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Generating D-amino acids and other NCAA alpha-amino acids through covalent modification for RoseTTAFold-All-Atom #143

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tsamdin opened this issue Oct 9, 2024 · 0 comments

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@tsamdin
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tsamdin commented Oct 9, 2024

If I want to predict the structure of a protein that contains both L and D amino acids, could I submit a sequence where the D-residues are given as glycine, with each glycine bearing the appropriate covalent modification and change in stereochemistry to give the D side chain? I think I would just have to provide each sidechain as the appropriate sdf file? Would this approach using glycine as base work for other NCAA alpha-amino acids with L or D stereochemistry?

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