diff --git a/mysql-test/main/desc_index_range.result b/mysql-test/main/desc_index_range.result
index edf130108290e..94176270dbfb5 100644
--- a/mysql-test/main/desc_index_range.result
+++ b/mysql-test/main/desc_index_range.result
@@ -186,6 +186,29 @@ CREATE OR REPLACE TABLE t1 (pk INT, a INT, b int, KEY(a), PRIMARY KEY(pk DESC))
 INSERT INTO t1 VALUES (1,4,5),(2,9,6),(3,NULL,7),(4,NULL,8);
 SELECT * FROM t1 WHERE pk > 10 OR a > 0;
 pk	a	b
-1	4	5
 2	9	6
+1	4	5
 DROP TABLE t1;
+#
+#  MDEV-27529: Wrong result upon query using index_merge with DESC key (#2)
+#
+create table t1 (
+pk int, 
+a int, 
+b int,
+primary key(pk desc),
+key(a),
+key(b)
+) engine=innodb;
+insert into t1 values (0, 111111, 255);
+insert into t1 select seq+50000, NULL, seq+1000 from seq_1_to_260;
+insert into t1 values (10000, NULL, 255);
+insert into t1 select seq+20000, seq+20000, seq+20000 from seq_1_to_1500;
+# Must use ROR-intersect:
+explain select * from t1 where b = 255 AND a IS NULL;
+id	select_type	table	type	possible_keys	key	key_len	ref	rows	Extra
+1	SIMPLE	t1	index_merge	a,b	b,a	5,5	NULL	1	Using intersect(b,a); Using where; Using index
+select * from t1 where b = 255 AND a IS NULL;
+pk	a	b
+10000	NULL	255
+drop table t1;
diff --git a/mysql-test/main/desc_index_range.test b/mysql-test/main/desc_index_range.test
index 2f3d36c830575..db59922e17746 100644
--- a/mysql-test/main/desc_index_range.test
+++ b/mysql-test/main/desc_index_range.test
@@ -96,3 +96,30 @@ INSERT INTO t1 VALUES (1,4,5),(2,9,6),(3,NULL,7),(4,NULL,8);
 
 SELECT * FROM t1 WHERE pk > 10 OR a > 0;
 DROP TABLE t1;
+
+
+--echo #
+--echo #  MDEV-27529: Wrong result upon query using index_merge with DESC key (#2)
+--echo #
+
+create table t1 (
+  pk int, 
+  a int, 
+  b int,
+  primary key(pk desc),
+  key(a),
+  key(b)
+) engine=innodb;
+
+insert into t1 values (0, 111111, 255);
+
+insert into t1 select seq+50000, NULL, seq+1000 from seq_1_to_260;
+
+insert into t1 values (10000, NULL, 255);
+insert into t1 select seq+20000, seq+20000, seq+20000 from seq_1_to_1500;
+
+--echo # Must use ROR-intersect:
+explain select * from t1 where b = 255 AND a IS NULL;
+select * from t1 where b = 255 AND a IS NULL;
+
+drop table t1;
diff --git a/storage/innobase/handler/ha_innodb.cc b/storage/innobase/handler/ha_innodb.cc
index 56250ea54867c..3d13fa5370955 100644
--- a/storage/innobase/handler/ha_innodb.cc
+++ b/storage/innobase/handler/ha_innodb.cc
@@ -16772,7 +16772,8 @@ ha_innobase::cmp_ref(
 		}
 
 		if (result) {
-
+			if (key_part->key_part_flag & HA_REVERSE_SORT)
+				result = -result;
 			return(result);
 		}