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Creamer_2012.bngl
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begin parameters
NA 6.0221415e23 # Avogadro's number (molecues/mol)
Vo 1.0e-10 # Extracellular volume=1/cell_density (L)
#Initial values
EGF_tot 5*1.0e-9*NA*Vo
HRG_tot 5*1.0e-9*NA*Vo
EGFR_tot 4.27672520173064e5
ErbB2_tot 1.42093237149675e4
ErbB3_tot 1.74843554666751e5
ErbB4_tot 8.91594202782983e4
p52Shc1_tot 6.01531854462274e4
Grb2_tot 5.91055062496997e4
Sos1_tot 4.09301535229042e4
Gab1_tot 4.80466223642856e4
PI3K_tot 3.56731320547328e5
PDK1_tot 8.92880892502848e5
Akt1_tot 3.4017537819372e5
RAS_tot 8.65718002843658e5
p120RasGAP_tot 9.32786886419808e4
Raf1_tot 4.80188361349246e4
MEK1_tot 6.63956495470586e4
ERK2_tot 6.16394706849877e5
#Setting K values
EGFequil1 = 1.82539211740452e-6 # EGFkp1/EGFkm1
EGFequil2 = 3.24395882030410e-6 # EGFkp2/EGFkm2
EGFequil3 = 2.88434511422028e-6 # EGFkp3/EGFkm3
HRG3equil1 = 2.7585877061741e-6 # HRG3kp1/HRG3km1
HRG3equil2 = 3.4169236535230e-5 # HRG3kp2/HRG3km2
HRG3equil3 = 3.03813568286261e-5 # HRG3kp3/HRG3km3
HRG4equil1 = 3.55574858868965e-6# HRG4kp1/HRG4km1
HRG4equil2 = 3.58838215596531e-5# HRG4kp2/HRG4km2
HRG4equil3 = 3.19058690718630e-5# HRG4kp3/HRG4km3
EGFkp1 0 #1.6752764844066e-6
EGFkp2 0 #1.31766379762354e-6
EGFkp3 0 #2.82831275074602e-7
EGFkm1 9.17762528080067e-1
EGFkm2 4.06190050680118e-1
EGFkm3 9.80573627199459e-2
HRG3kp1 0 #2.25177730824231e-7
HRG3kp2 0 #5.48266629995157e-6
HRG3kp3 0 #1.56149921651503e-5 #HRG3km3*EGFequil3*HRG3equil2/EGFequil2
HRG3km1 8.16279034087813e-2
HRG3km2 1.60456213128985e-1
HRG3km3 5.13966254148249e-1
HRG4kp1 0 #2.88261678079618e-6
HRG4kp2 0 #5.1027110057525e-6
HRG4kp3 0 #7.73131997833758e-6 #HRG4km3*EGFequil3*HRG4equil2/EGFequil2
HRG4km1 8.10691956671343e-1
HRG4km2 1.422008800615e-1
HRG4km3 2.42316545614977e-1
DimEquil1 = Dimkp1/Dimkm1
DimEquil2 = Dimkp2/Dimkm2
DimEquil4 = Dimkp4/Dimkm4
DimEquil6 = Dimkp6/Dimkm6
DimEquil7 = Dimkp7/Dimkm7
DimEquil10 = Dimkp10/Dimkm10
DimEquil11 = Dimkp11/Dimkm11
DimEquil15 = Dimkp15/Dimkm15
DimEquil17 = Dimkp17/Dimkm17
DimEquil19 = Dimkp19/Dimkm19
DimEquil20 = Dimkp20/Dimkm20
DimEquil22 = Dimkp22/Dimkm22
DimEquil23 = Dimkp23/Dimkm23
DimEquil26 = Dimkp26/Dimkm26
DimEquil27 = Dimkp27/Dimkm27
Dimkp1 5.0959890629278e-6
Dimkp2 Dimkm2*DimEquil1*EGFequil2/EGFequil1
Dimkp3 Dimkm3*DimEquil2*EGFequil3/EGFequil1
Dimkp4 3.55124048645837e-7
Dimkp5 Dimkm5*DimEquil4*EGFequil2/EGFequil1
Dimkp6 5.93863482345085e-7
Dimkp7 Dimkm7*DimEquil6*EGFequil2/EGFequil1
Dimkp8 Dimkm8*DimEquil6*HRG3equil2/HRG3equil1
Dimkp9 Dimkm9*DimEquil7*EGFequil3/EGFequil1
Dimkp10 5.95858524293305e-6
Dimkp11 Dimkm11*DimEquil10*EGFequil2/EGFequil1
Dimkp12 Dimkm12*DimEquil10*HRG4equil2/HRG4equil1
Dimkp13 Dimkm13*DimEquil11*EGFequil3/EGFequil1
Dimkp14 9.40444138151105e-7
Dimkp15 8.64565481767477e-6
Dimkp16 Dimkm16*DimEquil15*HRG3equil2/HRG3equil1
Dimkp17 6.60964194053378e-7
Dimkp18 Dimkm18*DimEquil17*HRG4equil2/HRG4equil1
Dimkp19 2.34931041558104e-6
Dimkp20 Dimkm20*DimEquil19*HRG3equil2/HRG3equil1
Dimkp21 Dimkm21*DimEquil20*HRG3equil3/HRG3equil1
Dimkp22 9.44327814569465e-6
Dimkp23 Dimkm23*DimEquil22*HRG3equil2/HRG3equil1
Dimkp24 Dimkm24*DimEquil22*HRG4equil2/HRG4equil1
Dimkp25 Dimkm25*DimEquil23*HRG3equil3/HRG3equil1
Dimkp26 2.43135131855894e-6
Dimkp27 Dimkm27*DimEquil26*HRG4equil2/HRG4equil1
Dimkp28 Dimkm28*DimEquil27*HRG4equil3/HRG4equil1
Dimkm1 6.82335881150971e-1
Dimkm2 8.60446362688242e-1
Dimkm3 5.30901820046591e-1
Dimkm4 3.2906848719399e-2
Dimkm5 3.61328871705183e-1
Dimkm6 2.91209182767864e-2
Dimkm7 4.10248490881162e-2
Dimkm8 7.06334928569754e-1
Dimkm9 5.064620571136e-1
Dimkm10 5.4868243150637e-2
Dimkm11 2.09675101809484e-1
Dimkm12 2.87423426816554e-1
Dimkm13 5.48638129462967e-1
Dimkm14 5.35056553608581e-2
Dimkm15 4.45127253423715e-1
Dimkm16 2.24099123790756e-1
Dimkm17 3.39468196721401e-1
Dimkm18 7.43735228789512e-2
Dimkm19 1.51427204579608e-2
Dimkm20 6.47926498517387e-2
Dimkm21 7.82869781142506e-2
Dimkm22 8.48650355450826e-1
Dimkm23 6.61204708354308e-1
Dimkm24 9.19541811794608e-1
Dimkm25 3.37299538300942e-2
Dimkm26 2.04189992563573e-1
Dimkm27 7.29286884022918e-1
Dimkm28 7.43108065474286e-1
Intkp1 8.32705126548996e-2
Intkp15 5.86246294682792e-3
iLigkp1 8.93979864006803e-1
iLigkp2 7.56616609711335e-1
iLigkp3 1.40929275291501e-2
iLigkp4 6.46661221517235e-2
iDimkp1 3.5207168888922e-2
iDimkp2 9.17315380364937e-1
iDimkp3 7.93734840774044e-1
iDimkp4 9.78655334522932e-2
iDimkp5 3.65206163171712e-1
iDimkp6 6.86255010679577e-1
iDimkp7 1.99168704665789e-1
iDimkp8 9.6335351868629e-2
iDimkp9 7.87528140525939e-1
iDimkp10 1.66421484864486e-2
Phosphokp1 8.88772107233018e-1
Phosphokp2 4.2878246307489e-1
Phosphokp3 1.95396201245302e-2
Phosphokp4 2.00161517127765e-1
Phosphokp5 7.06003182769046e-1
Phosphokp6 7.6616659390412e-2
Phosphokp7 1.80218044939915e-1
Phosphokp8 4.34778121114391e-1
Phosphokp9 6.39089429079519e-1
Phosphokp10 5.9756050915588e-2
Phosphokp11 2.53799737608887e-1
Phosphokp12 5.63302566441462e-2
Phosphokp13 2.82790620799852e-1
Phosphokp14 1.22324552773364e-1
Phosphokp15 9.67835541778362e-1
Phosphokp16 3.51414620272385e-2
Phosphokp17 5.21022165483879e-2
Phosphokp18 3.1157068215756e-2
Phosphokp19 8.443340013154e-2
Phosphokp20 6.80116300490647e-2
Phosphokp21 4.51367418859485e-1
Phosphokp22 7.74887216709453e-2
Phosphokp23 4.60083703581773e-1
Phosphokp24 2.05792755059326e-1
Phosphokp25 1.9661113965264e-2
Phosphokp26 2.95134086701501e-1
Phosphokp27 9.07050520292188e-1
Phosphokp28 1.21049084190338e-2
Phosphokp29 9.50488082789428e-2
Phosphokp30 9.35460962603844e-2
Phosphokp31 6.54846548500461e-2
Phosphokp32 3.94313272466951e-1
Phosphokp33 3.14072666810171e-1
Phosphokp34 8.45442806483862e-1
Phosphokp35 6.99553162146515e-1
Phosphokp36 3.93438369234849e-2
Phosphokp37 1.4547403805293e-2
Phosphokp38 1.17107729876903e-2
Phosphokp39 4.02838224075356e-2
Phosphokp40 2.78079467363796e-2
Phosphokp41 6.21195843955167e-2
Phosphokp42 3.84566849273881e-2
Phosphokp43 6.53045295503028e-2
Phosphokp44 5.56999926968433e-1
Phosphokp45 1.5472022436839e-2
Phosphokp46 2.78694500019026e-2
Phosphokp47 5.72714409115287e-2
Phosphokp48 7.71759002007548e-1
Phosphokp49 6.01611442493851e-2
Phosphokp50 4.87347060541873e-2
Phosphokp51 4.35687421786884e-2
Phosphokp52 1.18362096686366e-2
Phosphokp53 6.36787651207112e-1
Phosphokp54 3.54646060845124e-1
Phosphokp55 5.90317591027224e-1
Phosphokp56 8.4467134352829e-2
Phosphokm1 7.26993260956493e-3
Phosphokm2 9.74974910327381e-2
Phosphokm3 2.68584632202874e-1
Phosphokm4 5.50094046126816e-1
Phosphokm5 7.67126639405035e-1
Phosphokm6 2.75612797520029e-3
Phosphokm7 6.85030301720076e-3
Phosphokm8 4.87439992623973e-2
Phosphokm9 5.72269724841397e-1
Phosphokm10 9.44031999570728e-1
Phosphokm11 8.81635543298421e-2
Phosphokm12 6.65205478076501e-2
Phosphokm13 7.3601652035394e-2
Phosphokm14 1.5084976290579e-1
Phosphokm15 2.74034930234802e-2
Phosphokm16 4.79850299988658e-2
Phosphokm17 3.67233415392832e-3
Phosphokm18 7.13755713699078e-2
Phosphokm19 1.20814195649541e-2
Phosphokm20 5.91549834797695e-2
Grb2kp1 9.48751042996452e-6
Grb2kp2 4.49259489482017e-7
Grb2kp3 6.03697072678887e-6
Grb2kp4 7.26714190078701e-7
Grb2kp5 7.80974367513346e-6
Grb2km1 6.74470404588556e-2
Grb2km2 3.21266715315215e-1
Grb2km3 9.2695034884224e-1
Grb2km4 1.27959374406095e-2
Grb2km5 7.21220480153556e-1
Shc1kp0 1.97883551485319e-7
Shc1kp1 4.57411536575194e-6
Shc1kp2 4.74191085720764e-6
Shc1kp3 3.28710008853551e-6
Shc1kp4 4.34278757626282e-7
Shc1kp5 4.57221757547808e-6
Shc1kp6 5.72021770430524e-6
Shc1kp7 3.23935077662424e-7
Shc1kp8 9.25660200452455e-6
Shc1km0 4.49575735437162e-2
Shc1km1 6.67230763160359e-2
Shc1km2 5.79656246540662e-2
Shc1km3 7.47800677001061e-1
Shc1km4 9.51265970211182e-1
Shc1km5 6.50096102370838e-1
Shc1km6 1.55457060924141e-1
Shc1km7 1.24736961289233e-1
Shc1km8 3.83019454603652e-1
Shc1kp9 5.69833036091512e-1
Shc1kp10 5.59482986809144e-1
Shc1kp11 2.42858250499268e-1
Shc1kp12 1.5443440933692e-2
Shc1kp13 9.89657844783909e-1
Shc1kp14 1.53725031821727e-2
Shc1kp15 4.22356483806294e-2
Shc1kp16 7.44568988338312e-1
Shc1kp17 1.14399259149258e-2
Shc1kp18 6.63532129002988e-1
Shc1kp19 8.5178640861298e-2
Shc1kp20 5.94148145316552e-1
Shc1kp21 2.0700566805906e-1
Shc1kp22 6.23710111799534e-1
Shc1kp23 2.63775121304968e-1
Shc1kp24 5.32149459123519e-1
Shc1kp25 9.49394026611117e-1
Shc1kp26 4.953415509737e-1
Shc1kp27 7.6819206332508e-1
Shc1kp28 4.85997292760425e-1
Shc1kp29 7.82487101445372e-1
Shc1kp30 3.00808468223011e-1
Shc1kp31 2.65779406020073e-2
Shc1kp32 5.29010839763077e-2
Shc1km14 8.88151462022222e-2
Scafoldkp1 7.81993810926309e-7
Scafoldkp2 5.2905293019769e-6
Scafoldkp3 5*Scafoldkp2
Scafoldkm1 3.39662220127485e-1
Scafoldkm2 6.38794564439524e-2
Scafoldkm3 Scafoldkm2
Sos1kp1 2.83307444159129e-6
Sos1kp3 1.10049191751608e-6
Sos1kp5 2.32751420105001e-2
Sos1kp6 5*Sos1kp5
Sos1kp7 3.68445191357574e-2
Sos1kp8 1.58767045993943e-1
Sos1kp9 7.79377967231056e-2
Sos1km5 3.82133045165284e-2
Sos1km6 5*Sos1km5
MAPKkp1 2.34858647510049e-6
MAPKkp2 7.97187030086059e-1
MAPKkp3 3.76471948496902e-1
MAPKkp4 8.40146299281042e-1
MAPKkp5 8.65474093754534e-1
MAPKkp6 8.25953667549936e-2
MAPKkp7 7.41979697938558e-2
MAPKkp8 1.37135935836113e-3
MAPKkp9 8.18059543701685e-7
MAPKkp10 8.54707689482359e-6
MAPKkp11 9.11852147803069e-2
MAPKkp12 9.50469680832043e-1
MAPKkp13 4.20150542888183e-2
MAPKkp15 2.33197003501971e-2
MAPKkp16 8.50946608676458e-7
MAPKkp17 4.62874983163874e-1
MAPKkp18 3.35431298757868e-2
MAPKkp19 3.32559533601363e-1
MAPKkp20 2.09334798311488e-2
MAPKkp21 3.06698724199856e-7
MAPKkp22 8.88161417106301e-6
MAPKkp23 7.08681212084929e-6
MAPKkp24 4.08615417714418e-7
MAPKkp25 4.90729612515253e-6
MAPKkp26 1.84517732382585e-6
MAPKkp27 2.24786074034722e-6
MAPKkp28 1.96454339477236e-7
MAPKkp29 2.22526846482702e-7
MAPKkp30 1.90968360095593e-6
MAPKkp31 7.79954799619554e-7
MAPKkp32 7.75963929608389e-7
MAPKkp33 2.59665864412602e-2
MAPKkp34 2.43591083356245e-2
MAPKkp35 7.16980303326022e-2
MAPKkp36 2.49429517376035e-1
MAPKkp37 8.55283324348136e-2
MAPKkp38 4.45729674507919e-2
MAPKkp39 4.2054915619633e-1
MAPKkp40 7.34095564918618e-2
MAPKkp41 1.10316513094398e-2
MAPKkp42 5.88228995495206e-2
MAPKkp43 9.61443776159791e-1
MAPKkp44 5.54780338440048e-2
MAPKkp45 4.48285458762001e-3
MAPKkp46 1.80883788097742e-2
MAPKkp47 4.99203801450802e-3
MAPKkp48 8.31336309299819e-3
MAPKkp49 8.56531321402417e-2
MAPKkp50 4.51531525768462e-1
MAPKkp51 2.41716382509588e-2
MAPKkp52 4.80306028262771e-1
Gab1kp1 1.96995906486126e-6
Gab1kp3 1.26884248252077e-1
Gab1kp4 6.59955402545501e-2
Gab1kp5 2.74649622535037e-1
Gab1kp6 4.3149249204576e-2
Gab1kp7 7.43735567137946e-1
Gab1kp8 5.09433307106832e-1
Gab1kp9 7.84981187122992e-1
Gab1kp10 9.58526974679023e-2
Gab1kp11 6.89178573211149e-1
Gab1kp12 9.68556225363977e-1
Gab1kp13 9.43317263519674e-2
Gab1kp14 4.94750548020704e-2
Gab1kp15 8.06143925513339e-2
Gab1kp16 2.19269118931788e-1
Gab1kp17 1.89942763529712e-2
Gab1kp18 1.89528365333723e-1
Gab1kp19 6.03030348115124e-2
Gab1kp20 3.54071892177262e-2
Gab1kp21 3.99232860454623e-1
Gab1kp22 5.63319907552716e-2
Gab1kp23 3.10843424122953e-2
Gab1kp24 6.84002889697763e-2
Gab1kp25 6.39876833170325e-1
Gab1kp26 9.82736084289934e-2
Gab1kp27 9.18433441172982e-2
Gab1kp28 3.82822878829575e-1
Gab1kp29 8.21161423705763e-1
Gab1kp30 9.20446819241408e-2
Gab1kp31 2.21644107443666e-1
Gab1kp32 3.63754251476098e-2
Gab1kp33 2.3667792426341e-2
Gab1kp34 4.44827588111809e-2
Gab1kp35 3.08440990344997e-1
Gab1kp36 5.54549199955773e-2
Gab1kp37 7.74552310273276e-1
Gab1kp38 7.50355932645846e-2
Gab1kp39 5.76021606139506e-2
Gab1kp40 4.53089771642914e-1
Gab1kp41 8.99505991878266e-2
Gab1kp42 3.78959951192263e-1
Gab1kp43 6.50754783263528e-1
Gab1kp44 6.81419244007412e-1
Gab1kp45 1.89643033383857e-1
Gab1kp46 1.02351033220879e-2
Gab1kp47 4.73869586053684e-1
Gab1kp48 2.45137939979401e-1
Gab1kp49 7.44917984527444e-1
Gab1kp50 1.26045363101139e-2
Gab1kp51 3.16955880399047e-1
Gab1kp52 4.33161963713894e-2
Gab1kp53 5.17343683338817e-2
Gab1kp54 7.48601277549528e-2
Gab1kp55 6.92340425584058e-1
Gab1kp56 4.07780811638111e-2
Gab1kp57 1.40041104876053e-2
Gab1kp58 9.48753480457526e-2
Gab1kp59 7.5016080657968e-1
Gab1kp60 3.66672032784976e-2
Gab1kp61 1.79009642048845e-2
Gab1kp62 6.38332656408699e-2
Gab1kp63 6.84007275429656e-2
Gab1kp64 1.0710450029589e-1
Gab1kp65 5.41563482962238e-2
Gab1kp66 8.84462541321437e-1
Gab1kp67 7.47350965386988e-1
Gab1kp68 5.65594739491638e-2
Gab1kp69 7.17689305501494e-1
Gab1kp70 1.79330734762095e-1
Gab1kp71 6.88931712557604e-1
Gab1kp72 9.22136524885445e-2
Gab1kp73 2.98344535037069e-1
Gab1kp74 7.64644004450076e-2
Gab1kp75 9.3958164303171e-2
Gab1kp76 8.8252420049796e-1
Gab1kp77 2.65565223728305e-1
Gab1kp78 8.4993010543607e-1
Gab1kp79 9.93832547054416e-1
Gab1kp80 2.85970169779949e-2
Gab1kp81 8.60664808545255e-1
Gab1kp82 3.64938764618722e-1
Gab1kp83 3.97312566269352e-2
Gab1kp84 3.20288574330021e-1
Gab1kp85 9.43054858692847e-1
Gab1kp86 1.51265490820168e-1
Gab1kp87 8.35850377271163e-1
Gab1kp88 3.9780775924408e-2
Gab1kp89 6.30932503134102e-1
Gab1kp90 3.32391948687405e-2
Gab1kp91 9.02017698365222e-2
Gab1kp92 5.37650024214315e-1
Gab1kp93 1.52462712529331e-1
Gab1kp94 7.44822529477142e-2
Gab1kp95 3.81255548764085e-2
Gab1kp96 6.72974270318821e-2
Gab1kp97 5.72918654990821e-2
Gab1kp98 5.45264200264478e-1
Gab1kp99 7.84350181988844e-2
Gab1kp100 1.34235843242573e-2
Gab1kp101 3.65112322534793e-1
Gab1kp102 4.42764099548992e-1
Gab1kp103 3.82546347527449e-1
Gab1kp104 6.35883074076855e-1
Gab1kp105 2.59756886335555e-2
Gab1kp106 8.67259547156402e-1
Gab1kp107 4.86156447305251e-1
Gab1kp108 3.77418118675064e-2
Gab1kp109 3.90671913515649e-1
Gab1kp110 3.56725621880395e-2
Gab1kp111 3.82074278974778e-1
Gab1kp112 5.25107067249229e-2
Gab1kp113 5.39435189730705e-1
Gab1kp114 9.34735231509552e-1
Gab1kp115 1.45329501078618e-2
Gab1kp116 8.51311537687985e-2
Gab1kp117 3.54169909715336e-1
Gab1kp118 4.33863429051934e-1
Gab1kp119 3.39300906504241e-1
Gab1kp120 3.85128293076843e-1
Gab1kp121 3.6412969122229e-2
Gab1kp122 3.42139323434344e-1
Gab1kp123 1.25890011675489e-1
Gab1kp124 1.94813470549195e-1
Gab1kp125 9.8003934982591e-2
Gab1kp126 4.92423817966665e-2
Gab1kp127 9.76560811665314e-1
Gab1kp128 3.92729076406397e-2
Gab1kp129 5.53728123038621e-1
Gab1kp130 7.69883583742472e-2
Gab1kp131 7.27273779712493e-2
Gab1kp132 2.73106646626792e-2
Gab1kp133 8.93155681304097e-1
Gab1kp134 4.5877312169635e-2
Gab1kp135 2.02635815571568e-2
Gab1kp136 3.65005005212328e-1
Gab1kp137 3.62453153129877e-2
Gab1kp138 6.56010933793874e-1
Gab1kp139 1.20687516377745e-2
Gab1kp140 9.0068597109921e-1
Gab1kp141 7.94889774029508e-1
Gab1kp142 1.47879843065186e-2
Gab1kp143 3.82145997625815e-1
Gab1kp144 7.39492359635028e-1
Gab1kp145 3.14858173375256e-1
Gab1kp146 9.07136916358093e-1
Gab1kp147 2.13946826210275e-1
Gab1kp148 2.22305968575301e-1
Gab1kp149 8.14790581270913e-1
Gab1kp150 3.52672941805116e-1
Gab1kp151 2.3375040442304e-1
Gab1kp152 3.75503845672807e-2
Gab1kp153 2.22274772107301e-1
Gab1kp154 8.4191964204494e-2
Gab1kp155 8.54033761596293e-2
Gab1kp156 1.46657846706313e-6
Gab1kp157 6.834203762122e-7
Gab1kp158 2.28068860916886e-7
Gab1kp159 2.38343153678147e-6
Gab1kp160 7.4594943271976e-6
Gab1kp161 4.58433700010636e-6
Gab1kp162 9.21239244666731e-1
Gab1kp163 4.83857466703586e-1
Gab1kp164 3.68569830054378e-1
Gab1kp165 3.04402959768407e-2
Gab1kp166 1.4605078022521e-2
Gab1kp167 1.5471681936429e-1
Gab1kp168 9.42829803930488e-2
Gab1kp169 7.09585670734958e-1
Gab1kp170 9.99307828310231e-2
Gab1kp171 4.60012468602565e-7
Gab1kp172 4.62955624807586e-2
PI3Kkp1 5.88410107982645e-7
PI3Kkp2 9.80542618619103e-6
PI3Kkp3 6.66744738668615e-7
PI3Kkp4 3.10295546030824e-1
PI3Kkp5 8.27527892544981e-6
PI3Kkp6 4.44842583219685e-2
PI3Kkp7 1.94595846478239e-6
PI3Kkp8 1.76813220419643e-6
PI3Kkp9 6.386829800952e-6
PI3Kkp10 5.15064097908112e-6
PI3Kkp11 7.85287947262356e-7
PI3Kkp12 4.37909434779328e-6
PI3Kkp13 4.60027889585098e-7
PI3Kkm7 7.0508917514033e-1
PI3Kkm8 6.72236279174069e-1
PI3Kkm9 4.97861425615832e-2
PI3Kkm10 1.41917372721451e-2
PI3Kkm11 5.77649463506566e-1
PI3Kkm12 8.78805058758934e-2
PI3Kkm13 1.7532444673634e-2
PIP3kp1 5.48782230800754e-2
PIP3kp1_5 5*PIP3kp1
PIP3kp3 9.67988792384551e-3
Akt1kp1 9.88533437962741e-7
Akt1kp2 2.21983420789547e-6
Akt1kp3 1.02753819132869e-6
Akt1kp4 5.0119136591926e-1
Akt1kp5 8.34868759634759e-1
Akt1kp6 3.61676724413996e-2
Akt1kp7 3.69211236144935e-7
Akt1kp8 2.62409039589227e-2
Akt1kp9 4.76384581518204e-2
Akt1kp10 2.05533084211891e-2
Akt1kp11 5.36964405281211e-2
Akt1kp12 2.74620431360807e-3
Akt1km1 1.73047023274262e-2
Akt1km2 1.43226416524573e-1
rGAPkp1 7.97543429085357e-7
rGAPkp2 7.27732102199911e-6
rGAPkp3 7.89216962179904e-2
rGAPkp4 4.1163628948874e-1
rGAPkm1 9.63672004244575e-1
end parameters
begin molecule types
# Each species needs a location tag (outside,membrane,cytoplasms,destroyed etc..)
EGF(EGFL,deg~F~T,loc~Ex~En)
HRG(EGFL,deg~F~T,loc~Ex~En)
EGFR(I_III,II,T669~O~P,Y992~O~P,Y1068~O~P,Y1086~O~P,Y1114~O~P,Y1148~O~P,Y1173~O~P,loc~M~En)
ErbB2(II,Y1139~O~P,Y1196~O~P,Y1222~O~P,Y1248~O~P,loc~M~En)
ErbB3(I_III,II,Y1054~O~P,Y1197~O~P,Y1222~O~P,Y1260~O~P,Y1276~O~P,Y1289~O~P,Y1328~O~P,loc~M~En)
ErbB4(I_III,II,Y1056~O~P,Y1188~O~P,Y1242~O~P,loc~M~En)
p52Shc1(PTB,Y317~O~P,loc~C)
Grb2(SH2r,SH2s,cSH3,nSH3,loc~C)
Sos1(PRS,REM,GEF,S1132~O~P,S1167~O~P,S1178~O~P,S1193~O~P,loc~C)
#S581 means S551, Y619 means Y627, Y657 means Y659
Gab1(PH,PRS1_PRS2,T312~O~P,S381~O~P,Y447~O~P,S454~O~P,Y472~O~P,T476~O~P,S581~O~P,S597~O~P,Y619~O~P,Y657~O~P,loc~C)
PI3K(lipid_kinase,R_p85_nSH2_cSH2,G_p85_nSH2_cSH2,p110_RBD,loc~C)
PIP3(C3P,two~F~T,loc~M)
PDK1(PH,STkinase,loc~C)
Akt1(PH,STkinase,T308~O~P,S473~O~P,loc~C)
KRas(GTPase,g~GDP~GTP,loc~M)
p120RasGAP(nSH2,GAP)
Raf1(RBD,STkinase,S29~O~P,S43~O~P,S259~O~P,S289~O~P,S296~O~P,S301~O~P,S338~O~P,Y341~O~P,S471~O~P,T491~O~P,S494~O~P,S642~O~P,loc~C)
MEK1(delta,S218~O~P,S222~O~P,T292~O~P,loc~C)
ERK2(CD,STkinase,T185~O~P,Y187~O~P,loc~C)
end molecule types
begin species
EGF(EGFL,deg~F,loc~Ex) EGF_tot
HRG(EGFL,deg~F,loc~Ex) HRG_tot
EGFR(I_III,II,T669~O,Y992~O,Y1068~O,Y1086~O,Y1114~O,Y1148~O,Y1173~O,loc~M) EGFR_tot
ErbB2(II,Y1139~O,Y1196~O,Y1222~O,Y1248~O,loc~M) ErbB2_tot
ErbB3(I_III,II,Y1054~O,Y1197~O,Y1222~O,Y1260~O,Y1276~O,Y1289~O,Y1328~O,loc~M) ErbB3_tot
ErbB4(I_III,II,Y1056~O,Y1188~O,Y1242~O,loc~M) ErbB4_tot
p52Shc1(PTB,Y317~O,loc~C) p52Shc1_tot
Grb2(SH2r,SH2s,cSH3,nSH3,loc~C) Grb2_tot
Sos1(PRS,REM,GEF,S1132~O,S1167~O,S1178~O,S1193~O,loc~C) Sos1_tot
Gab1(PH,PRS1_PRS2,T312~O,S381~O,Y447~O,S454~O,Y472~O,T476~O,S581~O,S597~O,Y619~O,Y657~O,loc~C) Gab1_tot
PI3K(lipid_kinase,G_p85_nSH2_cSH2,R_p85_nSH2_cSH2,p110_RBD,loc~C) PI3K_tot
PIP3(C3P,two~F,loc~M) 0
PDK1(PH,STkinase,loc~C) PDK1_tot
Akt1(PH,STkinase,T308~O,S473~O,loc~C) Akt1_tot
KRas(GTPase,g~GDP,loc~M) RAS_tot
p120RasGAP(nSH2,GAP) p120RasGAP_tot
Raf1(RBD,STkinase,S29~O,S43~O,S259~O,S289~O,S296~O,S301~O,S338~O,Y341~O,S471~O,T491~O,S494~O,S642~O,loc~C) Raf1_tot
MEK1(delta,S218~O,S222~O,T292~O,loc~C) MEK1_tot
ERK2(CD,STkinase,T185~O,Y187~O,loc~C) ERK2_tot
end species
#Species that are being observed
begin observables
Molecules EGFREGFR EGFR(II!1,loc~M).EGFR(II!1,loc~M)
Molecules EGFRErbB2 EGFR(II!1,loc~M).ErbB2(II!1,loc~M)
Molecules EGFRErbB3 EGFR(II!1,loc~M).ErbB3(II!1,loc~M)
Molecules EGFRErbB4 EGFR(II!1,loc~M).ErbB4(II!1,loc~M)
Molecules ErbB2ErbB2 ErbB2(II!1,loc~M).ErbB2(II!1,loc~M)
Molecules ErbB2ErbB3 ErbB2(II!1,loc~M).ErbB3(II!1,loc~M)
Molecules ErbB2ErbB4 ErbB2(II!1,loc~M).ErbB4(II!1,loc~M)
Molecules ErbB3ErbB3 ErbB3(II!1,loc~M).ErbB3(II!1,loc~M)
Molecules ErbB3ErbB4 ErbB3(II!1,loc~M).ErbB4(II!1,loc~M)
Molecules ErbB4ErbB4 ErbB4(II!1,loc~M).ErbB4(II!1,loc~M)
Molecules EGFREGFREn EGFR(II!1,loc~En).EGFR(II!1,loc~En)
Molecules EGFRErbB2En EGFR(II!1,loc~En).ErbB2(II!1,loc~En)
Molecules EGFRErbB3En EGFR(II!1,loc~En).ErbB3(II!1,loc~En)
Molecules EGFRErbB4En EGFR(II!1,loc~En).ErbB4(II!1,loc~En)
Molecules ErbB2ErbB2En ErbB2(II!1,loc~En).ErbB2(II!1,loc~En)
Molecules ErbB2ErbB3En ErbB2(II!1,loc~En).ErbB3(II!1,loc~En)
Molecules ErbB2ErbB4En ErbB2(II!1,loc~En).ErbB4(II!1,loc~En)
Molecules ErbB3ErbB3En ErbB3(II!1,loc~En).ErbB3(II!1,loc~En)
Molecules ErbB3ErbB4En ErbB3(II!1,loc~En).ErbB4(II!1,loc~En)
Molecules ErbB4ErbB4En ErbB4(II!1,loc~En).ErbB4(II!1,loc~En)
Molecules ERK_T185 ERK2(T185~P!?)
Molecules AKT_S473 Akt1(S473~P!?)
Molecules EGFR_669 EGFR(T669~P!?)
Molecules EGFR_992 EGFR(Y992~P!?)
Molecules EGFR_1068 EGFR(Y1068~P!?)
Molecules EGFR_1086 EGFR(Y1086~P!?)
Molecules EGFR_1114 EGFR(Y1114~P!?)
Molecules EGFR_1148 EGFR(Y1148~P!?)
Molecules EGFR_1173 EGFR(Y1173~P!?)
Molecules ErbB2_1139 ErbB2(Y1139~P!?)
Molecules ErbB2_1196 ErbB2(Y1196~P!?)
Molecules ErbB2_1222 ErbB2(Y1222~P!?)
Molecules ErbB2_1248 ErbB2(Y1248~P!?)
Molecules ErbB3_1054 ErbB3(Y1054~P!?)
Molecules ErbB3_1197 ErbB3(Y1197~P!?)
Molecules ErbB3_1222 ErbB3(Y1222~P!?)
Molecules ErbB3_1260 ErbB3(Y1260~P!?)
Molecules ErbB3_1276 ErbB3(Y1276~P!?)
Molecules ErbB3_1289 ErbB3(Y1289~P!?)
Molecules ErbB3_1328 ErbB3(Y1328~P!?)
Molecules ErbB4_1056 ErbB4(Y1056~P!?)
Molecules ErbB4_1188 ErbB4(Y1188~P!?)
Molecules ErbB4_1242 ErbB4(Y1242~P!?)
Molecules pSHC p52Shc1(Y317~P!?)
Molecules Sos1_1132 Sos1(S1132~P!?)
Molecules Sos1_1167 Sos1(S1167~P!?)
Molecules Sos1_1178 Sos1(S1178~P!?)
Molecules Sos1_1193 Sos1(S1193~P!?)
Molecules Gab1_312 Gab1(T312~P!?)
Molecules Gab1_381 Gab1(S381~P!?)
Molecules Gab1_447 Gab1(Y447~P!?)
Molecules Gab1_454 Gab1(S454~P!?)
Molecules Gab1_472 Gab1(Y472~P!?)
Molecules Gab1_476 Gab1(T476~P!?)
Molecules Gab1_581 Gab1(S581~P!?)
Molecules Gab1_597 Gab1(S597~P!?)
Molecules Gab1_619 Gab1(Y619~P!?)
Molecules Gab1_657 Gab1(Y657~P!?)
Molecules Raf1_29 Raf1(S29~P!?)
Molecules Raf1_43 Raf1(S43~P!?)
Molecules Raf1_259 Raf1(S259~P!?)
Molecules Raf1_289 Raf1(S289~P!?)
Molecules Raf1_296 Raf1(S296~P!?)
Molecules Raf1_301 Raf1(S301~P!?)
Molecules Raf1_338 Raf1(S338~P!?)
Molecules Raf1_341 Raf1(Y341~P!?)
Molecules Raf1_471 Raf1(S471~P!?)
Molecules Raf1_491 Raf1(T491~P!?)
Molecules Raf1_494 Raf1(S494~P!?)
Molecules Raf1_642 Raf1(S642~P!?)
Molecules MEK1_218 MEK1(S218~P!?)
Molecules MEK1_222 MEK1(S222~P!?)
Molecules MEK1_292 MEK1(T292~P!?)
Molecules pERK_Y187 ERK2(Y187~P!?)
Molecules AKT_T308 Akt1(T308~P!?)
end observables
####################### RULES BEGIN HERE #######################
begin reaction rules
############## LIGAND BINDING ##############
# EGF binding to an EGFR monomer
1 EGFR(I_III,II,loc~M) + EGF(EGFL,deg~F,loc~Ex) <-> EGFR(I_III!1,II,loc~M).EGF(EGFL!1,deg~F,loc~Ex) EGFkp1,EGFkm1
# HRG binding to an ErbB3 monomer
2 ErbB3(I_III,II,loc~M) + HRG(EGFL,deg~F,loc~Ex) <-> ErbB3(I_III!1,II,loc~M).HRG(EGFL!1,deg~F,loc~Ex) HRG3kp1,HRG3km1
# HRG binding to an ErbB4 monomer
3 ErbB4(I_III,II,loc~M) + HRG(EGFL,deg~F,loc~Ex) <-> ErbB4(I_III!1,II,loc~M).HRG(EGFL!1,deg~F,loc~Ex) HRG4kp1,HRG4km1
#EGF binding to an EGFR homodimer
4 EGFR(I_III,II!1,loc~M).EGFR(I_III,II!1,loc~M) + EGF(EGFL,deg~F,loc~Ex) <-> EGFR(I_III,II!1,loc~M).EGFR(I_III!2,II!1,loc~M).EGF(EGFL!2,deg~F,loc~Ex) EGFkp2,EGFkm2
5 EGF(EGFL!2,deg~F,loc~Ex).EGFR(I_III!2,II!1,loc~M).EGFR(I_III,II!1,loc~M) + EGF(EGFL,deg~F,loc~Ex) <-> EGF(EGFL!2,deg~F,loc~Ex).EGFR(I_III!2,II!1,loc~M).EGFR(I_III!3,II!1,loc~M).EGF(EGFL!3,deg~F,loc~Ex) EGFkp3,EGFkm3
#EGF binding to an EGFR-ErbB2 heterodimer
6 ErbB2(II!1,loc~M).EGFR(I_III,II!1,loc~M) + EGF(EGFL,deg~F,loc~Ex) <-> ErbB2(II!1,loc~M).EGFR(I_III!2,II!1,loc~M).EGF(EGFL!2,deg~F,loc~Ex) EGFkp2,EGFkm2
#Ligand binding to an EGFR-ErbB3 heterodimer
7 EGF(EGFL,deg~F,loc~Ex) + EGFR(I_III,II!1,loc~M).ErbB3(I_III,II!1,loc~M) <-> EGF(EGFL!2,deg~F,loc~Ex).EGFR(I_III!2,II!1,loc~M).ErbB3(I_III,II!1,loc~M) EGFkp2,EGFkm2
8 EGFR(I_III,II!1,loc~M).ErbB3(I_III,II!1,loc~M) + HRG(EGFL,deg~F,loc~Ex) <-> EGFR(I_III,II!1,loc~M).ErbB3(I_III!2,II!1,loc~M).HRG(EGFL!2,deg~F,loc~Ex) HRG3kp2,HRG3km2
9 EGF(EGFL!2,deg~F,loc~Ex).EGFR(I_III!2,II!1,loc~M).ErbB3(I_III,II!1,loc~M) + HRG(EGFL,deg~F,loc~Ex) <-> EGF(EGFL!2,deg~F,loc~Ex).EGFR(I_III!2,II!1,loc~M).ErbB3(I_III!3,II!1,loc~M).HRG(EGFL!3,deg~F,loc~Ex) HRG3kp3,HRG3km3
10 EGF(EGFL,deg~F,loc~Ex) + EGFR(I_III,II!1,loc~M).ErbB3(I_III!3,II!1,loc~M).HRG(EGFL!3,deg~F,loc~Ex) <-> EGF(EGFL!2,deg~F,loc~Ex).EGFR(I_III!2,II!1,loc~M).ErbB3(I_III!3,II!1,loc~M).HRG(EGFL!3,deg~F,loc~Ex) EGFkp3,EGFkm3
#Ligand binding to an EGFR-ErbB4 heterodimer
11 EGF(EGFL,deg~F,loc~Ex) + EGFR(I_III,II!1,loc~M).ErbB4(I_III,II!1,loc~M) <-> EGF(EGFL!2,deg~F,loc~Ex).EGFR(I_III!2,II!1,loc~M).ErbB4(I_III,II!1,loc~M) EGFkp2,EGFkm2
12 EGFR(I_III,II!1,loc~M).ErbB4(I_III,II!1,loc~M) + HRG(EGFL,deg~F,loc~Ex) <-> EGFR(I_III,II!1,loc~M).ErbB4(I_III!2,II!1,loc~M).HRG(EGFL!2,deg~F,loc~Ex) HRG4kp2,HRG4km2
13 EGF(EGFL!2,deg~F,loc~Ex).EGFR(I_III!2,II!1,loc~M).ErbB4(I_III,II!1,loc~M) + HRG(EGFL,deg~F,loc~Ex) <-> EGF(EGFL!2,deg~F,loc~Ex).EGFR(I_III!2,II!1,loc~M).ErbB4(I_III!3,II!1,loc~M).HRG(EGFL!3,deg~F,loc~Ex) HRG4kp3,HRG4km3
14 EGF(EGFL,deg~F,loc~Ex) + EGFR(I_III,II!1,loc~M).ErbB4(I_III!3,II!1,loc~M).HRG(EGFL!3,deg~F,loc~Ex) <-> EGF(EGFL!2,deg~F,loc~Ex).EGFR(I_III!2,II!1,loc~M).ErbB4(I_III!3,II!1,loc~M).HRG(EGFL!3,deg~F,loc~Ex) EGFkp3,EGFkm3
#HRG binding to an ErbB2-ErbB3 heterodimer
15 ErbB2(II!1,loc~M).ErbB3(I_III,II!1,loc~M) + HRG(EGFL,deg~F,loc~Ex) <-> ErbB2(II!1,loc~M).ErbB3(I_III!2,II!1,loc~M).HRG(EGFL!2,deg~F,loc~Ex) HRG3kp2,HRG3km2
#HRG binding to an ErbB2-ErbB4 heterodimer
16 ErbB2(II!1,loc~M).ErbB4(I_III,II!1,loc~M) + HRG(EGFL,deg~F,loc~Ex) <-> ErbB2(II!1,loc~M).ErbB4(I_III!2,II!1,loc~M).HRG(EGFL!2,deg~F,loc~Ex) HRG4kp2,HRG4km2
#HRG binding to an ErbB3 homodimer
17 ErbB3(I_III,II!1,loc~M).ErbB3(I_III,II!1,loc~M) + HRG(EGFL,deg~F,loc~Ex) <-> ErbB3(I_III,II!1,loc~M).ErbB3(I_III!2,II!1,loc~M).HRG(EGFL!2,deg~F,loc~Ex) HRG3kp2,HRG3km2
18 HRG(EGFL!2,deg~F,loc~Ex).ErbB3(I_III!2,II!1,loc~M).ErbB3(I_III,II!1,loc~M) + HRG(EGFL,deg~F,loc~Ex) <-> HRG(EGFL!2,deg~F,loc~Ex).ErbB3(I_III!2,II!1,loc~M).ErbB3(I_III!3,II!1,loc~M).HRG(EGFL!3,deg~F,loc~Ex) HRG3kp3,HRG3km3
#Ligand binding to an ErbB3-ErbB4 heterodimer
19 ErbB3(I_III,II!1,loc~M).ErbB4(I_III,II!1,loc~M) + HRG(EGFL,deg~F,loc~Ex) <-> ErbB3(I_III,II!1,loc~M).ErbB4(I_III!2,II!1,loc~M).HRG(EGFL!2,deg~F,loc~Ex) HRG4kp2,HRG4km2
20 HRG(EGFL,deg~F,loc~Ex) + ErbB3(I_III,II!1,loc~M).ErbB4(I_III,II!1,loc~M) <-> HRG(EGFL!2,deg~F,loc~Ex).ErbB3(I_III!2,II!1,loc~M).ErbB4(I_III,II!1,loc~M) HRG3kp2,HRG3km2
21 HRG(EGFL!2,deg~F,loc~Ex).ErbB3(I_III!2,II!1,loc~M).ErbB4(I_III,II!1,loc~M) + HRG(EGFL,deg~F,loc~Ex) <-> HRG(EGFL!2,deg~F,loc~Ex).ErbB3(I_III!2,II!1,loc~M).ErbB4(I_III!3,II!1,loc~M).HRG(EGFL!3,deg~F,loc~Ex) HRG4kp3,HRG4km3
22 HRG(EGFL,deg~F,loc~Ex) + ErbB3(I_III,II!1,loc~M).ErbB4(I_III!3,II!1,loc~M).HRG(EGFL!3,deg~F,loc~Ex) <-> HRG(EGFL!2,deg~F,loc~Ex).ErbB3(I_III!2,II!1,loc~M).ErbB4(I_III!3,II!1,loc~M).HRG(EGFL!3,deg~F,loc~Ex) HRG3kp3,HRG3km3
#HRG binding to an ErbB4 homodimer
23 ErbB4(I_III,II!1,loc~M).ErbB4(I_III,II!1,loc~M) + HRG(EGFL,deg~F,loc~Ex) <-> ErbB4(I_III,II!1,loc~M).ErbB4(I_III!2,II!1,loc~M).HRG(EGFL!2,deg~F,loc~Ex) HRG4kp2,HRG4km2
24 HRG(EGFL!2,deg~F,loc~Ex).ErbB4(I_III!2,II!1,loc~M).ErbB4(I_III,II!1,loc~M) + HRG(EGFL,deg~F,loc~Ex) <-> HRG(EGFL!2,deg~F,loc~Ex).ErbB4(I_III!2,II!1,loc~M).ErbB4(I_III!3,II!1,loc~M).HRG(EGFL!3,deg~F,loc~Ex) HRG4kp3,HRG4km3
############## RECEPTOR DIMERIZATION ##############
# EGFR-EGFR
# EGFR-EGFR dimerization with no EGF bound
25 EGFR(I_III,II,loc~M) + EGFR(I_III,II,loc~M) <-> EGFR(I_III,II!1,loc~M).EGFR(I_III,II!1,loc~M) Dimkp1,Dimkm1
# EGFR-EGFR dimerization with one EGF bound
26 EGFR(I_III!1,II,loc~M).EGF(EGFL!1,loc~Ex) + EGFR(I_III,II,loc~M) <-> EGFR(I_III!1,II!2,loc~M).EGF(EGFL!1,loc~Ex).EGFR(I_III,II!2,loc~M) Dimkp2,Dimkm2
# EGFR-EGFR dimerization with two EGF bound
27 EGFR(I_III!1,II,loc~M).EGF(EGFL!1,loc~Ex) + EGFR(I_III!2,II,loc~M).EGF(EGFL!2,loc~Ex) <-> EGFR(I_III!1,II!3,loc~M).EGF(EGFL!1,loc~Ex).EGFR(I_III!2,II!3,loc~M).EGF(EGFL!2,loc~Ex) Dimkp3,Dimkm3
# EGFR-ErbB2
# EGFR-ErbB2 dimerization with no EGF bound
28 EGFR(I_III,II,loc~M) + ErbB2(II,loc~M) <-> EGFR(I_III,II!1,loc~M).ErbB2(II!1,loc~M) Dimkp4,Dimkm4
# EGFR-ErbB2 dimerization with EGF bound
29 EGFR(I_III!1,II,loc~M).EGF(EGFL!1,loc~Ex) + ErbB2(II,loc~M) <-> EGFR(I_III!1,II!2,loc~M).EGF(EGFL!1,loc~Ex).ErbB2(II!2,loc~M) Dimkp5,Dimkm5
# EGFR-ErbB3
# EGFR-ErbB3 dimerization with no ligand bound
30 EGFR(I_III,II,loc~M) + ErbB3(I_III,II,loc~M) <-> EGFR(I_III,II!1,loc~M).ErbB3(I_III,II!1,loc~M) Dimkp6,Dimkm6
# EGFR-ErbB3 dimerization with EGF bound
31 EGFR(I_III!1,II,loc~M).EGF(EGFL!1,loc~Ex) + ErbB3(I_III,II,loc~M) <-> EGFR(I_III!1,II!2,loc~M).EGF(EGFL!1,loc~Ex).ErbB3(I_III,II!2,loc~M) Dimkp7,Dimkm7
# EGFR-ErbB3 dimerization with HRG bound
32 ErbB3(I_III!1,II,loc~M).HRG(EGFL!1,loc~Ex) + EGFR(I_III,II,loc~M) <-> ErbB3(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex).EGFR(I_III,II!2,loc~M) Dimkp8,Dimkm8
# EGFR-ErbB3 dimerization with EGF and HRG bound
33 EGFR(I_III!1,II,loc~M).EGF(EGFL!1,loc~Ex) + ErbB3(I_III!2,II,loc~M).HRG(EGFL!2,loc~Ex) <-> EGFR(I_III!1,II!3,loc~M).EGF(EGFL!1,loc~Ex).ErbB3(I_III!2,II!3,loc~M).HRG(EGFL!2,loc~Ex) Dimkp9,Dimkm9
# EGFR-ErbB4
# EGFR-ErbB4 dimerization with no ligand bound
34 EGFR(I_III,II,loc~M) + ErbB4(I_III,II,loc~M) <-> EGFR(I_III,II!1,loc~M).ErbB4(I_III,II!1,loc~M) Dimkp10,Dimkm10
# EGFR-ErbB4 dimerization with EGF bound
35 EGFR(I_III!1,II,loc~M).EGF(EGFL!1,loc~Ex) + ErbB4(I_III,II,loc~M) <-> EGFR(I_III!1,II!2,loc~M).EGF(EGFL!1,loc~Ex).ErbB4(I_III,II!2,loc~M) Dimkp11,Dimkm11
# EGFR-ErbB4 dimerization with HRG bound
36 ErbB4(I_III!1,II,loc~M).HRG(EGFL!1,loc~Ex) + EGFR(I_III,II,loc~M) <-> ErbB4(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex).EGFR(I_III,II!2,loc~M) Dimkp12,Dimkm12
# EGFR-ErbB4 dimerization with EGF and HRG bound
37 EGFR(I_III!1,II,loc~M).EGF(EGFL!1,loc~Ex) + ErbB4(I_III!2,II,loc~M).HRG(EGFL!2,loc~Ex) <-> EGFR(I_III!1,II!3,loc~M).EGF(EGFL!1,loc~Ex).ErbB4(I_III!2,II!3,loc~M).HRG(EGFL!2,loc~Ex) Dimkp13,Dimkm13
# ErbB2-ErbB2 dimerization
38 ErbB2(II,loc~M) + ErbB2(II,loc~M) <-> ErbB2(II!1,loc~M).ErbB2(II!1,loc~M) Dimkp14,Dimkm14
# ErbB2-ErbB3
# ErbB2-ErbB3 dimerization with no ligand bound
39 ErbB2(II,loc~M) + ErbB3(I_III,II,loc~M) <-> ErbB2(II!1,loc~M).ErbB3(I_III,II!1,loc~M) Dimkp15,Dimkm15
# ErbB2-ErbB3 dimerization with HRG bound
40 ErbB3(I_III!1,II,loc~M).HRG(EGFL!1,loc~Ex) + ErbB2(II,loc~M) <-> ErbB3(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex).ErbB2(II!2,loc~M) Dimkp16,Dimkm16
# ErbB2-ErbB4
# ErbB2-ErbB4 dimerization with no ligand bound
41 ErbB2(II,loc~M) + ErbB4(I_III,II,loc~M) <-> ErbB2(II!1,loc~M).ErbB4(I_III,II!1,loc~M) Dimkp17,Dimkm17
# ErbB2-ErbB4 dimerization with HRG bound
42 ErbB4(I_III!1,II,loc~M).HRG(EGFL!1,loc~Ex) + ErbB2(II,loc~M) <-> ErbB4(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex).ErbB2(II!2,loc~M) Dimkp18,Dimkm18
# ErbB3-ErbB3
# ErbB3-ErbB3 dimerization with no HRG bound
43 ErbB3(I_III,II,loc~M) + ErbB3(I_III,II,loc~M) <-> ErbB3(I_III,II!1,loc~M).ErbB3(I_III,II!1,loc~M) Dimkp19,Dimkm19
# ErbB3-ErbB3 dimerization with one HRG bound
44 ErbB3(I_III!1,II,loc~M).HRG(EGFL!1,loc~Ex) + ErbB3(I_III,II,loc~M) <-> ErbB3(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex).ErbB3(I_III,II!2,loc~M) Dimkp20,Dimkm20
# ErbB3-ErbB3 dimerization with two HRG bound
45 ErbB3(I_III!1,II,loc~M).HRG(EGFL!1,loc~Ex) + ErbB3(I_III!2,II,loc~M).HRG(EGFL!2,loc~Ex) <-> ErbB3(I_III!1,II!3,loc~M).HRG(EGFL!1,loc~Ex).ErbB3(I_III!2,II!3,loc~M).HRG(EGFL!2,loc~Ex) Dimkp21,Dimkm21
# ErbB3-ErbB4
# ErbB3-ErbB4 dimerization with no HRG bound
46 ErbB3(I_III,II,loc~M) + ErbB4(I_III,II,loc~M) <-> ErbB3(I_III,II!1,loc~M).ErbB4(I_III,II!1,loc~M) Dimkp22,Dimkm22
# ErbB3-ErbB4 dimerization with HRG bound on ErbB3
47 ErbB3(I_III!1,II,loc~M).HRG(EGFL!1,loc~Ex) + ErbB4(I_III,II,loc~M) <-> ErbB3(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex).ErbB4(I_III,II!2,loc~M) Dimkp23,Dimkm23
# ErbB3-ErbB4 dimerization with HRG bound on ErbB4
48 ErbB3(I_III,II,loc~M) + ErbB4(I_III!1,II,loc~M).HRG(EGFL!1,loc~Ex) <-> ErbB3(I_III,II!2,loc~M).ErbB4(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex) Dimkp24,Dimkm24
# ErbB3-ErbB4 dimerization with HRG bound on both receptors
49 ErbB3(I_III!1,II,loc~M).HRG(EGFL!1,loc~Ex) + ErbB4(I_III!2,II,loc~M).HRG(EGFL!2,loc~Ex) <-> ErbB3(I_III!1,II!3,loc~M).HRG(EGFL!1,loc~Ex).ErbB4(I_III!2,II!3,loc~M).HRG(EGFL!2,loc~Ex) Dimkp25,Dimkm25
# ErbB4-ErbB4
# ErbB4-ErbB4 dimerization with no HRG bound
50 ErbB4(I_III,II,loc~M) + ErbB4(I_III,II,loc~M) <-> ErbB4(I_III,II!1,loc~M).ErbB4(I_III,II!1,loc~M) Dimkp26,Dimkm26
# ErbB4-ErbB4 dimerization with one HRG bound
51 ErbB4(I_III!1,II,loc~M).HRG(EGFL!1,loc~Ex) + ErbB4(I_III,II,loc~M) <-> ErbB4(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex).ErbB4(I_III,II!2,loc~M) Dimkp27,Dimkm27
# ErbB4-ErbB4 dimerization with two HRG bound
52 ErbB4(I_III!1,II,loc~M).HRG(EGFL!1,loc~Ex) + ErbB4(I_III!2,II,loc~M).HRG(EGFL!2,loc~Ex) <-> ErbB4(I_III!1,II!3,loc~M).HRG(EGFL!1,loc~Ex).ErbB4(I_III!2,II!3,loc~M).HRG(EGFL!2,loc~Ex) Dimkp28,Dimkm28
############## RECEPTOR INTERNALIZATION ##############
#EGFR-EGFR
#EGFR-EGFR dimers get internalized with two EGF bound
53 EGFR(I_III!1,II!3,loc~M).EGF(EGFL!1,loc~Ex).EGFR(I_III!2,II!3,loc~M).EGF(EGFL!2,loc~Ex) -> EGFR(I_III!1,II!3,loc~En).EGF(EGFL!1,loc~En).EGFR(I_III!2,II!3,loc~En).EGF(EGFL!2,loc~En) Intkp1
#EGFR-EGFR dimers get internalized with one EGF bound
54 EGFR(I_III!1,II!2,loc~M).EGF(EGFL!1,loc~Ex).EGFR(I_III,II!2,loc~M) -> EGFR(I_III!1,II!2,loc~En).EGF(EGFL!1,loc~En).EGFR(I_III,II!2,loc~En) Intkp1
#EGFR-EGFR dimers get internalized with no ligand bound
55 EGFR(I_III,II!2,loc~M).EGFR(I_III,II!2,loc~M) -> EGFR(I_III,II!2,loc~En).EGFR(I_III,II!2,loc~En) Intkp1
#EGFR-ErbB2 dimers get internalized with EGF bound
56 EGFR(I_III!1,II!2,loc~M).EGF(EGFL!1,loc~Ex).ErbB2(II!2,loc~M) -> EGFR(I_III!1,II!2,loc~En).EGF(EGFL!1,loc~En).ErbB2(II!2,loc~En) Intkp1
#EGFR-ErbB2 dimers get internalized with no ligand bound
57 EGFR(I_III,II!2,loc~M).ErbB2(II!2,loc~M) -> EGFR(I_III,II!2,loc~En).ErbB2(II!2,loc~En) Intkp1
#EGFR-ErbB3 dimers get internalized with EGF and HRG bound
58 EGFR(I_III!1,II!3,loc~M).EGF(EGFL!1,loc~Ex).ErbB3(I_III!2,II!3,loc~M).HRG(EGFL!2,loc~Ex) -> EGFR(I_III!1,II!3,loc~En).EGF(EGFL!1,loc~En).ErbB3(I_III!2,II!3,loc~En).HRG(EGFL!2,loc~En) Intkp1
#EGFR-ErbB3 dimers get internalized with HRG bound
59 EGFR(I_III,II!3,loc~M).ErbB3(I_III!2,II!3,loc~M).HRG(EGFL!2,loc~Ex) -> EGFR(I_III,II!3,loc~En).ErbB3(I_III!2,II!3,loc~En).HRG(EGFL!2,loc~En) Intkp1
#EGFR-ErbB3 dimers get internalized with EGF bound
60 EGFR(I_III!1,II!3,loc~M).EGF(EGFL!1,loc~Ex).ErbB3(I_III,II!3,loc~M) -> EGFR(I_III!1,II!3,loc~En).EGF(EGFL!1,loc~En).ErbB3(I_III,II!3,loc~En) Intkp1
#EGFR-ErbB3 dimers get internalized with no ligand bound
61 EGFR(I_III,II!3,loc~M).ErbB3(I_III,II!3,loc~M) -> EGFR(I_III,II!3,loc~En).ErbB3(I_III,II!3,loc~En) Intkp1
#EGFR-ErbB4 dimers get internalized with EGF and HRG bound
62 EGFR(I_III!1,II!3,loc~M).EGF(EGFL!1,loc~Ex).ErbB4(I_III!2,II!3,loc~M).HRG(EGFL!2,loc~Ex) -> EGFR(I_III!1,II!3,loc~En).EGF(EGFL!1,loc~En).ErbB4(I_III!2,II!3,loc~En).HRG(EGFL!2,loc~En) Intkp1
#EGFR-ErbB4 dimers get internalized with HRG bound
63 EGFR(I_III,II!3,loc~M).ErbB4(I_III!2,II!3,loc~M).HRG(EGFL!2,loc~Ex) -> EGFR(I_III,II!3,loc~En).ErbB4(I_III!2,II!3,loc~En).HRG(EGFL!2,loc~En) Intkp1
#EGFR-ErbB4 dimers get internalized with EGF bound
64 EGFR(I_III!1,II!3,loc~M).EGF(EGFL!1,loc~Ex).ErbB4(I_III,II!3,loc~M) -> EGFR(I_III!1,II!3,loc~En).EGF(EGFL!1,loc~En).ErbB4(I_III,II!3,loc~En) Intkp1
#EGFR-ErbB4 dimers get internalized with no ligand bound
65 EGFR(I_III,II!3,loc~M).ErbB4(I_III,II!3,loc~M) -> EGFR(I_III,II!3,loc~En).ErbB4(I_III,II!3,loc~En) Intkp1
#ErbB2-ErbB2 dimers get internalized
66 ErbB2(II!1,loc~M).ErbB2(II!1,loc~M) -> ErbB2(II!1,loc~En).ErbB2(II!1,loc~En) Intkp1
#ErbB3-ErbB2 dimers get internalized with HRG bound
67 ErbB3(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex).ErbB2(II!2,loc~M) -> ErbB3(I_III!1,II!2,loc~En).HRG(EGFL!1,loc~En).ErbB2(II!2,loc~En) Intkp1
#ErbB3-ErbB2 dimers get internalized with no ligand bound
68 ErbB3(I_III,II!2,loc~M).ErbB2(II!2,loc~M) -> ErbB3(I_III,II!2,loc~En).ErbB2(II!2,loc~En) Intkp1
#ErbB4-ErbB2 dimers get internalized with HRG bound
69 ErbB4(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex).ErbB2(II!2,loc~M) -> ErbB4(I_III!1,II!2,loc~En).HRG(EGFL!1,loc~En).ErbB2(II!2,loc~En) Intkp1
#ErbB4-ErbB2 dimers get internalized with no ligand bound
70 ErbB4(I_III,II!2,loc~M).ErbB2(II!2,loc~M) -> ErbB4(I_III,II!2,loc~En).ErbB2(II!2,loc~En) Intkp1
#ErbB3-ErbB3 dimers get internalized with two HRG bound
71 ErbB3(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex).ErbB3(I_III!3,II!2,loc~M).HRG(EGFL!3,loc~Ex) -> ErbB3(I_III!1,II!2,loc~En).HRG(EGFL!1,loc~En).ErbB3(I_III!3,II!2,loc~En).HRG(EGFL!3,loc~En) Intkp1
#ErbB3-ErbB3 dimers get internalized with one HRG bound
72 ErbB3(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex).ErbB3(I_III,II!2,loc~M) -> ErbB3(I_III!1,II!2,loc~En).HRG(EGFL!1,loc~En).ErbB3(I_III,II!2,loc~En) Intkp1
#ErbB3-ErbB3 dimers get internalized with no HRG bound
73 ErbB3(I_III,II!2,loc~M).ErbB3(I_III,II!2,loc~M) -> ErbB3(I_III,II!2,loc~En).ErbB3(I_III,II!2,loc~En) Intkp1
#ErbB3-ErbB4 dimers get internalized with two HRG bound
74 ErbB3(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex).ErbB4(I_III!3,II!2,loc~M).HRG(EGFL!3,loc~Ex) -> ErbB3(I_III!1,II!2,loc~En).HRG(EGFL!1,loc~En).ErbB4(I_III!3,II!2,loc~En).HRG(EGFL!3,loc~En) Intkp1
#ErbB3-ErbB4 dimers get internalized with HRG bound to ErbB3
75 ErbB3(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex).ErbB4(I_III,II!2,loc~M) -> ErbB3(I_III!1,II!2,loc~En).HRG(EGFL!1,loc~En).ErbB4(I_III,II!2,loc~En) Intkp1
#ErbB3-ErbB4 dimers get internalized with HRG bound to ErbB4
76 ErbB3(I_III,II!2,loc~M).ErbB4(I_III!1,II!2,loc~M).HRG(EGFL!1,loc~Ex) -> ErbB3(I_III,II!2,loc~En).ErbB4(I_III!1,II!2,loc~En).HRG(EGFL!1,loc~En) Intkp1
#ErbB3-ErbB4 dimers get internalized with no HRG bound to both receptors
77 ErbB3(I_III,II!2,loc~M).ErbB4(I_III,II!2,loc~M) -> ErbB3(I_III,II!2,loc~En).ErbB4(I_III,II!2,loc~En) Intkp1