diff --git a/README.md b/README.md
index ce2ab7c..2c370d9 100644
--- a/README.md
+++ b/README.md
@@ -77,7 +77,6 @@ We recommend to install it locally since Binder needs to be refreshed every time
 ```bash
 conda create -n DeepPurpose python=3.6
 conda activate DeepPurpose
-conda install -c conda-forge rdkit
 conda install -c conda-forge notebook
 pip install git+https://github.com/bp-kelley/descriptastorus 
 pip install DeepPurpose
diff --git a/requirements.txt b/requirements.txt
index 33fcdc4..48afd2e 100644
--- a/requirements.txt
+++ b/requirements.txt
@@ -1,3 +1,4 @@
+rdkit-pypi
 numpy
 pandas
 tqdm