diff --git a/debug/src/debug.js b/debug/src/debug.js
index 749288053d..58a6e40ef0 100644
--- a/debug/src/debug.js
+++ b/debug/src/debug.js
@@ -357,6 +357,27 @@ export function initDebug() {
 				keys.push(key);
 			}
 		}
+
+		if (vnode._component != null && vnode._component.__hooks != null) {
+			// Validate that none of the hooks in this component contain arguments that are NaN.
+			// This is a common mistake that can be hard to debug, so we want to catch it early.
+			const hooks = vnode._component.__hooks._list;
+			if (hooks) {
+				for (let i = 0; i < hooks.length; i += 1) {
+					const hook = hooks[i];
+					if (hook._args) {
+						for (const arg of hook._args) {
+							if (Number.isNaN(arg)) {
+								const componentName = getDisplayName(vnode);
+								throw new Error(
+									`Invalid argument passed to hook. Hooks should not be called with NaN in the dependency array. Hook index ${i} in component ${componentName} was called with NaN.`
+								);
+							}
+						}
+					}
+				}
+			}
+		}
 	};
 }
 
diff --git a/debug/test/browser/validateHookArgs.test.js b/debug/test/browser/validateHookArgs.test.js
new file mode 100644
index 0000000000..19f7cb7fd3
--- /dev/null
+++ b/debug/test/browser/validateHookArgs.test.js
@@ -0,0 +1,74 @@
+import { createElement, render, createRef } from 'preact';
+import {
+	useState,
+	useEffect,
+	useLayoutEffect,
+	useCallback,
+	useMemo,
+	useImperativeHandle
+} from 'preact/hooks';
+import { setupRerender } from 'preact/test-utils';
+import { setupScratch, teardown } from '../../../test/_util/helpers';
+import 'preact/debug';
+
+/** @jsx createElement */
+
+describe('Hook argument validation', () => {
+	/**
+	 * @param {string} name
+	 * @param {(arg: number) => void} hook
+	 */
+	function validateHook(name, hook) {
+		const TestComponent = ({ initialValue }) => {
+			const [value, setValue] = useState(initialValue);
+			hook(value);
+
+			return (
+				<button type="button" onClick={() => setValue(NaN)}>
+					Set to NaN
+				</button>
+			);
+		};
+
+		it(`should error if ${name} is mounted with NaN as an argument`, async () => {
+			expect(() =>
+				render(<TestComponent initialValue={NaN} />, scratch)
+			).to.throw(/Hooks should not be called with NaN in the dependency array/);
+		});
+
+		it(`should error if ${name} is updated with NaN as an argument`, async () => {
+			render(<TestComponent initialValue={0} />, scratch);
+
+			expect(() => {
+				scratch.querySelector('button').click();
+				rerender();
+			}).to.throw(
+				/Hooks should not be called with NaN in the dependency array/
+			);
+		});
+	}
+
+	/** @type {HTMLElement} */
+	let scratch;
+	/** @type {() => void} */
+	let rerender;
+
+	beforeEach(() => {
+		scratch = setupScratch();
+		rerender = setupRerender();
+	});
+
+	afterEach(() => {
+		teardown(scratch);
+	});
+
+	validateHook('useEffect', arg => useEffect(() => {}, [arg]));
+	validateHook('useLayoutEffect', arg => useLayoutEffect(() => {}, [arg]));
+	validateHook('useCallback', arg => useCallback(() => {}, [arg]));
+	validateHook('useMemo', arg => useMemo(() => {}, [arg]));
+
+	const ref = createRef();
+	validateHook('useImperativeHandle', arg => {
+		useImperativeHandle(ref, () => undefined, [arg]);
+	});
+});