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PTN000542090 () #5597

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sjm41 opened this issue Jan 7, 2025 · 0 comments
Open

PTN000542090 () #5597

sjm41 opened this issue Jan 7, 2025 · 0 comments

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@sjm41
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sjm41 commented Jan 7, 2025

  • PTHR ID & PTN node:
    PTN000542090

  • Sequences with problematic annotation (ID + gene/protein name):
    D. melanogaster Prm (FBgn0003149, P35415 / P35416)

  • Type of Issue: Erroneous source or erroneous propagation, or other issue
    erroneous propagation

D. melanogaster Prm (Paramyosin) is getting 'Rho-dependent protein serine/threonine kinase activity' via PTN000542090, for which the sources are O75116 (human Rho-associated protein kinase 2, ROCK2) and Q13464 (human Rho-associated protein kinase 1, ROCK1).
But Prm has no kinase domains and just has a 'myosin tail' (it's characterized as a structural component of invertebrate muscle thick filaments. (e.g. PMID:16020538))

Can you check, and if you agree, block the kinase annotation to Prm?

This previously came up in #2888

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