diff --git a/.azure-pipelines.yml b/.azure-pipelines.yml
index 820005f39..f84d8da51 100644
--- a/.azure-pipelines.yml
+++ b/.azure-pipelines.yml
@@ -53,10 +53,6 @@ stages:
               repository: tiledb/tiledbvcf-py
               context: .
               test_cmd: -c "import tiledbvcf; print(tiledbvcf.version)"
-            # dask:
-            #   dockerfile: docker/Dockerfile-dask-py
-            #   repository: tiledb/tiledbvcf-dask
-            #   context: .
         steps:
         - template: ci/build-images.yml
 
diff --git a/.github/workflows/macos.yml b/.github/workflows/macos.yml
index 5367f0481..96752bd51 100644
--- a/.github/workflows/macos.yml
+++ b/.github/workflows/macos.yml
@@ -86,8 +86,6 @@ jobs:
         with:
           environment-name: ci
           create-args: tiledb
-      - name: Install dependencies
-        run: python -m pip install --prefer-binary pyarrow==10.0.1
       - name: Build tiledbvcf-py
         env:
           LIBTILEDBVCF_PATH: "${{ github.workspace }}/dist"
@@ -163,8 +161,6 @@ jobs:
         uses: actions/setup-python@v5
         with:
           python-version: "3.11"
-      - name: Install dependencies
-        run: python -m pip install --prefer-binary pyarrow==10.0.1
       - name: Build tiledbvcf-py
         run: cd apis/python && python -m pip install -v .[test]
       - name: Confirm linking
diff --git a/apis/python/conda-env.yml b/apis/python/conda-env.yml
deleted file mode 100644
index 9d632ab56..000000000
--- a/apis/python/conda-env.yml
+++ /dev/null
@@ -1,17 +0,0 @@
-name: tiledbvcf-py
-channels:
-  - conda-forge
-dependencies:
-  - numpy<2
-  - python<3.12 # based on available tiledb-py wheels
-  - pybind11
-  - pyarrow>=14.0.2 # for pyarrow security fix
-  - fsspec
-  - dask
-  - pip
-  - setuptools
-  - setuptools_scm
-  - setuptools_scm_git_archive
-  - pip:
-    - pytest
-    - pytest-runner
diff --git a/apis/python/pyproject.toml b/apis/python/pyproject.toml
index f984f995f..bc179fd86 100644
--- a/apis/python/pyproject.toml
+++ b/apis/python/pyproject.toml
@@ -29,18 +29,18 @@ dynamic = ["version"]
 description = "TileDB-VCF Python client"
 license = { text = "MIT" }
 authors = []
-requires-python = "~=3.8"
+requires-python = "~=3.9"
 classifiers = [
     "Development Status :: 4 - Beta",
     "License :: OSI Approved :: MIT License",
     "Programming Language :: Python :: 3 :: Only",
-    "Programming Language :: Python :: 3.8",
     "Programming Language :: Python :: 3.9",
     "Programming Language :: Python :: 3.10",
     "Programming Language :: Python :: 3.11",
+    "Programming Language :: Python :: 3.12",
 ]
 
-dependencies = ["pandas", "pyarrow", "pyarrow-hotfix", "numpy<2"]
+dependencies = ["pandas", "pyarrow>=14.0.1", "numpy"]
 
 [project.optional-dependencies]
 test = ["dask[distributed]", "pytest", "tiledb"]
diff --git a/apis/python/src/tiledbvcf/__init__.py b/apis/python/src/tiledbvcf/__init__.py
index 2e833e154..6a629c8ac 100644
--- a/apis/python/src/tiledbvcf/__init__.py
+++ b/apis/python/src/tiledbvcf/__init__.py
@@ -1,6 +1,5 @@
 # Initialize pyarrow first.
 import pyarrow
-import pyarrow_hotfix
 
 import ctypes
 import os
diff --git a/ci/gha-win-env.yml b/ci/gha-win-env.yml
index 8289dae4b..017ca5ae7 100644
--- a/ci/gha-win-env.yml
+++ b/ci/gha-win-env.yml
@@ -8,13 +8,12 @@ dependencies:
   - cmake
   - git
   - m2w64-htslib
-  - tiledb=2.15
+  - tiledb=2.25
   - vs2019_win-64
   # build tiledbvcf-py
-  - numpy<2
-  - pandas<2.0
-  - pyarrow=9.0
-  - pyarrow-hotfix
+  - numpy
+  - pandas
+  - pyarrow>=14.0.1
   - pybind11
   - python
   - rpdb
diff --git a/ci/nightly/build-tiledb-py.sh b/ci/nightly/build-tiledb-py.sh
index bbc988ace..d9e297458 100644
--- a/ci/nightly/build-tiledb-py.sh
+++ b/ci/nightly/build-tiledb-py.sh
@@ -19,7 +19,7 @@ fi
 export TILEDB_PATH=$GITHUB_WORKSPACE/install/
 
 cd TileDB-Py/
-python -m pip install -Cskbuild.cmake.define.TILEDB_REMOVE_DEPRECATIONS=OFF -v . pyarrow==12
+python -m pip install -Cskbuild.cmake.define.TILEDB_REMOVE_DEPRECATIONS=OFF -v .
 
 # Can't run the import inside of the Git repo because Python automatically looks
 # for `./module/__init.py__`
diff --git a/ci/nightly/build-tiledbvcf-py.sh b/ci/nightly/build-tiledbvcf-py.sh
index ef50f77ce..54fc1af45 100644
--- a/ci/nightly/build-tiledbvcf-py.sh
+++ b/ci/nightly/build-tiledbvcf-py.sh
@@ -20,7 +20,7 @@ fi
 export LIBTILEDBVCF_PATH=$GITHUB_WORKSPACE/install/
 
 cd TileDB-VCF/apis/python
-python -m pip install .[test] pyarrow==12
+python -m pip install .[test]
 python -c "import tiledbvcf; print(tiledbvcf.version)"
 
 pytest
diff --git a/docker/Dockerfile-dask-py b/docker/Dockerfile-dask-py
deleted file mode 100644
index 9f61f9fa0..000000000
--- a/docker/Dockerfile-dask-py
+++ /dev/null
@@ -1,25 +0,0 @@
-FROM daskdev/dask:latest
-
-RUN conda config --prepend channels conda-forge
-
-# Install some dependencies
-RUN apt-get update \
-    && apt-get install --no-install-recommends -y \
-    wget cmake git gcc g++ build-essential autoconf automake \
-    libssl-dev libbz2-dev liblz4-dev libcurl4-openssl-dev \
-    zlib1g-dev liblzma-dev \
-    python3 python3-dev python3-venv \
-    ninja-build \
-    && rm -rf /var/lib/apt/lists/*
-
-# Copy the TileDB-VCF Python directory and build it.
-WORKDIR /tmp/
-COPY . tiledbvcf
-RUN cd tiledbvcf \
-    && rm -rf libtiledbvcf/build dist \
-    && cd apis/python \
-    && conda env update -n base -f conda-env.yml \
-    && pip install -v . \
-    && cd /tmp \
-    && rm -rf tiledbvcf \
-    && conda clean -a -y