diff --git a/girder/girder_large_image/web_client/vue/components/CompositeLayers.vue b/girder/girder_large_image/web_client/vue/components/CompositeLayers.vue
index 268e6a4f0..7c91c6277 100644
--- a/girder/girder_large_image/web_client/vue/components/CompositeLayers.vue
+++ b/girder/girder_large_image/web_client/vue/components/CompositeLayers.vue
@@ -2,7 +2,7 @@
 import {restRequest} from '@girder/core/rest';
 import {Chrome} from 'vue-color';
 
-import {CHANNEL_COLORS, OTHER_COLORS} from '../utils/colors';
+import {OTHER_COLORS, getChannelColor} from '../utils/colors';
 import HistogramEditor from './HistogramEditor.vue';
 
 export default {
@@ -10,7 +10,7 @@ export default {
         'color-picker': Chrome,
         HistogramEditor
     },
-    props: ['itemId', 'currentFrame', 'currentStyle', 'layers', 'layerMap', 'active'],
+    props: ['itemId', 'currentFrame', 'currentStyle', 'histogramParamStyle', 'layers', 'layerMap', 'active'],
     emits: ['updateStyle'],
     data() {
         return {
@@ -20,17 +20,21 @@ export default {
             compositeLayerInfo: {},
             expandedRows: [],
             autoRangeForAll: undefined,
-            histogramParams: {
+            showKeyboardShortcuts: false
+        };
+    },
+    computed: {
+        histogramParams() {
+            return {
                 frame: this.currentFrame,
                 width: 1024,
                 height: 1024,
                 bins: 512,
                 resample: false,
-                style: '{}',
+                style: this.histogramParamStyle,
                 roundRange: true
-            },
-            showKeyboardShortcuts: false
-        };
+            };
+        }
     },
     watch: {
         active() {
@@ -44,6 +48,9 @@ export default {
             if (this.currentStyle.preset) {
                 this.initializeStateFromStyle();
             }
+        },
+        histogramParams() {
+            this.fetchCurrentFrameHistogram();
         }
     },
     mounted() {
@@ -114,13 +121,11 @@ export default {
             // Assign colors
             this.layers.forEach((layerName) => {
                 if (!this.compositeLayerInfo[layerName].palette) {
-                    // Search for case-insensitive regex match among known channel-colors
-                    Object.entries(CHANNEL_COLORS).forEach(([channelPattern, color]) => {
-                        if (layerName.match(new RegExp(channelPattern, 'i')) && !usedColors.includes(color)) {
-                            this.compositeLayerInfo[layerName].palette = color;
-                            usedColors.push(color);
-                        }
-                    });
+                    const channelColor = getChannelColor(layerName);
+                    if (channelColor) {
+                        this.compositeLayerInfo[layerName].palette = channelColor;
+                        usedColors.push(channelColor);
+                    }
                 }
             });
             this.layers.forEach((layerName) => {
diff --git a/girder/girder_large_image/web_client/vue/components/DualInput.vue b/girder/girder_large_image/web_client/vue/components/DualInput.vue
index 1586a5f94..f1aad0b02 100644
--- a/girder/girder_large_image/web_client/vue/components/DualInput.vue
+++ b/girder/girder_large_image/web_client/vue/components/DualInput.vue
@@ -1,10 +1,11 @@
 <script>
 export default {
-    props: ['label', 'currentValue', 'valueMax', 'sliderLabels'],
-    emits: ['updateValue'],
+    props: ['label', 'currentValue', 'valueMax', 'sliderLabels', 'maxMerge'],
+    emits: ['updateValue', 'updateMaxMerge'],
     data() {
         return {
-            value: this.currentValue
+            value: this.currentValue,
+            merge: this.maxMerge
         };
     },
     watch: {
@@ -13,6 +14,12 @@ export default {
         },
         value(v) {
             this.$emit('updateValue', v);
+        },
+        maxMerge(v) {
+            this.merge = v;
+        },
+        merge(v) {
+            this.$emit('updateMaxMerge', v);
         }
     }
 };
@@ -28,15 +35,17 @@ export default {
         name="numberControl"
         min="0"
         :max="valueMax"
+        :disabled="merge"
       >
     </td>
-    <td style="width:90%">
+    <td style="width: 100%">
       <input
         v-model="value"
         type="range"
         name="sliderControl"
         min="0"
         :max="valueMax"
+        :disabled="merge"
       >
       <div class="bubble-wrap">
         <output
@@ -53,12 +62,25 @@ export default {
         />
       </div>
     </td>
+    <td
+      v-show="merge !== undefined"
+      style="min-width: 150px; text-align: right;"
+    >
+      <input
+        :id="'maxMerge'+label"
+        v-model="merge"
+        type="checkbox"
+        style="margin: 0px 5px 0px 10px"
+      >
+      <label :for="'maxMerge'+label">Max Merge</label>
+    </td>
   </tr>
 </template>
 
 <style scoped>
 .dual-controls > * > * {
     margin-right: 15px;
+    white-space: nowrap;
 }
 .dual-controls.tall {
     height: 40px;
diff --git a/girder/girder_large_image/web_client/vue/components/FrameSelector.vue b/girder/girder_large_image/web_client/vue/components/FrameSelector.vue
index dacd059ff..9fb676713 100644
--- a/girder/girder_large_image/web_client/vue/components/FrameSelector.vue
+++ b/girder/girder_large_image/web_client/vue/components/FrameSelector.vue
@@ -1,6 +1,8 @@
 <script>
 import Vue from 'vue';
 
+import {getChannelColor} from '../utils/colors';
+
 import CompositeLayers from './CompositeLayers.vue';
 import DualInput from './DualInput.vue';
 import PresetsMenu from './PresetsMenu.vue';
@@ -18,7 +20,8 @@ export default Vue.extend({
             indices: [],
             indexInfo: {},
             style: {},
-            modesShown: {1: true}
+            modesShown: {1: true},
+            histogramParamStyles: {}
         };
     },
     computed: {
@@ -63,14 +66,39 @@ export default Vue.extend({
                     })
             );
         },
+        updateHistogramParamStyles() {
+            this.histogramParamStyles = {};
+            Array.from([2, 3]).forEach((modeID) => {
+                const mergedStyle = this.maxMergeStyle();
+                if (mergedStyle.bands.length) {
+                    const simpleMergedStyleString = JSON.stringify({
+                        dtype: 'source',
+                        bands: mergedStyle.bands.map((b) => ({
+                            framedelta: b.framedelta,
+                            band: b.band
+                            // including min, max, and palette gives strange results
+                        }))
+                    });
+                    this.histogramParamStyles[modeID] = simpleMergedStyleString;
+                } else {
+                    this.histogramParamStyles[modeID] = '{}';
+                }
+            });
+        },
         updateStyle(idx, style) {
             this.$set(this.style, idx, style);
+            this.updateHistogramParamStyles();
             this.update();
         },
         updateAxisSlider(event) {
             this.indexInfo[event.index].current = event.frame;
             this.update();
         },
+        updateMaxMergeAxis(event) {
+            this.indexInfo[event.index].maxMerge = event.maxMerge;
+            this.update();
+            this.updateHistogramParamStyles();
+        },
         updateFrameSlider(frame) {
             this.currentFrame = frame;
             this.frameUpdate(frame, undefined);
@@ -80,14 +108,73 @@ export default Vue.extend({
             this.indices.forEach((index) => {
                 if (this.sliderIndices.includes(index)) {
                     const info = this.indexInfo[index];
-                    frame += info.current * info.stride;
+                    if (!info.maxMerge) {
+                        frame += info.current * info.stride;
+                    }
                 }
             });
             this.currentFrame = frame;
-            const style = this.currentModeId > 1 ? Object.assign({}, this.style[this.currentModeId]) : undefined;
+            let style = this.currentModeId > 1 ? Object.assign({}, this.style[this.currentModeId]) : undefined;
             if (style && style.preset) delete style.preset;
+            style = this.maxMergeStyle(style);
             this.frameUpdate(frame, style);
         },
+        maxMergeStyle(style) {
+            const bandsArray = (style ? style.bands : []) || [];
+            let newBandsArray = [];
+            let frameDeltas = [];
+            Object.entries(this.indexInfo).forEach(([indexName, {range, stride, maxMerge}]) => {
+                if (this.currentModeId === 2 && indexName === 'IndexC') {
+                    // channel compositing is already in bandsArray
+                    // skip permutations for this axis
+                } else if (maxMerge) {
+                    const axisFrameDeltas = [...Array(range + 1).keys()].map((i) => i * stride);
+                    if (frameDeltas.length) {
+                        const newFrameDeltas = [];
+                        frameDeltas.forEach((d) => {
+                            axisFrameDeltas.forEach((a) => {
+                                newFrameDeltas.push(d + a);
+                            });
+                        });
+                        frameDeltas = newFrameDeltas;
+                    } else {
+                        frameDeltas = axisFrameDeltas;
+                    }
+                }
+            });
+
+            if (frameDeltas.length) {
+                if (bandsArray.length) {
+                    // some style already applied, add permutations
+                    bandsArray.forEach((b) => {
+                        frameDeltas.forEach((framedelta) => {
+                            newBandsArray.push(
+                                Object.assign({}, b, {
+                                    framedelta: b.framedelta ? b.framedelta + framedelta : framedelta
+                                })
+                            );
+                        });
+                    });
+                } else {
+                    // no style applied yet, create new permutations list
+                    const {bands} = this.metadata;
+                    bands.forEach((b, i) => {
+                        const bandPalette = getChannelColor(b);
+                        frameDeltas.forEach((framedelta) => {
+                            newBandsArray.push({
+                                band: i + 1,
+                                framedelta,
+                                palette: bandPalette
+                            });
+                        });
+                    });
+                }
+            } else {
+                // no max merge permutations to apply, keep old bandsArray
+                newBandsArray = bandsArray;
+            }
+            return {bands: newBandsArray};
+        },
         fillMetadata() {
             if (!this.metadata.frames) {
                 this.metadata.frames = [{
@@ -242,6 +329,8 @@ export default Vue.extend({
         :value-max="indexInfo[index].range"
         :label="index.replace('Index', '')"
         :slider-labels="index === 'IndexC' ? imageMetadata.channels : []"
+        :max-merge="indexInfo[index].maxMerge || false"
+        @updateMaxMerge="(v) => updateMaxMergeAxis({index, maxMerge: v})"
         @updateValue="(v) => updateAxisSlider({index, frame: v})"
       />
     </table>
@@ -255,6 +344,7 @@ export default Vue.extend({
         :item-id="itemId"
         :current-frame="currentFrame"
         :current-style="style[2]"
+        :histogram-param-style="histogramParamStyles[2]"
         :layers="metadata.channels"
         :layer-map="metadata.channelmap"
         :active="currentModeId === 2"
@@ -267,6 +357,7 @@ export default Vue.extend({
         :item-id="itemId"
         :current-frame="currentFrame"
         :current-style="style[3]"
+        :histogram-param-style="histogramParamStyles[3]"
         :layers="metadata.bands"
         :layer-map="undefined"
         :active="currentModeId === 3"
diff --git a/girder/girder_large_image/web_client/vue/components/HistogramEditor.vue b/girder/girder_large_image/web_client/vue/components/HistogramEditor.vue
index d6a584469..60f966819 100644
--- a/girder/girder_large_image/web_client/vue/components/HistogramEditor.vue
+++ b/girder/girder_large_image/web_client/vue/components/HistogramEditor.vue
@@ -28,6 +28,9 @@ export default {
         currentFrame() {
             this.fetchHistogram();
         },
+        currentFrameHistogram() {
+            this.fetchHistogram();
+        },
         histogram() {
             // allow rerender to occur first
             Vue.nextTick().then(() => {
@@ -290,10 +293,11 @@ export default {
         class="handles-svg"
       >
         <text
+          v-if="vRange[0] !== undefined"
           x="5"
           y="43"
           class="small"
-        >{{ vRange[0] }}</text>
+        >{{ +vRange[0].toFixed(2) || 0 }}</text>
         <rect
           ref="minExclusionBox"
           x="5"
@@ -314,10 +318,11 @@ export default {
           y2="30"
         />
         <text
+          v-if="vRange[1] !== undefined"
           :x="xRange[1] && vRange[1] ? xRange[1] - (`${vRange[1]}`.length * 6): 0"
           y="43"
           class="small"
-        >{{ vRange[1] }}</text>
+        >{{ +vRange[1].toFixed(2) || 1 }}</text>
         <rect
           ref="maxExclusionBox"
           x="5"
diff --git a/girder/girder_large_image/web_client/vue/utils/colors.js b/girder/girder_large_image/web_client/vue/utils/colors.js
index 11a2e7034..91487094a 100644
--- a/girder/girder_large_image/web_client/vue/utils/colors.js
+++ b/girder/girder_large_image/web_client/vue/utils/colors.js
@@ -12,6 +12,15 @@ export const CHANNEL_COLORS = {
     '^gr[ae]y(|scale)$': '#FFFFFF'
 };
 
+export function getChannelColor(name) {
+    // Search for case-insensitive regex match among known channel-colors
+    for (const [channelPattern, color] of Object.entries(CHANNEL_COLORS)) {
+        if (name.match(new RegExp(channelPattern, 'i'))) {
+            return color;
+        }
+    }
+}
+
 export const OTHER_COLORS = [
     '#FF0000',
     '#00FF00',