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<!DOCTYPE html>
<html lang="en">
<head>
<meta http-equiv="content-type" content="text/html; charset=UTF-8">
<meta charset="utf-8">
<title>Metabolic Syndrome :: Validation</title>
<meta name="generator" content="Bootply" />
<meta name="viewport" content="width=device-width, initial-scale=1, maximum-scale=1">
<link href="images/favicon-16x16.png" rel="shortcut icon">
<link href="css/bootstrap.min.css" rel="stylesheet">
<!--[if lt IE 9]>
<script src="//html5shim.googlecode.com/svn/trunk/html5.js"></script>
<![endif]-->
<link href="css/styles.css" rel="stylesheet">
<link href="css/angular-switcher.min.css" rel="stylesheet">
</head>
<body ng-app="mets" ng-controller="Idioma">
<div class="wrapper">
<div class="box">
<div class="row row-offcanvas row-offcanvas-left">
<!-- sidebar -->
<div class="column col-sm-2 col-xs-1 sidebar-offcanvas" id="sidebar">
<ul class="nav">
<li><a href="#" data-toggle="offcanvas" class="visible-xs text-center"><i class="glyphicon glyphicon-chevron-right"></i></a></li>
</ul>
<!-- Menu Inglés -->
<div ng-if="Idioma == 'EN'">
<ul class="nav hidden-xs" id="lg-menu">
<li><a href="sm.html"><i class="glyphicon glyphicon-info-sign"></i> MS</a></li>
<li><a href="wt.html"><i class="glyphicon glyphicon-repeat"></i> WtHR</a></li>
<li><a href="ht.html"><i class="glyphicon glyphicon-heart"></i> HT</a></li>
<li class="active"><a href="vl.html"><i class="glyphicon glyphicon-ok"></i> Validation</a></li>
<li><a href="au.html"><i class="glyphicon glyphicon-user"></i> Authors</a></li>
<li><a href="ab.html"><i class="glyphicon glyphicon-edit"></i> About</a></li>
</ul>
<ul class="list-unstyled hidden-xs" id="sidebar-footer">
<li>
<h3>
<a href="http://www.uco.es" target="_blank"><img src="images/logo-footer.png" width="28px"></a>
<a href="http://imibic.org" target="_blank"><img src="images/imibic.png" width="130px"></a>
<hr><p>NIM MetS</p>
</h3> Metabolic Syndrome
</li>
</ul>
</div>
<!-- Menu Español -->
<div ng-if="Idioma == 'ES'">
<ul class="nav hidden-xs" id="lg-menu">
<li><a href="sm.html"><i class="glyphicon glyphicon-info-sign"></i> SM</a></li>
<li><a href="wt.html"><i class="glyphicon glyphicon-repeat"></i> ICT</a></li>
<li><a href="ht.html"><i class="glyphicon glyphicon-heart"></i> HTA</a></li>
<li class="active"><a href="vl.html"><i class="glyphicon glyphicon-ok"></i> Validación</a></li>
<li><a href="au.html"><i class="glyphicon glyphicon-user"></i> Autores</a></li>
<li><a href="ab.html"><i class="glyphicon glyphicon-edit"></i> Acerca de</a></li>
</ul>
<ul class="list-unstyled hidden-xs" id="sidebar-footer">
<li>
<h3>
<a href="http://www.uco.es" target="_blank"><img src="images/logo-footer.png" width="28px"></a>
<a href="http://imibic.org" target="_blank"><img src="images/imibic.png" width="130px"></a>
<hr><p>NIM MetS</p>
</h3> Síndrome Metabólico
</li>
</ul>
</div>
<!-- tiny only nav-->
<ul class="nav visible-xs" id="xs-menu">
<li><a href="sm.html" class="text-center"><i class="glyphicon glyphicon-info-sign"></i></a></li>
<li><a href="wt.html" class="text-center"><i class="glyphicon glyphicon-repeat"></i></a></li>
<li><a href="ht.html" class="text-center"><i class="glyphicon glyphicon-heart"></i></a></li>
<li class="active"><a href="vl.html" class="text-center"><i class="glyphicon glyphicon-ok"></i></a></li>
<li><a href="au.html" class="text-center"><i class="glyphicon glyphicon-user"></i></a></li>
<li><a href="ab.html" class="text-center"><i class="glyphicon glyphicon-edit"></i></a></li>
</ul>
</div>
<!-- /sidebar -->
<!-- main right col -->
<div class="column col-sm-10 col-xs-11" id="main">
<!-- top nav -->
<div class="navbar navbar-blue navbar-static-top">
<div class="navbar-header">
<button class="navbar-toggle" type="button" data-toggle="collapse" data-target=".navbar-collapse">
<span class="sr-only">Toggle</span>
<span class="icon-bar"></span>
<span class="icon-bar"></span>
<span class="icon-bar"></span>
</button>
<img class="navbar-brand logo-lang" ng-src="images/{{Idioma}}.png" width="25px;" ng-click="cambiame()">
<a href="index.html" class="navbar-brand logo">NIM MetS</a>
</div>
</div>
<!-- /top nav -->
<div class="padding">
<div class="full col-sm-12">
<!-- content -->
<div class="row">
<!-- main col left -->
<div class="bs-callout bs-callout-info" id="callout-alerts-no-default">
<!-- En Inglés -->
<div ng-if="Idioma == 'EN'">
<h4>Metabolic Syndrome</h4>
<h5>Validation of the new method of early detection of MetS: diagnostic test accuracy study.</h5>
<p>To check the validity and safety of the proposed model, a diagnostic test accuracy study was carried out, and the method was used with a new sample of workers. These were selected randomly and stratified by age and gender, with a total of 550 new workers, with a mean age of 44.8 ± 8.3 years, of which 358 were men (65.1%), without significant differences found between both work populations. As a reference standard test for the diagnostic contrast, the NCEP ATP III definition guide was used.</p>
<p>Table 1 shows the diagnostic criteria and the probabili- ties of developing MetS of the new method being validated. It can be seen that, according to the two variables in the method (WtHR–hypertension), four different situations can arise with a different probability of suffering from MetS. This method of screening considers it to be a ‘case’ of MetS when workers meet both positive criteria, that is, WtHR ⩾0.55 (WtHR=1) and BP ⩾128/85 mmHg (hypertension=1); and they therefore have a probability of developing MetS of over 60%.</p>
<p>With regard to the validation of the method for the early detection of MetS, 83 out of the 550 workers were diagnosed as having MetS according to the NCEP ATP III. The proposed new method identified 76 of the 83 subjects with MetS and 447 of the 467 subjects without MetS, thus achieving a sensitivity of 91.6% and a specificity of 95.7%, with a validity index of 94.2%, kappa clinical concordance index of 0.82 and Youden’s index of 0,87 (see Table 2).</p>
<hr>
<p>
<h5>Table 1. MetS classification criteria for the new method of early detection. Probability of developing MetS decision tree.</h5>
<div class="table-responsive">
<table class="table table-striped table-bordered table-hover">
<tbody>
<tr class="info">
<th>WtHR</th>
<th>Hypertension</th>
<th>P Value (Mets+)</th>
<th>Classification by the model MetS (Yes/No)</th>
</tr>
<tr>
<td>0</td>
<td>0</td>
<td>0.5%</td>
<td>No</td>
</tr>
<tr>
<td>0</td>
<td>1</td>
<td>9.5%</td>
<td>No</td>
</tr>
<tr>
<td>1</td>
<td>0</td>
<td>16.9%</td>
<td>No</td>
</tr>
<tr class="info">
<td>1</td>
<td>1</td>
<td>61.7%</td>
<td>Yes</td>
</tr>
</tbody>
</table>
</div>
<p>
<h5>Table 2. Main indicators in model for early detection of MetS in the diagnostic test accuracy study.</h5>
<div class="table-responsive">
<table class="table table-striped table-bordered table-hover">
<tbody>
<tr class="info">
<th>Indicator</th>
<th>CI Value</th>
<th></th>
</tr>
<tr>
<td>Prevalence</td>
<td>15.1%</td>
<td>(12.2-18.2)</td>
</tr>
<tr>
<td>Sensitivity</td>
<td>91.6%</td>
<td>(93.8-97.7)</td>
</tr>
<tr>
<td>Specificity</td>
<td>95.7%</td>
<td>(93.2-97)</td>
</tr>
<tr>
<td>PPV</td>
<td>79.2%</td>
<td>(70.5-87.8)</td>
</tr>
<tr>
<td>NPV</td>
<td>98.5%</td>
<td>(97.2-99.7)</td>
</tr>
<tr>
<td>LH+</td>
<td>21.4</td>
<td>(13.9-33)</td>
</tr>
<tr>
<td>LH-</td>
<td>0.09</td>
<td>(0.04-0.18)</td>
</tr>
<tr>
<td>Validity index</td>
<td>92.4%</td>
<td>(89.9-98.5)</td>
</tr>
<tr>
<td>Youden's index</td>
<td>0.87</td>
<td>(0.8-0.94)</td>
</tr>
<tr>
<td>Kappa index</td>
<td>0.82</td>
<td>(0.75-0.88)</td>
</tr>
</tbody>
</table>
</div>
<hr>
<a href="index.html"><i class="glyphicon glyphicon-share"></i></a> Return Test
</div> <!-- Fin de INglés -->
<!-- En Español -->
<div ng-if="Idioma == 'ES'">
<h4>Sindrome Metabólico</h4>
<h5>Validación del nuevo método de diagnóstico precoz de SM. Estudio de prueba diagnóstica.</h5>
<p>Para comprobar la validez y seguridad del modelo propuesto, se ha llevado a cabo un estudio de pruebas diagnósticas, aplicando este método a una nueva muestra de trabajadores. Se han seleccionado aleatoriamente y estratificados por edad y sexo, a 550 nuevos trabajadores, con una edad media de 44,8 ± 8,3 años, y de los cuales 358 fueron hombres (65,1%). Como prueba de referencia para el contraste diagnóstico se ha empleado la guía de definición de NCEP-ATPIII.</p>
<p>La tabla 1 muestra los criterios diagnósticos y las probabilidades de presentar SM del nuevo método que se valida. Se observa que, en función de las dos variables del método (ICT – HTA), se pueden dar cuatro situaciones con una probabilidad distinta de presentar SM. Este método de diagnóstico precoz considera “caso” de SM aquellos trabajadores que reúnen ambos criterios positivos, o sea, ICT ≥0,55 (ICT=1) y TA≥128/85 mm Hg (HTA=1); y por tanto, presentar una probabilidad de padecer SM mayor del 60%.</p>
<p>Por lo que respecta a la validación del método de detección precoz de SM, de los 550 trabajadores, 83 fueron diagnosticados de SM según NCEP-ATPIII. El nuevo método propuesto identificó a 76 de los 83 sujetos con SM y a 447 de los 467 sujetos exentes de SM, consiguiendo una sensibilidad 91,6%, una especificidad del 95,7%, el índice de validez fue del 94,2%, y el índice Kappa de concordancia clínica fue del 0,82 (Tabla 2).</p>
<hr>
<p>
<h5>Tabla 1. Criterios de clasificación de SM para el nuevo método de detección precoz. Probabilidades de presentar SM según árbol de decisión.</h5>
<div class="table-responsive">
<table class="table table-striped table-bordered table-hover">
<tbody>
<tr class="info">
<th>ICT</th>
<th>HTA</th>
<th>P (SM+)</th>
<th>Clasificación del Modelo SM (Sí/No)</th>
</tr>
<tr>
<td>0</td>
<td>0</td>
<td>0.5%</td>
<td>No</td>
</tr>
<tr>
<td>0</td>
<td>1</td>
<td>9.5%</td>
<td>No</td>
</tr>
<tr>
<td>1</td>
<td>0</td>
<td>16.9%</td>
<td>No</td>
</tr>
<tr class="info">
<td>1</td>
<td>1</td>
<td>61.7%</td>
<td>Yes</td>
</tr>
</tbody>
</table>
</div>
<p>
<h5>Table 2. Principales indicadores del modelo de detección precoz de SM en el estudio de prueba diagnóstica.</h5>
<div class="table-responsive">
<table class="table table-striped table-bordered table-hover">
<tbody>
<tr class="info">
<th>Indicador</th>
<th>Valor IC (95%)</th>
<th></th>
</tr>
<tr>
<td>Prevalencia</td>
<td>15.1%</td>
<td>(12.2-18.2)</td>
</tr>
<tr>
<td>Sensitividad</td>
<td>91.6%</td>
<td>(93.8-97.7)</td>
</tr>
<tr>
<td>Especificidad</td>
<td>95.7%</td>
<td>(93.2-97)</td>
</tr>
<tr>
<td>VP+</td>
<td>79.2%</td>
<td>(70.5-87.8)</td>
</tr>
<tr>
<td>VP-</td>
<td>98.5%</td>
<td>(97.2-99.7)</td>
</tr>
<tr>
<td>RV+</td>
<td>21.4</td>
<td>(13.9-33)</td>
</tr>
<tr>
<td>RV-</td>
<td>0.09</td>
<td>(0.04-0.18)</td>
</tr>
<tr>
<td>Índice de validez</td>
<td>92.4%</td>
<td>(89.9-98.5)</td>
</tr>
<tr>
<td>Índice Youden</td>
<td>0.87</td>
<td>(0.8-0.94)</td>
</tr>
<tr>
<td>Índice Kappa</td>
<td>0.82</td>
<td>(0.75-0.88)</td>
</tr>
</tbody>
</table>
</div>
<hr>
<a href="index.html"><i class="glyphicon glyphicon-share"></i></a> Volver al Test
</div> <!-- Español -->
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