diff --git a/requirements.txt b/requirements.txt
index 1c24310775..78536f31e0 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -42,11 +42,10 @@ clint==0.5.1
     # via commcare-cloud (setup.py)
 couchdb-cluster-admin==0.7.2
     # via commcare-cloud (setup.py)
-cryptography==41.0.6
+cryptography==42.0.0
     # via
     #   ansible-core
     #   commcare-cloud (setup.py)
-    #   pyopenssl
 datadog==0.42.0
     # via commcare-cloud (setup.py)
 deprecated==1.2.13
@@ -103,8 +102,6 @@ pyjwt==2.4.0
     # via pygithub
 pynacl==1.4.0
     # via pygithub
-pyopenssl==23.2.0
-    # via commcare-cloud (setup.py)
 pyparsing==3.0.9
     # via packaging
 python-dateutil==2.8.2
diff --git a/setup.py b/setup.py
index 51f06c9c1a..855fc8ace0 100644
--- a/setup.py
+++ b/setup.py
@@ -11,7 +11,7 @@
     'boto3>=1.9.131',
     'clint',
     'couchdb-cluster-admin',
-    'cryptography~=41.0',
+    'cryptography~=42.0',
     'datadog>=0.2.0',
     'dimagi-memoized>=1.1.0',
     'dnspython',
@@ -23,7 +23,6 @@
     'passlib',
     'pycryptodome>=3.6.6',  # security update
     'PyGithub>=1.43.3',
-    'pyOpenSSL~=23.2',
     'pytz',
     'simplejson',
     'six',