diff --git a/pint/facets/numpy/quantity.py b/pint/facets/numpy/quantity.py
index 5257766bc..9039a1f85 100644
--- a/pint/facets/numpy/quantity.py
+++ b/pint/facets/numpy/quantity.py
@@ -266,7 +266,7 @@ def __setitem__(self, key, value):
                 isinstance(self._magnitude, np.ma.MaskedArray)
                 and np.ma.is_masked(value)
                 and getattr(value, "size", 0) == 1
-            ) or math.isnan(value):
+            ) or (getattr(value, "ndim", 0) == 0 and math.isnan(value)):
                 self._magnitude[key] = value
                 return
         except TypeError: