diff --git a/CHANGELOG.md b/CHANGELOG.md
index adfe22a07..40d9b577a 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -5,6 +5,9 @@
 ### Improvements
 - Style can specify a dtype of 'source' to maintain the original dtype even when compositing frames ([#1326](../../pull/1326))
 
+### Changes
+- Prohibit bioformats and vips from reading mrxs directly ([#1328](../../pull/1328))
+
 ## 1.25.0
 
 ### Features
diff --git a/sources/bioformats/large_image_source_bioformats/__init__.py b/sources/bioformats/large_image_source_bioformats/__init__.py
index 37ac3cc03..0783c9dbd 100644
--- a/sources/bioformats/large_image_source_bioformats/__init__.py
+++ b/sources/bioformats/large_image_source_bioformats/__init__.py
@@ -62,7 +62,7 @@
 
 # Default to ignoring files with no extension and some specific extensions.
 config.ConfigValues['source_bioformats_ignored_names'] = \
-    r'(^[^.]*|\.(jpg|jpeg|jpe|png|tif|tiff|ndpi|nd2|ome|nc|json|isyntax))$'
+    r'(^[^.]*|\.(jpg|jpeg|jpe|png|tif|tiff|ndpi|nd2|ome|nc|json|isyntax|mrxs))$'
 
 
 def _monitor_thread():
diff --git a/sources/vips/large_image_source_vips/__init__.py b/sources/vips/large_image_source_vips/__init__.py
index 1fbb36b90..b015a47c7 100644
--- a/sources/vips/large_image_source_vips/__init__.py
+++ b/sources/vips/large_image_source_vips/__init__.py
@@ -22,7 +22,7 @@
 
 # Default to ignoring files with no extension and some specific extensions.
 config.ConfigValues['source_vips_ignored_names'] = \
-    r'(^[^.]*|\.(yml|yaml|json|png|svs))$'
+    r'(^[^.]*|\.(yml|yaml|json|png|svs|mrxs))$'
 
 
 def _clearVipsCache():