diff --git a/qiskit_experiments/framework/base_experiment.py b/qiskit_experiments/framework/base_experiment.py
index bb14cdc610..024911a0e4 100644
--- a/qiskit_experiments/framework/base_experiment.py
+++ b/qiskit_experiments/framework/base_experiment.py
@@ -85,6 +85,9 @@ def __init__(
         if isinstance(backend, Backend):
             self._set_backend(backend)
 
+        # Optional user-defined custom transpiled circuits
+        self._custom_transpiled_circuits = None
+
     @property
     def experiment_type(self) -> str:
         """Return experiment type."""
@@ -133,6 +136,26 @@ def _set_backend(self, backend: Backend):
         self._backend = backend
         self._backend_data = BackendData(backend)
 
+    @property
+    def custom_transpiled_circuits(self):
+        """Custom transpiled circuits as defined by the user. The user is responsible for providing
+        the circuit metadata expected by experiment analysis."""
+        return self._custom_transpiled_circuits
+
+    @custom_transpiled_circuits.setter
+    def custom_transpiled_circuits(self, circuits: List[QuantumCircuit]):
+        """Set custom transpiled circuits."""
+        if not isinstance(circuits, List) and all(isinstance(i, QuantumCircuit) for i in circuits):
+            raise TypeError("Custom transpiled circuits must be a list of QuantumCircuit objects.")
+        self._set_custom_transpiled_circuits(circuits)
+
+    def _set_custom_transpiled_circuits(self, circuits: List[QuantumCircuit]):
+        """Set custom transpiled circuits.
+
+        Subclasses can override this method to add circuit verification or modify
+        the user-provided circuit and/or its metadata."""
+        self._custom_transpiled_circuits = circuits
+
     def copy(self) -> "BaseExperiment":
         """Return a copy of the experiment"""
         # We want to avoid a deep copy be default for performance so we
@@ -233,8 +256,11 @@ def run(
         # Finalize experiment before executions
         experiment._finalize()
 
-        # Generate and transpile circuits
-        transpiled_circuits = experiment._transpiled_circuits()
+        if self.custom_transpiled_circuits:
+            transpiled_circuits = self.custom_transpiled_circuits
+        else:
+            # Generate and transpile circuits
+            transpiled_circuits = experiment._transpiled_circuits()
 
         # Initialize result container
         experiment_data = experiment._initialize_experiment_data()
diff --git a/test/framework/test_framework.py b/test/framework/test_framework.py
index 265630371e..07f6a28f19 100644
--- a/test/framework/test_framework.py
+++ b/test/framework/test_framework.py
@@ -15,6 +15,7 @@
 from test.fake_experiment import FakeExperiment, FakeAnalysis
 from test.base import QiskitExperimentsTestCase
 from itertools import product
+import unittest
 import ddt
 
 from qiskit import QuantumCircuit
@@ -116,6 +117,16 @@ def circuits(self):
                 num_jobs += 1
         self.assertEqual(len(job_ids), num_jobs)
 
+    def test_custom_transpiled_circuits(self):
+        """Test that custom transpiled circuits can be injected."""
+        exp = FakeExperiment((0,))
+        backend = FakeBackend()
+        exp._transpiled_circuits = unittest.mock.Mock()
+        exp.custom_transpiled_circuits = [QuantumCircuit(0)]
+        expdata = exp.run(backend)
+        self.assertExperimentDone(expdata)
+        exp._transpiled_circuits.assert_not_called()
+
     def test_analysis_replace_results_true(self):
         """Test running analysis with replace_results=True"""
         analysis = FakeAnalysis()