diff --git a/girder/girder_large_image/__init__.py b/girder/girder_large_image/__init__.py
index 56b6d29e3..8e4ddbbf9 100644
--- a/girder/girder_large_image/__init__.py
+++ b/girder/girder_large_image/__init__.py
@@ -140,7 +140,7 @@ def checkForLargeImageFiles(event):
     mimeType = file.get('mimeType')
     if mimeType in girder_tilesource.KnownMimeTypes:
         possible = True
-    exts = [ext.split()[0] for ext in file.get('exts')]
+    exts = [ext.split()[0] for ext in file.get('exts') if ext]
     if set(exts[-2:]).intersection(girder_tilesource.KnownExtensions):
         possible = True
     if not file.get('itemId') or not possible:
diff --git a/girder/girder_large_image/girder_tilesource.py b/girder/girder_large_image/girder_tilesource.py
index eef3d2e72..b0b3ebe08 100644
--- a/girder/girder_large_image/girder_tilesource.py
+++ b/girder/girder_large_image/girder_tilesource.py
@@ -148,7 +148,7 @@ def getGirderTileSourceName(item, file=None, *args, **kwargs):
         loadGirderTileSources()
     if not file:
         file = File().load(item['largeImage']['fileId'], force=True)
-    extensions = [entry.lower().split()[0] for entry in file['exts']]
+    extensions = [entry.lower().split()[0] for entry in file['exts'] if entry]
     sourceList = []
     for sourceName in AvailableGirderTileSources:
         if not getattr(AvailableGirderTileSources[sourceName], 'girderSource', False):
diff --git a/girder/test_girder/test_tiles_rest.py b/girder/test_girder/test_tiles_rest.py
index 0bcf2a207..992c82002 100644
--- a/girder/test_girder/test_tiles_rest.py
+++ b/girder/test_girder/test_tiles_rest.py
@@ -1129,3 +1129,33 @@ def testTilesInternalMetadata(server, admin, fsAssetstore):
     itemId = str(file['itemId'])
     resp = server.request(path='/item/%s/tiles/internal_metadata' % itemId)
     assert resp.json['tilesource'] == 'tiff'
+
+
+@pytest.mark.usefixtures('unbindLargeImage')  # noqa
+@pytest.mark.usefixtures('girderWorker')  # noqa
+@pytest.mark.plugin('large_image')
+def testTilesFromMultipleDotName(boundServer, admin, fsAssetstore, girderWorker):  # noqa
+    # Unicode file names shouldn't cause problems when generating tiles.
+    file = utilities.uploadTestFile('yb10kx5k.png', admin, fsAssetstore)
+    # Our normal testing method doesn't pass through the unicode name
+    # properly, so just change it after upload.
+    file = File().load(file['_id'], force=True)
+    file['name'] = 'A name with...dots.png'
+    file = File().save(file)
+    fileId = str(file['_id'])
+
+    itemId = str(file['itemId'])
+    item = Item().load(itemId, force=True)
+    item['name'] = 'A name with...dots.png'
+    item = Item().save(item)
+
+    tileMetadata = _postTileViaHttp(boundServer, admin, itemId, fileId)
+    assert tileMetadata['tileWidth'] == 256
+    assert tileMetadata['tileHeight'] == 256
+    assert tileMetadata['sizeX'] == 10000
+    assert tileMetadata['sizeY'] == 5000
+    assert tileMetadata['levels'] == 7
+    assert tileMetadata['magnification'] is None
+    assert tileMetadata['mm_x'] is None
+    assert tileMetadata['mm_y'] is None
+    _testTilesZXY(boundServer, admin, itemId, tileMetadata)