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---
layout: default
---
<p style="font-size:115%;">Welcome to the AsthmaMap project, a community-driven effort focused on a comprehensive description of asthma mechanisms and its applications for developing models, data interpretation and hypothesis generation.</p>
<h2>AsthmaMap architecture</h2>
<p>The AsthmaMap includes three interconnected layers of granularity: Cellular Interactions (CI), a high-level overview; Activity Flow (AF), the intermediate level of details; Process Description (PD), the most detailed layer.</p>
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<table>
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<td style="width: 300px; text-align: center; padding-bottom:15px;"><a href="/ci"><strong>AsthmaMap Cellular Interactions</strong></a></td>
<td style="width: 300px; text-align: center; padding-bottom:15px;"><a href="/af"><strong>AsthmaMap Activity Flow</strong></a></td>
<td style="width: 300px; text-align: center; padding-bottom:15px;"><a href="/pd"><strong>AsthmaMap Process Description</strong></a></td>
</tr>
</table>
<table>
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<td style="width: 300px; text-align: center;"><a href="/ci"><img src="/images/layers/new-CI-cut.jpg" width="270" style="border:1px solid grey"/></a></td>
<td style="width: 300px; text-align: center;"><a href="/af"><img src="/images/layers/F002-AirwayEpithelialCell-cut.png" width="270" style="border:1px solid grey"/></a></td>
<td style="width: 300px; text-align: center;"><a href="/pd"><img src="/images/layers/new-PD-cut.jpg" width="270" style="border:1px solid grey"/></a></td>
</tr>
</table>
<p style="font-size:20px">
<table>
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<td style="width: 300px;"><p style="margin:10px; font-size:14px"><strong>Content:</strong> cell-to-cell communication, each receptor represents the corresponding pathway of the AF and PD layers.</p><p style="margin:10px; font-size:14px"><strong>Format:</strong> activity flows.</p><p style="margin:10px; font-size:14px"><strong>Purpose:</strong> disease overview, defining the content for the detailed maps, disease endotype visualisation.</p></td>
<td style="width: 300px;"><p style="margin:10px; font-size:14px"><strong>Content:</strong> all the proteins from the PD layer without details on molecular interactions.</p><p style="margin:10px; font-size:14px"><strong>Format:</strong> activity flows.</p><p style="margin:10px; font-size:14px"><strong>Purpose:</strong> ‘omics visualisation, network-
enrichment analysis, interpretation and hypothesis generation, logical models.</p></td>
<td style="width: 300px;"><p style="margin:10px; font-size:14px"><strong>Content:</strong> comprehensive detailed maps - integrated detailed metabolic, signalling and gene regulatory pathways.</p><p style="margin:10px; font-size:14px"><strong>Format:</strong> process descriptions.</p><p style="margin:10px; font-size:14px"><strong>Purpose:</strong> unambiguous visualisation of molecular processes, the basis for modelling and simulation, mapping drug action mechanisms.</p></td>
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</table>