diff --git a/omics/cli/sample/__init__.py b/omics/cli/sample/__init__.py
new file mode 100644
index 0000000..e69de29
diff --git a/omics/cli/sample/samplesheet.py b/omics/cli/sample/samplesheet.py
new file mode 100644
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+++ b/omics/cli/sample/samplesheet.py
@@ -0,0 +1,98 @@
+#!/usr/bin/env python3
+"""
+Command-line tool to create a sample sheet from active readsets
+
+Usage: omics-samples [<sequenceStoreId>]
+                   [--start=<date>]
+                   [--end=<date>]
+                   [--out=<path>]
+                   [--profile=<profile>]
+                   [--region=<region>]
+                   [--sampleId=<sample>]
+                   [--subjectId=<subject>]
+                   [--help]
+
+Options:
+ -s, --start=<date>            Show runs completed after specified date/time (UTC)
+ -e, --end=<date>              Show runs completed before specified date/time (UTC)
+ --sampleId=<sampleId>         Select the sampleId
+ --subjectId=<subjectId>       Select the subjectId
+ -o, --out=<path>              Write output to file
+ -p, --profile=<profile>       AWS profile
+ -r, --region=<region>         AWS region
+ -h, --help                    Show help text
+
+Examples:
+ # Create a sample sheet with samples created after the specified date
+ omics-samples 1234567890 -s 2023-07-01
+"""
+import boto3
+from botocore.config import Config
+import docopt
+from dateutil import parser
+import logging
+import sys 
+
+opts = docopt.docopt(__doc__)
+config = Config(retries={"max_attempts": 10, "mode": "standard"})
+session = boto3.session.Session(profile_name=opts["--profile"], region_name=opts["--region"])
+omics_client = session.client("omics", config=config)
+
+logging.basicConfig(level=logging.INFO)
+
+
+def get_samples(sqnid, filter):
+    samples = []
+    paginator = omics_client.get_paginator("list_read_sets")
+
+    params = {"sequenceStoreId": sqnid, "filter": filter}
+
+    for page in paginator.paginate(**params):
+        read_sets = page.get("readSets", [])
+        for read_set in read_sets:
+            logging.info(f"Processing read set {read_set['id']}")
+            data = omics_client.get_read_set_metadata(id=read_set["id"], sequenceStoreId=sqnid)
+            sample = data["sampleId"]
+            uri = data["files"]["source1"]["s3Access"]["s3Uri"]
+            samples.append(f"{sqnid},{sample},{uri}")
+    return samples
+
+
+def get_filter(cli_opts) -> dict:
+    filter = {"status": "ACTIVE"}
+    if opts["--start"]:
+        filter["createdAfter"] = parser.parse(opts["--start"])
+    if opts["--end"]:
+        filter["createdBefore"] = parser.parse(opts["--end"])
+    if opts["--sampleId"]:
+        filter["sampleId"] = opts["--sampleId"]
+    if opts["--subjectId"]:
+        filter["subjectId"] = opts["--subjectId"]
+    return filter
+
+
+def write_samples(samples, outpath):
+    headers = ["sequenceStoreId", "sampleId", "s3Uri"]
+    with open(outpath, "w") as out:
+        out.write(",".join(headers) + "\n")
+        for sample in samples:
+            out.write(sample + "\n")
+
+
+def main():
+    sequence_store = opts["<sequenceStoreId>"]
+    filter = get_filter(opts)
+    samples = get_samples(sequence_store, filter)
+    if opts["--out"]:
+        write_samples(samples, opts["--out"])
+    else:
+        for sample in samples:
+            print(sample)
+
+
+if __name__ == "__main__":
+    if opts["--sampleId"]:
+        if not opts["--subjectId"]:
+            logging.error("If using --sampleId you must also specify --sampleId")
+            sys.exit(1)
+    main()