.0685353293585248,0.0591076624971775,0,-0.197526628678793,-0.245862068965505,-1.60966201613485
500,"Ile","Asn","p.Ile500Asn",0.0315961912238198,1.0360419119837e-14,-0.00269297629330322,0.0249154667278681,1.76161168985445e-15,-0.0592698761330439,0.284137931034507,-0.992069711828108
500,"Ile","Asp","p.Ile500Asp",0.0644171411091487,1.73472347597681e-18,0.0587270247874379,0.0436701580202026,0,-0.048283744049618,-0.0699999999999912,-0.693500547330667
500,"Ile","Cys","p.Ile500Cys",0.066218230905946,0,0.0394234230288773,0.0341007684868672,0,0.0092002659896169,1.05068965517242,-1.2001379741532
500,"Ile","Gln","p.Ile500Gln",0.0626116178135933,1.73472347597681e-18,0.0416622306864902,0.0241045870070695,3.63547129683325e-09,-0.19973809689508,0.146206896551717,-0.555556006648448
500,"Ile","Glu","p.Ile500Glu",0.0245385701174366,3.87133416787007e-06,-0.0525807425851414,0.0604527645410808,0,0.0586092616638894,-0.142413793103452,-0.568519784706999
500,"Ile","Gly","p.Ile500Gly",0.0546812592222198,8.67361737988404e-19,0.0239616215063994,0.0274461163247649,5.63785129692462e-18,-0.272125737526887,0.517241379310345,-2.36701045599749
500,"Ile","His","p.Ile500His",0.0719418515609578,0,0.00998390600959013,0.0336684228804006,8.67361737988404e-19,-0.0832061171761916,0.0509195402298832,-1.09518519146379
500,"Ile","Leu","p.Ile500Leu",0.0598444223863805,0,0.0175758529977295,0.058819941325177,0,0.0130408618544629,-0.0096551724138,-1.33663539329956
500,"Ile","Lys","p.Ile500Lys",0.0668032379745991,0,-0.00737256263416641,0.119929392964504,0,0.00139373618058809,0.0172413793104076,-1.53309680463689
500,"Ile","Met","p.Ile500Met",0.0468000893530718,0,0.0857330231737592,0.0694914560340058,0,-0.0304263843273265,0.373448275862098,-1.75088877896216
500,"Ile","Phe","p.Ile500Phe",0.0418663878854025,0,0.0849218537631071,0.0318265868821524,0,-0.121822231841269,0.160344827586257,-2.58906227353849
500,"Ile","Pro","p.Ile500Pro",0.0491531268560022,2.60208521396521e-18,-0.00948201754620496,0.0270605612174047,2.60208521396521e-18,-0.0871435142482064,0.157931034482787,-1.09754165556281
500,"Ile","Ser","p.Ile500Ser",0.0606631666265577,3.46944695195361e-18,-0.037387913443176,0.092333818690781,0,0.0322358900645229,-0.00344827586206583,-1.01244231610209
500,"Ile","Thr","p.Ile500Thr",0.0311778391068003,4.42571326808583e-16,-0.00670286556897369,0.0168192204079028,3.32038636658731e-20,0.0403266654658843,0.300689655172438,-1.12205133442598
500,"Ile","Trp","p.Ile500Trp",0.0618843021964837,0,0.245640094437498,0.193176578865248,0,-0.0247669233601607,-0.188620689655155,-2.96393064603326
500,"Ile","Tyr","p.Ile500Tyr",0.0675446047382722,0,0.111071568368464,0.0188119593499781,1.43224221763085e-34,-0.200508846602985,0.170000000000057,-2.96393064603326
500,"Ile","Val","p.Ile500Val",0.0329000956224333,0,-0.0264606972799533,0.0668523754435406,0,-0.0200431719234274,0.112758620689655,-0.37862356622227
501,"Ile","Ala","p.Ile501Ala",0.0275204377053723,7.02189399291384e-11,0.100233527095007,0.0524573420150318,0,-0.271390415961439,3.24862068965511,-1.43077880525039
501,"Ile","Arg","p.Ile501Arg",0.0860970987174552,0,0.196946984199968,0.076139526826414,0,-0.618112289625808,4.89137931034473,-3.79764782678741
501,"Ile","Asn","p.Ile501Asn",0.0556986812897009,3.46944695195361e-18,0.154253606897206,0.0901174374387236,0,-0.300590987607373,2.27586206896541,-3.25237026205473
501,"Ile","Asp","p.Ile501Asp",0.0660995585675394,0,0.120588721294235,0.063236985164985,0,-0.580697112148549,2.71275862068956,-2.82641674281832
501,"Ile","Cys","p.Ile501Cys",0.0346329063915204,1.30104260698261e-18,0.180784632867251,0.04990838960275,1.73472347597681e-18,0.0772631917800153,2.7250574712643,-1.14730081894011
501,"Ile","Gln","p.Ile501Gln",0.0627927483725242,0,0.0433880900448925,0.0419447706310904,1.73472347597681e-18,-0.413116239001764,2.17413793103443,-2.78330224026743
501,"Ile","Glu","p.Ile501Glu",0.0320318548543437,2.6768580798156e-10,0.0579253316014433,0.0473586264870911,0,-0.642851959797071,3.85862068965511,-2.79008728652616
501,"Ile","Gly","p.Ile501Gly",0.0528844237411389,0,0.0226514717069244,0.0690479005404195,0,-0.523360148135854,5.16149425287348,-2.79103892294107
501,"Ile","His","p.Ile501His",0.0889083349323067,6.93889390390723e-18,0.000401215301315282,0.0449925281928185,0,-0.0379739504720608,3.63241379310341,-3.25237026205473
501,"Ile","Leu","p.Ile501Leu",0.0883978780862395,3.46944695195361e-18,0.0203999895667059,0.0512288878459317,0,-0.235444696051795,1.51321839080452,-1.05920455300623
501,"Ile","Lys","p.Ile501Lys",0.0583764730592586,0,0.00672636482078422,0.129573951768738,0,-0.470360943711674,4.94137931034472,-3.56253138008348
501,"Ile","Met","p.Ile501Met",0.0757634446017831,0,-0.0314877898515651,0.0371924579621804,0,-0.190454760125711,3.00137931034476,-1.52915253304014
501,"Ile","Phe","p.Ile501Phe",0.053552671259992,0,0.112150979179659,0.0346668938506697,0,-0.184703075325694,3.41471264367807,-1.87358791435228
501,"Ile","Pro","p.Ile501Pro",0.0616581673934918,0,-0.0325122737460824,0.0214870328406208,4.18671250020068e-10,-0.261802034442643,3.5558620689654,-2.89428780581374
501,"Ile","Ser","p.Ile501Ser",0.0650578811485936,0,0.00351895750226347,0.0628868537069145,6.93889390390723e-18,-0.304759891775454,3.71597701149417,-1.39778345057347
501,"Ile","Thr","p.Ile501Thr",0.0304742631613616,4.90276222397945e-16,-0.0963118532856344,0.0180891394278656,1.14599836422899e-20,-0.196323866167739,2.56206896551718,-1.2807748817388
501,"Ile","Trp","p.Ile501Trp",0.060234083491597,3.46944695195361e-18,0.347712535383003,0.0444081264828639,0,-0.507049381146445,2.20965517241368,-2.78269373250731
501,"Ile","Tyr","p.Ile501Tyr",0.0340694742938127,8.5868812060852e-17,0.100340546519735,0.0351490808617014,0,-0.380703192936576,5.27586206896542,-2.41630828325474
501,"Ile","Val","p.Ile501Val",0.0208650897912233,7.55870813227793e-46,0.0838439160021559,0.0720273859888279,0,0.131378879282325,0.725402298850487,-0.237336017956718
502,"Asn","Ala","p.Asn502Ala",0.0645809007896283,5.20417042793042e-18,0.272203389918481,0.0734250917498452,0,-0.211388540087845,1.1448275862069,-2.32588011416895
502,"Asn","Arg","p.Asn502Arg",0.104420668975229,3.46944695195361e-18,0.116816941728391,0.0476318335632196,0,-0.10973626434448,0.0280459770114844,-1.02791618084186
502,"Asn","Asp","p.Asn502Asp",0.0728037472081405,1.73472347597681e-18,-0.0414218125766725,0.0239106933116659,4.33509565050949e-14,0.0294456509919505,0.104137931034503,-1.46670413611567
502,"Asn","Cys","p.Asn502Cys",0.04508206830548,0,0.200161714644583,0.0494366798169874,0,-0.127496879458813,1.10149425287357,-2.98910697555945
502,"Asn","Gln","p.Asn502Gln",0.0647370231027946,3.46944695195361e-18,-0.00538409992747709,0.0779388598995398,0,-0.0596379940649255,0.8911494252874,-0.995257466931607
502,"Asn","Glu","p.Asn502Glu",0.0565658018824121,1.73472347597681e-18,-0.0610694020017777,0.101181101468233,1.38777878078145e-17,-0.0394558290331015,0.57390804597703,-1.36715495473079
502,"Asn","Gly","p.Asn502Gly",0.0591992592364573,0,0.0181278693261809,0.0562894773265157,6.93889390390723e-18,-0.15225676593593,1.39758620689659,-2.09677555622948
502,"Asn","His","p.Asn502His",0.082935660613599,3.46944695195361e-18,0.0939324521680102,0.0606989702369118,0,-0.10109777680336,-0.188965517241354,-1.09990082601429
502,"Asn","Ile","p.Asn502Ile",0.0641626785712382,1.73472347597681e-18,0.313519106610331,0.0281594743082957,1.13295573010014e-11,-0.1311188616498,0.121149425287419,-3.05673714513879
502,"Asn","Leu","p.Asn502Leu",0.0656108067155801,5.20417042793042e-18,0.260563704826504,0.0666054353937802,0,-0.0585182404824787,-0.136206896551692,-2.2553344637362
502,"Asn","Lys","p.Asn502Lys",0.0412993918864308,4.85722573273506e-17,-0.0246528116089993,0.0752966460277752,0,-0.0642399511930827,0.274712643678199,-0.362420263355397
502,"Asn","Met","p.Asn502Met",0.0694067494337816,0,0.264286463293578,0.0517204977625521,1.73472347597681e-18,-0.0839761744186424,0.597816091954052,-2.44586289629042
502,"Asn","Phe","p.Asn502Phe",0.0390265423560087,0,0.418666965737668,0.0394107582988623,8.67361737988404e-19,-0.21920157079234,-0.419885057471267,-2.72432914651776
502,"Asn","Pro","p.Asn502Pro",0.0756243599648476,0,0.106007172586701,0.0769207306933843,0,-0.0806266146594802,1.78126436781613,-3.12255653774896
502,"Asn","Ser","p.Asn502Ser",0.0234354801280347,9.73652613509812e-52,-0.0637577335585786,0.0384708957085648,0,-0.197546825471131,0.521839080459818,-2.09317969578993
502,"Asn","Thr","p.Asn502Thr",0.081584863237892,3.46944695195361e-18,0.00799814832567562,0.0201575261624347,6.6720135054898e-18,0.0602689567900215,-0.101149425287317,-2.14810750299167
502,"Asn","Trp","p.Asn502Trp",0.104111771673702,0,0.552789109040995,0.0461468215905498,0,-0.192073264283409,-1.24218390804593,-3.4040469292734
502,"Asn","Tyr","p.Asn502Tyr",0.106210730998486,6.93889390390723e-18,0.241910836802923,0.0468397050651031,0,-0.245184907616829,-0.21080459770113,-2.69556696442431
502,"Asn","Val","p.Asn502Val",0.0666585331388049,0,0.230032147101937,0.0391804274230396,1.73472347597681e-18,-0.214054293411301,0.088390804597754,-2.60601668937495
503,"Leu","Ala","p.Leu503Ala",0.0600122520838158,1.73472347597681e-18,0.0350011819107118,0.0348650399802352,2.18020046460765e-14,-0.339966729215073,2.82620689655177,-4.41674948285792
503,"Leu","Arg","p.Leu503Arg",0.105607451206738,0,-0.148498990501162,0.0273597385666573,8.13635619625329e-34,-0.374002860343161,2.70000000000005,-5.06100747920529
503,"Leu","Asn","p.Leu503Asn",0.107195048318092,0,-0.113775773945576,0.0472299289075632,0,-0.275575268301736,2.6262068965518,-4.41674948285792
503,"Leu","Asp","p.Leu503Asp",0.0351343211325176,8.90882741492668e-10,0.00873894375673785,0.0424543640152736,3.46944695195361e-18,-0.341355226047779,3.2283908045978,-4.07851841419104
503,"Leu","Cys","p.Leu503Cys",0.0449771126247538,6.86083134748827e-16,0.00928411076018007,0.108306312864123,0,-0.373227047756233,2.9220689655173,-4.41674948285792
503,"Leu","Gln","p.Leu503Gln",0.0698589380096592,0,0.00890144689428653,0.134998978942429,4.16333634234434e-17,-0.399580884326493,2.27597701149435,-3.91050269351467
503,"Leu","Glu","p.Leu503Glu",0.106405526127092,0,-0.0482651484791019,0.0296338412122014,2.57755934651716e-10,-0.282402843403345,2.97655172413803,-4.41674948285792
503,"Leu","Gly","p.Leu503Gly",0.0461825796410261,0,0.0801397655892162,0.0435751854878181,1.82145964977565e-17,-0.640904499244326,5.0633333333334,-5.06100747920529
503,"Leu","His","p.Leu503His",0.0794642829312566,3.46944695195361e-18,-0.0473915451285892,0.0484801283255005,5.16947595841089e-16,-0.389210024160891,1.18517241379315,-4.41674948285792
503,"Leu","Ile","p.Leu503Ile",0.0707642052208766,0,-0.134169749511383,0.115596886250028,2.77555756156289e-17,-0.16817565659142,0.917241379310452,-1.78324358153987
503,"Leu","Lys","p.Leu503Lys",0.0427171633217239,1.0230711243453e-11,-0.119385668318444,0.0911775987411919,0,-0.285127765689527,3.30137931034493,-5.06100747920529
503,"Leu","Met","p.Leu503Met",0.113833574553978,0,-0.103133229541035,0.0898872916269756,1.38777878078145e-17,-0.296223765068624,2.23758620689664,-2.06941827453023
503,"Leu","Phe","p.Leu503Phe",0.0653488084673905,5.20417042793042e-18,0.204027727822338,0.0332586928831276,0,-0.00956802436605133,0.139770114942621,-2.44566394026361
503,"Leu","Pro","p.Leu503Pro",0.0804062990102484,6.93889390390723e-18,0.0190882721484315,0.0637451457271545,0,-0.496108628414075,5.64896551724148,-3.94432512727913
503,"Leu","Ser","p.Leu503Ser",0.0284759991149905,1.07258746665813e-09,-0.082836612988447,0.0504355620232483,0,-0.188719266975663,3.60068965517249,-4.41674948285792
503,"Leu","Thr","p.Leu503Thr",0.0357872605510607,2.11031357325322e-14,-0.0315657862988542,0.0730136259630745,0,-0.528535671163738,3.84172413793111,-3.88937990514387
503,"Leu","Trp","p.Leu503Trp",0.0273628298404241,1.70246454279949e-30,0.114336270883152,0.0689977903026671,0,-0.294924466871844,0.0726436781609789,-3.51979339424076
503,"Leu","Tyr","p.Leu503Tyr",0.0368448129140356,8.67361737988404e-19,0.555801943292356,0.119862326497278,0,-0.0789943504991363,0.402068965517299,-2.79597509400633
503,"Leu","Val","p.Leu503Val",0.0620673342767217,1.73472347597681e-18,-0.0585097761079983,0.0255763637252038,1.32716395667561e-08,-0.440399591166799,1.95954022988514,-2.0183958369257
504,"Thr","Ala","p.Thr504Ala",0.0576584382419596,1.73472347597681e-18,-0.000413748247236678,0.0353389399959471,1.04083408558608e-17,-0.133681687405737,-0.476896551724151,-1.26962283014783
504,"Thr","Arg","p.Thr504Arg",0.0885979198660303,0,0.0428158361597487,0.0500263896434335,5.20417042793042e-18,-0.00727041871652091,-0.352183908045986,-1.83672357686545
504,"Thr","Asn","p.Thr504Asn",0.0797452182567613,3.46944695195361e-18,0.0243845615023692,0.134866503690941,0,-0.0950520893762869,-0.342183908045987,-1.22158773935706
504,"Thr","Asp","p.Thr504Asp",0.0408199118450553,3.39353978945356e-13,-0.0127407854092979,0.0565091719295398,6.93889390390723e-18,0.0133163267910333,-0.703448275862056,-2.05081903609944
504,"Thr","Cys","p.Thr504Cys",0.0776232555176562,1.73472347597681e-18,0.111210354898086,0.0255497705854618,1.02972965786782e-11,-0.247285764847581,0.479080459770103,-2.16056299104925
504,"Thr","Gln","p.Thr504Gln",0.0513565036482929,3.72965547335014e-17,-0.0415151323682022,0.139205942432712,0,-0.209279442280638,0.0725287356321937,-1.94141530787848
504,"Thr","Glu","p.Thr504Glu",0.0364978304446156,3.25601629869437e-06,-0.0279548807556977,0.0302010419755039,4.32497180647209e-10,0.0205981843551126,-0.814827586206916,-1.99501927319847
504,"Thr","Gly","p.Thr504Gly",0.0932377045301938,3.46944695195361e-18,0.0462844676886163,0.0646160226809086,1.04083408558608e-17,-0.126104457237357,0.357011494252873,-2.93946767797355
504,"Thr","His","p.Thr504His",0.0688460651698302,0,0.111973453871994,0.0725586091795616,0,-0.00118706035346519,-0.332758620689627,-2.71092280267601
504,"Thr","Ile","p.Thr504Ile",0.0601859782461163,0,0.360842112331437,0.0251964549912087,3.17226809321264e-07,-0.0807505855022973,-0.624482758620689,-2.09935771773522
504,"Thr","Leu","p.Thr504Leu",0.0535996869706569,0,0.230183562916393,0.108784886475571,0,-0.142486089730708,-0.895862068965502,-2.01155542451787
504,"Thr","Lys","p.Thr504Lys",0.0560963890850241,0,-0.0260989907309454,0.179345809788257,2.77555756156289e-17,-0.178021900425808,-0.555172413793095,-1.80395266920917
504,"Thr","Met","p.Thr504Met",0.0308990464054477,5.46214565861672e-27,0.13394812987029,0.0252452315739656,9.34991394787464e-11,-0.147892775549895,-0.581609195402267,-2.1141132241753
504,"Thr","Phe","p.Thr504Phe",0.0805842045298392,3.46944695195361e-18,0.433750518044435,0.0434236139230864,0,0.00648049122520425,-0.829655172413802,-3.95259335461262
504,"Thr","Pro","p.Thr504Pro",0.0338342213207353,5.90878492180427e-18,-0.0770655827021142,0.208575911332129,0,-0.161888347072456,5.03988505747126,-3.35809025380609
504,"Thr","Ser","p.Thr504Ser",0.0663778821401071,1.73472347597681e-18,0.0045112389642119,0.0663908818053436,6.93889390390723e-18,-0.0813044859134129,-0.364367816091962,-0.379901304880468
504,"Thr","Trp","p.Thr504Trp",0.081589014373305,6.93889390390723e-18,0.52712664366166,0.0313663399901341,4.38017677684144e-17,0.0117226530356452,-0.91712643678164,-3.95259335461262
504,"Thr","Tyr","p.Thr504Tyr",0.0735858324243479,0,0.450454716799338,0.0287393835498244,7.9872175238533e-06,-0.192900419510352,-0.648735632183935,-3.95259335461262
504,"Thr","Val","p.Thr504Val",0.0991658848556902,0,0.0959788650215098,0.0683134881792841,3.46944695195361e-18,-0.258303520772264,-0.134827586206923,-2.32924690472746
505,"Ser","Ala","p.Ser505Ala",0.0740054406882777,3.46944695195361e-18,-0.00177183082832665,0.030506195627664,9.02828880666362e-10,-0.205858086768306,-0.942413793103587,-1.84183318257902
505,"Ser","Arg","p.Ser505Arg",0.0738511944698965,1.73472347597681e-18,0.362448709491092,0.0616716906927184,3.38271077815477e-16,-0.855851141183958,0.295172413793023,-4.07780146571565
505,"Ser","Asn","p.Ser505Asn",0.0830245802726318,0,-0.00732175306991114,0.0778898139413258,0,-0.428715637914537,0.173103448275767,-5.16978275301313
505,"Ser","Asp","p.Ser505Asp",0.0302660568903905,1.34619097971726e-06,0.145820080812296,0.0689404962421413,0,-0.696748090402742,1.15068965517233,-5.16978275301313
505,"Ser","Cys","p.Ser505Cys",0.0358914273025952,1.82971968739482e-11,-0.0240501627312025,0.0701104687795322,0,-0.390618357423783,0.440574712643583,-2.40098622228498
505,"Ser","Gln","p.Ser505Gln",0.0540148260939209,8.67361737988404e-18,-0.0231685345014996,0.08753946793356,0,-0.687062643952814,0.52137931034473,-5.16978275301313
505,"Ser","Glu","p.Ser505Glu",0.0662861133225886,0,-0.00515376760137428,0.0871692728205863,0,-0.602851317539943,0.646551724137853,-5.16978275301313
505,"Ser","Gly","p.Ser505Gly",0.0937568158578954,3.46944695195361e-18,0.0154080843166482,0.0944828704503936,0,-0.30683617962579,0.706551724137845,-4.0004288867389
505,"Ser","His","p.Ser505His",0.0679139048910086,0,0.149457435412966,0.101118030149035,1.38777878078145e-17,-0.455599213886386,0.0603448275861128,-5.16978275301313
505,"Ser","Ile","p.Ser505Ile",0.0895701363942685,0,0.479044226016118,0.0412972985286718,2.87286817853697e-27,-1.00377339969893,1.945172413793,-4.63109467656012
505,"Ser","Leu","p.Ser505Leu",0.0399099673456786,5.27666797625961e-10,0.389222691994904,0.0419575674566491,9.9588274833795e-08,-0.89554418817236,-0.267241379310428,-4.63109467656012
505,"Ser","Lys","p.Ser505Lys",0.0751607781511255,0,0.234137453034872,0.146420024756395,0,-0.584357373076381,0.419310344827471,-4.77577773830725
505,"Ser","Met","p.Ser505Met",0.0525274822523647,0,0.313759698838319,0.0523295738787116,9.93576566507559e-11,-0.834991768182231,0.0747126436780668,-4.63109467656012
505,"Ser","Phe","p.Ser505Phe",0.0659287289356328,0,0.112430060739581,0.0480909857744963,4.24006824163679e-06,-0.93300649531149,-0.340344827586339,-4.87137640093909
505,"Ser","Pro","p.Ser505Pro",0.061237075417631,1.73472347597681e-18,-0.0980708679255863,0.0386718824450778,2.02095284951298e-16,-0.389850251269003,1.6987356321838,-4.66896270403935
505,"Ser","Thr","p.Ser505Thr",0.0538747659958282,8.79246328522321e-13,-0.0389384299739992,0.0850452886678466,6.93889390390723e-18,-0.124220960280587,0.160574712643592,-1.93265619484816
505,"Ser","Trp","p.Ser505Trp",0.0409159944171984,2.46505542974423e-10,0.220116606388731,0.0507723065388526,7.97972798949331e-16,-0.733326572408894,0.425977011494137,-5.16978275301313
505,"Ser","Tyr","p.Ser505Tyr",0.100111487343512,0,0.18907631919669,0.0986251341969029,0,-0.690478966030858,0.482068965517132,-5.16978275301313
505,"Ser","Val","p.Ser505Val",0.114856700063314,6.93889390390723e-18,0.133892601577218,0.0617138624826969,0,-0.801159958963958,0.18781609195392,-3.83506006102983
506,"Val","Ala","p.Val506Ala",0.0293807379146267,6.76571780703668e-06,0.132281369622562,0.0272068281563278,1.07336483350017e-18,-0.407805913734526,2.62160919540227,-3.10656698405247
506,"Val","Arg","p.Val506Arg",0.0376072661225076,5.66961598227973e-09,0.0076307819637305,0.107245880740775,1.38777878078145e-17,-0.793187108906961,7.3626436781609,-2.86856704861293
506,"Val","Asn","p.Val506Asn",0.0312762680514531,1.57983829515451e-69,0.0139378136955744,0.0440044531939403,1.2106175437121e-12,-0.67020967608932,3.3686206896552,-3.66457642966157
506,"Val","Asp","p.Val506Asp",0.0566659212309528,0,0.559682903330235,0.0379883959276978,9.81621297305358e-14,-0.924358447287979,4.96931034482758,-3.66457642966157
506,"Val","Cys","p.Val506Cys",0.0406973338737968,4.69524865493419e-09,0.130881027141719,0.0867924881415544,0,-0.665780891279831,3.19482758620688,-3.5535574151884
506,"Val","Gln","p.Val506Gln",0.0774409078102738,0,0.179069543354687,0.071903347484807,8.06908667192602e-08,-1.06336961245115,4.16436781609196,-3.41501300676565
506,"Val","Glu","p.Val506Glu",0.0679047199584071,0,0.545705098079727,0.0469359833756408,3.06173797236513e-17,-1.02145279265464,5.01839080459768,-3.66457642966157
506,"Val","Gly","p.Val506Gly",0.0830413661649649,0,0.444335324725689,0.0587689404949549,3.46944695195361e-18,-0.93131768781936,5.09781609195401,-4.1956104688692
506,"Val","His","p.Val506His",0.071235297664172,0,0.166962073291847,0.0634126817033578,1.22065552110584e-13,-0.796641146512511,5.42655172413793,-3.66457642966157
506,"Val","Ile","p.Val506Ile",0.0341775405415829,1.01010316753219e-14,-0.0476250227674813,0.156726975974786,2.77555756156289e-17,0.153878331984979,0.811494252873583,-0.370163576827725
506,"Val","Leu","p.Val506Leu",0.0293261679747986,1.65482947319019e-06,-0.0301734708586934,0.0459504060772973,0,-0.182207653368355,2.01195402298849,-1.22530842527502
506,"Val","Lys","p.Val506Lys",0.0958014321664121,0,0.0517726318414021,0.161358511140806,0,-0.924992862916027,7.59333333333332,-3.5535574151884
506,"Val","Met","p.Val506Met",0.0986269793656415,0,0.0410021349903705,0.0369180585588102,2.64492526157699e-08,-0.275031869875502,2.50597701149427,-1.50590022616555
506,"Val","Phe","p.Val506Phe",0.0495528531222242,8.67361737988404e-19,0.50782852941653,0.0538439636371045,0,-0.846350523506057,5.34275862068965,-3.96690655664345
506,"Val","Pro","p.Val506Pro",0.0938495369941462,3.46944695195361e-18,0.266538250388507,0.177014873798504,2.77555756156289e-17,-0.759846563960317,6.15620689655175,-4.1956104688692
506,"Val","Ser","p.Val506Ser",0.143979511025878,0,0.334471326933684,0.046081172259222,7.52668578070328e-78,-0.937704118191558,3.84620689655175,-3.5535574151884
506,"Val","Thr","p.Val506Thr",0.0629723705876795,0,0.0905758664688241,0.0973619021226534,0,-0.570413977244947,2.46114942528736,-3.11886945074486
506,"Val","Trp","p.Val506Trp",0.0721375995860767,3.46944695195361e-18,0.222107289469415,0.0980365505244923,6.93889390390723e-18,-0.681058468600004,5.55586206896549,-3.96690655664345
506,"Val","Tyr","p.Val506Tyr",0.0709594353499573,0,0.446472181806421,0.0731304619837679,4.16333634234434e-17,-1.02794822889586,8.05643678160921,-3.96690655664345
507,"Leu","Ala","p.Leu507Ala",0.0893379502362082,8.50014503228635e-17,-0.037073184431047,0.184448011048597,5.55111512312578e-17,-0.402802764116884,1.62873563218394,-2.27865443074414
507,"Leu","Arg","p.Leu507Arg",0.11400976292162,0,-0.152310556532609,0.180093389062394,0,-0.143177823870687,0.353908045977032,-0.730517634107305
507,"Leu","Asn","p.Leu507Asn",0.0668942248759574,3.51900828510976e-13,-0.161938670521404,0.05114018264148,2.42852758827893e-15,-0.157492161126576,1.80816091954026,-1.49363929803639
507,"Leu","Asp","p.Leu507Asp",0.127662719581474,0,-0.0648145006655971,0.0981757546066967,2.08166817117217e-17,-0.541384401987209,2.56241379310349,-1.70765999425322
507,"Leu","Cys","p.Leu507Cys",0.0504155951147967,3.39330651010048e-06,0.0186460161763658,0.145859169089349,0,-0.109507118017166,2.47183908045978,-2.38476866125187
507,"Leu","Gln","p.Leu507Gln",0.0531487395508589,1.97791924162466e-22,0.0142949908279521,0.0536099732819366,1.10476077071209e-10,-0.0250757352079634,1.2063218390805,-1.06806226891566
507,"Leu","Glu","p.Leu507Glu",0.0633628841764325,1.16363699714283e-08,-0.037293990333675,0.0583705972012749,2.05874686779199e-39,-0.19226956588346,1.60390804597706,-1.58184977249679
507,"Leu","Gly","p.Leu507Gly",0.052498996062874,9.22276114670548e-06,-0.0779526394080312,0.129303796767738,0,-0.253689845532937,2.86229885057472,-3.3458103195561
507,"Leu","His","p.Leu507His",0.0770435943323827,3.46944695195361e-18,0.139294900659148,0.0454802087722119,5.50295132139372e-12,-0.139201547892646,0.893218390804619,-1.42998009961912
507,"Leu","Ile","p.Leu507Ile",0.0523264197369803,1.03326511257287e-52,-0.0120650117160328,0.0404832322036123,1.2390112074548e-29,-0.0756591088786692,0.433678160919582,-1.42544290434903
507,"Leu","Lys","p.Leu507Lys",0.079755481436491,7.95101148643475e-24,-0.046965287643059,0.453957429306993,6.66133814775094e-16,0.289784102977623,1.3709195402299,-0.626256453678056
507,"Leu","Met","p.Leu507Met",0.0993019657410973,0,-0.0941762911348381,0.112106672960581,0,-0.0502182791868702,1.11919540229889,-1.64683211217486
507,"Leu","Phe","p.Leu507Phe",0.0969094325350768,0,-0.023196153664584,0.0680661745182897,0,-0.0637049158658183,0.876436781609222,-3.24943744325171
507,"Leu","Pro","p.Leu507Pro",0.0939137988619545,8.67361737988404e-18,0.192644652820747,0.0891161422345377,1.72242530308009e-09,-1.08718856934783,6.40678160919543,-4.25754480801817
507,"Leu","Thr","p.Leu507Thr",0.0881707375497878,6.74664287966583e-05,-0.108950729134899,0.180861922317111,0,-0.58645135133496,2.09528735632187,-2.21467279829406
507,"Leu","Trp","p.Leu507Trp",0.0548212660696112,7.89299181569447e-17,0.575310182219448,0.0334103834754311,4.69064304629749e-70,-0.0927347479257506,-0.178160919540172,-3.74828957446078
507,"Leu","Tyr","p.Leu507Tyr",0.0655274670770816,9.92925164668406e-07,0.248341980193083,0.0965031791936845,0,-0.224883018133139,1.40356321839081,-3.74828957446078
507,"Leu","Val","p.Leu507Val",0.0610544016138424,1.61514661793591e-05,-0.0584862496301785,0.113866458183022,2.77555756156289e-17,-0.000485674677700346,0.975057471264388,-1.64557485933274
508,"Ser","Ala","p.Ser508Ala",0.0757052039470534,9.47416072518815e-32,0.115025893848142,0.160871052113907,5.55111512312578e-17,-0.203321692864538,-0.982873563218461,-1.31438723188028
508,"Ser","Asn","p.Ser508Asn",0.0708850060562133,1.81316857783596e-13,0.0712937598829902,0.0871154390056331,0,0.0771769989285694,-0.0603448275862958,-0.589845747883746
508,"Ser","Asp","p.Ser508Asp",0.133245741992778,0,0.109415744791033,0.101898588884701,0,-0.032375809704217,-0.0360919540230498,-0.203879924126371
508,"Ser","Cys","p.Ser508Cys",0.0556453442030682,2.52951281069764e-06,0.139800381182521,0.17450155283592,0,-0.145252159560694,0.338965517241335,-2.03326409091045
508,"Ser","Gln","p.Ser508Gln",0.139314934609715,0,0.0525530805845139,0.195874570444195,0,-0.0592430091226267,-0.112758620689707,-0.767095707207057
508,"Ser","Glu","p.Ser508Glu",0.0832254531177868,6.28576292542372e-05,0.163586821197464,0.16337029016577,0,0.335860024316088,-0.839770114942586,-0.181702167400765
508,"Ser","Gly","p.Ser508Gly",0.0766447320259344,1.95436249574086e-06,0.217041021835638,0.0571665941909739,4.08276710345671e-05,0.137922193437493,0.165172413793039,-2.89948208487507
508,"Ser","His","p.Ser508His",0.228252454742003,0,-0.0682802306956693,0.0787302993226274,1.88731790612406e-11,-0.232903865111638,-0.402183908046058,-1.03225416082578
508,"Ser","Ile","p.Ser508Ile",0.161033269317758,0,0.180398396477933,0.151098486978111,0,0.294380053299709,-0.924137931034557,-2.24634583869885
508,"Ser","Leu","p.Ser508Leu",0.0625423897053025,1.95608942760694e-25,0.0582539802859332,0.152255638988539,2.77555756156289e-17,0.0796335686173595,-0.792758620689726,-2.0922017555254
508,"Ser","Lys","p.Ser508Lys",0.116081284181248,2.84143440200391e-09,-0.140057852070905,0.0616117210455291,2.75109861399853e-06,0.0207797896140876,-0.317931034482846,-1.33719849563482
508,"Ser","Met","p.Ser508Met",0.20421707340914,0,0.312226476621651,0.0867139208055913,2.18575157973078e-16,-0.100567714382639,-0.448620689655253,-2.71113835387319
508,"Ser","Phe","p.Ser508Phe",0.0609502206765823,2.79175291743912e-12,0.258991005773359,0.290802300592905,0,0.222183678756447,-0.469885057471313,-2.74414600153587
508,"Ser","Pro","p.Ser508Pro",0.189050998736984,0,-0.0144256976029391,0.0412215661592725,1.84033957620692e-05,-0.144653399440754,9.46149425287349,-3.59240567923711
508,"Ser","Thr","p.Ser508Thr",0.0692900045147447,1.44294763171943e-05,0.0611344457330585,0.134852962450701,2.77555756156289e-17,0.0370120482398991,-0.641264367816165,-0.222225126186403
508,"Ser","Trp","p.Ser508Trp",0.0691362967269408,1.32085297568669e-24,0.29629226281914,0.0805244247678396,1.83880688453542e-16,-0.0630521308977571,-0.991609195402372,-3.08084583876993
508,"Ser","Tyr","p.Ser508Tyr",0.0506225384676958,2.50536603853797e-07,0.180877305909213,0.0412612651484294,4.90045913149466e-11,-0.0443747956337925,-0.395977011494298,-2.49242815842969
508,"Ser","Val","p.Ser508Val",0.0641954715067758,9.1080472204878e-07,0.110430593797776,0.0984546880812732,0,0.13616927637286,-0.745287356321883,-2.26321574207083
509,"Leu","Ala","p.Leu509Ala",0.147707408612285,0,0.150847661163086,0.181947356154259,0,-0.532641028104081,2.49908045977011,-5.12220794696459
509,"Leu","Arg","p.Leu509Arg",0.102712787236392,6.93889390390723e-18,0.148526339268344,0.0446302298940448,2.12418545990454e-05,-0.906728537682716,2.90977011494254,-5.41686481342062
509,"Leu","Asn","p.Leu509Asn",0.0586389361716294,0,0.238312525898076,0.107558615725767,0,-1.09781113468226,3.15942528735633,-3.94572923344505
509,"Leu","Asp","p.Leu509Asp",0.0650603759236952,3.46944695195361e-18,0.547970051435646,0.0399625686829151,2.55842323181912e-27,-1.11789193033944,4.59804597701149,-4.73269275684488
509,"Leu","Cys","p.Leu509Cys",0.0299177651272832,4.49537510403276e-07,0.0758453925006198,0.0629172703385708,6.93889390390723e-18,-0.732840877543844,3.18701149425286,-5.12220794696459
509,"Leu","Gln","p.Leu509Gln",0.0884315040944704,0,0.0857219583685309,0.130283596395756,0,-0.950900592615261,2.38655172413792,-4.73269275684488
509,"Leu","Glu","p.Leu509Glu",0.0388334483374553,1.15289212434892e-05,0.402729645531839,0.0631885469317335,9.51981002708657e-10,-1.04381354949893,3.76954022988507,-4.73269275684488
509,"Leu","Gly","p.Leu509Gly",0.0328916670190757,1.53646065271726e-10,0.376992895883588,0.112961089511165,2.77555756156289e-17,-0.975366260223,4.25264367816092,-5.41686481342062
509,"Leu","His","p.Leu509His",0.0775696422186002,0,0.333863402870473,0.0424379722855138,2.21901405158855e-40,-0.962374990046018,3.03022988505748,-4.73269275684488
509,"Leu","Ile","p.Leu509Ile",0.0890261431216438,3.46944695195361e-18,0.0991628929483984,0.108848395977913,1.38777878078145e-17,0.0459421375801729,0.520000000000013,-2.09771045098448
509,"Leu","Lys","p.Leu509Lys",0.0651608191511548,1.73472347597681e-18,0.0976160755381235,0.0459884015326804,4.97652756844645e-36,-0.930313689472605,2.45632183908045,-5.41686481342062
509,"Leu","Met","p.Leu509Met",0.0346697701960553,1.1881092540391e-15,0.0610950407896087,0.0709566990627794,0,-0.254551413846207,1.78942528735629,-1.75081477855398
509,"Leu","Phe","p.Leu509Phe",0.0608299099660017,1.73472347597681e-18,0.164137887544291,0.0452226230971809,1.10060927385747e-11,-0.652078487712339,2.66931034482758,-5.41686481342062
509,"Leu","Pro","p.Leu509Pro",0.0692032534575017,0,0.437519290603667,0.0508571394642759,6.86910171617361e-21,-1.07781981769414,8.2222988505747,-5.41686481342062
509,"Leu","Ser","p.Leu509Ser",0.0586393613777336,1.73472347597681e-18,0.045108525867682,0.0285011493711465,1.43419690914825e-27,-0.472079307569086,3.75057471264372,-5.12220794696459
509,"Leu","Thr","p.Leu509Thr",0.136915440627269,1.38777878078145e-17,0.216853342956091,0.0484449942715456,3.10210412385846e-06,-0.901191013810271,2.54850574712644,-5.12220794696459
509,"Leu","Trp","p.Leu509Trp",0.074743625688346,0,0.489515135676751,0.0491393362056516,3.93979113175458e-05,-0.960594719914092,2.03540229885058,-5.41686481342062
509,"Leu","Tyr","p.Leu509Tyr",0.122918798259783,0,0.432108299480248,0.0421261098381754,1.00315575078733e-17,-1.03216742336503,2.63747126436781,-5.41686481342062
509,"Leu","Val","p.Leu509Val",0.091726141119256,3.46944695195361e-18,0.164673304549337,0.0890759745270724,0,-0.763749153324791,1.58678160919541,-1.7533900558515
510,"Gln","Ala","p.Gln510Ala",0.139377206045461,1.38777878078145e-17,0.154266694416442,0.0564302946837352,1.10848830114918e-15,-0.0440238602756457,1.13632183908053,-1.8496156225129
510,"Gln","Arg","p.Gln510Arg",0.0673998382418377,8.34115762571308e-14,-0.0501288063929169,0.0768470824142787,6.93889390390723e-18,-0.138698130879489,1.15586206896557,0.388958799562918
510,"Gln","Asn","p.Gln510Asn",0.0823586681223841,1.72490494110278e-13,-0.0410233645398851,0.141187456739319,1.38777878078145e-17,-0.612697403449865,1.54482758620696,-2.08795783946255
510,"Gln","Asp","p.Gln510Asp",0.0772758986733256,1.73472347597681e-18,0.196220393347652,0.083859794519607,1.69697589313955e-13,-0.982437748352794,3.04402298850579,-1.8826885107997
510,"Gln","Glu","p.Gln510Glu",0.0435843565348944,2.36349342763328e-40,0.12002258270907,0.0592405183321961,3.46944695195361e-18,-0.325807736744333,1.38632183908053,-1.68168938043605
510,"Gln","Gly","p.Gln510Gly",0.0906257782603964,1.98368405035509e-12,0.105442692985832,0.069961011906018,1.00726520465827e-10,-0.570540527739373,2.96459770114947,-3.33762639127659
510,"Gln","His","p.Gln510His",0.060385731431096,1.95191740643039e-10,0.191967636245147,0.0558284471339555,5.94829437142168e-10,-0.40484197291336,2.12275862068972,-1.61435347344479
510,"Gln","Ile","p.Gln510Ile",0.0778536581308148,1.73472347597681e-18,0.226667657767177,0.114625605526382,0,-0.214752045778813,-0.208620689655126,-0.934191994785545
510,"Gln","Leu","p.Gln510Leu",0.0509911054914948,5.43758589649477e-08,0.176383999970095,0.0587330840150421,1.71375066915225e-13,-0.144262151799541,0.748160919540284,-0.781511342566346
510,"Gln","Lys","p.Gln510Lys",0.0600068814456907,2.73350245972771e-08,-0.0750772711638569,0.0900144657477694,0,-0.164642219580899,2.14551724137936,-0.617970853804098
510,"Gln","Met","p.Gln510Met",0.0813190034512322,0,0.140406613841589,0.164409576555133,0,-0.0625817199150782,0.170574712643748,-1.13149737454662
510,"Gln","Phe","p.Gln510Phe",0.118352432381791,0,0.161113530727426,0.100658583552109,2.08166817117217e-17,-0.690346995559219,2.14057471264371,-2.75279610052055
510,"Gln","Pro","p.Gln510Pro",0.112436288694568,0,1.00841672808438,0.16099351601403,0,-1.00586348295598,9.41850574712649,-3.33762639127659
510,"Gln","Ser","p.Gln510Ser",0.0519335532590044,1.25476487251697e-07,0.160980496415712,0.0530675787679877,1.20865926002451e-25,-0.451728618137999,2.37908045977018,-2.07226645812778
510,"Gln","Trp","p.Gln510Trp",0.0641280785219358,1.12449440208408e-81,0.206053855202997,0.0551588825084591,7.17626272277866e-08,-0.0910721220569321,0.224367816092032,-2.20518460032273
510,"Gln","Tyr","p.Gln510Tyr",0.0975418366937801,6.93889390390723e-18,0.0828381319675431,0.0565813258980255,7.25085907300526e-24,-0.339383715904175,2.41712643678169,-2.515013041059
510,"Gln","Val","p.Gln510Val",0.0586077580361303,1.61964614479488e-06,0.134414365932255,0.0502912687218318,3.84174609604152e-05,-0.289826181899827,0.251494252873627,-0.995777400477004
511,"Glu","Ala","p.Glu511Ala",0.073416422198729,0,0.0651112675865526,0.0907074820554012,0,-0.206311745719863,0.0373563218390595,-0.63684685613344
511,"Glu","Arg","p.Glu511Arg",0.0672807578234331,0,0.0900133772646625,0.0297077266075586,2.01566812353154e-07,-0.111486316346548,-0.149425287356343,-1.35469021501411
511,"Glu","Asn","p.Glu511Asn",0.14342951456382,1.38777878078145e-17,0.112452973549765,0.0344377722290744,7.24345311048112e-11,-0.19187586539595,0.300114942528748,-1.04331484815294
511,"Glu","Asp","p.Glu511Asp",0.0821894032783045,3.46944695195361e-18,0.00635554527584671,0.0834024702472652,0,0.066897950331262,0.530229885057452,-1.22196616862174
511,"Glu","Cys","p.Glu511Cys",0.0394591399598148,1.22065640798322e-10,0.112053029071212,0.0951136778527242,0,-0.110516858790123,0.964482758620698,-2.22999717215463
511,"Glu","Gln","p.Glu511Gln",0.0376362008815587,3.52234382704651e-09,0.107757160690566,0.111141665925627,2.77555756156289e-17,-0.066365163002431,0.394137931034493,-0.370115542178883
511,"Glu","Gly","p.Glu511Gly",0.0440713821570861,1.30104260698261e-18,-0.0791087568653375,0.0275819214426877,1.8593191303002e-09,-0.0932386154307272,0.913333333333349,-2.45712906843915
511,"Glu","His","p.Glu511His",0.0578479598872178,0,0.138442994037026,0.0790978398672024,0,-0.0187632563123323,0.0874712643678385,-1.07526149071311
511,"Glu","Ile","p.Glu511Ile",0.0838300110745318,0,0.401542854599769,0.0371240087842374,3.19140543754218e-16,-0.326941646956122,-0.400689655172426,-2.2737300886398
511,"Glu","Leu","p.Glu511Leu",0.0365800639952556,1.06892686954977e-24,0.239924690508527,0.0290998154387797,6.92763544795954e-24,-0.0722929611387059,-0.280000000000017,-2.05121973382251
511,"Glu","Lys","p.Glu511Lys",0.0971264228532097,0,-0.0509221596947299,0.0936352325090836,0,-0.0896249190375548,-0.0343678160919515,-0.480756192044329
511,"Glu","Met","p.Glu511Met",0.0654298469330165,8.67361737988404e-18,0.0429333716089666,0.128418511349025,0,-0.293905142838617,0.176091954022954,-2.08050987615312
511,"Glu","Phe","p.Glu511Phe",0.0346390133457213,2.97055248640017e-37,0.320483709777488,0.0874464972015098,0,-0.192421611686408,0.281954022988477,-3.67190303629407
511,"Glu","Pro","p.Glu511Pro",0.0417439422344178,1.93755766297703e-08,0.545705645700046,0.0779082703072227,6.31959762298351e-14,-1.09853670152861,7.32160919540228,-3.89998311605732
511,"Glu","Ser","p.Glu511Ser",0.0420760795778157,1.36819377672128e-05,0.209679029568593,0.0364548210895594,1.84577773025899e-07,-0.112160891527374,0.675747126436771,-0.920285164041215
511,"Glu","Thr","p.Glu511Thr",0.0568783069211518,7.68627436004143e-12,0.0670658728441432,0.078394530433851,0,0.0241220381150942,0.145862068965492,-1.18573696273431
511,"Glu","Trp","p.Glu511Trp",0.0562710650685619,0,0.580916878761043,0.0618651871769065,0,0.0629588601973467,-0.446321839080438,-3.67190303629407
511,"Glu","Tyr","p.Glu511Tyr",0.0666032527717146,0,0.243652966843061,0.185682245032245,0,-0.112252830630001,0.232298850574682,-3.67190303629407
511,"Glu","Val","p.Glu511Val",0.0760193836224214,0,0.229737438358468,0.0567796723051373,0,-0.0637098214297626,-0.277011494252883,-2.35942264632239
512,"Glu","Ala","p.Glu512Ala",0.0325384567818432,7.89884559664441e-06,0.0794786420557715,0.160597252987127,8.32667268468867e-17,0.0402589270624077,0.71724137931032,-1.01505265308582
512,"Glu","Arg","p.Glu512Arg",0.109003518504328,0,-0.0955566955936441,0.047192744401934,0,-0.179660035815711,0.539310344827613,-2.01977668442369
512,"Glu","Asn","p.Glu512Asn",0.0903344043645911,6.93889390390723e-18,0.0132603262022112,0.0795134995861045,1.38777878078145e-17,0.0636610325043166,1.55275862068968,-1.22610823124784
512,"Glu","Asp","p.Glu512Asp",0.0812272470530459,0,0.0858471930144637,0.0243539130621109,2.7075851735373e-10,-0.0441760668758594,0.764137931034446,-0.861069214937611
512,"Glu","Cys","p.Glu512Cys",0.0442475274610707,4.68132477227101e-14,0.0599819162755199,0.0775221697104238,0,-0.0427169586331957,1.73724137931035,-2.67065487158182
512,"Glu","Gln","p.Glu512Gln",0.0375899283665132,6.18576583193489e-08,-0.0584128653991636,0.0719487238274377,0,-0.0476092366021763,1.21528735632182,-1.30745381765646
512,"Glu","Gly","p.Glu512Gly",0.0376641322510671,2.81892564846231e-17,0.0103349912824436,0.0572697500221345,0,-0.115773614125134,1.72448275862068,-2.56006204880322
512,"Glu","His","p.Glu512His",0.0705933751690685,0,0.108532480796475,0.113398559759418,4.16333634234434e-17,-0.0285802864296824,0.562068965517279,-1.49476204000801
512,"Glu","Ile","p.Glu512Ile",0.0375548818240829,5.31068093354412e-20,0.00835636189358989,0.059208823356251,6.93889390390723e-18,-0.240460726337237,0.526551724137946,-2.23894570770696
512,"Glu","Leu","p.Glu512Leu",0.0683496281160083,0,0.127341703992154,0.0398842616586396,1.15841364422761e-07,-0.439504335107657,0.400804597701159,-2.38012385218525
512,"Glu","Lys","p.Glu512Lys",0.0640558462878021,1.30104260698261e-17,-0.00774988340070336,0.141585113747229,0,-0.0922528594228174,0.979655172413757,-2.02830536416615
512,"Glu","Met","p.Glu512Met",0.0752975994823559,0,-0.0490230493109977,0.12340385011475,0,0.025052905292935,0.712413793103433,-2.2437477278777
512,"Glu","Phe","p.Glu512Phe",0.0776712170907251,0,0.176293673463341,0.134263493497624,4.16333634234434e-17,-0.374641269373407,0.171609195402292,-3.52010315678534
512,"Glu","Pro","p.Glu512Pro",0.0382579326261721,1.92118067222106e-08,0.169080754308639,0.13639446613307,4.16333634234434e-17,-0.960214468025254,6.8796551724138,-4.23166195306382
512,"Glu","Ser","p.Glu512Ser",0.048222955576644,2.48022088977784e-15,0.0554716056821313,0.043457018660185,2.7079033459998e-15,-0.116218054330111,1.41965517241378,-1.76787788173972
512,"Glu","Thr","p.Glu512Thr",0.0749875673729056,1.73472347597681e-18,-0.0334882433356861,0.069878044534089,0,-0.0992673554793618,0.980689655172431,-1.90202128848945
512,"Glu","Trp","p.Glu512Trp",0.0433609670918734,5.77513936867759e-09,0.149784958425685,0.0653693133773616,0,-0.652795841923362,-0.761264367816097,-3.85593655033932
512,"Glu","Tyr","p.Glu512Tyr",0.0813058557080854,0,0.187276387236778,0.0299907975299368,1.31502782793438e-43,-0.298083021221306,0.323793103448303,-3.85593655033932
512,"Glu","Val","p.Glu512Val",0.0304403994379283,1.8594848382369e-08,0.000179271489026424,0.0463257804243355,0,-0.219517312997008,0.63206896551727,-2.21673340924815
513,"Ile","Ala","p.Ile513Ala",0.0555714940545146,0,0.150212868738342,0.0543013309822018,0,-0.373011631491789,2.56885057471264,-2.48567428458743
513,"Ile","Arg","p.Ile513Arg",0.03202802635615,8.97620963059332e-06,0.0591583244577288,0.0704244006632458,3.46944695195361e-18,-0.516254805924909,3.18735632183908,-3.45590760296762
513,"Ile","Asn","p.Ile513Asn",0.0435411793902445,1.88398827788427e-11,0.2172130194946,0.0448016332073537,9.92149725872005e-51,-0.858805198363407,2.78816091954021,-4.26711325036778
513,"Ile","Asp","p.Ile513Asp",0.0297207664261166,3.77899082190802e-23,0.753456782203461,0.114394689368513,1.38777878078145e-17,-1.118951530814,3.556091954023,-4.26711325036778
513,"Ile","Cys","p.Ile513Cys",0.0557881604906404,8.67361737988404e-19,0.0671202792630477,0.0646276259030383,0,0.0595754881171654,3.00091954022988,-2.59910344034419
513,"Ile","Gln","p.Ile513Gln",0.063911930934784,0,0.315393160682384,0.0933693097525278,0,-1.02085055906043,2.74080459770115,-4.26711325036778
513,"Ile","Glu","p.Ile513Glu",0.0930036312822538,0,0.617447044514043,0.097869091920641,0,-1.01276845352455,3.70758620689656,-4.26711325036778
513,"Ile","Gly","p.Ile513Gly",0.0633056621783636,0,0.463909558643877,0.0388644633685573,2.24325424920357e-17,-1.03829706862625,4.29436781609199,-4.51470542326379
513,"Ile","His","p.Ile513His",0.0439833658969745,3.02200538898623e-13,0.276549286327294,0.0461788107942929,1.86466582252978e-08,-1.01604889891555,2.26540229885058,-4.26711325036778
513,"Ile","Leu","p.Ile513Leu",0.0536857488314064,8.67361737988404e-19,0.129646101829181,0.0923452789508501,0,-0.346605870278831,0.953103448275879,-1.29254112804835
513,"Ile","Lys","p.Ile513Lys",0.0724435329022903,0,0.220844400805473,0.0807168939651569,0,-0.78000917236481,3.28241379310345,-3.93981420094233
513,"Ile","Met","p.Ile513Met",0.0978324799802305,2.08166817117217e-17,0.124652569799269,0.096244515444207,0,-0.679546873925201,1.67954022988504,-1.47332610668115
513,"Ile","Phe","p.Ile513Phe",0.0456367755605897,7.17898700555719e-12,0.192272917789544,0.0967761794803241,6.93889390390723e-18,-0.888874147475297,1.79183908045979,-1.97074013918445
513,"Ile","Pro","p.Ile513Pro",0.0337239311087844,1.80378065955398e-11,0.510439821272146,0.0753104775749016,0,-1.05905800309988,8.75448275862069,-4.51470542326379
513,"Ile","Ser","p.Ile513Ser",0.0332797598808595,3.09830923586466e-09,0.191174239239365,0.0428885094993812,1.61955275319176e-09,-0.64547849026918,3.66298850574712,-2.7640843666175
513,"Ile","Thr","p.Ile513Thr",0.0500076878020013,0,-0.0376768074754827,0.0324380154393633,3.88769693521196e-10,-0.291971332573529,2.52954022988504,-2.44710434982768
513,"Ile","Trp","p.Ile513Trp",0.0636176570262547,3.46944695195361e-18,0.512604934051164,0.0900614973696584,0,-1.04818114197946,2.46827586206896,-2.72425374528879
513,"Ile","Tyr","p.Ile513Tyr",0.0526794148652739,8.67361737988404e-19,0.322065407700517,0.0413406351006475,2.04879317588503e-16,-0.991502038065895,2.94505747126438,-3.3947068893339
513,"Ile","Val","p.Ile513Val",0.026548236701423,3.04520060405513e-50,-0.0445001127248828,0.0544215706814839,0,0.0348600258259238,1.45747126436782,-0.57964747166475
514,"Asn","Ala","p.Asn514Ala",0.109601954080397,6.93889390390723e-18,0.150814666442327,0.0479270711461789,3.46944695195361e-18,0.00672162409209952,-0.0366666666666359,-1.35660890651213
514,"Asn","Arg","p.Asn514Arg",0.0329912546623624,4.0153618425685e-08,0.0100119589852489,0.0397328421465504,8.67361737988404e-19,0.0463000067862366,-0.616781609195348,-0.937276995115281
514,"Asn","Asp","p.Asn514Asp",0.0268840062895585,5.56011465166142e-34,0.000971667618227918,0.0520108836308469,0,-0.12081287387704,0.162298850574717,-0.302571283531742
514,"Asn","Cys","p.Asn514Cys",0.0690618036361594,0,0.0865117482311457,0.108700666042348,1.38777878078145e-17,-0.0651460426262234,0.751724137931057,-1.45736843353865
514,"Asn","Gln","p.Asn514Gln",0.0697951666478377,0,0.0811608503401498,0.089908887816518,6.93889390390723e-18,0.0464181932768062,0.131609195402323,-0.648413898669153
514,"Asn","Glu","p.Asn514Glu",0.0802628533174338,0,0.184218985771298,0.0417864483819902,2.60208521396521e-18,0.035573833096781,-0.191379310344797,-0.688717132060567
514,"Asn","Gly","p.Asn514Gly",0.0599568510656147,0,0.0580397980861936,0.119402985086954,2.77555756156289e-17,0.0641542548971604,1.07275862068969,-2.13161066555309
514,"Asn","His","p.Asn514His",0.0582999546093278,0,-0.0260542605326159,0.0252021301206947,1.32804991132412e-63,-0.0343785653881585,-0.381034482758601,-1.34785098275333
514,"Asn","Ile","p.Asn514Ile",0.0580991501089573,0,0.126888927450133,0.0475950386140951,0,0.031094198005704,-0.479310344827542,-1.72119844974882
514,"Asn","Leu","p.Asn514Leu",0.096573426699336,0,0.195785936708816,0.116216410196634,0,0.168693668070388,-0.88494252873564,-1.5476436194518
514,"Asn","Lys","p.Asn514Lys",0.0951230805957531,0,-0.0530010143536238,0.0407287481480551,0,-0.0168204852828251,-0.447931034482751,-1.04675075449804
514,"Asn","Met","p.Asn514Met",0.078207470546743,0,0.108595345951491,0.0772757074168336,0,0.0134909331225319,-0.272643678160902,-1.67311544147655
514,"Asn","Phe","p.Asn514Phe",0.0686855323252115,0,0.276630437721002,0.0920480498568872,0,0.0214644230583752,-1.01931034482755,-2.14437174712757
514,"Asn","Pro","p.Asn514Pro",0.109849645294342,6.93889390390723e-18,0.0910998255734356,0.0489640519439378,1.42550467957525e-12,-0.631629660866407,5.26954022988506,-3.25953794516054
514,"Asn","Ser","p.Asn514Ser",0.0270165113998082,1.16746402539574e-29,0.00143211384615736,0.0227003673443984,1.63253196286515e-25,-0.115600577899607,0.623678160919532,-0.525506186770945
514,"Asn","Thr","p.Asn514Thr",0.0692632363073619,1.73472347597681e-18,0.155813182856475,0.0346584373061913,1.68224809082851e-15,-0.101623058201851,0.30609195402299,-0.755800410187292
514,"Asn","Trp","p.Asn514Trp",0.0964555110990285,0,0.2987737700259,0.0434238225143872,0,0.029681483012947,-1.25839080459766,-2.66848453385709
514,"Asn","Tyr","p.Asn514Tyr",0.100237362546634,6.93889390390723e-18,0.277413122150322,0.0690493558162403,6.93889390390723e-18,0.0287607567394059,-0.874252873563191,-2.32856528991115
514,"Asn","Val","p.Asn514Val",0.0625715804619257,0,0.0292187102696999,0.103365717323738,1.38777878078145e-17,0.0103837969005679,-0.365632183908024,-1.01433171545333
515,"Glu","Ala","p.Glu515Ala",0.0335230301225867,3.887790880211e-51,0.0511857606404099,0.109519358634297,1.38777878078145e-17,-0.0357682924873046,-0.0512643678160296,-0.444966091939151
515,"Glu","Arg","p.Glu515Arg",0.0437425179836957,1.72376853242728e-10,-0.0768131869128917,0.0277051674744195,6.67365301304379e-30,-0.119202413479253,-0.28356321839079,-0.911398160488393
515,"Glu","Asn","p.Glu515Asn",0.0316836278047534,2.28359960350093e-06,0.00464179265357908,0.0537763458379023,0,-0.0222683802131895,0.154942528735679,-0.15071177229364
515,"Glu","Asp","p.Glu515Asp",0.0476577867689196,0,0.0453891825925583,0.0421067029745452,0,0.0279347053163742,0.439195402298867,-0.220967023995018
515,"Glu","Cys","p.Glu515Cys",0.0477071304964907,2.60208521396521e-18,0.182247117350582,0.0251447340765095,6.06192178688812e-14,-0.163292094167988,0.977471264367857,-0.852816367137975
515,"Glu","Gln","p.Glu515Gln",0.0873147612656408,3.46944695195361e-18,0.0983732294378926,0.0557758738554784,0,-0.103008475820262,0.108045977011527,-0.470912256136682
515,"Glu","Gly","p.Glu515Gly",0.0240661835548612,9.56230521440359e-10,-0.030571915987089,0.0308626589961992,0,-0.0798150969260561,0.800804597701213,-1.19901512526991
515,"Glu","His","p.Glu515His",0.0767220585251698,3.46944695195361e-18,0.0932972743002949,0.0710538243662631,0,0.000246272997162752,-0.150804597701085,-0.831743601327477
515,"Glu","Ile","p.Glu515Ile",0.0494105712590097,8.67361737988404e-19,0.0736311262378025,0.0244501008385843,2.24114180243191e-17,-0.148044262259987,0.00252873563222865,-1.37578407423144
515,"Glu","Leu","p.Glu515Leu",0.0886208001373681,3.46944695195361e-18,0.0606089970114207,0.0293678403047062,1.36113162951638e-07,-0.0132750106135937,-0.325632183908029,-1.23718480665719
515,"Glu","Lys","p.Glu515Lys",0.0694970245542796,1.73472347597681e-18,-0.0197528382760798,0.114245236104936,0,-0.0648010951052451,-0.0314942528735241,-0.670053314854706
515,"Glu","Met","p.Glu515Met",0.0494625124863592,1.73472347597681e-18,0.175217681917459,0.0609835825607004,3.46944695195361e-18,0.0136002571307213,-0.0805747126436284,-1.68362455796502
515,"Glu","Phe","p.Glu515Phe",0.069177632919468,0,0.252811782339599,0.0422437567124665,0,-0.0114745253422128,0.362068965517278,-2.10056379906694
515,"Glu","Pro","p.Glu515Pro",0.0788158413241628,0,0.165369004523288,0.0747638100726154,0,-0.985350418388759,5.59114942528741,-2.22893465690664
515,"Glu","Ser","p.Glu515Ser",0.0433476741653268,7.12460550625349e-11,0.00765888659501828,0.103981129188279,0,-0.185253075830154,0.64666666666669,-0.217187676424022
515,"Glu","Thr","p.Glu515Thr",0.0600420432535923,0,0.0812801429240398,0.0442597770863299,0,0.0554932102833218,0.375747126436835,-0.848625095931827
515,"Glu","Trp","p.Glu515Trp",0.0664976294966545,0,0.416423664227589,0.0346333839063591,1.52655665885959e-16,-0.187539306069714,-0.449540229884986,-2.10056379906694
515,"Glu","Tyr","p.Glu515Tyr",0.0480051466990104,2.25514051876985e-17,0.22055100048768,0.0691816907147462,0,-0.0777306302095353,0.262183908046023,-2.10056379906694
515,"Glu","Val","p.Glu515Val",0.0484279165797361,1.04083408558608e-17,0.161777369816842,0.0541009448077825,0,-0.16794557870726,0.300000000000067,-1.31040933031346
516,"Gln","Ala","p.Gln516Ala",0.0907174396459752,3.46944695195361e-18,0.157516397263157,0.0755557582743026,1.04083408558608e-17,0.0176964823108876,-0.12114942528734,-1.05327007862456
516,"Gln","Arg","p.Gln516Arg",0.0346150351381294,3.04791856809273e-19,-0.0254225862063909,0.0270505084386909,3.10219600993708e-11,0.0385783036620467,-0.450344827586195,-0.437032495521821
516,"Gln","Asn","p.Gln516Asn",0.14467201815338,6.93889390390723e-18,0.0565364620873065,0.0906057116233372,0,0.206512948759629,-0.212643678160909,-0.393015034498996
516,"Gln","Asp","p.Gln516Asp",0.0528338453228848,6.60327912141434e-12,0.0715155959734726,0.0558072754837732,3.46944695195361e-18,-0.119176790358281,0.338390804597723,-0.636192342576716
516,"Gln","Cys","p.Gln516Cys",0.0776318370175905,5.20417042793042e-18,-0.0261905351005762,0.10916019933468,0,-0.0461934081120392,0.164022988505789,-1.25589568201738
516,"Gln","Glu","p.Gln516Glu",0.0996784395386169,0,0.121942282629087,0.0608472008562963,2.37657116208823e-16,-0.128015155258416,0.103103448275881,-0.849622731136559
516,"Gln","Gly","p.Gln516Gly",0.0889150275808538,0,0.0207735803307698,0.0804598671413786,0,0.227280845707418,0.462298850574731,-1.59149269441622
516,"Gln","His","p.Gln516His",0.0443270580510558,1.99783091226369e-55,-0.0315788727910912,0.0487367426189765,6.59194920871187e-17,-0.12539872244602,0.0318390804597751,-1.10446306289481
516,"Gln","Ile","p.Gln516Ile",0.0448803418781462,6.00026084678451e-16,0.0208568612734125,0.0943381816828203,0,0.122173219613663,-0.396666666666643,-1.69643506066262
516,"Gln","Leu","p.Gln516Leu",0.0568552470819612,4.53630188967935e-14,0.0906667693414541,0.0295650416767391,8.88126828185747e-15,0.0368017072515416,-0.788045977011468,-1.90400617222281
516,"Gln","Lys","p.Gln516Lys",0.0863213726076685,0,-0.0369901964652146,0.0282884250401384,1.73316230112329e-31,-0.059014442528428,-0.228505747126417,-1.01805903091016
516,"Gln","Met","p.Gln516Met",0.0514751085525651,6.21074372486596e-15,0.0661769855766184,0.0963642545924523,0,-0.11102878518311,-0.577011494252845,-2.34951974337736
516,"Gln","Phe","p.Gln516Phe",0.117843356367137,0,0.111339610955435,0.139985886586164,0,-0.0353479944524788,0.0556321839080633,-2.87499462095986
516,"Gln","Pro","p.Gln516Pro",0.0476876864986646,8.37034219805001e-07,0.25961552769019,0.0529908148261821,8.64259947807453e-28,-0.897233386658401,4.70977011494254,-2.30472440826998
516,"Gln","Ser","p.Gln516Ser",0.0434859050566237,8.97814364095346e-25,0.0406853292592704,0.0875582295953776,0,0.111333308750602,0.373563218390831,-0.907870668344129
516,"Gln","Thr","p.Gln516Thr",0.0759716202624292,1.73472347597681e-18,0.0646365010234972,0.154587544606948,0,0.0213176962779143,0.478850574712663,-1.00491489772899
516,"Gln","Trp","p.Gln516Trp",0.0972573343590818,0,0.416248494472991,0.171010917825899,2.77555756156289e-17,-0.275658869321783,-1.11551724137928,-2.87499462095986
516,"Gln","Tyr","p.Gln516Tyr",0.0382197071443608,5.20529015535571e-58,0.143433752347772,0.102898015995711,1.38777878078145e-17,-0.119618111632248,0.350919540229898,-2.87499462095986
516,"Gln","Val","p.Gln516Val",0.101260522004861,0,0.0800506354921917,0.0427400684790034,4.33680868994202e-18,0.215520913604917,-0.079770114942498,-1.71699834742708
517,"Gly","Ala","p.Gly517Ala",0.0674986776439643,1.73472347597681e-18,-0.00157673957493383,0.156354950614961,0,0.115213823501724,-1.35356321839084,0.484799339537825
517,"Gly","Arg","p.Gly517Arg",0.109364328772442,6.93889390390723e-18,0.0571201290194015,0.0537005065189517,3.46944695195361e-18,0.00525882484681758,-0.456436781609222,-1.18042035096015
517,"Gly","Asn","p.Gly517Asn",0.155989946441024,0,0.0995773750330364,0.0680019512315456,6.93889390390723e-18,-0.143566311801421,-0.573103448275874,-1.1633286559239
517,"Gly","Asp","p.Gly517Asp",0.0863888534137785,1.04083408558608e-17,0.055069246609705,0.155971910602572,0,0.0385555320784357,0.274367816091921,-0.960164974891186
517,"Gly","Cys","p.Gly517Cys",0.0881009031932163,3.46944695195361e-18,0.153270200683348,0.041178640965062,1.73472347597681e-18,-0.0872868113791778,-0.224367816091954,0.250894977252808
517,"Gly","Gln","p.Gly517Gln",0.0940158232241326,1.04083408558608e-17,0.0454899196498205,0.0264440808727018,3.43684055731983e-08,0.0261875491101444,-0.811494252873557,-0.950371530194476
517,"Gly","Glu","p.Gly517Glu",0.0826335445616438,0,0.163299350324406,0.156187502075381,2.77555756156289e-17,0.195881191123336,-0.114137931034502,-0.607152609977384
517,"Gly","His","p.Gly517His",0.0411787825586374,1.1704675948171e-05,0.0874526007898054,0.0350121432570549,2.03127423475252e-09,0.0497493485134807,-0.365862068965543,-1.14632511812972
517,"Gly","Ile","p.Gly517Ile",0.0848207796199657,0,0.163167839748283,0.0894301224377045,6.93889390390723e-18,-0.526859163987206,0.358505747126453,-0.77963220955687
517,"Gly","Leu","p.Gly517Leu",0.0813033631333009,0,0.0515396407201434,0.0502870905050455,1.73472347597681e-18,-0.172598014972159,-1.88873563218391,-0.756890111958574
517,"Gly","Lys","p.Gly517Lys",0.0733416581754573,1.73472347597681e-18,0.0801319918620139,0.0571548373124702,0,-0.240777764237851,-0.00206896551724472,-1.11963130092178
517,"Gly","Met","p.Gly517Met",0.0591402661761142,1.73472347597681e-18,0.0948870520333079,0.073584184776822,3.46944695195361e-18,-0.248051016939172,-1.17057471264367,-0.281245637804842
517,"Gly","Phe","p.Gly517Phe",0.0699296126477107,1.73472347597681e-18,0.173410527732692,0.076550466714548,1.04083408558608e-17,-0.34358121544566,-1.29919540229886,-1.32402958367607
517,"Gly","Pro","p.Gly517Pro",0.0345614577104088,1.72254900257715e-37,0.185212076689722,0.0754226871277017,5.55111512312578e-17,-0.946253572676324,5.24356321839077,-2.04590755587305
517,"Gly","Ser","p.Gly517Ser",0.0650613024303036,3.46944695195361e-18,0.106400024353183,0.0796187377338948,6.93889390390723e-18,0.0132181526505061,-0.541724137931057,0.238581426323917
517,"Gly","Thr","p.Gly517Thr",0.0418798539660112,1.41557142893479e-25,0.080055121378855,0.0735947946489455,6.93889390390723e-18,-0.185965163622617,-0.889540229885088,0.218514341742246
517,"Gly","Trp","p.Gly517Trp",0.037338252905384,2.41721384591348e-11,0.35343182005183,0.0888306842418862,1.38777878078145e-17,-0.536146076271356,-0.54988505747125,-1.9091151763807
517,"Gly","Tyr","p.Gly517Tyr",0.106530752774489,0,0.181176605596081,0.0397406637020705,6.06230326355428e-11,-0.00595859138833582,-1.23574712643678,-1.06738977881845
517,"Gly","Val","p.Gly517Val",0.070677601236153,0,0.0494809458759753,0.0348763762387987,5.77735412046902e-29,-0.187317092438271,-1.02206896551727,-0.707097492966041
518,"His","Ala","p.His518Ala",0.06334350528026,0,-0.0325400561143407,0.0776315646161741,6.93889390390723e-18,0.00226996395813428,1.35448275862068,-1.77056556979296
518,"His","Arg","p.His518Arg",0.031921578822266,1.67186858480471e-22,0.00363836363117563,0.0593801704229584,0,-0.225390889084462,1.44896551724138,-3.23117504334159
518,"His","Asn","p.His518Asn",0.0302881581000859,2.9306227110546e-19,0.100620047292317,0.0255744629830065,6.61008428711308e-18,-0.00614272106002657,0.260689655172417,-0.875961378350818
518,"His","Asp","p.His518Asp",0.0715409752003146,3.46944695195361e-18,-0.041487708118589,0.0647578627495174,0,0.295001469955986,0.680344827586218,-1.42004688496965
518,"His","Cys","p.His518Cys",0.105505655548824,0,0.0623430853776583,0.0385484641926775,0,0.094650704481245,1.23540229885055,-2.42673025428221
518,"His","Gln","p.His518Gln",0.0427857259222036,1.47118414148099e-08,0.0720418034334881,0.0260564080417787,3.01097592086023e-15,-0.0530094182789836,1.64632183908047,-1.69428854286379
518,"His","Glu","p.His518Glu",0.0422959368047145,7.49334692881621e-06,-0.034875290322489,0.0728190148201663,0,0.0409713842323363,0.457471264367792,-1.85024067779077
518,"His","Gly","p.His518Gly",0.0438085132253455,5.59178601859667e-11,-0.0312223014270057,0.143247453751485,0,0.0363107716953709,3.38034482758619,-4.55744129614681
518,"His","Ile","p.His518Ile",0.0479396944126534,1.87291290731205e-31,0.0342635828564285,0.115594398689179,0,-0.262914423928872,0.799655172413779,-3.04794006106508
518,"His","Leu","p.His518Leu",0.0344617496751691,4.54958757912566e-16,0.114919258557229,0.175849609039675,1.38777878078145e-16,0.141151609652233,0.240459770114928,-1.80479006949271
518,"His","Lys","p.His518Lys",0.108588767911231,3.46944695195361e-18,-0.0688973379273345,0.115696411986452,0,-0.410933412313194,1.81402298850574,-3.27624470746178
518,"His","Met","p.His518Met",0.0507601966660622,1.02456584882837e-12,0.0460040402311454,0.177249085595475,0,-0.123457281900829,0.731379310344834,-3.72068187335277
518,"His","Phe","p.His518Phe",0.0748360135819977,0,0.183700810054313,0.0647037724915518,0,-0.108593976098903,0.925057471264394,-3.52309730100258
518,"His","Pro","p.His518Pro",0.0821202031082519,0,0.373795590860525,0.102612167978719,6.93889390390723e-18,-1.00555877564841,7.44298850574712,-3.95839057460164
518,"His","Ser","p.His518Ser",0.0966397157825049,1.04083408558608e-17,-0.0194613037452898,0.0936270052656293,0,0.014036487810346,1.59620689655172,-1.93287531261302
518,"His","Thr","p.His518Thr",0.0468771507705749,5.97634160735827e-08,0.00627243556756143,0.134744571449383,0,-0.1943413581849,2.05068965517243,-2.4156906940883
518,"His","Trp","p.His518Trp",0.0483560105504867,8.67361737988404e-19,0.0707784674219413,0.0260555018741595,7.31395990631409e-42,-0.205349913122158,0.884827586206907,-3.90631590502933
518,"His","Tyr","p.His518Tyr",0.0590089184895637,1.73472347597681e-18,0.0442432872734989,0.114311199459128,0,-0.0708717447138078,0.934367816091943,-3.39059766291954
518,"His","Val","p.His518Val",0.103807644412512,1.38777878078145e-17,0.028986881674241,0.086345354526965,0,0.0374737792070457,1.68195402298848,-3.72068187335277
519,"Glu","Ala","p.Glu519Ala",0.0639073091380458,0,0.0909861239358636,0.0641936423504944,0,0.0467245823550375,0.839425287356335,-0.167669657195594
519,"Glu","Arg","p.Glu519Arg",0.0801282101950048,3.46944695195361e-18,0.231278398841387,0.0991904198849908,0,0.0233365260100434,0.113563218390889,-0.568953465874592
519,"Glu","Asn","p.Glu519Asn",0.0544592458915854,0,0.10290033655894,0.038634706371681,8.67361737988404e-19,-0.0801135368130338,0.622873563218428,-1.19986751881782
519,"Glu","Asp","p.Glu519Asp",0.0917859097159533,3.46944695195361e-18,0.0581523825985658,0.0500360124718803,1.73472347597681e-18,0.0421114027645884,0.059425287356354,-0.923682536033235
519,"Glu","Cys","p.Glu519Cys",0.0666853767656003,0,0.102377625103595,0.0511754916803964,3.46944695195361e-18,-0.0134768472389651,1.90793103448283,-1.72577162732827
519,"Glu","Gln","p.Glu519Gln",0.0981167121675359,1.04083408558608e-17,0.117295673544748,0.10072278409403,0,0.0264419870173513,0.330000000000037,-0.92399219490702
519,"Glu","Gly","p.Glu519Gly",0.0382104902147874,0,0.0176166189537711,0.0359761630230195,0,0.07811397301166,1.28770114942536,-2.32832283928975
519,"Glu","His","p.Glu519His",0.0556128346198499,0,0.157446293608713,0.0325789800699144,2.58163716099213e-13,-0.040794956379442,0.30735632183913,-1.18767293779774
519,"Glu","Ile","p.Glu519Ile",0.05406999417319,8.67361737988404e-19,0.177433408561283,0.0450610757365773,3.46944695195361e-18,-0.303633080516174,0.102873563218441,-1.53050529487206
519,"Glu","Leu","p.Glu519Leu",0.0511345848433871,0,0.117550126035275,0.0494192572578822,0,-0.11662180339474,0.126206896551771,-1.26387346582754
519,"Glu","Lys","p.Glu519Lys",0.0290843321582413,7.69533344509786e-12,0.119251120127689,0.0442698448001256,0,-0.134642888418222,0.595287356321901,-0.429853150996994
519,"Glu","Met","p.Glu519Met",0.0874276820000876,0,0.160748834032422,0.0509242853471344,0,-0.116434469506263,0.281609195402356,-1.38027011712338
519,"Glu","Phe","p.Glu519Phe",0.085915638091133,3.46944695195361e-18,0.15951190994862,0.0401456196213119,0,-0.127122192064901,0.000114942528759049,-2.33365131958009
519,"Glu","Pro","p.Glu519Pro",0.0589546015040115,8.67361737988404e-19,0.241254535402309,0.0397983628098886,2.60208521396521e-18,0.0471487940448522,1.60931034482766,-1.33439008561203
519,"Glu","Ser","p.Glu519Ser",0.0977452106010337,3.46944695195361e-18,0.162469033034967,0.0803269851185063,1.38777878078145e-17,0.00395537876735434,0.688045977011532,-0.818995715279126
519,"Glu","Thr","p.Glu519Thr",0.0482253369301876,0,0.0831652717201263,0.0712593400962714,3.46944695195361e-18,0.0161244229060576,0.694712643678198,-0.416296773225443
519,"Glu","Trp","p.Glu519Trp",0.0253231106132769,6.11878015701782e-06,0.339517301658268,0.0513617848624969,1.73472347597681e-18,-0.0745128672423958,-0.145057471264283,-2.75245145299935
519,"Glu","Tyr","p.Glu519Tyr",0.0752710470934885,0,0.274901009220255,0.0842529648436122,6.93889390390723e-18,-0.138425643420303,0.046666666666687,-2.75245145299935
519,"Glu","Val","p.Glu519Val",0.0680481616209092,3.46944695195361e-18,0.117261985770773,0.0208574338861741,9.25862429127725e-43,-0.117131192645146,0.332988505747145,-1.16602197953977
520,"Val","Ala","p.Val520Ala",0.024255325378835,5.81039816045016e-20,0.0158272403775129,0.0328061220130033,8.67361737988404e-19,-0.0388292934783253,0.475402298850571,0.200187274592672
520,"Val","Arg","p.Val520Arg",0.0509204033982864,0,0.136177201375311,0.0779726354368052,0,-0.161195111148907,0.584482758620694,-1.21683401053556
520,"Val","Asn","p.Val520Asn",0.0308056570001869,2.65641440680246e-09,0.0328681499486551,0.019225490493902,2.04903237323413e-15,0.0248917218635664,0.486436781609192,-0.119189127295062
520,"Val","Asp","p.Val520Asp",0.0328098153400986,1.40972086434821e-13,0.0189294894428165,0.0181718798914372,5.14420370669124e-17,-0.0370869807469616,0.16298850574714,-0.276440723993433
520,"Val","Cys","p.Val520Cys",0.0759887188387595,0,0.0874515882702999,0.052073846193901,3.46944695195361e-18,-0.00542294825708769,1.8041379310345,-0.919778658824229
520,"Val","Gln","p.Val520Gln",0.0434454930299224,0,0.0197045753481045,0.0285500930425887,1.12019768461202e-15,-0.0213409417036452,0.772068965517253,-0.561346855218742
520,"Val","Glu","p.Val520Glu",0.0507885347049781,0,0.0395490329547811,0.13917104216863,0,0.0860120684526643,-0.240574712643687,-0.256771394053248
520,"Val","Gly","p.Val520Gly",0.0593981598228261,3.46944695195361e-18,0.112678117983668,0.0825417772770225,0,-0.057596385505389,0.786206896551741,0.26907373059259
520,"Val","His","p.Val520His",0.0520755971777329,1.73472347597681e-18,0.0528703707219242,0.14898080478123,0,0.277444112758767,0.342528735632186,-0.565921140944266
520,"Val","Ile","p.Val520Ile",0.0928073969922062,0,0.116121367269249,0.0587477973363294,6.93889390390723e-18,-0.0248659859311593,-0.0247126436781515,-1.06587471584412
520,"Val","Leu","p.Val520Leu",0.0790932481182083,0,0.0764514090364226,0.0792675036341515,6.93889390390723e-18,-0.0703373087944182,0.190919540229892,-1.19022523512919
520,"Val","Lys","p.Val520Lys",0.0639227533011976,0,0.069116797355793,0.0270214403672134,3.76454736968709e-09,-0.209326314293728,0.424942528735672,-1.49144603546133
520,"Val","Met","p.Val520Met",0.0408773872798567,8.67361737988404e-19,0.165526367856455,0.0975637062105861,0,-0.055704369566942,0.398045977011517,-1.2386106232985
520,"Val","Phe","p.Val520Phe",0.106532595146056,0,0.0965599650307532,0.0229099749447662,3.59795936718133e-09,0.1434777790378,-0.762988505747143,-1.66711854233618
520,"Val","Pro","p.Val520Pro",0.077719192932249,1.73472347597681e-18,0.0357603937775581,0.0567786268746935,0,-0.0910079165795069,2.43206896551725,-1.11026679629059
520,"Val","Ser","p.Val520Ser",0.0546125498563463,8.67361737988404e-19,0.0390086734376063,0.0454449120767501,1.73472347597681e-18,-0.203119945852386,0.80666666666667,0.200550909968452
520,"Val","Thr","p.Val520Thr",0.0920756045303834,0,0.035526431205177,0.112604045885708,0,0.0211970730406509,0.77770114942527,0.165279990959421
520,"Val","Tyr","p.Val520Tyr",0.0423674964381374,0,0.280849088603011,0.0605014327946591,0,-0.042210357294694,-1.03816091954025,-2.18658110430886
521,"Leu","Ala","p.Leu521Ala",0.0231387749594204,1.93840714361176e-32,0.0598311936745771,0.0167798197456347,1.55444752746523e-08,0.0336399538590077,2.28080459770124,-2.9182265419227
521,"Leu","Arg","p.Leu521Arg",0.0752190230023454,0,0.169631517978733,0.0907391508562743,1.38777878078145e-17,-1.07121420762001,2.4383908045978,-5.26059858723633
521,"Leu","Asn","p.Leu521Asn",0.0253862587910762,4.78094373881696e-06,0.0429798313879309,0.0555883905868798,0,-0.301706540353376,1.90080459770126,-4.59284279736742
521,"Leu","Asp","p.Leu521Asp",0.0582842494308579,5.20417042793042e-18,0.0757710904679216,0.05485833161802,6.93889390390723e-18,-0.547672718560327,3.0028735632185,-4.59284279736742
521,"Leu","Cys","p.Leu521Cys",0.0513102343950074,0,0.060016901066333,0.0234139713994679,5.12153253834358e-14,-0.136688678554975,2.95229885057481,-3.47670602657301
521,"Leu","Gln","p.Leu521Gln",0.0584800518785089,0,0.0623364462166668,0.0676939916170736,0,-0.504079598524046,2.43793103448289,-4.59284279736742
521,"Leu","Glu","p.Leu521Glu",0.0470201274254754,0,0.136965920472137,0.0630502073479816,0,-0.881934924204014,2.92045977011504,-3.97590422604342
521,"Leu","Gly","p.Leu521Gly",0.025932929118747,7.98370733421066e-09,0.0850704976907321,0.0344329902351446,3.12250225675825e-17,-0.464927678456301,4.20632183908057,-5.26059858723633
521,"Leu","His","p.Leu521His",0.0872454978119849,0,-0.0152029218170267,0.0797827669123691,0,-0.276067011607745,2.55655172413803,-4.59284279736742
521,"Leu","Ile","p.Leu521Ile",0.0887364825198223,0,0.0477533896327144,0.0583824680769753,3.46944695195361e-18,-0.141821371604453,1.02103448275873,-1.39314950310509
521,"Leu","Lys","p.Leu521Lys",0.0325001141281178,4.17391108220933e-13,0.0939885603992644,0.0487412175156675,3.94528298919283e-11,-0.98419605939973,3.35080459770126,-5.26059858723633
521,"Leu","Met","p.Leu521Met",0.0265077031889463,6.10654418465071e-25,-0.0421964056781264,0.0293494388722267,1.37563571644961e-15,0.050805922822047,0.982068965517357,-1.17804190442855
521,"Leu","Phe","p.Leu521Phe",0.0398717744958039,0,0.101039102326609,0.0648163054767838,0,-0.0452068173865293,1.12344827586216,-3.54901660113493
521,"Leu","Pro","p.Leu521Pro",0.0343238932872256,6.36233126787228e-08,0.0889414552213108,0.0782018439869932,6.93889390390723e-18,-0.795615480942271,5.31850574712654,-5.26059858723633
521,"Leu","Ser","p.Leu521Ser",0.0279219550141399,7.19696742546675e-06,-0.0578172608674937,0.0710272806964752,3.46944695195361e-18,0.0718104489152342,3.39448275862079,-3.86350754737494
521,"Leu","Thr","p.Leu521Thr",0.0476777013338564,0,-0.0440186012815963,0.0808645547646414,0,0.022081470520046,2.54137931034492,-3.27409428767841
521,"Leu","Trp","p.Leu521Trp",0.0351398414208212,1.70525486092865e-14,0.0507746309546162,0.0446642129447148,0,-0.222559096529184,0.41206896551735,-4.34897011009953
521,"Leu","Tyr","p.Leu521Tyr",0.0255975766226208,1.60529154090804e-07,-0.10658041043629,0.0888650173945434,0,-0.166870180964356,0.90390804597712,-4.34897011009953
521,"Leu","Val","p.Leu521Val",0.0456514292537798,0,0.0640081938668773,0.0741463568500818,0,-0.172858279382696,1.70942528735643,-1.43637974962457
522,"Arg","Ala","p.Arg522Ala",0.0527414420297661,0,0.133832761437937,0.0686058099224663,0,-0.111672344905332,0.122988505747145,-1.34868183363981
522,"Arg","Asn","p.Arg522Asn",0.0822442343365036,0,0.187041221747083,0.0958734311695562,0,-0.21283888008185,0.930229885057506,-1.90227098923245
522,"Arg","Asp","p.Arg522Asp",0.0619114943460607,0,0.281722849912145,0.0891231303814707,2.08166817117217e-17,-0.743472308633936,1.5172413793104,-1.89246710644332
522,"Arg","Cys","p.Arg522Cys",0.082128139438969,0,0.26000408762595,0.0478207539241198,0,-0.120125109196271,1.19068965517246,-1.36460498942732
522,"Arg","Gln","p.Arg522Gln",0.0400589158997332,2.87885019060932e-07,0.182670901791589,0.0835434383105998,6.93889390390723e-18,0.0183193624492012,0.444482758620764,-0.468615904105325
522,"Arg","Glu","p.Arg522Glu",0.0306818643714408,7.65129951785912e-06,0.186074238406975,0.142118206917296,0,-0.00691129004705396,0.379885057471298,-1.86369572297921
522,"Arg","Gly","p.Arg522Gly",0.0358007723209679,1.73472347597681e-18,0.168981042226576,0.0754211784176472,0,-0.0944464369431326,1.36747126436786,-2.73869666656224
522,"Arg","His","p.Arg522His",0.0328993180871716,1.55845258610442e-16,0.151366241144621,0.0447653699905037,0,-0.191119869852244,-0.466781609195393,-1.56074899435974
522,"Arg","Ile","p.Arg522Ile",0.0633167468043427,0,0.165707937478051,0.0604338870966453,0,-0.396882161731366,-0.249080459770079,-1.98546014695091
522,"Arg","Leu","p.Arg522Leu",0.0700949899092685,0,0.274040073478342,0.0588070615459142,0,-0.125812842255421,-1.19287356321836,-1.53589212823576
522,"Arg","Lys","p.Arg522Lys",0.04772452136705,2.58881457937399e-14,-0.0270364031717132,0.067388539394917,0,0.0775731339202247,0.0502298850575118,-0.99916352414656
522,"Arg","Met","p.Arg522Met",0.0793720726141338,0,0.234886952250864,0.0292227644522139,3.85239148285692e-09,-0.120500672472342,-0.372643678160889,-1.57425137682367
522,"Arg","Phe","p.Arg522Phe",0.0300449926214012,7.39922888792484e-06,0.388543380374744,0.0622088968130126,3.46944695195361e-18,-0.330583875016745,-1.97643678160916,-2.87923044105491
522,"Arg","Pro","p.Arg522Pro",0.0518855152973292,0,0.393977038727887,0.0716826592206596,6.93889390390723e-18,-1.08805502142632,7.45609195402303,-4.03703321125135
522,"Arg","Ser","p.Arg522Ser",0.0458751796630142,8.67361737988404e-19,0.406341663819918,0.0626842239981258,0,0.174135365484034,0.986551724137967,-0.797010271909359
522,"Arg","Thr","p.Arg522Thr",0.0810547616338125,0,0.130195396221222,0.0655835076741465,0,-0.000364771298354058,0.453333333333381,-1.25269375426348
522,"Arg","Trp","p.Arg522Trp",0.0821745363711913,6.93889390390723e-18,0.452965540707878,0.0249423527498091,1.28336010485144e-52,-0.14178458745233,-2.11873563218385,-2.87554085693399
522,"Arg","Tyr","p.Arg522Tyr",0.0276452037189516,8.27116430818719e-07,0.198221638824909,0.0584226183238327,0,-0.176178830170364,-1.44344827586202,-2.68198714011103
522,"Arg","Val","p.Arg522Val",0.0825660407319137,0,0.136317737773607,0.0235858656731025,1.04196176402298e-21,-0.227656500529148,0.290574712643733,-1.68926048815898
523,"Glu","Ala","p.Glu523Ala",0.0617952300348328,1.73472347597681e-18,0.048211685046267,0.0751129360354422,6.93889390390723e-18,-0.057983698398728,0.086091954022939,-2.41942798705162
523,"Glu","Arg","p.Glu523Arg",0.0328478461893433,2.25717444453364e-60,0.181653415165297,0.0713949193183621,0,-0.189697315064202,-0.278735632183929,-2.16528390547437
523,"Glu","Asn","p.Glu523Asn",0.0299558434778507,4.26774010661673e-25,0.0975629396987555,0.147610944685981,0,-0.112450323898019,0.416206896551657,-1.37829048967837
523,"Glu","Asp","p.Glu523Asp",0.0679524671435211,0,0.049529313680264,0.0538180096530972,0,0.155757214342983,0.575402298850532,-0.457152948056377
523,"Glu","Cys","p.Glu523Cys",0.0657030985716299,3.46944695195361e-18,0.114954168028245,0.130801633608477,0,-0.0222839919426584,1.2059770114942,-3.36007615852122
523,"Glu","Gln","p.Glu523Gln",0.0982834276853377,3.46944695195361e-18,0.0977429090008434,0.0413518709401096,0,-0.0949551020872143,-0.0674712643678671,-1.34588040868209
523,"Glu","Gly","p.Glu523Gly",0.0213052484688297,1.25570195614607e-44,0.0637716787077577,0.0177584232651889,4.45005215749731e-19,-0.169171095450685,1.06091954022986,-3.14540857753035
523,"Glu","His","p.Glu523His",0.0369473505883876,1.2170089155189e-12,0.101818041462779,0.0214222211701228,2.7132272041883e-44,0.0495359724048119,-0.0717241379310633,-1.36691356441443
523,"Glu","Ile","p.Glu523Ile",0.0468797487214062,1.30494573480355e-15,0.131003072211343,0.053858218690815,0,-0.233202851237218,-0.230229885057489,-4.28180097124674
523,"Glu","Leu","p.Glu523Leu",0.0719213714558705,0,0.146771173165458,0.0278396972142417,4.95034568892549e-13,-0.208459552252954,-0.312183908046017,-4.28180097124674
523,"Glu","Lys","p.Glu523Lys",0.075219526219941,0,0.0765179692095404,0.0486096681504099,0,-0.0291319424532085,0.03494252873559,-2.00020256201794
523,"Glu","Met","p.Glu523Met",0.088313654619581,0,0.126696721922325,0.0526614738735731,0,-0.169030293708925,0.0471264367815925,-4.28180097124674
523,"Glu","Phe","p.Glu523Phe",0.0569851475420334,0,0.204351287261127,0.0670055573598325,0,-0.183411865500912,-0.28977011494255,-4.99904228677873
523,"Glu","Pro","p.Glu523Pro",0.0563218362840544,0,0.0974365445815707,0.152842194833255,2.77555756156289e-17,-0.983623370421619,5.86206896551724,-3.76671685441719
523,"Glu","Ser","p.Glu523Ser",0.0840367264274392,0,0.0437864549265464,0.058935460466873,3.46944695195361e-18,-0.0222835441931596,0.727931034482716,-2.4136867232314
523,"Glu","Thr","p.Glu523Thr",0.121925731741501,6.93889390390723e-18,0.0892947565931668,0.0440878214602912,7.45931094670027e-17,-0.070597539946323,0.264712643678121,-2.31766068528546
523,"Glu","Trp","p.Glu523Trp",0.0709618529870676,0,0.324748384790039,0.0708280317982883,0,-0.264155307666928,-0.283563218390842,-4.99904228677873
523,"Glu","Tyr","p.Glu523Tyr",0.0498744643062768,0,0.265807337438333,0.0736214553673283,3.46944695195361e-18,-0.357180227988524,0.129425287356293,-4.99904228677873
523,"Glu","Val","p.Glu523Val",0.0720816788945408,0,0.0867348312468761,0.0941687747155736,0,-0.104543162654509,-0.0557471264367962,-3.60193209945986
524,"Met","Ala","p.Met524Ala",0.0456704483152888,0,0.00665863357856681,0.135143809950018,2.77555756156289e-17,-0.112641610374514,2.34379310344834,-2.84107524998831
524,"Met","Arg","p.Met524Arg",0.0792579605995017,0,0.110382843025886,0.036375320588106,7.39638327200258e-96,-0.865851762923141,2.73287356321842,-3.63643897539415
524,"Met","Asn","p.Met524Asn",0.0302128502370008,1.49902730961667e-08,-0.0114695037955587,0.0314856945208388,2.89591657139162e-10,-1.02407463561074,2.50413793103454,-4.1943856077051
524,"Met","Asp","p.Met524Asp",0.10127855432113,0,-0.0676594107481517,0.036556362300315,3.60344684293074e-07,-1.02262090903007,3.0014942528736,-4.1943856077051
524,"Met","Cys","p.Met524Cys",0.0684659972178287,0,0.16750948241397,0.0689146506859802,6.93889390390723e-18,-0.161766822426573,2.79356321839087,-3.07270513236758
524,"Met","Gln","p.Met524Gln",0.0702091238449883,0,0.0565296496792218,0.102917737321142,6.93889390390723e-18,-0.565180125912533,2.15689655172418,-3.45464395714055
524,"Met","Glu","p.Met524Glu",0.0955559846494719,0,0.0952337523005044,0.0597037969008265,0,-1.07668300609072,2.26356321839086,-4.1943856077051
524,"Met","Gly","p.Met524Gly",0.0886366930387401,3.46944695195361e-18,-0.144791329759114,0.0796064136392089,6.93889390390723e-18,-0.79369867429221,3.97563218390809,-4.95864181874658
524,"Met","His","p.Met524His",0.0613903995269913,1.73472347597681e-18,0.0898282618380399,0.0441318259485222,1.37364859070788e-12,-0.860457179850429,1.55471264367819,-4.1943856077051
524,"Met","Ile","p.Met524Ile",0.0779276455334627,0,0.0755295296606898,0.0605827480525601,0,0.0187681090139166,0.262988505747154,-1.19580913333457
524,"Met","Leu","p.Met524Leu",0.054035212521902,1.73472347597681e-18,0.0182458812574439,0.0674129930762275,0,0.0333975769189905,0.380229885057523,-0.946708396662862
524,"Met","Lys","p.Met524Lys",0.109635140211312,0,0.0832435710120756,0.0634465501679662,1.04083408558608e-17,-0.792623999866762,3.75965517241388,-3.67585922996603
524,"Met","Phe","p.Met524Phe",0.0599851879655733,3.46944695195361e-18,0.263857041376356,0.0393096010886187,0,-0.24931076797741,-0.916321839080405,-2.95454192132098
524,"Met","Pro","p.Met524Pro",0.0527234200479746,0,-0.0909448685076278,0.109992032563979,0,-1.06434118845649,9.82195402298856,-4.95864181874658
524,"Met","Ser","p.Met524Ser",0.0283386599292037,7.43647045971965e-41,0.0688749806410459,0.104583286746733,0,-0.961519455222437,3.26908045977014,-2.39093966792553
524,"Met","Thr","p.Met524Thr",0.0398200008342546,2.16840434497101e-18,0.0310111788030314,0.0215846841064543,9.22059310593518e-37,-0.164524735346243,1.88793103448281,-2.39329564597478
524,"Met","Trp","p.Met524Trp",0.0907899582954982,5.0315728660176e-06,0.468545411141577,0.252544822039174,0,-0.785560052940519,0.131149425287391,-3.8697075980869
524,"Met","Tyr","p.Met524Tyr",0.063760872093332,1.73472347597681e-18,0.251813654376711,0.0425546301447134,1.32450428229347e-10,-0.895771658438458,-0.178275862068931,-3.8697075980869
524,"Met","Val","p.Met524Val",0.0211886593759956,2.61910429499005e-06,0.0339117684927155,0.0651518707721158,0,0.00776815725716543,0.842643678160961,-1.17816890343347
525,"Leu","Ala","p.Leu525Ala",0.0447591334476096,3.69608124839257e-09,0.049655789249466,0.0625507528206878,6.72070202998101e-07,-0.920031347957778,3.91770114942529,-4.41155320763161
525,"Leu","Arg","p.Leu525Arg",0.129633370803631,0,0.0973806996899084,0.0774641805976298,6.32133234645949e-15,-1.00641033710297,4.76931034482761,-4.67404804490966
525,"Leu","Asn","p.Leu525Asn",0.100177907158029,0,0.0321360639470192,0.0866793776170691,0,-0.96948772411276,3.77770114942531,-4.67404804490966
525,"Leu","Asp","p.Leu525Asp",0.0848310468425369,0,0.335146020497097,0.0729028020572331,2.08166817117217e-17,-1.04087853788336,4.57643678160923,-4.67404804490966
525,"Leu","Cys","p.Leu525Cys",0.0901087465813009,0,0.122655830005969,0.0822768494761672,0,-0.625726548818839,3.92218390804598,-4.41155320763161
525,"Leu","Gln","p.Leu525Gln",0.0491745939839794,1.31753829485694e-10,0.0938814478548609,0.065045808365313,1.41148295114464e-13,-1.07123226238442,3.3291954022989,-4.67404804490966
525,"Leu","Glu","p.Leu525Glu",0.115053329588375,0,0.298276259708569,0.0803661420219473,7.93191901049539e-13,-1.09958615497262,3.98034482758625,-4.67404804490966
525,"Leu","Gly","p.Leu525Gly",0.120996861068591,1.38777878078145e-17,-0.0322106744123044,0.0466548107031271,3.77891746073702e-11,-1.03643289976591,5.5183908045977,-4.67404804490966
525,"Leu","His","p.Leu525His",0.136406347963234,0,0.0812697096535822,0.0741086974004345,1.42247325030098e-16,-0.987178002033728,2.65908045977012,-4.67404804490966
525,"Leu","Ile","p.Leu525Ile",0.0832678096679195,0,0.095460112801904,0.0492702173057764,0,-0.148179154004449,0.574482758620721,-0.42485511909277
525,"Leu","Lys","p.Leu525Lys",0.116313913827612,0,-0.0320014618157964,0.143937749944008,0,-1.14733229537633,5.67494252873564,-4.67404804490966
525,"Leu","Met","p.Leu525Met",0.0385788451977267,1.63623040455938e-06,0.0413416640423636,0.0840983329208338,0,-0.165132423216777,1.40850574712645,-1.42500248265478
525,"Leu","Phe","p.Leu525Phe",0.162065253741678,0,0.036121247570659,0.136466906110322,4.16333634234434e-17,-0.0493419270541853,0.801954022988516,-1.15789942314306
525,"Leu","Pro","p.Leu525Pro",0.0579538525245081,1.30008850907082e-14,0.245677379421781,0.0570558327175553,3.12684796503227e-31,-1.09990764236746,10.2159770114943,-4.67404804490966
525,"Leu","Ser","p.Leu525Ser",0.0357706636637452,2.56020918089891e-16,-0.12818654332082,0.0625125543252301,0,-0.508909204917846,4.7337931034483,-4.41155320763161
525,"Leu","Thr","p.Leu525Thr",0.0544460249544849,6.18212286675192e-20,0.126341541329831,0.0719797632687137,2.3510886430992e-06,-0.96946232417955,3.27931034482761,-4.41155320763161
525,"Leu","Trp","p.Leu525Trp",0.0566944757809813,0,0.424648864848273,0.0455854199081083,4.20950229355958e-46,-0.974155660052,1.8367816091954,-2.10662287452455
525,"Leu","Tyr","p.Leu525Tyr",0.0932995427525468,6.93889390390723e-18,-0.0354583647639669,0.0689489368414339,3.56571878697143e-07,-1.03858347662378,2.54977011494255,-2.66757525819792
525,"Leu","Val","p.Leu525Val",0.0666327915336695,0,0.163053166330007,0.103365583688281,0,-0.452279032808862,1.71540229885062,-1.10752525203323
526,"His","Ala","p.His526Ala",0.0634299106482274,3.46944695195361e-18,-0.00317254499062093,0.0651077674166607,1.04083408558608e-17,-0.0946073577756967,0.509655172413816,-0.939818941259455
526,"His","Arg","p.His526Arg",0.0234381479860829,7.06280447344722e-10,0.0419046277261106,0.0172314913168381,3.59949973696663e-47,0.0613234580059487,0.340229885057502,0.0594909036236097
526,"His","Asn","p.His526Asn",0.0959279928585036,0,0.0415329986673583,0.0206120300265802,1.19910123093951e-07,-0.0209155293581378,1.4166666666667,-1.06086659270201
526,"His","Asp","p.His526Asp",0.0640472654959948,1.73472347597681e-18,0.139155416828934,0.0203588488764933,8.47769279794209e-35,-0.161901595535898,2.78586206896558,-1.5254558426716
526,"His","Cys","p.His526Cys",0.0466864284601239,0,0.0766713811395109,0.117351207406405,0,0.0771149258051617,1.60689655172417,-1.3261711295357
526,"His","Gln","p.His526Gln",0.0353731960827802,8.17705278488567e-16,0.122000261105007,0.0736215332549786,0,-0.10457420183502,1.41965517241383,-0.389101042605953
526,"His","Glu","p.His526Glu",0.0510191454727604,0,0.0219649873673209,0.132803219849865,0,0.17808421700061,1.20310344827587,-0.88573191633282
526,"His","Gly","p.His526Gly",0.0964460424570397,0,0.142132788798045,0.0380426135029751,8.67361737988404e-19,-0.0580032227433907,1.64724137931036,-1.37305355057995
526,"His","Ile","p.His526Ile",0.0507846412753224,0,0.0495755132990352,0.0675706019843315,1.38777878078145e-17,0.000635248097855955,0.788275862069012,-3.13299167993758
526,"His","Leu","p.His526Leu",0.0566335250921206,3.46944695195361e-18,0.0900938120018139,0.0756202392271281,0,-0.0694654531483747,0.3791954022989,-3.13299167993758
526,"His","Lys","p.His526Lys",0.0540916739532687,0,0.0996876154181825,0.0222590191243576,3.66593950157927e-18,-0.0763083254553277,0.849425287356333,-0.507767889372205
526,"His","Met","p.His526Met",0.0926544040000132,3.46944695195361e-18,0.16244397573976,0.0206199171356237,1.03521247697896e-41,-0.0208866703365847,0.735862068965548,-2.64021157120147
526,"His","Phe","p.His526Phe",0.0478810147745195,0,0.106446201159864,0.0892070216586893,2.08166817117217e-17,0.00407740758347974,0.558735632183946,-3.25947652041192
526,"His","Pro","p.His526Pro",0.0873287172031489,3.46944695195361e-18,0.36416033301405,0.0369068979651649,9.064920810889e-33,-1.00447303982073,7.70298850574716,-3.47570378338759
526,"His","Ser","p.His526Ser",0.0756827389016467,3.46944695195361e-18,0.0410403366717821,0.117847115827016,0,0.0219568533809481,1.21402298850576,-0.938110105109234
526,"His","Thr","p.His526Thr",0.0395648939394088,4.25007251614318e-17,0.180216854390042,0.080240652323615,0,0.0527515028554428,1.12873563218395,-1.13281945543693
526,"His","Trp","p.His526Trp",0.102259339597048,0,0.174569353689777,0.100931704728551,0,-0.290165482321991,0.760114942528768,-3.25947652041192
526,"His","Tyr","p.His526Tyr",0.0488348725046208,8.67361737988404e-19,0.161080458909367,0.0705213372391871,3.46944695195361e-18,-0.0636897451332389,0.770344827586233,-3.25947652041192
526,"His","Val","p.His526Val",0.0448096738422554,1.30104260698261e-18,0.0962700882568282,0.0436219391064769,1.73472347597681e-18,0.1014018220394,1.40827586206899,-3.13299167993758
527,"Asn","Ala","p.Asn527Ala",0.0243060047601527,2.97377867051134e-11,-0.0220383191504974,0.0110807377718125,2.84985377874589e-14,-0.0830039465285624,0.729770114942547,-1.56494314263515
527,"Asn","Arg","p.Asn527Arg",0.0437227719330938,7.65917141095608e-08,0.0803534197437982,0.0916214900541787,0,-0.0680432670362234,0.144367816092016,-1.61143577026231
527,"Asn","Asp","p.Asn527Asp",0.0296134935051727,1.59174490751131e-18,-0.0507659185578973,0.0731714259905245,0,0.0930132651691613,0.487356321839108,-0.171606598151495
527,"Asn","Cys","p.Asn527Cys",0.0531227678531136,8.67361737988404e-19,0.0170768492999032,0.0303071449298653,0,-0.0661048871151209,1.19206896551728,-1.64567218349933
527,"Asn","Gln","p.Asn527Gln",0.0276047868857782,3.0253288126899e-06,-0.0074620867316403,0.0647217184544389,0,0.0690477347062276,0.775172413793146,-0.833791741024118
527,"Asn","Glu","p.Asn527Glu",0.0286388258810919,3.658383366469e-17,0.0542298240661273,0.0148715673790183,3.18937237731021e-12,0.199790826228186,0.725977011494283,-0.473486793012123
527,"Asn","Gly","p.Asn527Gly",0.0304957395625645,1.01482385862772e-12,-0.00133602171983321,0.0229920350156613,3.46944695195361e-18,0.173280046586227,1.1277011494253,-1.00210118333046
527,"Asn","His","p.Asn527His",0.0295446800947902,6.41481849609644e-47,0.0131105260222051,0.0941728313460165,0,0.00943727692712249,0.0997701149425478,-1.01239611669901
527,"Asn","Ile","p.Asn527Ile",0.0642021958526105,0,0.211070459801542,0.0663874209364392,3.46944695195361e-17,-0.503931753330143,1.41873563218394,-3.05094739701332
527,"Asn","Leu","p.Asn527Leu",0.0283269721163351,1.25067368287831e-39,0.0188227022880912,0.0241574285820907,0,0.0099240181178217,-0.0740229885056955,-3.05094739701332
527,"Asn","Lys","p.Asn527Lys",0.0387084921948403,3.04858693751181e-114,-0.014327514358385,0.0817512515971931,0,0.0841368412667418,0.553563218390834,-0.932935712754026
527,"Asn","Met","p.Asn527Met",0.0408982244500985,1.0177916538607e-18,0.0492844577570458,0.037526566975725,5.20417042793042e-18,0.0506758243823342,0.141839080459814,-3.05094739701332
527,"Asn","Phe","p.Asn527Phe",0.0295307239022535,3.6914022913524e-11,0.0250831715905287,0.0461673907086009,0,-0.174089320126627,-0.115057471264365,-1.61240008272783
527,"Asn","Pro","p.Asn527Pro",0.0568174313781651,1.28216343358439e-09,0.610888666783786,0.0457900782159689,2.33425606661562e-11,-0.970665911173292,5.40287356321846,-3.05094739701332
527,"Asn","Ser","p.Asn527Ser",0.0365097333723886,4.25762118255862e-22,-0.0211687404586985,0.112112930176623,0,-0.214106202664929,1.17689655172414,-0.669359266083257
527,"Asn","Thr","p.Asn527Thr",0.0282286767196984,2.28595734403148e-79,0.0611310056510954,0.0779162305760226,1.38777878078145e-17,-0.0481870037164069,1.58436781609199,-1.40418619805091
527,"Asn","Trp","p.Asn527Trp",0.0223695697385781,3.35613853293424e-16,0.0205133287799272,0.0113304070658333,8.8982075851104e-40,-0.226211753454958,-0.0405747126436334,-2.57332375092769
527,"Asn","Tyr","p.Asn527Tyr",0.0249793734701335,6.38321540933923e-07,0.00518830485421918,0.0707583955431139,1.38777878078145e-17,-0.0621163964515959,0.135977011494278,-2.06175717494319
527,"Asn","Val","p.Asn527Val",0.0447580192673228,1.79859590881215e-33,0.0750809029059574,0.0240418115273952,5.39718809874809e-42,-0.155437359439643,1.33333333333335,-3.05094739701332
528,"His","Ala","p.His528Ala",0.0237599071437757,1.58060575419895e-09,-0.00736362608429514,0.0460006053175339,3.46944695195361e-18,-0.00811764604702182,0.831034482758623,-1.94500657437743
528,"His","Arg","p.His528Arg",0.0278789174993092,3.97389445568747e-12,0.123409997294546,0.0177488312667099,1.25033347671096e-22,-0.940758955555433,3.76954022988507,-4.54405892228693
528,"His","Asn","p.His528Asn",0.0447961803278927,1.85558859944202e-12,0.0302059770178207,0.101229043276936,5.55111512312578e-17,-0.425530981996428,1.99517241379312,-1.49571800757187
528,"His","Asp","p.His528Asp",0.0275794530937558,1.0842021724855e-18,0.242214410579788,0.0424266620115629,0,-1.06029408370403,3.47850574712645,-2.41452109836133
528,"His","Cys","p.His528Cys",0.0184752535001218,6.81771434368606e-11,0.0527834291990663,0.10752328925636,0,0.021144833362844,1.12701149425285,-1.69363776492019
528,"His","Gln","p.His528Gln",0.0552867616892672,0,0.0381676235411398,0.0961835778274855,0,-0.0891388432054705,1.08827586206895,-0.961349169947625
528,"His","Glu","p.His528Glu",0.0210598512346401,7.41741583764648e-73,0.0449124897160521,0.0221138631841907,8.67361737988404e-19,-0.456452787269987,2.30000000000003,-2.41452109836133
528,"His","Gly","p.His528Gly",0.0292296362173331,2.16840434497101e-19,0.112797152135032,0.09636623654744,2.77555756156289e-17,-0.582764421129404,2.11758620689658,-4.02550477833508
528,"His","Ile","p.His528Ile",0.0282473284308075,1.4997768651992e-14,0.0868316023075311,0.0502438477445872,1.38777878078145e-17,-0.0590755893258011,0.456666666666688,-2.42771873976965
528,"His","Leu","p.His528Leu",0.0215189063157737,1.57181126068189e-09,0.103075365393261,0.0404209354665284,0,-0.0210237043996031,-1.20126436781609,-1.65289644523682
528,"His","Met","p.His528Met",0.0329359550275192,2.91748396274993e-13,0.106884187634219,0.0817750256874859,0,0.0471611957511862,0.188390804597689,-1.53306693390187
528,"His","Phe","p.His528Phe",0.0250850116475957,7.77142994490023e-34,0.0693428587266027,0.094206627562922,0,-0.0734492867724108,0.252183908045972,-3.07987254032673
528,"His","Pro","p.His528Pro",0.0274373034398733,1.46309471634918e-07,-0.0160222874348082,0.0479875698149888,0,-1.07244465034658,5.37068965517243,-3.40383025044154
528,"His","Ser","p.His528Ser",0.0202413647333312,2.67121410371824e-48,0.0744433242544029,0.044245592667442,3.46944695195361e-18,-0.116691504497561,1.5944827586207,-1.37782086429205
528,"His","Thr","p.His528Thr",0.0547455276555153,0,0.189281122655069,0.125562143909771,0,-0.263745188415464,1.78632183908045,-2.57568142057741
528,"His","Trp","p.His528Trp",0.0287758157507581,1.01915004213637e-17,0.246490331696077,0.042781526489015,0,-0.675556396263906,1.78758620689657,-3.63897335156918
528,"His","Tyr","p.His528Tyr",0.0300052827648047,1.19262238973405e-16,0.178683003356414,0.0812802541502985,2.77555756156289e-17,-0.672270707834613,1.77494252873566,-2.88129791714761
528,"His","Val","p.His528Val",0.0332835265015426,5.16651761730108e-10,0.134700772384043,0.148162080017983,1.11022302462516e-16,0.111235259250885,0.373448275862046,-2.79836293391278
529,"Ser","Ala","p.Ser529Ala",0.0293353829816643,3.84380613524086e-09,0.0469964912913913,0.122205933234954,5.55111512312578e-17,0.0247231352961814,0.157931034482709,-1.5572923021855
529,"Ser","Arg","p.Ser529Arg",0.0315548361221763,5.78635043626454e-28,0.0379494875877071,0.0135937856595323,3.36251612542143e-13,-0.107914207884654,-1.00977011494259,-3.5421465763595
529,"Ser","Asn","p.Ser529Asn",0.0309135022094421,5.09125771055996e-12,0.00236133401074197,0.10658146963951,0,0.0833072373425363,-0.251379310344842,-2.94721970105413
529,"Ser","Asp","p.Ser529Asp",0.0343477198179451,3.71773185153801e-12,0.123414679295047,0.0734068562519849,0,-0.109542909275099,-0.136896551724194,-3.82587710717581
529,"Ser","Cys","p.Ser529Cys",0.0282877031039942,1.20801983700615e-55,0.0504936972972138,0.0547860266491523,1.38777878078145e-17,-0.0355018834559156,0.444482758620607,-1.97272305603866
529,"Ser","Gln","p.Ser529Gln",0.0443460245004418,4.33680868994202e-19,-0.0185318644210493,0.0193754621569206,0,0.0417292373505295,-0.648965517241401,-3.22484859777339
529,"Ser","Glu","p.Ser529Glu",0.0379500916638424,3.0213146082619e-17,-0.0519882102434081,0.110612931982826,2.77555756156289e-17,-0.149538431305942,-0.162988505747193,-3.4927027415844
529,"Ser","Gly","p.Ser529Gly",0.0354072270926968,1.21430643318376e-17,0.0542800229992734,0.157606017035328,1.11022302462516e-16,0.0159427087119351,1.54206896551716,-4.82159044774238
529,"Ser","His","p.Ser529His",0.0412321785105414,1.73472347597681e-18,-0.0215308128579148,0.0741801801734992,0,0.156268518020736,-0.449310344827624,-3.82587710717581
529,"Ser","Ile","p.Ser529Ile",0.0621511151893701,0,0.0623354331706991,0.0500149933189558,0,-0.0803838377375369,-1.5741379310345,-1.81859567201984
529,"Ser","Leu","p.Ser529Leu",0.0337534907108628,4.68521143951774e-09,0.0796802437927302,0.0463335366075758,0,-0.0284408163707615,-1.10620689655175,-2.4237024647162
529,"Ser","Lys","p.Ser529Lys",0.0370040426228169,4.08701157073936e-56,-0.0141263333025331,0.0822688871803156,0,0.23040293500969,-0.261034482758642,-2.02236426633634
529,"Ser","Met","p.Ser529Met",0.0259457449080536,6.28393154586246e-52,0.0706764324617205,0.150649466838638,0,-0.118504551255703,-1.36701149425293,-2.95035714397451
529,"Ser","Phe","p.Ser529Phe",0.0326511049449542,2.01945597706244e-37,0.159973230767315,0.060749077554993,0,-0.00300773207413913,-0.738965517241468,-3.10620757815563
529,"Ser","Pro","p.Ser529Pro",0.0351539616884709,6.11033949746414e-07,0.0163887479920398,0.0276926642453677,2.96838983635073e-21,-0.896054627298739,4.23137931034481,-4.82159044774238
529,"Ser","Thr","p.Ser529Thr",0.0270279749769347,2.81194863718368e-08,-0.0187850069977028,0.0539443083777078,0,-0.0698590311940129,-0.291034482758638,-0.436647480546551
529,"Ser","Trp","p.Ser529Trp",0.0268003694147103,5.23366072702203e-15,0.232651179618365,0.0238647525454841,0,-0.568810564820164,-1.06758620689663,-4.06618812787911
529,"Ser","Tyr","p.Ser529Tyr",0.0560738653819077,2.60208521396521e-18,0.182586268884316,0.0393669187827031,3.46944695195361e-18,0.102095977403075,-0.532873563218439,-3.553668866674
529,"Ser","Val","p.Ser529Val",0.036869213667884,2.60208521396521e-17,0.0600185108476375,0.0634543950422456,0,0.0734207493677554,-1.01000000000003,-1.78578143261227
530,"Phe","Ala","p.Phe530Ala",0.0258875753999564,1.41785279295004e-15,0.0397082274369702,0.0501804753670791,1.38777878078145e-17,-1.04541684940617,4.1527586206897,-5.19183709625341
530,"Phe","Arg","p.Phe530Arg",0.0734640359567457,0,-0.0635588742567456,0.030455879099251,7.98177330606319e-28,-0.992505359456503,3.81724137931038,-5.19183709625341
530,"Phe","Asn","p.Phe530Asn",0.0633445184919801,0,-0.0795638699522875,0.0583097092856316,0,-0.987138346480445,4.30517241379315,-4.18721306063242
530,"Phe","Asp","p.Phe530Asp",0.0317049772760629,2.68844215576879e-13,-0.316555816673619,0.0674338104441984,0,-0.997444516229311,5.80862068965518,-4.62629831163455
530,"Phe","Cys","p.Phe530Cys",0.0501015551785943,4.60135402002848e-16,-0.0595069264674458,0.0425951820022517,1.51804662590349e-11,-1.10795570223268,4.60586206896556,-5.19183709625341
530,"Phe","Gln","p.Phe530Gln",0.0230430685469717,2.28363158289468e-08,-0.0599769268186538,0.023288656901998,3.94774922604299e-09,-1.0097064451146,3.99678160919542,-4.62629831163455
530,"Phe","Glu","p.Phe530Glu",0.02681951711533,2.98525507360939e-11,-0.327832880922271,0.0206894903647488,2.24712441523755e-41,-0.975202443051192,5.43793103448275,-4.62629831163455
530,"Phe","Gly","p.Phe530Gly",0.04124575921583,0,-0.191752647094234,0.0665430467493988,0,-1.10092352375948,5.47712643678167,-5.19183709625341
530,"Phe","His","p.Phe530His",0.0214846474758553,4.37300124071192e-184,0.103944565764672,0.0181402523338188,5.65521539617759e-10,-0.971568038905592,2.78068965517247,-4.11543329057055
530,"Phe","Ile","p.Phe530Ile",0.0408446656708341,1.98344520091645e-08,0.137456961611168,0.0857946563947927,0,-0.59009666417494,2.36241379310346,-3.44085745620181
530,"Phe","Leu","p.Phe530Leu",0.0363905031612528,2.10016899704346e-13,0.0544149758115885,0.131791197767272,8.32667268468867e-17,-0.534934563561304,2.47850574712647,-3.12834906050281
530,"Phe","Met","p.Phe530Met",0.03863814524047,1.40521275171501e-14,0.0733360264584105,0.143505490178238,0,-0.66722338900803,2.24528735632188,-3.96972811525706
530,"Phe","Pro","p.Phe530Pro",0.0267794244509006,7.12363735299192e-16,-0.338853803582941,0.0651586353510373,1.38777878078145e-17,-0.912790661443114,4.3789655172414,-5.19183709625341
530,"Phe","Ser","p.Phe530Ser",0.034913795795438,3.6234736500336e-10,-0.0708825314199488,0.0794031974967374,0,-0.957446819118013,4.76793103448276,-5.19183709625341
530,"Phe","Thr","p.Phe530Thr",0.0279128414776043,1.25167148801746e-08,0.0408879928007507,0.0455911552360443,3.46944695195361e-18,-0.962795910671602,4.26103448275866,-5.19183709625341
530,"Phe","Trp","p.Phe530Trp",0.0469566723634674,0,0.0312178978004204,0.0909106255768558,4.16333634234434e-17,-0.176490352631199,0.638735632183936,-1.85262515596237
530,"Phe","Tyr","p.Phe530Tyr",0.0261518081593086,3.28127158053688e-13,0.131661349228009,0.11107765382352,5.55111512312578e-17,-0.459733305727007,0.995057471264412,-0.985871143136053
530,"Phe","Val","p.Phe530Val",0.053893161113807,0,0.150135768838166,0.127350313931683,0,-0.875167748273889,3.07034482758621,-3.24971955295178
531,"Val","Ala","p.Val531Ala",0.0333222249099074,1.66724761447881e-13,0.0740661962609112,0.0880815747956243,0,-0.337092852086654,1.92551724137933,-4.62724147929222
531,"Val","Arg","p.Val531Arg",0.0445947287800956,8.12129443555909e-13,-0.230703030535834,0.154606033986903,5.55111512312578e-17,-0.17843975122196,1.23011494252874,-5.1913246548319
531,"Val","Asn","p.Val531Asn",0.0480208121770932,0,0.176134750061707,0.118722215973035,2.77555756156289e-17,-0.847893212979847,1.6231034482759,-5.1913246548319
531,"Val","Asp","p.Val531Asp",0.0343317101309584,1.02704303395207e-14,0.0725439495651013,0.0659042258125972,0,-1.00211310674699,1.65586206896556,-5.1913246548319
531,"Val","Cys","p.Val531Cys",0.0256890052050994,2.25686937041874e-07,0.0610947084168598,0.0364954297161805,1.21430643318376e-17,-0.0573010227944162,1.86482758620692,-4.62724147929222
531,"Val","Gln","p.Val531Gln",0.021730690616888,3.47808812856308e-41,-0.0239910838971698,0.128262374360799,8.32667268468867e-17,-0.395960106215692,1.19747126436783,-5.1913246548319
531,"Val","Glu","p.Val531Glu",0.0377929055674469,2.35552635228e-12,0.0170159417007562,0.194894759540185,0,-0.553333380814869,1.87701149425289,-5.1913246548319
531,"Val","Gly","p.Val531Gly",0.0340590849237319,7.18288448984915e-45,0.0476532443759028,0.0559601300002687,6.93889390390723e-18,-0.663054211700121,3.27724137931039,-5.1913246548319
531,"Val","His","p.Val531His",0.0308454678957575,1.75021080169941e-10,-0.140236539138484,0.0165458437593548,1.01123344822362e-06,-0.0981984215027107,1.66298850574711,-5.1913246548319
531,"Val","Ile","p.Val531Ile",0.0373952552136654,5.48823810232117e-07,-0.0695077811021243,0.0138174958161926,1.86757777062748e-11,0.0806282542051893,0.123448275862077,-1.43195188845578
531,"Val","Leu","p.Val531Leu",0.0345980899020078,1.6587421272792e-08,-0.0884237293533732,0.0937469669422607,0,0.0637108789786679,-0.221034482758647,-2.25820130063688
531,"Val","Lys","p.Val531Lys",0.0518456578467185,2.30327909522821e-15,-0.223407575709005,0.0878660426388663,0,-0.201460069350311,1.21379310344827,-5.1913246548319
531,"Val","Met","p.Val531Met",0.0373799363175794,8.51820829801328e-10,-0.168012501481063,0.0140211609363691,5.84738190731905e-94,-0.271022973795033,0.48195402298853,-2.02486233886575
531,"Val","Phe","p.Val531Phe",0.0256720463346309,3.72031633585646e-34,0.00401875048109633,0.0808543895950429,0,-0.258365382854797,1.20379310344827,-5.1913246548319
531,"Val","Pro","p.Val531Pro",0.0514332720889501,7.63210080088908e-29,-0.868143030113934,0.0419974052378446,1.23092597217582e-32,-1.08235303333163,5.76241379310345,-5.1913246548319
531,"Val","Ser","p.Val531Ser",0.0396519130313265,5.97545841054184e-36,0.141211965008298,0.0413700741767272,1.35134958778593e-15,-0.828169365959979,2.39839080459773,-4.62724147929222
531,"Val","Thr","p.Val531Thr",0.0398108112375193,0,0.108095459441062,0.0132119263930743,3.32355354338529e-06,-0.496611754229069,1.16850574712646,-4.0576053330275
531,"Val","Trp","p.Val531Trp",0.0299466339967506,8.50156797712679e-51,-0.513835283995579,0.0723318217016357,1.38777878078145e-17,-0.496857362496431,0.676896551724126,-5.1913246548319
531,"Val","Tyr","p.Val531Tyr",0.0249891295543534,8.93439776661981e-27,-0.290855320775253,0.0713536858296526,1.38777878078145e-17,-0.248631075200275,1.24551724137934,-5.1913246548319
532,"Gly","Ala","p.Gly532Ala",0.043837884233015,5.64187399056115e-11,-0.122501354194049,0.0709318629900358,0,-0.0526098998518619,0.316206896551774,-3.4174039418681
532,"Gly","Arg","p.Gly532Arg",0.0408722441752917,4.28077712166797e-14,-0.450016973511395,0.0558984675552574,6.93889390390723e-18,0.308658176802237,-0.323908045976931,-5.84565215986053
532,"Gly","Asn","p.Gly532Asn",0.0421988988669796,4.8139941206368e-85,-0.0996905250112732,0.0171315215721115,8.9731265025676e-10,0.390349635703772,0.524482758620754,-5.34166377243403
532,"Gly","Asp","p.Gly532Asp",0.034918623436323,3.39354413666034e-67,-0.207150383013942,0.0546135883091832,0,0.0194761574460563,0.328965517241441,-5.34166377243403
532,"Gly","Cys","p.Gly532Cys",0.0717437454695649,0,-0.124911710692314,0.0221470259571266,0,-0.219082106460658,0.420344827586303,-4.70570123427028
532,"Gly","Gln","p.Gly532Gln",0.0571026872044545,1.06428701520181e-08,-0.249998760140114,0.0586448832189627,0,0.539563922592381,0.483333333333403,-5.34166377243403
532,"Gly","Glu","p.Gly532Glu",0.0405299603584849,1.77366659013595e-31,-0.246726149429182,0.0801352777537246,1.38777878078145e-17,-0.00631863633469085,0.578275862069012,-5.34166377243403
532,"Gly","His","p.Gly532His",0.0444141636685907,9.0013465930093e-10,-0.0513198650539565,0.125755326321771,0,0.470432401126729,-0.201724137930969,-5.34166377243403
532,"Gly","Ile","p.Gly532Ile",0.0333099571723771,5.72313934689673e-13,-0.265877432058337,0.0663401721162532,0,-0.0921173684606952,0.654482758620737,-5.84565215986053
532,"Gly","Leu","p.Gly532Leu",0.0284939170098105,2.37061047718185e-06,-0.160526326264182,0.050760535778859,0,0.254049085005202,-0.536206896551668,-5.84565215986053
532,"Gly","Lys","p.Gly532Lys",0.057907373420576,0,-0.305639032234014,0.0378664294602086,0,0.284908953452101,0.340000000000062,-5.84565215986053
532,"Gly","Met","p.Gly532Met",0.041119957233552,9.81840090786342e-16,-0.167320583429164,0.110714424373748,2.77555756156289e-17,-0.148178563533055,-0.247586206896473,-5.84565215986053
532,"Gly","Phe","p.Gly532Phe",0.0280451333422548,3.82488605913245e-23,-0.292507705864516,0.0710181689466891,1.38777878078145e-17,-0.084431762149226,-0.226551724137905,-5.84565215986053
532,"Gly","Pro","p.Gly532Pro",0.0634041398370491,1.98575444376949e-33,-1.48108112085048,0.0336949165214451,9.96315277399169e-63,-1.09989183736375,9.5806896551725,-5.84565215986053
532,"Gly","Ser","p.Gly532Ser",0.0363239858815031,8.16061774029953e-78,-0.160151685170644,0.0433887279685998,0,0.219694883079553,0.572068965517278,-4.02355958665667
532,"Gly","Thr","p.Gly532Thr",0.0385481868363131,9.47512369350719e-17,-0.248835508259131,0.0600527589672657,0,0.0043511595706468,0.390000000000029,-4.70570123427028
532,"Gly","Trp","p.Gly532Trp",0.0329681836329322,4.2073875100516e-54,-0.317570492622041,0.0297422952942718,1.73472347597681e-18,0.0515617336699872,-0.23264367816088,-5.84565215986053
532,"Gly","Tyr","p.Gly532Tyr",0.0350724029495749,9.49238343600949e-10,-0.307766866493006,0.119435651354966,0,-0.126597936639401,0.0768965517242013,-5.84565215986053
532,"Gly","Val","p.Gly532Val",0.0353834231957259,7.81319453579954e-15,-0.0869917663133501,0.0543912699986737,1.38777878078145e-17,-0.347050275274316,0.796091954023059,-5.84565215986053
533,"Cys","Ala","p.Cys533Ala",0.024204540256965,4.64513292692495e-60,0.00146085901306124,0.0986715029403394,0,0.0682325024476585,0.471724137931092,-1.52421220212547
533,"Cys","Arg","p.Cys533Arg",0.0559370414963968,2.13649652389411e-33,-0.313541100024417,0.0367493817336421,1.82285733111868e-25,-0.864225576107313,3.47172413793103,-4.78032043245949
533,"Cys","Asn","p.Cys533Asn",0.0354667580716561,7.14363537100566e-47,0.0442021955344713,0.0761599527758789,0,-0.0138484180799232,0.0848275862069292,-3.8295728123861
533,"Cys","Asp","p.Cys533Asp",0.03783491868272,1.27158675479942e-11,-0.175889986925284,0.0860803115256891,0,-0.985428727283285,1.41793103448279,-4.13211931322666
533,"Cys","Gln","p.Cys533Gln",0.0337683910213708,3.48614366540989e-15,0.0843545558979541,0.046210563500451,3.46944695195361e-18,-0.885267845235692,0.535287356321857,-4.13211931322666
533,"Cys","Glu","p.Cys533Glu",0.047799107057522,0,-0.0030918343705488,0.0642757415866624,6.93889390390723e-18,-0.95950797826977,2.86000000000003,-4.13211931322666
533,"Cys","Gly","p.Cys533Gly",0.0509456981851305,9.18273981988097e-06,0.0607752236074363,0.0587772985839632,1.44133142920833e-11,-1.09605445055109,2.44862068965521,-4.78032043245949
533,"Cys","His","p.Cys533His",0.0326119615799174,3.21688150719201e-07,-0.0563875000345154,0.0388521102877753,6.93889390390723e-18,0.0201626256317474,0.604137931034466,-3.45227148294934
533,"Cys","Ile","p.Cys533Ile",0.042761381783947,8.67361737988404e-19,-0.0691043871691464,0.0494029831550606,0,0.0610553340359521,-0.672068965517187,-1.52782542031863
533,"Cys","Leu","p.Cys533Leu",0.0266547621012755,1.33722835472021e-15,-0.0412824124962478,0.114030072919346,2.77555756156289e-17,-0.0875483698722183,0.584482758620746,-1.55048967817346
533,"Cys","Lys","p.Cys533Lys",0.0760983578754805,1.23097315168687e-39,-0.712350396295201,0.14872364463039,0,-1.05556538279356,3.51011494252874,-4.78032043245949
533,"Cys","Met","p.Cys533Met",0.0306784010302812,1.26018791172608e-10,-0.0187867584518441,0.189384782239686,0,-0.383919973951016,-0.553448275862049,-1.50813885287703
533,"Cys","Phe","p.Cys533Phe",0.0323684229055255,3.86425915468548e-06,-0.0804747291520416,0.0817525301928695,0,-0.0187825660460843,-0.168390804597692,-2.48886766559338
533,"Cys","Pro","p.Cys533Pro",0.0400613552937448,2.6623668547554e-15,0.14882449213254,0.0539237848198372,0,-0.681466041278094,1.43827586206898,-3.006609235086
533,"Cys","Ser","p.Cys533Ser",0.0291475621167722,1.26564483776385e-25,-0.0233426019305966,0.0159842164862186,8.99750576713147e-09,-0.112057289350524,1.3372413793104,-1.02408159373137
533,"Cys","Thr","p.Cys533Thr",0.0781326173273294,0,0.0515684669963847,0.0120975964740415,1.37344501457482e-06,0.0646058263400398,-0.16149425287356,-1.52523859821205
533,"Cys","Trp","p.Cys533Trp",0.0272942248919322,6.17840774948599e-25,0.0227899602478009,0.106352313251595,2.77555756156289e-17,-0.608122048616585,1.16137931034488,-3.42414203693244
533,"Cys","Tyr","p.Cys533Tyr",0.0332048022822192,4.03346380957603e-09,-0.0782767273513642,0.0797714818962161,0,-0.0407528457050308,1.22482758620694,-3.0468197693342
533,"Cys","Val","p.Cys533Val",0.0359595596288277,1.05164804516513e-20,-0.0313854245462232,0.0150071211157167,6.52908851916001e-88,0.0881244772429819,-0.395862068965513,-1.47755295651137
534,"Val","Ala","p.Val534Ala",0.0717263112995044,1.37448043349143e-170,0.186159054431943,0.182356579143076,0,-0.156604009546263,1.77344827586208,-1.93302028980697
534,"Val","Arg","p.Val534Arg",0.0352793449595886,8.13446532355044e-14,0.154339663579367,0.0517976107388728,0,-0.881720130946285,0.768620689655187,-4.99297890675626
534,"Val","Asn","p.Val534Asn",0.0466647804571995,0,0.158734206954742,0.0417499745943879,0,-1.04146997766976,1.34586206896552,-4.99297890675626
534,"Val","Asp","p.Val534Asp",0.0323819716967744,6.09244332724343e-50,0.0956503388473171,0.0332207634066743,9.05503660768303e-10,-1.0099122975178,1.6237931034483,-4.99297890675626
534,"Val","Cys","p.Val534Cys",0.0381239833805656,2.21921439558237e-13,0.0301586206945232,0.046894237478051,0,0.184821015251061,1.71793103448275,-2.31085544505353
534,"Val","Gln","p.Val534Gln",0.0281363457435816,3.90894694574533e-08,0.13239255236959,0.04439486780026,3.46944695195361e-18,-0.956406659207461,0.793103448275846,-4.99297890675626
534,"Val","Glu","p.Val534Glu",0.0401069699323136,7.60790448327546e-06,0.180245850467165,0.0939171210522149,8.32667268468867e-17,-0.942930994916738,0.953103448275826,-4.99297890675626
534,"Val","Gly","p.Val534Gly",0.0342602949885053,5.52506019116258e-37,0.153170477122437,0.0986271621782636,2.77555756156289e-17,-0.948713912377805,3.05275862068968,-4.99297890675626
534,"Val","His","p.Val534His",0.0308022755924794,2.24564725934759e-17,0.205513983209591,0.0627347221469571,0,-0.736624565729469,1.65000000000003,-4.99297890675626
534,"Val","Ile","p.Val534Ile",0.0362456802569071,2.08291392167631e-15,0.0558713682904831,0.119293512408163,0,0.0695650963072268,-0.696896551724124,-0.700520161957108
534,"Val","Leu","p.Val534Leu",0.0439681331193631,1.30104260698261e-18,-0.0891709513872364,0.0638948082796135,0,-0.117750579515912,-0.670344827586193,-1.60924216131302
534,"Val","Lys","p.Val534Lys",0.0239092036042924,7.46074749594757e-46,0.194935760571152,0.0620232597019047,1.38777878078145e-17,-0.953909253575791,1.20770114942527,-4.99297890675626
534,"Val","Met","p.Val534Met",0.0358920187833604,1.60986350118686e-12,0.0333636530165029,0.0344910339924496,3.46944695195361e-18,-0.135690442752937,0.444137931034487,-2.56612833118996
534,"Val","Phe","p.Val534Phe",0.0221246554394133,2.46321951697803e-08,0.104357148747836,0.0843309097016,1.38777878078145e-17,-0.252044798581984,1.70551724137931,-4.12365837899858
534,"Val","Pro","p.Val534Pro",0.0326305001566549,1.47793886157155e-09,0.0501385675245001,0.0929676265854422,0,-0.0267924362343307,4.53252873563218,-4.04547358977354
534,"Val","Ser","p.Val534Ser",0.023556846169239,3.38899008638551e-14,0.109492309699088,0.0688913230867332,1.38777878078145e-17,-0.723632443775085,2.00689655172412,-2.37317056415025
534,"Val","Thr","p.Val534Thr",0.038477115856998,5.15932277260834e-10,0.0741686319216848,0.0851262572010606,1.38777878078145e-17,-0.484281696650779,1.30758620689652,-2.36980298548028
534,"Val","Trp","p.Val534Trp",0.0304736774004303,2.26953353064738e-50,0.291583021577268,0.0977508246403039,2.77555756156289e-17,-0.111276855567526,-0.29379310344828,-4.55227058715704
534,"Val","Tyr","p.Val534Tyr",0.0317699721725731,2.5305322409135e-06,0.184719175843932,0.0508014018058986,6.93889390390723e-18,-0.423440722298326,1.71103448275862,-4.55227058715704
535,"Asn","Ala","p.Asn535Ala",0.0317836400957611,4.13353404757506e-11,0.0137428240535478,0.0544291968535384,6.93889390390723e-18,-0.144014931723982,1.51034482758624,-2.43322721874681
535,"Asn","Arg","p.Asn535Arg",0.128742603499188,0,0.203296546111796,0.0597035671152279,2.10452523463633e-11,-0.990859279122855,1.35172413793106,-2.77686262084621
535,"Asn","Asp","p.Asn535Asp",0.0231364310707231,5.13652377710768e-12,0.0228120305675426,0.0284382398765021,0,0.106285944194845,0.178275862068984,-0.476877051876965
535,"Asn","Cys","p.Asn535Cys",0.0487438008197602,6.96682295187045e-13,0.00530600188339731,0.0305693477980961,0,-0.014205901079625,1.29482758620693,-2.02465006203413
535,"Asn","Gln","p.Asn535Gln",0.0248483885063581,5.40115925994168e-07,0.0945691668724192,0.104654752286344,0,-0.452639996013131,1.86137931034488,-1.642624536892
535,"Asn","Glu","p.Asn535Glu",0.0403932865682549,9.08728455495732e-13,-0.0404032990580028,0.0770887507445561,0,-0.129564832316185,1.5948275862069,-0.87278992349833
535,"Asn","Gly","p.Asn535Gly",0.0321195283757036,9.82803259062305e-07,0.0543234195280139,0.069287286243087,0,-0.0315933626450981,2.03862068965518,-3.04286823739142
535,"Asn","His","p.Asn535His",0.0602111927912947,0,0.0994176307660107,0.101370885550632,0,-0.552693308855207,2.1948275862069,-1.86118668318514
535,"Asn","Ile","p.Asn535Ile",0.0354203644460411,2.55294770199164e-61,0.0479875197462712,0.0523159407764335,3.46944695195361e-18,-0.879749612272817,1.59965517241384,-3.66932690942107
535,"Asn","Leu","p.Asn535Leu",0.0450670734460409,7.51205904338942e-10,0.132445152260604,0.0712639434540889,0,-0.724710772784541,1.61827586206896,-3.66932690942107
535,"Asn","Lys","p.Asn535Lys",0.0899809682751229,6.93737573463638e-10,-0.053273118990815,0.0425907553201442,2.16778010430329e-08,-0.570854682126463,2.09034482758625,-2.19751382419153
535,"Asn","Phe","p.Asn535Phe",0.030374435083675,2.99294623318998e-33,0.200404566893883,0.0804171647482966,0,-0.984158880226957,2.03000000000006,-3.66932690942107
535,"Asn","Pro","p.Asn535Pro",0.0346797678750793,1.54264963501451e-18,-0.552846967662622,0.048607152860107,3.46944695195361e-18,-1.05086233672549,6.74896551724142,-3.66932690942107
535,"Asn","Ser","p.Asn535Ser",0.0230047156038426,5.4984351838283e-22,0.0857415518077975,0.0449227027104462,6.93889390390723e-18,0.0460979865486019,0.669999999999994,-0.775458501469915
535,"Asn","Thr","p.Asn535Thr",0.0313039234255867,1.79055670459001e-66,-0.0117388667847692,0.0236261678093357,0,0.0213505326186193,0.528275862069018,-0.986051725623077
535,"Asn","Trp","p.Asn535Trp",0.0643174331562998,3.18274920307893e-12,0.137492932700333,0.0470698016372815,3.35778297237339e-27,-0.983931349211219,1.89,-3.66932690942107
535,"Asn","Tyr","p.Asn535Tyr",0.0242397436236247,8.59465025190853e-10,0.237475917768535,0.0301096459314607,0,-0.981474978930421,2.09551724137931,-3.66932690942107
535,"Asn","Val","p.Asn535Val",0.0372972428939023,4.33680868994202e-19,0.104355028779839,0.0675673920333797,0,-0.353549514569427,1.21551724137934,-3.66932690942107
536,"Pro","Arg","p.Pro536Arg",0.031512141467131,4.45387314965505e-16,-0.0621331476061617,0.0681830667727977,0,-0.529906455109303,1.17413793103447,-1.50998170045018
536,"Pro","Asn","p.Pro536Asn",0.073359805383522,6.93889390390723e-18,0.119826850999053,0.11605272078493,2.77555756156289e-17,-0.868821358525901,0.651724137931069,-1.0859953408077
536,"Pro","Asp","p.Pro536Asp",0.0210733861976189,2.50285548125245e-47,0.0588499488479951,0.044920523402675,0,-0.957929474405431,2.57885057471263,-1.01351054946038
536,"Pro","Cys","p.Pro536Cys",0.0190562719529481,1.38727775137212e-06,-0.0505851174374922,0.0114098245061222,1.19392343234104e-14,-0.205430771484421,0.450689655172419,-1.652188770437
536,"Pro","Gln","p.Pro536Gln",0.0229121146246115,5.73559127086407e-71,0.0429844877445724,0.0294465553184874,0,-0.076913346934109,0.0179310344827266,-0.784624369173731
536,"Pro","Glu","p.Pro536Glu",0.0489391907693498,1.73472347597681e-18,0.00108150855851388,0.0703891454675094,0,0.0843188848139205,0.611034482758598,-0.532447531743635
536,"Pro","Gly","p.Pro536Gly",0.0306829496341146,4.86197473881103e-06,0.102941433077639,0.0648955579842793,0,-0.167416568529363,1.32965517241379,-2.38519508817
536,"Pro","His","p.Pro536His",0.0389443569063953,1.52066992582138e-12,-0.114509915887016,0.138289234744858,0,0.0514178255831895,0.57413793103447,-1.22387490512365
536,"Pro","Ile","p.Pro536Ile",0.0644129123581425,3.46944695195361e-18,-0.0155036391352036,0.0707050398852894,0,-0.0281486826266563,4.19873563218391,-2.12207687125909
536,"Pro","Leu","p.Pro536Leu",0.0213211367279222,6.16427055966308e-13,-0.063200246194823,0.085112078126075,2.77555756156289e-17,-0.233955242797449,2.67448275862072,-1.64054097838468
536,"Pro","Lys","p.Pro536Lys",0.0304248625248559,3.20651210744824e-08,0.0491623717192216,0.075940521405139,0,-0.10833660876709,1.5662068965517,-1.41675146381178
536,"Pro","Met","p.Pro536Met",0.0333557567988913,6.73752052029834e-10,-0.0661715393916664,0.075307143638095,1.38777878078145e-17,-0.224671902564389,0.519655172413814,-2.41922973941843
536,"Pro","Phe","p.Pro536Phe",0.030171362877964,5.35074756854645e-11,-0.0672426224974309,0.0230982521947114,0,-0.200223495413983,7.10632183908044,-3.49682239137857
536,"Pro","Ser","p.Pro536Ser",0.0268565081376168,2.22513720165868e-08,0.0306886578069182,0.0833841447129471,1.38777878078145e-17,0.0570529552972233,0.768620689655187,-1.56251406729864
536,"Pro","Thr","p.Pro536Thr",0.0613691032062563,1.73472347597681e-18,0.007339440615087,0.0302163900930781,1.73472347597681e-18,-0.164902083122132,1.08862068965515,-1.48886391477434
536,"Pro","Trp","p.Pro536Trp",0.0325634955461243,9.27686746865497e-14,-0.00885419838779564,0.0273423881455175,8.67361737988404e-19,-0.320694823459632,1.41896551724138,-3.49682239137857
536,"Pro","Tyr","p.Pro536Tyr",0.0224494802972569,5.67766913650773e-64,-0.0931314611239809,0.0476838046309534,0,-0.160299355480343,1.02241379310347,-2.67363778997429
536,"Pro","Val","p.Pro536Val",0.0201849915916407,2.20779138329942e-76,0.0903869666947587,0.0384784753441004,3.46944695195361e-18,0.0719409878289683,2.4710344827586,-2.04328190366649
537,"Gln","Ala","p.Gln537Ala",0.0420249611102407,0,-0.00384424512964753,0.0612856467423474,2.77555756156289e-17,-0.0901456771896928,0.185517241379314,-1.82580742356095
537,"Gln","Arg","p.Gln537Arg",0.0406471072875326,8.67361737988404e-19,0.0766122492362097,0.0792347290498523,0,-0.196151336597237,0.747126436781609,-1.67588495082049
537,"Gln","Asn","p.Gln537Asn",0.0441983638929579,1.17809580016739e-10,-0.0311827723035311,0.0464476010820307,0,-0.238992058746503,0.71206896551726,-1.3646900714065
537,"Gln","Asp","p.Gln537Asp",0.0273848406536068,1.68666023753107e-13,0.0298479494223116,0.017071987201913,7.32046801649178e-14,-0.114170285953973,0.642758620689666,-1.60060875538605
537,"Gln","Cys","p.Gln537Cys",0.054304748738096,4.35086987878724e-09,-0.00922661389696134,0.0998584006331688,1.38777878078145e-17,-0.1696738452749,0.667586206896525,-1.50225322824144
537,"Gln","Glu","p.Gln537Glu",0.15068648657325,0,0.0766892859130118,0.105867133623987,0,0.00425603785373611,-0.40689655172416,-0.955386054786315
537,"Gln","Gly","p.Gln537Gly",0.0481752916898895,1.69135538907739e-17,0.0146186114073147,0.0650932374349469,0,-0.234251275592596,1.57655172413789,-3.23504089640331
537,"Gln","His","p.Gln537His",0.0279727052534896,2.3076266995373e-63,0.15991572811186,0.0679627835046155,2.08166817117217e-17,-0.470129555395054,0.0731034482758322,-1.45966716905869
537,"Gln","Ile","p.Gln537Ile",0.0446388735257885,3.19384687967605e-11,0.195059051865855,0.0531989407510822,0,-0.323448951565262,-0.0768965517241229,-1.89526450587665
537,"Gln","Leu","p.Gln537Leu",0.0263104719619201,1.65140367659007e-29,0.186874842764333,0.0219553777383065,9.24846537175168e-16,-0.944523473503098,-0.391379310344824,-2.20176770527137
537,"Gln","Lys","p.Gln537Lys",0.064155330458398,0,0.00832161176533746,0.124456386590422,0,-0.133034969063302,0.407931034482756,-1.60507282174216
537,"Gln","Met","p.Gln537Met",0.0602205845189245,1.73472347597681e-18,0.048971395648212,0.0660386934702518,0,0.14540518289651,-0.136551724137969,-2.40482181542429
537,"Gln","Phe","p.Gln537Phe",0.0409474079284829,1.18143229393514e-43,-0.0328698318184018,0.101203591789474,1.38777878078145e-17,-0.991877008724601,-0.267586206896549,-3.01636645555978
537,"Gln","Pro","p.Gln537Pro",0.0367164628432383,4.71978632727202e-84,0.188675388217388,0.033142474184531,2.26366692048869e-08,-0.991890765635332,5.31724137931034,-4.10786128677905
537,"Gln","Ser","p.Gln537Ser",0.0373492315909776,1.18928566327319e-22,-0.0519815119327847,0.150320470260728,0,-0.166313941637764,1.18022988505745,-1.29502558726195
537,"Gln","Thr","p.Gln537Thr",0.045469308571517,1.30104260698261e-18,0.0135101095350777,0.0930648592867774,0,-0.0582421859308634,0.52310344827588,-1.52207397513715
537,"Gln","Trp","p.Gln537Trp",0.0399337151190699,7.72288898499843e-33,0.0346699904468992,0.0361321732816946,4.63072171252072e-44,-1.0032328788625,-0.228275862069004,-3.80945902027045
537,"Gln","Tyr","p.Gln537Tyr",0.0550080107042161,2.56730400827188e-14,0.0646260161216701,0.0308258302620041,8.03374496156196e-30,-0.838627736788208,-0.213563218390799,-3.19134079536447
537,"Gln","Val","p.Gln537Val",0.031253614404237,3.68921820176338e-12,0.0074810658289931,0.0708906328242428,1.38777878078145e-17,-0.0600105546691897,-0.437701149425287,-1.89108348672821
538,"Trp","Ala","p.Trp538Ala",0.0399260183648407,1.77351294216167e-06,0.00969964063763616,0.104503184741985,0,-0.884718339493337,4.25425287356321,-2.61904793451781
538,"Trp","Arg","p.Trp538Arg",0.0283770522354761,1.4762187741903e-19,-0.0401723220177725,0.0308714672407675,3.30213287269565e-14,-0.979051442449862,2.85137931034483,-1.4948325534317
538,"Trp","Asn","p.Trp538Asn",0.0509833001419889,3.12250225675825e-16,-0.00647391306095114,0.0944236027626283,0,-0.959916486046107,3.86977011494252,-2.1131937118896
538,"Trp","Asp","p.Trp538Asp",0.084756038991531,0,-0.0659280960998187,0.0410512476718175,2.56912546792165e-15,-1.07549489974528,4.39747126436779,-2.97227794726265
538,"Trp","Cys","p.Trp538Cys",0.0239615551760028,1.41026013454076e-20,-0.0216109247049976,0.0170095208322446,2.62665849711478e-43,-0.845913111661769,4.46896551724139,-2.22107411201974
538,"Trp","Gln","p.Trp538Gln",0.048078954412296,0,0.0494621573661312,0.0267677969768177,1.47425301521114e-54,-0.990608471761931,3.97793103448278,-1.70403172188752
538,"Trp","Glu","p.Trp538Glu",0.0598693962650478,9.83848825476026e-44,0.10774954876866,0.0558805218629628,7.89104805784882e-07,-1.06113389421945,4.08252873563216,-2.35401007005464
538,"Trp","Gly","p.Trp538Gly",0.0320852801428298,2.43148262092931e-19,-0.203490012688046,0.0464158694627073,3.46944695195361e-18,-0.931106912701995,5.95942528735632,-4.73805203471994
538,"Trp","His","p.Trp538His",0.0776221408577039,0,0.0643002924818024,0.126638818537004,0,-0.667267332919048,2.88563218390805,-1.56492051128865
538,"Trp","Ile","p.Trp538Ile",0.0561008781288132,0,-0.0381263594956968,0.096292176729167,0,0.0858759844158213,3.1789655172414,-2.11739387537578
538,"Trp","Leu","p.Trp538Leu",0.0356600456140004,3.92169235294982e-29,0.0247664041169805,0.0873050550473584,0,0.0624663562139215,1.97252873563219,-1.29531065207342
538,"Trp","Lys","p.Trp538Lys",0.0641928323791399,8.67361737988404e-19,-0.0874957829196813,0.0995487884634146,0,-1.03976842667453,4.08643678160918,-1.66132039045402
538,"Trp","Met","p.Trp538Met",0.0391495316103542,8.33767716326705e-11,-0.082302080820086,0.126826362190256,0,-0.152022626482906,2.38988505747128,-2.06939949463196
538,"Trp","Phe","p.Trp538Phe",0.0537726374944586,1.73472347597681e-18,0.00271770434435322,0.0829519339191824,0,0.0450074451212812,1.19310344827585,-1.00594769061823
538,"Trp","Ser","p.Trp538Ser",0.0299683296315555,1.44672237234995e-39,0.054608844019554,0.0632034156726825,6.93889390390723e-18,-0.904915002064891,4.8894252873563,-1.91449882213558
538,"Trp","Thr","p.Trp538Thr",0.0547584167255295,1.30104260698261e-17,0.0658244909032824,0.123110098505364,5.55111512312578e-17,-0.835720103388352,3.98942528735633,-2.13930849957446
538,"Trp","Tyr","p.Trp538Tyr",0.0567502554770532,1.73472347597681e-18,-0.0618244061101985,0.0809075284743696,1.38777878078145e-17,0.0103645469262158,1.37114942528734,-1.26710627312109
538,"Trp","Val","p.Trp538Val",0.0322123677150632,3.64318788830496e-09,-0.0516969844707614,0.0546107272827551,0,-0.0151333477198095,3.22160919540228,-2.19385174509074
539,"Ala","Arg","p.Ala539Arg",0.0607012275989208,2.18647420480516e-38,-1.34559516649815,0.0928161059491463,0,-1.06130193256885,8.30988505747122,-2.329621563511
539,"Ala","Asn","p.Ala539Asn",0.0493835290760192,0,-0.393266988705172,0.0464717003833872,0,-1.07067274679976,2.16678160919536,-4.01268592257513
539,"Ala","Asp","p.Ala539Asp",0.0412192392389518,4.33401424091652e-24,-1.25250263946156,0.0911944228817422,0,-0.97471459784172,2.8581609195402,-4.01268592257513
539,"Ala","Cys","p.Ala539Cys",0.0372913613628948,6.55352057351568e-22,0.0456831068619637,0.0935971665530135,0,-0.207205047269296,0.561839080459735,-1.52073369510151
539,"Ala","Gln","p.Ala539Gln",0.0428528877555313,1.67921232474555e-15,-0.548104484702675,0.0453132020114659,0,-1.00906297696648,4.30666666666662,-3.33415352454041
539,"Ala","Glu","p.Ala539Glu",0.0704173966650113,0,-1.28012317705109,0.0235125851433409,1.62885660436865e-07,-1.04152129962402,4.97482758620684,-3.44859087533738
539,"Ala","Gly","p.Ala539Gly",0.0548961747917698,1.73472347597681e-18,0.112080727925505,0.111588138192146,5.55111512312578e-17,-0.248628308001263,2.25977011494251,-2.69203110754903
539,"Ala","His","p.Ala539His",0.0351849230548313,1.00202169706835e-06,-0.158085264337344,0.0493012607523639,0,-1.05156208495232,4.48448275862065,-4.01268592257513
539,"Ala","Ile","p.Ala539Ile",0.0273972919731665,7.92945557579633e-40,0.058162849070385,0.026310946921675,0,-0.562113715680864,-0.0496551724138473,-2.51377464923403
539,"Ala","Leu","p.Ala539Leu",0.0662460643441179,1.73472347597681e-18,-0.0533768866765394,0.103063236412206,0,-0.993577493432747,5.80919540229879,-2.20120900204286
539,"Ala","Lys","p.Ala539Lys",0.0561217717871444,1.03144515429859e-12,-1.5009956794462,0.0440397458761152,4.79475893017112e-10,-1.08412779808864,9.02597701149418,-3.10093277413042
539,"Ala","Met","p.Ala539Met",0.0506585987786939,3.60432170221081e-15,0.195058340099087,0.0533768531301161,4.85722573273506e-17,-1.07274181985071,3.07666666666662,-2.41639575061604
539,"Ala","Phe","p.Ala539Phe",0.0418025567313594,2.73318694066216e-14,0.0136250936387719,0.0335574371350296,2.15256564309318e-10,-1.04440155315406,4.92310344827585,-2.62625225531828
539,"Ala","Pro","p.Ala539Pro",0.0516418809208901,3.24699591606331e-09,-1.7018948381842,0.0447457943158176,1.04083408558608e-17,-1.03489272729052,9.59494252873559,-4.76079107937945
539,"Ala","Ser","p.Ala539Ser",0.0358863213746195,5.54615061775648e-09,0.0185912649279048,0.0267713844966798,0,-0.116096622697894,1.29149425287355,-0.954198346060151
539,"Ala","Thr","p.Ala539Thr",0.0436602895724866,4.33680868994202e-19,0.0686395606463368,0.064971686338416,1.38777878078145e-17,-0.539822136628841,0.818505747126422,-0.597920973538341
539,"Ala","Trp","p.Ala539Trp",0.124607806930561,6.93889390390723e-18,-0.516839273032252,0.0364076194473362,3.82698572870228e-11,-1.09145321890042,5.26287356321834,-3.69486934511437
539,"Ala","Tyr","p.Ala539Tyr",0.0469047266425213,0,0.109523147311364,0.0949313905786261,0,-0.181843078216546,5.34862068965516,-3.69486934511437
539,"Ala","Val","p.Ala539Val",0.0335897855159021,5.98989926211424e-06,0.0320281419343374,0.0445337994321018,3.46944695195361e-18,0.0589787229880429,-0.399770114942562,-2.04100042132071
540,"Leu","Ala","p.Leu540Ala",0.0304639868123484,8.76446854002934e-10,0.0314027281301952,0.0449079519938303,0,-0.252537161959693,2.58999999999999,-3.37162838318712
540,"Leu","Arg","p.Leu540Arg",0.0566113520487779,3.97018396655545e-25,-1.78499322023657,0.0688091984092291,6.93889390390723e-18,-1.02811122967359,1.43655172413791,-5.16617592783661