# FL genes
## Origins of FL genes
![sankey](FL_sankey-1.svg)
## Tier 1 FL genes
|Category|Gene|FL Mutation frequency|gene|protein|
| :---: | :----: | :---: | :---: | :---: |
|1-a|[ACTB](ACTB)|5.31|[view](images/proteinpaint/ACTB.svg)|[view](images/proteinpaint/ACTB_NM_001101.svg)|
|1|[ARID1A](ARID1A)|12.47|[view](images/proteinpaint/ARID1A.svg)|[view](images/proteinpaint/ARID1A_NM_006015.svg)|
|1|[ATP6AP1](ATP6AP1)|4.85|[view](images/proteinpaint/ATP6AP1.svg)|[view](images/proteinpaint/ATP6AP1_NM_001183.svg)|
|1|[ATP6V1B2](ATP6V1B2)|7.39|[view](images/proteinpaint/ATP6V1B2.svg)|[view](images/proteinpaint/ATP6V1B2_NM_001693.svg)|
|1|[B2M](B2M)|8.55|[view](images/proteinpaint/B2M.svg)|[view](images/proteinpaint/B2M_NM_004048.svg)|
|1-a|[BCL2](BCL2)|50.35|[view](images/proteinpaint/BCL2.svg)|[view](images/proteinpaint/BCL2_NM_000633.svg)|
|1-a|[BCL6](BCL6)|5.77|[view](images/proteinpaint/BCL6.svg)|[view](images/proteinpaint/BCL6_NM_001706.svg)|
|1-a|[BCL7A](BCL7A)|13.86|[view](images/proteinpaint/BCL7A.svg)|[view](images/proteinpaint/BCL7A_NM_020993.svg)|
|1|[BIRC6](BIRC6)|3.70|[view](images/proteinpaint/BIRC6.svg)|[view](images/proteinpaint/BIRC6_NM_016252.svg)|
|1-a|[BTG1](BTG1)|6.47|[view](images/proteinpaint/BTG1.svg)|[view](images/proteinpaint/BTG1_NM_001731.svg)|
|1-a|[BTG2](BTG2)|4.39|[view](images/proteinpaint/BTG2.svg)|[view](images/proteinpaint/BTG2_NM_006763.svg)|
|1|[BTK](BTK)|6.93|[view](images/proteinpaint/BTK.svg)|[view](images/proteinpaint/BTK_NM_000061.svg)|
|1|[CARD11](CARD11)|14.78|[view](images/proteinpaint/CARD11.svg)|[view](images/proteinpaint/CARD11_NM_032415.svg)|
|1|[CCND3](CCND3)|3.23|[view](images/proteinpaint/CCND3.svg)|[view](images/proteinpaint/CCND3_NM_001760.svg)|
|1-a|[CD83](CD83)|1.85|[view](images/proteinpaint/CD83.svg)|[view](images/proteinpaint/CD83_NM_004233.svg)|
|1|[CREBBP](CREBBP)|65.13|[view](images/proteinpaint/CREBBP.svg)|[view](images/proteinpaint/CREBBP_NM_004380.svg)|
|1|[CTSS](CTSS)|3.93|[view](images/proteinpaint/CTSS.svg)|[view](images/proteinpaint/CTSS_NM_004079.svg)|
|1-a|[DTX1](DTX1)|5.54|[view](images/proteinpaint/DTX1.svg)|[view](images/proteinpaint/DTX1_NM_004416.svg)|
|1-a|[EBF1](EBF1)|8.55|[view](images/proteinpaint/EBF1.svg)|[view](images/proteinpaint/EBF1_NM_024007.svg)|
|1|[EP300](EP300)|12.47|[view](images/proteinpaint/EP300.svg)|[view](images/proteinpaint/EP300_NM_001429.svg)|
|1|[EZH2](EZH2)|24.94|[view](images/proteinpaint/EZH2.svg)|[view](images/proteinpaint/EZH2_NM_001203247.svg)|
|1|[FAS](FAS)|5.08|[view](images/proteinpaint/FAS.svg)|[view](images/proteinpaint/FAS_NM_000043.svg)|
|1|[FOXO1](FOXO1)|12.93|[view](images/proteinpaint/FOXO1.svg)|[view](images/proteinpaint/FOXO1_NM_002015.svg)|
|1|[GNA13](GNA13)|10.16|[view](images/proteinpaint/GNA13.svg)|[view](images/proteinpaint/GNA13_NM_006572.svg)|
|1|[GNAI2](GNAI2)|4.16|[view](images/proteinpaint/GNAI2.svg)|[view](images/proteinpaint/GNAI2_NM_002070.svg)|
|1|[HIST1H1B](HIST1H1B)(H1-5)|5.54|[view](images/proteinpaint/HIST1H1B.svg)|[view](images/proteinpaint/HIST1H1B_NM_005322.svg)|
|1|[HIST1H1C](HIST1H1C)(H1-2)|5.08|[view](images/proteinpaint/HIST1H1C.svg)|[view](images/proteinpaint/HIST1H1C_NM_005319.svg)|
|1|[HIST1H1D](HIST1H1D)(H1-3)|3.23|[view](images/proteinpaint/HIST1H1D.svg)|[view](images/proteinpaint/HIST1H1D_NM_005320.svg)|
|1|[HIST1H1E](HIST1H1E)(H1-4)|12.93|[view](images/proteinpaint/HIST1H1E.svg)|[view](images/proteinpaint/HIST1H1E_NM_005321.svg)|
|1|[HIST1H2AC](HIST1H2AC)(H2AC6)|2.31|[view](images/proteinpaint/HIST1H2AC.svg)|[view](images/proteinpaint/H2AC6_NM_003512.svg)|
|1|[HIST1H2AG](HIST1H2AG)(H2AC11)|2.08|[view](images/proteinpaint/HIST1H2AG.svg)|[view](images/proteinpaint/HIST1H2AG_NM_021064.svg)|
|1|[HIST1H2AM](HIST1H2AM)(H2AC17)|3.70|[view](images/proteinpaint/HIST1H2AM.svg)|[view](images/proteinpaint/HIST1H2AM_NM_003514.svg)|
|1|[HIST1H2BC](HIST1H2BC)(H2BC4)|3.46|[view](images/proteinpaint/HIST1H2BC.svg)|[LOAD](https://morinlab.github.io/LLMPP/GAMBL/HIST1H2BC_protein.html)|
|1|[HIST1H2BD](HIST1H2BD)(H2BC5)|1.15|[view](images/proteinpaint/HIST1H2BD.svg)|[LOAD](https://morinlab.github.io/LLMPP/GAMBL/HIST1H2BD_protein.html)|
|1|[HIST1H2BG](HIST1H2BG)(H2BC8)|2.08|[view](images/proteinpaint/HIST1H2BG.svg)|[LOAD](https://morinlab.github.io/LLMPP/GAMBL/HIST1H2BG_protein.html)|
|1|[HIST1H3B](HIST1H3B)(H3C2)|1.62|[view](images/proteinpaint/HIST1H3B.svg)|[view](images/proteinpaint/H3C2_NM_003537.svg)|
|1|[HIST1H3G](HIST1H3G)(H3C8)|1.62|[view](images/proteinpaint/HIST1H3G.svg)|[view](images/proteinpaint/HIST1H3G_NM_003534.svg)|
|1|[HVCN1](HVCN1)|6.47|[view](images/proteinpaint/HVCN1.svg)|[view](images/proteinpaint/HVCN1_NM_001040107.svg)|
|1-a|[IRF4](IRF4)|1.15|[view](images/proteinpaint/IRF4.svg)|[view](images/proteinpaint/IRF4_NM_002460.svg)|
|1-a|[IRF8](IRF8)|12.01|[view](images/proteinpaint/IRF8.svg)|[view](images/proteinpaint/IRF8_NM_002163.svg)|
|1-a|[ITPKB](ITPKB)|3.23|[view](images/proteinpaint/ITPKB.svg)|[view](images/proteinpaint/ITPKB_NM_002221.svg)|
|1-a|[KLF2](KLF2)|2.31|[view](images/proteinpaint/KLF2.svg)|[view](images/proteinpaint/KLF2_NM_016270.svg)|
|1-a|[KLHL6](KLHL6)|7.16|[view](images/proteinpaint/KLHL6.svg)|[view](images/proteinpaint/KLHL6_NM_130446.svg)|
|1|[KMT2D](KMT2D)|67.67|[view](images/proteinpaint/KMT2D.svg)|[view](images/proteinpaint/KMT2D_NM_003482.svg)|
|1-a|[LTB](LTB)|8.78|[view](images/proteinpaint/LTB.svg)|[view](images/proteinpaint/LTB_NM_002341.svg)|
|1|[MAP2K1](MAP2K1)|1.39|[view](images/proteinpaint/MAP2K1.svg)|[view](images/proteinpaint/MAP2K1_NM_002755.svg)|
|1-a|[MEF2B](MEF2B)|12.93|[view](images/proteinpaint/MEF2B.svg)|[view](images/proteinpaint/MEF2B_NM_001145785.svg)|
|1-a|[MEF2C](MEF2C)|6.24|[view](images/proteinpaint/MEF2C.svg)|[view](images/proteinpaint/MEF2C_NM_002397.svg)|
|1|[PCLO](PCLO)|9.24|[view](images/proteinpaint/PCLO.svg)|[view](images/proteinpaint/PCLO_NM_033026.svg)|
|1-a|[PIM1](PIM1)|9.24|[view](images/proteinpaint/PIM1.svg)|[view](images/proteinpaint/PIM1_NM_002648.svg)|
|1-a|[POU2AF1](POU2AF1)|12.24|[view](images/proteinpaint/POU2AF1.svg)|[view](images/proteinpaint/POU2AF1_NM_006235.svg)|
|1|[POU2F2](POU2F2)|6.24|[view](images/proteinpaint/POU2F2.svg)|[view](images/proteinpaint/POU2F2_NM_002698.svg)|
|1|[PTPRD](PTPRD)|3.70|[view](images/proteinpaint/PTPRD.svg)|[view](images/proteinpaint/PTPRD_NM_002839.svg)|
|1|[RRAGC](RRAGC)|10.85|[view](images/proteinpaint/RRAGC.svg)|[view](images/proteinpaint/RRAGC_NM_022157.svg)|
|1-a|[S1PR2](S1PR2)|6.24|[view](images/proteinpaint/S1PR2.svg)|[view](images/proteinpaint/S1PR2_NM_004230.svg)|
|1-a|[SGK1](SGK1)|6.00|[view](images/proteinpaint/SGK1.svg)|[view](images/proteinpaint/SGK1_NM_005627.svg)|
|1|[SMARCA4](SMARCA4)|4.16|[view](images/proteinpaint/SMARCA4.svg)|[view](images/proteinpaint/SMARCA4_NM_001128849.svg)|
|1-a|[SOCS1](SOCS1)|9.70|[view](images/proteinpaint/SOCS1.svg)|[view](images/proteinpaint/SOCS1_NM_003745.svg)|
|1|[STAT6](STAT6)|15.94|[view](images/proteinpaint/STAT6.svg)|[view](images/proteinpaint/STAT6_NM_003153.svg)|
|1|[TBL1XR1](TBL1XR1)|3.93|[view](images/proteinpaint/TBL1XR1.svg)|[view](images/proteinpaint/TBL1XR1_NM_024665.svg)|
|1-a|[TMSB4X](TMSB4X)|4.39|[view](images/proteinpaint/TMSB4X.svg)|[view](images/proteinpaint/TMSB4X_NM_021109.svg)|
|1|[TNFAIP3](TNFAIP3)|4.85|[view](images/proteinpaint/TNFAIP3.svg)|[view](images/proteinpaint/TNFAIP3_NM_006290.svg)|
|1|[TNFRSF14](TNFRSF14)|40.42|[view](images/proteinpaint/TNFRSF14.svg)|[view](images/proteinpaint/TNFRSF14_NM_003820.svg)|
|1|[TP53](TP53)|6.93|[view](images/proteinpaint/TP53.svg)|[view](images/proteinpaint/TP53_NM_000546.svg)|
|1|[VMA21](VMA21)|5.08|[view](images/proteinpaint/VMA21.svg)|[view](images/proteinpaint/VMA21_NM_001017980.svg)|