diff --git a/pkg/util/fieldindex/register.go b/pkg/util/fieldindex/register.go
index 52bf7c9f84..ac292afb66 100644
--- a/pkg/util/fieldindex/register.go
+++ b/pkg/util/fieldindex/register.go
@@ -20,21 +20,24 @@ import (
 	"context"
 	"sync"
 
-	"sigs.k8s.io/controller-runtime/pkg/client"
-
 	appsv1alpha1 "github.com/openkruise/kruise/apis/apps/v1alpha1"
 	utildiscovery "github.com/openkruise/kruise/pkg/util/discovery"
+
 	batchv1 "k8s.io/api/batch/v1"
 	v1 "k8s.io/api/core/v1"
 	metav1 "k8s.io/apimachinery/pkg/apis/meta/v1"
 	"sigs.k8s.io/controller-runtime/pkg/cache"
+	"sigs.k8s.io/controller-runtime/pkg/client"
 )
 
 const (
-	IndexNameForPodNodeName = "spec.nodeName"
-	IndexNameForOwnerRefUID = "ownerRefUID"
-	IndexNameForController  = ".metadata.controller"
-	IndexNameForIsActive    = "isActive"
+	IndexNameForPodNodeName          = "spec.nodeName"
+	IndexNameForOwnerRefUID          = "ownerRefUID"
+	IndexNameForController           = ".metadata.controller"
+	IndexNameForIsActive             = "isActive"
+	IndexNameForSidecarSetNamespace  = "namespace"
+	IndexValueSidecarSetClusterScope = "ClusterScope"
+	LabelMetadataName                = "kubernetes.io/metadata.name"
 )
 
 var (
@@ -87,6 +90,12 @@ func RegisterFieldIndexes(c cache.Cache) error {
 				return
 			}
 		}
+		// sidecar spec namespaces
+		if utildiscovery.DiscoverObject(&appsv1alpha1.SidecarSet{}) {
+			if err = indexSideCarSet(c); err != nil {
+				return
+			}
+		}
 	})
 	return err
 }
@@ -152,3 +161,32 @@ func indexImagePullJobActive(c cache.Cache) error {
 		return []string{isActive}
 	})
 }
+
+func IndexSideCarSet(rawObj client.Object) []string {
+	obj := rawObj.(*appsv1alpha1.SidecarSet)
+	if obj == nil {
+		return nil
+	}
+	if obj.Spec.Namespace != "" {
+		return []string{obj.Spec.Namespace}
+	}
+	if obj.Spec.NamespaceSelector != nil {
+		if obj.Spec.NamespaceSelector.MatchLabels != nil {
+			if v, ok := obj.Spec.NamespaceSelector.MatchLabels[LabelMetadataName]; ok {
+				return []string{v}
+			}
+		}
+		for _, item := range obj.Spec.NamespaceSelector.MatchExpressions {
+			if item.Key == LabelMetadataName && item.Operator == metav1.LabelSelectorOpIn {
+				return item.Values
+			}
+		}
+	}
+	return []string{IndexValueSidecarSetClusterScope}
+}
+
+func indexSideCarSet(c cache.Cache) error {
+	return c.IndexField(context.TODO(), &appsv1alpha1.SidecarSet{}, IndexNameForSidecarSetNamespace, func(rawObj client.Object) []string {
+		return IndexSideCarSet(rawObj)
+	})
+}
diff --git a/pkg/webhook/pod/mutating/sidecarset.go b/pkg/webhook/pod/mutating/sidecarset.go
index 2d0a1a3dd0..0043577d84 100644
--- a/pkg/webhook/pod/mutating/sidecarset.go
+++ b/pkg/webhook/pod/mutating/sidecarset.go
@@ -23,6 +23,8 @@ import (
 	"sort"
 	"strings"
 
+	"github.com/openkruise/kruise/pkg/util/fieldindex"
+
 	appsv1alpha1 "github.com/openkruise/kruise/apis/apps/v1alpha1"
 	"github.com/openkruise/kruise/pkg/control/sidecarcontrol"
 	"github.com/openkruise/kruise/pkg/util"
@@ -35,6 +37,7 @@ import (
 	metav1 "k8s.io/apimachinery/pkg/apis/meta/v1"
 	"k8s.io/apimachinery/pkg/util/sets"
 	"k8s.io/klog/v2"
+	"sigs.k8s.io/controller-runtime/pkg/client"
 	"sigs.k8s.io/controller-runtime/pkg/webhook/admission"
 )
 
@@ -64,13 +67,21 @@ func (h *PodCreateHandler) sidecarsetMutatingPod(ctx context.Context, req admiss
 	}
 
 	// DisableDeepCopy:true, indicates must be deep copy before update sidecarSet objection
+
 	sidecarsetList := &appsv1alpha1.SidecarSetList{}
-	if err = h.Client.List(ctx, sidecarsetList, utilclient.DisableDeepCopy); err != nil {
+	sidecarsetList2 := &appsv1alpha1.SidecarSetList{}
+	podNamespace := pod.Namespace
+	if podNamespace == "" {
+		podNamespace = "default"
+	}
+	if err := h.Client.List(ctx, sidecarsetList, client.MatchingFields{fieldindex.IndexNameForSidecarSetNamespace: podNamespace}, utilclient.DisableDeepCopy); err != nil {
+		return false, err
+	}
+	if err := h.Client.List(ctx, sidecarsetList2, client.MatchingFields{fieldindex.IndexNameForSidecarSetNamespace: fieldindex.IndexValueSidecarSetClusterScope}, utilclient.DisableDeepCopy); err != nil {
 		return false, err
 	}
-
 	matchedSidecarSets := make([]sidecarcontrol.SidecarControl, 0)
-	for _, sidecarSet := range sidecarsetList.Items {
+	for _, sidecarSet := range append(sidecarsetList.Items, sidecarsetList2.Items...) {
 		if sidecarSet.Spec.InjectionStrategy.Paused {
 			continue
 		}
diff --git a/pkg/webhook/pod/mutating/sidecarset_test.go b/pkg/webhook/pod/mutating/sidecarset_test.go
index 0326f40112..4a7b3ae2d8 100644
--- a/pkg/webhook/pod/mutating/sidecarset_test.go
+++ b/pkg/webhook/pod/mutating/sidecarset_test.go
@@ -24,6 +24,8 @@ import (
 	"path/filepath"
 	"testing"
 
+	"github.com/openkruise/kruise/pkg/util/fieldindex"
+
 	utilruntime "k8s.io/apimachinery/pkg/util/runtime"
 
 	"github.com/openkruise/kruise/apis"
@@ -525,7 +527,10 @@ func TestInjectMetadata(t *testing.T) {
 		},
 	}
 	decoder, _ := admission.NewDecoder(scheme.Scheme)
-	client := fake.NewClientBuilder().WithObjects(demo1, demo2).Build()
+	client := fake.NewClientBuilder().WithObjects(demo1, demo2).WithIndex(
+		&appsv1alpha1.SidecarSet{}, fieldindex.IndexNameForSidecarSetNamespace, fieldindex.IndexSideCarSet,
+	).Build()
+
 	podHandler := &PodCreateHandler{Decoder: decoder, Client: client}
 	req := newAdmission(admissionv1.Create, runtime.RawExtension{}, runtime.RawExtension{}, "")
 	podHandler.sidecarsetMutatingPod(context.Background(), req, podIn)