diff --git a/output/multidisciplinary.json b/output/multidisciplinary.json index 1d8c7f2..a632a0d 100644 --- a/output/multidisciplinary.json +++ b/output/multidisciplinary.json @@ -198,31 +198,31 @@ "filter": 1 }, { - "title": "One-quarter of unresponsive people with brain injuries are conscious", - "authors": "Julian Nowogrodzki", - "url": "http://dx.doi.org/10.1038/d41586-024-02614-z", - "doi": "10.1038/d41586-024-02614-z", + "title": "Field observations of Ambula tardus on Planet IN-409", + "authors": "Rebecca Roland", + "url": "http://dx.doi.org/10.1038/d41586-024-02459-6", + "doi": "10.1038/d41586-024-02459-6", "filter": 1 }, { - "title": "Weather and climate predicted accurately — without using a supercomputer", - "authors": "Oliver Watt-Meyer", - "url": "http://dx.doi.org/10.1038/d41586-024-02558-4", - "doi": "10.1038/d41586-024-02558-4", + "title": "Daily briefing: Deepfakes hawk fake drugs using scientists’ faces", + "authors": "Flora Graham", + "url": "http://dx.doi.org/10.1038/d41586-024-02645-6", + "doi": "10.1038/d41586-024-02645-6", "filter": 1 }, { - "title": "Geology’s biggest mystery: when did plate tectonics start to reshape Earth?", - "authors": "Michael Marshall", - "url": "http://dx.doi.org/10.1038/d41586-024-02602-3", - "doi": "10.1038/d41586-024-02602-3", + "title": "Dismantle ‘zombie’ wildlife protection conventions once their work is done", + "authors": "Peter Bridgewater, Rakhyun E. Kim, Robert Blasiak, Nikolas Sellheim", + "url": "http://dx.doi.org/10.1038/d41586-024-02604-1", + "doi": "10.1038/d41586-024-02604-1", "filter": 1 }, { - "title": "Has your paper been used to train an AI model? Almost certainly", - "authors": "Elizabeth Gibney", - "url": "http://dx.doi.org/10.1038/d41586-024-02599-9", - "doi": "10.1038/d41586-024-02599-9", + "title": "Are the Cosmic Gems the earliest star clusters ever detected?", + "authors": "Lamiya Mowla", + "url": "http://dx.doi.org/10.1038/d41586-024-02438-x", + "doi": "10.1038/d41586-024-02438-x", "filter": 1 }, { @@ -233,24 +233,24 @@ "filter": 1 }, { - "title": "How a trove of cancer genomes could improve kids’ leukaemia treatment", - "authors": "Giorgia Guglielmi", - "url": "http://dx.doi.org/10.1038/d41586-024-02613-0", - "doi": "10.1038/d41586-024-02613-0", + "title": "Has your paper been used to train an AI model? Almost certainly", + "authors": "Elizabeth Gibney", + "url": "http://dx.doi.org/10.1038/d41586-024-02599-9", + "doi": "10.1038/d41586-024-02599-9", "filter": 1 }, { - "title": "Dismantle ‘zombie’ wildlife protection conventions once their work is done", - "authors": "Peter Bridgewater, Rakhyun E. Kim, Robert Blasiak, Nikolas Sellheim", - "url": "http://dx.doi.org/10.1038/d41586-024-02604-1", - "doi": "10.1038/d41586-024-02604-1", + "title": "Geology’s biggest mystery: when did plate tectonics start to reshape Earth?", + "authors": "Michael Marshall", + "url": "http://dx.doi.org/10.1038/d41586-024-02602-3", + "doi": "10.1038/d41586-024-02602-3", "filter": 1 }, { - "title": "Are the Cosmic Gems the earliest star clusters ever detected?", - "authors": "Lamiya Mowla", - "url": "http://dx.doi.org/10.1038/d41586-024-02438-x", - "doi": "10.1038/d41586-024-02438-x", + "title": "How a trove of cancer genomes could improve kids’ leukaemia treatment", + "authors": "Giorgia Guglielmi", + "url": "http://dx.doi.org/10.1038/d41586-024-02613-0", + "doi": "10.1038/d41586-024-02613-0", "filter": 1 }, { @@ -260,17 +260,17 @@ "filter": 1 }, { - "title": "Field observations of Ambula tardus on Planet IN-409", - "authors": "Rebecca Roland", - "url": "http://dx.doi.org/10.1038/d41586-024-02459-6", - "doi": "10.1038/d41586-024-02459-6", + "title": "Weather and climate predicted accurately — without using a supercomputer", + "authors": "Oliver Watt-Meyer", + "url": "http://dx.doi.org/10.1038/d41586-024-02558-4", + "doi": "10.1038/d41586-024-02558-4", "filter": 1 }, { - "title": "Daily briefing: Deepfakes hawk fake drugs using scientists’ faces", - "authors": "Flora Graham", - "url": "http://dx.doi.org/10.1038/d41586-024-02645-6", - "doi": "10.1038/d41586-024-02645-6", + "title": "One-quarter of unresponsive people with brain injuries are conscious", + "authors": "Julian Nowogrodzki", + "url": "http://dx.doi.org/10.1038/d41586-024-02614-z", + "doi": "10.1038/d41586-024-02614-z", "filter": 1 }, { @@ -322,10 +322,17 @@ "filter": 1 }, { - "title": "Five ways science is tackling the antibiotic resistance crisis", - "authors": "Amber Dance", - "url": "http://dx.doi.org/10.1038/d41586-024-02601-4", - "doi": "10.1038/d41586-024-02601-4", + "title": "Famine exposure in the womb doubles diabetes risk decades later", + "authors": "Gemma Conroy", + "url": "http://dx.doi.org/10.1038/d41586-024-02563-7", + "doi": "10.1038/d41586-024-02563-7", + "filter": 1 + }, + { + "title": "How the human brain creates cognitive maps of related concepts", + "authors": "Mitchell Ostrow, Ila Fiete", + "url": "http://dx.doi.org/10.1038/d41586-024-02433-2", + "doi": "10.1038/d41586-024-02433-2", "filter": 1 }, { @@ -342,17 +349,10 @@ "filter": 1 }, { - "title": "Famine exposure in the womb doubles diabetes risk decades later", - "authors": "Gemma Conroy", - "url": "http://dx.doi.org/10.1038/d41586-024-02563-7", - "doi": "10.1038/d41586-024-02563-7", - "filter": 1 - }, - { - "title": "How the human brain creates cognitive maps of related concepts", - "authors": "Mitchell Ostrow, Ila Fiete", - "url": "http://dx.doi.org/10.1038/d41586-024-02433-2", - "doi": "10.1038/d41586-024-02433-2", + "title": "Five ways science is tackling the antibiotic resistance crisis", + "authors": "Amber Dance", + "url": "http://dx.doi.org/10.1038/d41586-024-02601-4", + "doi": "10.1038/d41586-024-02601-4", "filter": 1 }, { @@ -486,10 +486,10 @@ "filter": 2 }, { - "title": "Structure of a fully assembled γδ T-cell antigen receptor", - "authors": "Benjamin S. Gully, João Ferreira Fernandes, Sachith D. Gunasinghe, Mai T. Vuong, Yuan Lui, Michael T. Rice, Liam Rashleigh, Chan-sien Lay, Dene R. Littler, Sumana Sharma, Ana Mafalda Santos, Hariprasad Venugopal, Jamie Rossjohn, Simon J. Davis", - "url": "http://dx.doi.org/10.1038/s41586-024-07920-0", - "doi": "10.1038/s41586-024-07920-0", + "title": "Author Correction: Amazon forest biogeography predicts resilience and vulnerability to drought", + "authors": "Shuli Chen, Scott C. Stark, Antonio Donato Nobre, Luz Adriana Cuartas, Diogo de Jesus Amore, Natalia Restrepo-Coupe, Marielle N. Smith, Rutuja Chitra-Tarak, Hongseok Ko, Bruce W. Nelson, Scott R. Saleska", + "url": "http://dx.doi.org/10.1038/s41586-024-07896-x", + "doi": "10.1038/s41586-024-07896-x", "filter": 2 }, { @@ -500,6 +500,13 @@ "doi": "10.1038/s41586-024-07652-1", "filter": 2 }, + { + "title": "Human organoids with an autologous tissue-resident immune compartment", + "authors": "Timothy Recaldin, Linda Steinacher, Bruno Gjeta, Marius F. Harter, Lukas Adam, Kristina Kromer, Marisa Pimentel Mendes, Marina Bellavista, Mikhail Nikolaev, Giacomo Lazzaroni, Rok Krese, Umut Kilik, Doris Popovic, Bilgenaz Stoll, Régine Gerard, Michael Bscheider, Marc Bickle, Lauriane Cabon, J. Gray Camp, Nikolche Gjorevski", + "url": "http://dx.doi.org/10.1038/s41586-024-07791-5", + "doi": "10.1038/s41586-024-07791-5", + "filter": 2 + }, { "title": "Twist-assisted all-antiferromagnetic tunnel junction in the atomic limit", "authors": "Yuliang Chen, Kartik Samanta, Naafis A. Shahed, Haojie Zhang, Chi Fang, Arthur Ernst, Evgeny Y. Tsymbal, Stuart S. P. Parkin", @@ -517,17 +524,10 @@ "filter": 2 }, { - "title": "Author Correction: Amazon forest biogeography predicts resilience and vulnerability to drought", - "authors": "Shuli Chen, Scott C. Stark, Antonio Donato Nobre, Luz Adriana Cuartas, Diogo de Jesus Amore, Natalia Restrepo-Coupe, Marielle N. Smith, Rutuja Chitra-Tarak, Hongseok Ko, Bruce W. Nelson, Scott R. Saleska", - "url": "http://dx.doi.org/10.1038/s41586-024-07896-x", - "doi": "10.1038/s41586-024-07896-x", - "filter": 2 - }, - { - "title": "Human organoids with an autologous tissue-resident immune compartment", - "authors": "Timothy Recaldin, Linda Steinacher, Bruno Gjeta, Marius F. Harter, Lukas Adam, Kristina Kromer, Marisa Pimentel Mendes, Marina Bellavista, Mikhail Nikolaev, Giacomo Lazzaroni, Rok Krese, Umut Kilik, Doris Popovic, Bilgenaz Stoll, Régine Gerard, Michael Bscheider, Marc Bickle, Lauriane Cabon, J. Gray Camp, Nikolche Gjorevski", - "url": "http://dx.doi.org/10.1038/s41586-024-07791-5", - "doi": "10.1038/s41586-024-07791-5", + "title": "Structure of a fully assembled γδ T-cell antigen receptor", + "authors": "Benjamin S. Gully, João Ferreira Fernandes, Sachith D. Gunasinghe, Mai T. Vuong, Yuan Lui, Michael T. Rice, Liam Rashleigh, Chan-sien Lay, Dene R. Littler, Sumana Sharma, Ana Mafalda Santos, Hariprasad Venugopal, Jamie Rossjohn, Simon J. Davis", + "url": "http://dx.doi.org/10.1038/s41586-024-07920-0", + "doi": "10.1038/s41586-024-07920-0", "filter": 2 }, { @@ -1007,16 +1007,34 @@ "filter": 2 }, { - "title": "Reply to Huysseune and Witten: Oral tooth bud formation in zebrafish", - "authors": "William R. Jackman, Lyn S. Miranda Portillo, Carol K. Cox, Alison Ambrosio, Yann Gibert", - "url": "http://dx.doi.org/10.1073/pnas.2413644121", - "doi": "10.1073/pnas.2413644121", + "title": "Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2", + "authors": "Wenlin Ren, Chonglei Fu, Yu Zhang, Xiaohui Ju, Xi Jiang, Jingwei Song, Mingli Gong, Zhuoyang Li, Wenchun Fan, Jun Yao, Qiang Ding", + "abstract": "The ZIKA virus (ZIKV) evades the host immune response by degrading STAT2 through its NS5 protein, thereby inhibiting type I interferon (IFN)-mediated antiviral immunity. However, the molecular mechanism underlying this process has remained elusive. In this study, we performed a genome-wide CRISPR/Cas9 screen, revealing that ZSWIM8 as the substrate receptor of Cullin3-RING E3 ligase is required for NS5-mediated STAT2 degradation. Genetic depletion of ZSWIM8 and CUL3 substantially impeded NS5-mediated STAT2 degradation. Biochemical analysis illuminated that NS5 enhances the interaction between STAT2 and the ZSWIM8–CUL3 E3 ligase complex, thereby facilitating STAT2 ubiquitination. Moreover, ZSWIM8 knockout endowed A549 and Huh7 cells with partial resistance to ZIKV infection and protected cells from the cytopathic effects induced by ZIKV, which was attributed to the restoration of STAT2 levels and the activation of IFN signaling. Subsequent studies in a physiologically relevant model, utilizing human neural progenitor cells, demonstrated that ZSWIM8 depletion reduced ZIKV infection, resulting from enhanced IFN signaling attributed to the sustained levels of STAT2. Our findings shed light on the role of ZIKV NS5, serving as the scaffold protein, reprograms the ZSWIM8–CUL3 E3 ligase complex to orchestrate STAT2 proteasome-dependent degradation, thereby facilitating evasion of IFN antiviral signaling. Our study provides unique insights into ZIKV–host interactions and holds promise for the development of antivirals and prophylactic vaccines.", + "url": "http://dx.doi.org/10.1073/pnas.2403235121", + "doi": "10.1073/pnas.2403235121", "filter": 2 }, { - "title": "Correction for Mehta et al., Neural auditory contrast enhancement in humans", - "url": "http://dx.doi.org/10.1073/pnas.2414866121", - "doi": "10.1073/pnas.2414866121", + "title": "QnAs with Susan T. Lovett", + "authors": "Sarah C. P. Williams", + "url": "http://dx.doi.org/10.1073/pnas.2413366121", + "doi": "10.1073/pnas.2413366121", + "filter": 2 + }, + { + "title": "Lipidomic scanning of self-lipids identifies headless antigens for natural killer T cells", + "authors": "Tan-Yun Cheng, T. Praveena, Srinath Govindarajan, Catarina F. Almeida, Daniel G. Pellicci, Wellington C. Arkins, Ildiko Van Rhijn, Koen Venken, Dirk Elewaut, Dale I. Godfrey, Jamie Rossjohn, D. Branch Moody", + "abstract": "To broadly measure the spectrum of cellular self-antigens for natural killer T cells (NKT), we developed a sensitive lipidomics system to analyze lipids trapped between CD1d and NKT T cell receptors (TCRs). We captured diverse antigen complexes formed in cells from natural endogenous lipids, with or without inducing endoplasmic reticulum (ER) stress. After separating protein complexes with no, low, or high CD1d–TCR interaction, we eluted lipids to establish the spectrum of self-lipids that facilitate this interaction. Although this unbiased approach identified fifteen molecules, they clustered into only two related groups: previously known phospholipid antigens and unexpected neutral lipid antigens. Mass spectrometry studies identified the neutral lipids as ceramides, deoxyceramides, and diacylglycerols, which can be considered headless lipids because they lack polar headgroups that usually form the TCR epitope. The crystal structure of the TCR–ceramide–CD1d complex showed how the missing headgroup allowed the TCR to predominantly contact CD1d, supporting a model of CD1d autoreactivity. Ceramide and related headless antigens mediated physiological TCR binding affinity, weak NKT cell responses, and tetramer binding to polyclonal human and mouse NKT cells. Ceramide and sphingomyelin are oppositely regulated components of the “sphingomyelin cycle” that are altered during apoptosis, transformation, and ER stress. Thus, the unique molecular link of ceramide to NKT cell response, along with the recent identification of sphingomyelin blockers of NKT cell activation, provide two mutually reinforcing links for NKT cell response to sterile cellular stress conditions.", + "url": "http://dx.doi.org/10.1073/pnas.2321686121", + "doi": "10.1073/pnas.2321686121", + "filter": 2 + }, + { + "title": "The deflection of fatigued neck", + "authors": "Yu Zhou, Curran Reddy, Xudong Zhang", + "abstract": "The human neck is a unique mechanical structure, highly flexible but fatigue prone. The rising prevalence of neck pain and chronic injuries has been attributed to increasing exposure to fatigue loading in activities such as prolonged sedentary work and overuse of electronic devices. However, a causal relationship between fatigue and musculoskeletal mechanical changes remains elusive. This work aimed to establish this relationship through a unique experiment design, inspired by a cantilever beam mechanical model of the neck, and an orchestrated deployment of advanced motion-force measurement technologies including dynamic stereo-radiographic imaging. As a group of 24 subjects performed sustained-till-exhaustion neck exertions in varied positions—neutral, extended, and flexed, their cervical spine musculoskeletal responses were measured. Data verified the occurrence of fatigue and revealed fatigue-induced neck deflection which increased cervical lordosis or kyphosis by 4–5° to 11°, depending on the neck position. This finding and its interpretations render a renewed understanding of muscle fatigue from a more unified motor control perspective as well as profound implications on neck pain and injury prevention.", + "url": "http://dx.doi.org/10.1073/pnas.2401874121", + "doi": "10.1073/pnas.2401874121", "filter": 2 }, { @@ -1034,14 +1052,6 @@ "doi": "10.1073/pnas.2315006121", "filter": 2 }, - { - "title": "The deflection of fatigued neck", - "authors": "Yu Zhou, Curran Reddy, Xudong Zhang", - "abstract": "The human neck is a unique mechanical structure, highly flexible but fatigue prone. The rising prevalence of neck pain and chronic injuries has been attributed to increasing exposure to fatigue loading in activities such as prolonged sedentary work and overuse of electronic devices. However, a causal relationship between fatigue and musculoskeletal mechanical changes remains elusive. This work aimed to establish this relationship through a unique experiment design, inspired by a cantilever beam mechanical model of the neck, and an orchestrated deployment of advanced motion-force measurement technologies including dynamic stereo-radiographic imaging. As a group of 24 subjects performed sustained-till-exhaustion neck exertions in varied positions—neutral, extended, and flexed, their cervical spine musculoskeletal responses were measured. Data verified the occurrence of fatigue and revealed fatigue-induced neck deflection which increased cervical lordosis or kyphosis by 4–5° to 11°, depending on the neck position. This finding and its interpretations render a renewed understanding of muscle fatigue from a more unified motor control perspective as well as profound implications on neck pain and injury prevention.", - "url": "http://dx.doi.org/10.1073/pnas.2401874121", - "doi": "10.1073/pnas.2401874121", - "filter": 2 - }, { "title": "Diana Wall: A Champion for lives underfoot", "authors": "John C. Moore, David C. Coleman, Camille T. Dungy, Tony Frank, Kathleen A. Galvin, Peter C. de Ruiter, Diane M. McKnight, Johan Six, Wim H. van der Putten", @@ -1066,26 +1076,16 @@ "filter": 2 }, { - "title": "QnAs with Susan T. Lovett", - "authors": "Sarah C. P. Williams", - "url": "http://dx.doi.org/10.1073/pnas.2413366121", - "doi": "10.1073/pnas.2413366121", - "filter": 2 - }, - { - "title": "Lipidomic scanning of self-lipids identifies headless antigens for natural killer T cells", - "authors": "Tan-Yun Cheng, T. Praveena, Srinath Govindarajan, Catarina F. Almeida, Daniel G. Pellicci, Wellington C. Arkins, Ildiko Van Rhijn, Koen Venken, Dirk Elewaut, Dale I. Godfrey, Jamie Rossjohn, D. Branch Moody", - "abstract": "To broadly measure the spectrum of cellular self-antigens for natural killer T cells (NKT), we developed a sensitive lipidomics system to analyze lipids trapped between CD1d and NKT T cell receptors (TCRs). We captured diverse antigen complexes formed in cells from natural endogenous lipids, with or without inducing endoplasmic reticulum (ER) stress. After separating protein complexes with no, low, or high CD1d–TCR interaction, we eluted lipids to establish the spectrum of self-lipids that facilitate this interaction. Although this unbiased approach identified fifteen molecules, they clustered into only two related groups: previously known phospholipid antigens and unexpected neutral lipid antigens. Mass spectrometry studies identified the neutral lipids as ceramides, deoxyceramides, and diacylglycerols, which can be considered headless lipids because they lack polar headgroups that usually form the TCR epitope. The crystal structure of the TCR–ceramide–CD1d complex showed how the missing headgroup allowed the TCR to predominantly contact CD1d, supporting a model of CD1d autoreactivity. Ceramide and related headless antigens mediated physiological TCR binding affinity, weak NKT cell responses, and tetramer binding to polyclonal human and mouse NKT cells. Ceramide and sphingomyelin are oppositely regulated components of the “sphingomyelin cycle” that are altered during apoptosis, transformation, and ER stress. Thus, the unique molecular link of ceramide to NKT cell response, along with the recent identification of sphingomyelin blockers of NKT cell activation, provide two mutually reinforcing links for NKT cell response to sterile cellular stress conditions.", - "url": "http://dx.doi.org/10.1073/pnas.2321686121", - "doi": "10.1073/pnas.2321686121", + "title": "Correction for Mehta et al., Neural auditory contrast enhancement in humans", + "url": "http://dx.doi.org/10.1073/pnas.2414866121", + "doi": "10.1073/pnas.2414866121", "filter": 2 }, { - "title": "Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2", - "authors": "Wenlin Ren, Chonglei Fu, Yu Zhang, Xiaohui Ju, Xi Jiang, Jingwei Song, Mingli Gong, Zhuoyang Li, Wenchun Fan, Jun Yao, Qiang Ding", - "abstract": "The ZIKA virus (ZIKV) evades the host immune response by degrading STAT2 through its NS5 protein, thereby inhibiting type I interferon (IFN)-mediated antiviral immunity. However, the molecular mechanism underlying this process has remained elusive. In this study, we performed a genome-wide CRISPR/Cas9 screen, revealing that ZSWIM8 as the substrate receptor of Cullin3-RING E3 ligase is required for NS5-mediated STAT2 degradation. Genetic depletion of ZSWIM8 and CUL3 substantially impeded NS5-mediated STAT2 degradation. Biochemical analysis illuminated that NS5 enhances the interaction between STAT2 and the ZSWIM8–CUL3 E3 ligase complex, thereby facilitating STAT2 ubiquitination. Moreover, ZSWIM8 knockout endowed A549 and Huh7 cells with partial resistance to ZIKV infection and protected cells from the cytopathic effects induced by ZIKV, which was attributed to the restoration of STAT2 levels and the activation of IFN signaling. Subsequent studies in a physiologically relevant model, utilizing human neural progenitor cells, demonstrated that ZSWIM8 depletion reduced ZIKV infection, resulting from enhanced IFN signaling attributed to the sustained levels of STAT2. Our findings shed light on the role of ZIKV NS5, serving as the scaffold protein, reprograms the ZSWIM8–CUL3 E3 ligase complex to orchestrate STAT2 proteasome-dependent degradation, thereby facilitating evasion of IFN antiviral signaling. Our study provides unique insights into ZIKV–host interactions and holds promise for the development of antivirals and prophylactic vaccines.", - "url": "http://dx.doi.org/10.1073/pnas.2403235121", - "doi": "10.1073/pnas.2403235121", + "title": "Reply to Huysseune and Witten: Oral tooth bud formation in zebrafish", + "authors": "William R. Jackman, Lyn S. Miranda Portillo, Carol K. Cox, Alison Ambrosio, Yann Gibert", + "url": "http://dx.doi.org/10.1073/pnas.2413644121", + "doi": "10.1073/pnas.2413644121", "filter": 2 }, { @@ -1302,7 +1302,16 @@ { "journal_full": "Science", "journal_short": "Sci", - "articles": [], + "articles": [ + { + "title": "Mapping safe drinking water use in low- and middle-income countries", + "authors": "Esther E. Greenwood, Thomas Lauber, Johan van den Hoogen, Ayca Donmez, Robert E. S. Bain, Richard Johnston, Thomas W. Crowther, Timothy R. Julian", + "abstract": "Safe drinking water access is a human right, but data on safely managed drinking water services (SMDWS) is lacking for more than half of the global population. We estimate SMDWS use in 135 low- and middle-income countries (LMICs) at subnational levels with a geospatial modeling approach, combining existing household survey data with available global geospatial datasets. We estimate that only one in three people used SMDWS in LMICs in 2020 and identified fecal contamination as the primary limiting factor affecting almost half of the population of LMICs. Our results are relevant for raising awareness about the challenges and limitations of current global monitoring approaches and demonstrating how globally available geospatial data can be leveraged to fill data gaps and identify priority areas in LMICs.", + "url": "http://dx.doi.org/10.1126/science.adh9578", + "doi": "10.1126/science.adh9578", + "filter": 0 + } + ], "articles_hidden": [ { "title": "News at a glance", @@ -1575,11 +1584,11 @@ "filter": 2 }, { - "title": "Mapping safe drinking water use in low- and middle-income countries", - "authors": "Esther E. Greenwood, Thomas Lauber, Johan van den Hoogen, Ayca Donmez, Robert E. S. Bain, Richard Johnston, Thomas W. Crowther, Timothy R. Julian", - "abstract": "Safe drinking water access is a human right, but data on safely managed drinking water services (SMDWS) is lacking for more than half of the global population. We estimate SMDWS use in 135 low- and middle-income countries (LMICs) at subnational levels with a geospatial modeling approach, combining existing household survey data with available global geospatial datasets. We estimate that only one in three people used SMDWS in LMICs in 2020 and identified fecal contamination as the primary limiting factor affecting almost half of the population of LMICs. Our results are relevant for raising awareness about the challenges and limitations of current global monitoring approaches and demonstrating how globally available geospatial data can be leveraged to fill data gaps and identify priority areas in LMICs.", - "url": "http://dx.doi.org/10.1126/science.adh9578", - "doi": "10.1126/science.adh9578", + "title": "Predictive grid coding in the medial entorhinal cortex", + "authors": "Ayako Ouchi, Shigeyoshi Fujisawa", + "abstract": "The entorhinal cortex represents allocentric spatial geometry and egocentric speed and heading information required for spatial navigation. However, it remains unclear whether it contributes to the prediction of an animal’s future location. We discovered grid cells in the medial entorhinal cortex (MEC) that have grid fields representing future locations during goal-directed behavior. These predictive grid cells represented prospective spatial information by shifting their grid fields against the direction of travel. Predictive grid cells discharged at the trough phases of the hippocampal CA1 theta oscillation and, together with other types of grid cells, organized sequences of the trajectory from the current to future positions across each theta cycle. Our results suggest that the MEC provides a predictive map that supports forward planning in spatial navigation.", + "url": "http://dx.doi.org/10.1126/science.ado4166", + "doi": "10.1126/science.ado4166", "filter": 2 }, { @@ -1590,14 +1599,6 @@ "doi": "10.1126/science.ado5708", "filter": 2 }, - { - "title": "Predictive grid coding in the medial entorhinal cortex", - "authors": "Ayako Ouchi, Shigeyoshi Fujisawa", - "abstract": "The entorhinal cortex represents allocentric spatial geometry and egocentric speed and heading information required for spatial navigation. However, it remains unclear whether it contributes to the prediction of an animal’s future location. We discovered grid cells in the medial entorhinal cortex (MEC) that have grid fields representing future locations during goal-directed behavior. These predictive grid cells represented prospective spatial information by shifting their grid fields against the direction of travel. Predictive grid cells discharged at the trough phases of the hippocampal CA1 theta oscillation and, together with other types of grid cells, organized sequences of the trajectory from the current to future positions across each theta cycle. Our results suggest that the MEC provides a predictive map that supports forward planning in spatial navigation.", - "url": "http://dx.doi.org/10.1126/science.ado4166", - "doi": "10.1126/science.ado4166", - "filter": 2 - }, { "title": "Drivers of epidemic dynamics in real time from daily digital COVID-19 measurements", "authors": "Michelle Kendall, Luca Ferretti, Chris Wymant, Daphne Tsallis, James Petrie, Andrea Di Francia, Francesco Di Lauro, Lucie Abeler-Dörner, Harrison Manley, Jasmina Panovska-Griffiths, Alice Ledda, Xavier Didelot, Christophe Fraser", @@ -1644,14 +1645,6 @@ "doi": "10.1126/sciadv.ads0249", "filter": 1 }, - { - "title": "Curving expectations: The minimal impact of structural curvature in biological puncture mechanics", - "authors": "Bingyang Zhang, Bishal Baskota, Jules J. Chabain, Philip S. L. Anderson", - "abstract": "Living organisms have evolved various biological puncture tools, such as fangs, stingers, and claws, for prey capture, defense, and other critical biological functions. These tools exhibit diverse morphologies, including a wide range of structural curvatures, from straight cactus spines to crescent-shaped talons found in raptors. While the influence of such curvature on the strength of the tool has been explored, its biomechanical role in puncture performance remains untested. Here, we investigate the effect of curvature on puncture mechanics by integrating experiments with finite element simulations. Our findings reveal that within a wide biologically relevant range, structural curvature has a minimal impact on key metrics of damage initiation or the energies required for deep penetration in isotropic and homogeneous target materials. This unexpected result improves our understanding of the biomechanical pressures driving the morphological diversity of curved puncture tools and provides fundamental insights into the crucial roles of curvature in the biomechanical functions of living puncture systems.", - "url": "http://dx.doi.org/10.1126/sciadv.adp8157", - "doi": "10.1126/sciadv.adp8157", - "filter": 2 - }, { "title": "Water isotope ratios reflect convection intensity rather than rain type proportions in the pantropics", "authors": "Wusheng Yu, Rong Guo, Lonnie G. Thompson, Jingyi Zhang, Stephen Lewis, Zhaowei Jing, Junmei He, Yaoming Ma, Baiqing Xu, Guangjian Wu, Xu Zhou, Wenjun Tang, Qiaoyi Wang, Pengjie Ren, Zhuanxia Zhang, Dongmei Qu", @@ -1661,11 +1654,11 @@ "filter": 2 }, { - "title": "The genomic potential of photosynthesis in piconanoplankton is functionally redundant but taxonomically structured at a global scale", - "authors": "Alexandre Schickele, Pavla Debeljak, Sakina-Dorothée Ayata, Lucie Bittner, Eric Pelletier, Lionel Guidi, Jean-Olivier Irisson", - "abstract": "Carbon fixation is a key metabolic function shaping marine life, but the underlying taxonomic and functional diversity involved is only partially understood. Using metagenomic resources targeted at marine piconanoplankton, we provide a reproducible machine learning framework to derive the potential biogeography of genomic functions through the multi-output regression of gene read counts on environmental climatologies. Leveraging the Marine Atlas of Tara Oceans Unigenes, we investigate the genomic potential of primary production in the global ocean. The latter is performed by ribulose-1,5-bisphosphate carboxylase/oxygenase (RUBISCO) and is often associated with carbon concentration mechanisms in piconanoplankton, major marine unicellular photosynthetic organisms. We show that the genomic potential supporting C 4 enzymes and RUBISCO exhibits strong functional redundancy and important affinity toward tropical oligotrophic waters. This redundancy is taxonomically structured by the dominance of Mamiellophyceae and Prymnesiophyceae in mid and high latitudes. These findings enhance our understanding of the relationship between functional and taxonomic diversity of microorganisms and environmental drivers of key biogeochemical cycles.", - "url": "http://dx.doi.org/10.1126/sciadv.adl0534", - "doi": "10.1126/sciadv.adl0534", + "title": "Curving expectations: The minimal impact of structural curvature in biological puncture mechanics", + "authors": "Bingyang Zhang, Bishal Baskota, Jules J. Chabain, Philip S. L. Anderson", + "abstract": "Living organisms have evolved various biological puncture tools, such as fangs, stingers, and claws, for prey capture, defense, and other critical biological functions. These tools exhibit diverse morphologies, including a wide range of structural curvatures, from straight cactus spines to crescent-shaped talons found in raptors. While the influence of such curvature on the strength of the tool has been explored, its biomechanical role in puncture performance remains untested. Here, we investigate the effect of curvature on puncture mechanics by integrating experiments with finite element simulations. Our findings reveal that within a wide biologically relevant range, structural curvature has a minimal impact on key metrics of damage initiation or the energies required for deep penetration in isotropic and homogeneous target materials. This unexpected result improves our understanding of the biomechanical pressures driving the morphological diversity of curved puncture tools and provides fundamental insights into the crucial roles of curvature in the biomechanical functions of living puncture systems.", + "url": "http://dx.doi.org/10.1126/sciadv.adp8157", + "doi": "10.1126/sciadv.adp8157", "filter": 2 }, { @@ -1676,6 +1669,14 @@ "doi": "10.1126/sciadv.adn2378", "filter": 2 }, + { + "title": "The genomic potential of photosynthesis in piconanoplankton is functionally redundant but taxonomically structured at a global scale", + "authors": "Alexandre Schickele, Pavla Debeljak, Sakina-Dorothée Ayata, Lucie Bittner, Eric Pelletier, Lionel Guidi, Jean-Olivier Irisson", + "abstract": "Carbon fixation is a key metabolic function shaping marine life, but the underlying taxonomic and functional diversity involved is only partially understood. Using metagenomic resources targeted at marine piconanoplankton, we provide a reproducible machine learning framework to derive the potential biogeography of genomic functions through the multi-output regression of gene read counts on environmental climatologies. Leveraging the Marine Atlas of Tara Oceans Unigenes, we investigate the genomic potential of primary production in the global ocean. The latter is performed by ribulose-1,5-bisphosphate carboxylase/oxygenase (RUBISCO) and is often associated with carbon concentration mechanisms in piconanoplankton, major marine unicellular photosynthetic organisms. We show that the genomic potential supporting C 4 enzymes and RUBISCO exhibits strong functional redundancy and important affinity toward tropical oligotrophic waters. This redundancy is taxonomically structured by the dominance of Mamiellophyceae and Prymnesiophyceae in mid and high latitudes. These findings enhance our understanding of the relationship between functional and taxonomic diversity of microorganisms and environmental drivers of key biogeochemical cycles.", + "url": "http://dx.doi.org/10.1126/sciadv.adl0534", + "doi": "10.1126/sciadv.adl0534", + "filter": 2 + }, { "title": "Human population dynamics in Upper Paleolithic Europe inferred from fossil dental phenotypes", "authors": "Hannes Rathmann, Maria T. Vizzari, Judith Beier, Shara E. Bailey, Silvia Ghirotto, Katerina Harvati", @@ -1757,35 +1758,19 @@ "filter": 2 }, { - "title": "Long-read sequencing reveals extensive gut phageome structural variations driven by genetic exchange with bacterial hosts", - "authors": "Senying Lai, Huarui Wang, Peer Bork, Wei-Hua Chen, Xing-Ming Zhao", - "abstract": "Genetic variations are instrumental for unraveling phage evolution and deciphering their functional implications. Here, we explore the underlying fine-scale genetic variations in the gut phageome, especially structural variations (SVs). By using virome-enriched long-read metagenomic sequencing across 91 individuals, we identified a total of 14,438 nonredundant phage SVs and revealed their prevalence within the human gut phageome. These SVs are mainly enriched in genes involved in recombination, DNA methylation, and antibiotic resistance. Notably, a substantial fraction of phage SV sequences share close homology with bacterial fragments, with most SVs enriched for horizontal gene transfer (HGT) mechanism. Further investigations showed that these SV sequences were genetic exchanged between specific phage-bacteria pairs, particularly between phages and their respective bacterial hosts. Temperate phages exhibit a higher frequency of genetic exchange with bacterial chromosomes and then virulent phages. Collectively, our findings provide insights into the genetic landscape of the human gut phageome.", - "url": "http://dx.doi.org/10.1126/sciadv.adn3316", - "doi": "10.1126/sciadv.adn3316", - "filter": 2 - }, - { - "title": "Coral Sr/Ca-SST reconstruction from Fiji extending to ~1370 CE reveals insights into the Interdecadal Pacific Oscillation", - "authors": "Juan P. D’Olivo, Jens Zinke, Rishav Goyal, Matthew H. England, Ariaan Purich, Thierry Corrège, Eduardo Zorita, Denis Scholz, Michael Weber, José D. Carriquiry", - "abstract": "The southwestern tropical Pacific is a key center for the Interdecadal Pacific Oscillation (IPO), which regulates global climate. This study introduces a groundbreaking 627-year coral Sr/Ca sea surface temperature reconstruction from Fiji, representing the IPO’s southwestern pole. Merging this record with other Fiji and central tropical Pacific records, we reconstruct the SST gradient between the southwestern and central Pacific (SWCP), providing a reliable proxy for IPO variability from 1370 to 1997. This reconstruction reveals distinct centennial-scale temperature trends and insights into Pacific-wide climate impacts and teleconnections. Notably, the 20th century conditions, marked by simultaneous basin-scale warming and weak tropical Pacific zonal-meridional gradients, deviate from trends observed during the past six centuries. Combined with model simulations, our findings reveal that a weak SWCP gradient most markedly affects IPO-related rainfall patterns in the equatorial Pacific. Persistent synchronous western and central Pacific warming rates could lead to further drying climate across the Coral Sea region, adversely affecting Pacific Island nations.", - "url": "http://dx.doi.org/10.1126/sciadv.ado5107", - "doi": "10.1126/sciadv.ado5107", - "filter": 2 - }, - { - "title": "High-sensitivity luminescent temperature sensors: MFX:1%Sm 2+ (M = Sr, Ba, X = Cl, Br)", - "authors": "Lizhi Cui, Zhijie Dong, Dechao Yu, Yuhua Wang, Andries Meijerink", - "abstract": "The use of lanthanide luminescence has advanced the field of remote temperature sensing. Luminescence intensity ratio methods relying on emission from two thermally coupled energy levels are popular but suffer from a limited temperature range. Here, we present a versatile luminescent thermometer: Ba(Sr)FBr(Cl):Sm 2+ . The Sm 2+ ion benefits from multiple thermally coupled excited states to extend the temperature range and has strong parity-allowed 4f 6 →4f 5 5d 1 absorption to increase brightness. We conduct a comparative analysis of the temperature sensing performance of Sm 2+ in BaFBr, BaFCl, SrFBr, and SrFCl and address the role of concentration, host, and Boltzmann equilibration. Different thermal coupling schemes, 5 D 1 - 5 D 0 and 4f 5 5d 1 - 5 D 0 , and temperature-dependent lifetimes enable accurate sensing between 350 and 800 kelvin. Differences in 4f 5 5d 1 - 5 D 0 energy gap allows optimization for a temperature range of interest. This type of Sm 2+ -based thermometer holds great potential for temperature monitoring in the wide and relevant range up to 500°C.", - "url": "http://dx.doi.org/10.1126/sciadv.ado7737", - "doi": "10.1126/sciadv.ado7737", + "title": "Direct observation of degassing during decompression of basaltic magma", + "authors": "Barbara Bonechi, Margherita Polacci, Fabio Arzilli, Giuseppe La Spina, Jean-Louis Hazemann, Richard A. Brooker, Robert Atwood, Sebastian Marussi, Peter D. Lee, Roy A. Wogelius, Jonathan Fellowes, Mike R. Burton", + "abstract": "Transitions in eruptive style during volcanic eruptions strongly depend on how easily gas and magma decouple during ascent. Stronger gas-melt coupling favors highly explosive eruptions, whereas weaker coupling promotes lava fountaining and lava flows. The mechanisms producing these transitions are still poorly understood because of a lack of direct observations of bubble dynamics under natural magmatic conditions. Here, we combine x-ray radiography with a novel high-pressure/high-temperature apparatus to observe and quantify in real-time bubble growth and coalescence in basaltic magmas from 100 megapascals to surface. For low-viscosity magmas, bubbles coalesce and recover a spherical shape within 3 seconds, implying that, for lava fountaining activity, gas and melt remain coupled during the ascent up to the last hundred meters of the conduit. For higher-viscosity magmas, recovery times become longer, promoting connected bubble pathways. This apparatus opens frontiers in unraveling magmatic/volcanic processes, leading to improved hazard assessment and risk mitigation.", + "url": "http://dx.doi.org/10.1126/sciadv.ado2585", + "doi": "10.1126/sciadv.ado2585", "filter": 2 }, { - "title": "The iron nitrogenase reduces carbon dioxide to formate and methane under physiological conditions: A route to feedstock chemicals", - "authors": "Niels N. Oehlmann, Frederik V. Schmidt, Marcello Herzog, Annelise L. Goldman, Johannes G. Rebelein", - "abstract": "Nitrogenases are the only known enzymes that reduce molecular nitrogen (N 2 ) to ammonia. Recent findings have demonstrated that nitrogenases also reduce the greenhouse gas carbon dioxide (CO 2 ), suggesting CO 2 to be a competitor of N 2 . However, the impact of omnipresent CO 2 on N 2 fixation has not been investigated to date. Here, we study the competing reduction of CO 2 and N 2 by the two nitrogenases of Rhodobacter capsulatus , the molybdenum and the iron nitrogenase. The iron nitrogenase is almost threefold more efficient in CO 2 reduction and profoundly less selective for N 2 than the molybdenum isoform under mixtures of N 2 and CO 2 . Correspondingly, the growth rate of diazotrophically grown R. capsulatus strains relying on the iron nitrogenase notably decreased after adding CO 2 . The in vivo CO 2 activity of the iron nitrogenase facilitates the light-driven extracellular accumulation of formate and methane, one-carbon substrates for other microbes, and feedstock chemicals for a circular economy.", - "url": "http://dx.doi.org/10.1126/sciadv.ado7729", - "doi": "10.1126/sciadv.ado7729", + "title": "SERS surgical navigation with postsurgical immunotherapy of local microtumors and distant metastases for improved anticancer outcomes", + "authors": "Yu Wen, Ruoxuan Liu, Yangcenzi Xie, Xinyu Liu, Ming Li", + "abstract": "The standard of clinical care of most malignant solid cancers is surgery, followed by postsurgical adjuvant therapy, but microtumor lesions left behind after surgery and invisible distant metastases are the major reasons for treatment failure. Here, we report an integrated strategy combining surface-enhanced Raman spectroscopy (SERS) surgical navigation with postsurgical immunotherapy elicited by near-infrared II photothermal treatment and programmed death-1 antibody. The SERS surgical navigation is principally based on the multifunctional optical probes (namely, MATRA probes) integrating with T 1 -weighted magnetic resonance (MR) imaging, photothermal effect and Raman spectroscopic detection. We demonstrate in a 4T1 breast tumor mouse model that the pre-surgical MR/SERS dual-modal imaging is capable of providing comprehensive tumor information, and intraoperative SERS detection allows accurately delineating the tumor margins and guiding the surgical resection in real time with the least residual microscopic foci. We verify that the postsurgical immunotherapy effectively eradicates those local microtumor lesions and invisible distant metastases, greatly inhibiting the postsurgical cancer recurrence and distant metastasis.", + "url": "http://dx.doi.org/10.1126/sciadv.ado2741", + "doi": "10.1126/sciadv.ado2741", "filter": 2 }, { @@ -1797,51 +1782,43 @@ "filter": 2 }, { - "title": "SERS surgical navigation with postsurgical immunotherapy of local microtumors and distant metastases for improved anticancer outcomes", - "authors": "Yu Wen, Ruoxuan Liu, Yangcenzi Xie, Xinyu Liu, Ming Li", - "abstract": "The standard of clinical care of most malignant solid cancers is surgery, followed by postsurgical adjuvant therapy, but microtumor lesions left behind after surgery and invisible distant metastases are the major reasons for treatment failure. Here, we report an integrated strategy combining surface-enhanced Raman spectroscopy (SERS) surgical navigation with postsurgical immunotherapy elicited by near-infrared II photothermal treatment and programmed death-1 antibody. The SERS surgical navigation is principally based on the multifunctional optical probes (namely, MATRA probes) integrating with T 1 -weighted magnetic resonance (MR) imaging, photothermal effect and Raman spectroscopic detection. We demonstrate in a 4T1 breast tumor mouse model that the pre-surgical MR/SERS dual-modal imaging is capable of providing comprehensive tumor information, and intraoperative SERS detection allows accurately delineating the tumor margins and guiding the surgical resection in real time with the least residual microscopic foci. We verify that the postsurgical immunotherapy effectively eradicates those local microtumor lesions and invisible distant metastases, greatly inhibiting the postsurgical cancer recurrence and distant metastasis.", - "url": "http://dx.doi.org/10.1126/sciadv.ado2741", - "doi": "10.1126/sciadv.ado2741", - "filter": 2 - }, - { - "title": "Direct observation of degassing during decompression of basaltic magma", - "authors": "Barbara Bonechi, Margherita Polacci, Fabio Arzilli, Giuseppe La Spina, Jean-Louis Hazemann, Richard A. Brooker, Robert Atwood, Sebastian Marussi, Peter D. Lee, Roy A. Wogelius, Jonathan Fellowes, Mike R. Burton", - "abstract": "Transitions in eruptive style during volcanic eruptions strongly depend on how easily gas and magma decouple during ascent. Stronger gas-melt coupling favors highly explosive eruptions, whereas weaker coupling promotes lava fountaining and lava flows. The mechanisms producing these transitions are still poorly understood because of a lack of direct observations of bubble dynamics under natural magmatic conditions. Here, we combine x-ray radiography with a novel high-pressure/high-temperature apparatus to observe and quantify in real-time bubble growth and coalescence in basaltic magmas from 100 megapascals to surface. For low-viscosity magmas, bubbles coalesce and recover a spherical shape within 3 seconds, implying that, for lava fountaining activity, gas and melt remain coupled during the ascent up to the last hundred meters of the conduit. For higher-viscosity magmas, recovery times become longer, promoting connected bubble pathways. This apparatus opens frontiers in unraveling magmatic/volcanic processes, leading to improved hazard assessment and risk mitigation.", - "url": "http://dx.doi.org/10.1126/sciadv.ado2585", - "doi": "10.1126/sciadv.ado2585", + "title": "High-sensitivity luminescent temperature sensors: MFX:1%Sm 2+ (M = Sr, Ba, X = Cl, Br)", + "authors": "Lizhi Cui, Zhijie Dong, Dechao Yu, Yuhua Wang, Andries Meijerink", + "abstract": "The use of lanthanide luminescence has advanced the field of remote temperature sensing. Luminescence intensity ratio methods relying on emission from two thermally coupled energy levels are popular but suffer from a limited temperature range. Here, we present a versatile luminescent thermometer: Ba(Sr)FBr(Cl):Sm 2+ . The Sm 2+ ion benefits from multiple thermally coupled excited states to extend the temperature range and has strong parity-allowed 4f 6 →4f 5 5d 1 absorption to increase brightness. We conduct a comparative analysis of the temperature sensing performance of Sm 2+ in BaFBr, BaFCl, SrFBr, and SrFCl and address the role of concentration, host, and Boltzmann equilibration. Different thermal coupling schemes, 5 D 1 - 5 D 0 and 4f 5 5d 1 - 5 D 0 , and temperature-dependent lifetimes enable accurate sensing between 350 and 800 kelvin. Differences in 4f 5 5d 1 - 5 D 0 energy gap allows optimization for a temperature range of interest. This type of Sm 2+ -based thermometer holds great potential for temperature monitoring in the wide and relevant range up to 500°C.", + "url": "http://dx.doi.org/10.1126/sciadv.ado7737", + "doi": "10.1126/sciadv.ado7737", "filter": 2 }, { - "title": "Sprayable biomimetic double mask with rapid autophasing and hierarchical programming for scarless wound healing", - "authors": "Yuhe Yang, Di Suo, Tianpeng Xu, Shuai Zhao, Xiaoxiao Xu, Ho-Pan Bei, Kenneth Kak-yuen Wong, Qibin Li, Zijian Zheng, Bin Li, Xin Zhao", - "abstract": "Current sprayable hydrogel masks lack the stepwise protection, cleansing, and nourishment of extensive wounds, leading to delayed healing with scarring. Here, we develop a sprayable biomimetic double wound mask (BDM) with rapid autophasing and hierarchical programming for scarless wound healing. The BDMs comprise hydrophobic poly (lactide- co –propylene glycol– co -lactide) dimethacrylate (PLD) as top layer and hydrophilic gelatin methacrylate (GelMA) hydrogel as bottom layer, enabling swift autophasing into bilayered structure. After photocrosslinking, BDMs rapidly solidify with strong interfacial bonding, robust tissue adhesion, and excellent joint adaptiveness. Upon implementation, the bottom GelMA layer could immediately release calcium ion for rapid hemostasis, while the top PLD layer could maintain a moist, breathable, and sterile environment. These traits synergistically suppress the inflammatory tumor necrosis factor–α pathway while coordinating the cyclic guanosine monophosphate/protein kinase G–Wnt/calcium ion signaling pathways to nourish angiogenesis. Collectively, our BDMs with self-regulated construction of bilayered structure could hierarchically program the healing progression with transformative potential for scarless wound healing.", - "url": "http://dx.doi.org/10.1126/sciadv.ado9479", - "doi": "10.1126/sciadv.ado9479", + "title": "Coral Sr/Ca-SST reconstruction from Fiji extending to ~1370 CE reveals insights into the Interdecadal Pacific Oscillation", + "authors": "Juan P. D’Olivo, Jens Zinke, Rishav Goyal, Matthew H. England, Ariaan Purich, Thierry Corrège, Eduardo Zorita, Denis Scholz, Michael Weber, José D. Carriquiry", + "abstract": "The southwestern tropical Pacific is a key center for the Interdecadal Pacific Oscillation (IPO), which regulates global climate. This study introduces a groundbreaking 627-year coral Sr/Ca sea surface temperature reconstruction from Fiji, representing the IPO’s southwestern pole. Merging this record with other Fiji and central tropical Pacific records, we reconstruct the SST gradient between the southwestern and central Pacific (SWCP), providing a reliable proxy for IPO variability from 1370 to 1997. This reconstruction reveals distinct centennial-scale temperature trends and insights into Pacific-wide climate impacts and teleconnections. Notably, the 20th century conditions, marked by simultaneous basin-scale warming and weak tropical Pacific zonal-meridional gradients, deviate from trends observed during the past six centuries. Combined with model simulations, our findings reveal that a weak SWCP gradient most markedly affects IPO-related rainfall patterns in the equatorial Pacific. Persistent synchronous western and central Pacific warming rates could lead to further drying climate across the Coral Sea region, adversely affecting Pacific Island nations.", + "url": "http://dx.doi.org/10.1126/sciadv.ado5107", + "doi": "10.1126/sciadv.ado5107", "filter": 2 }, { - "title": "BLADE-ON-PETIOLE interacts with CYCLOIDEA to fine-tune CYCLOIDEA -mediated flower symmetry in monkeyflowers ( Mimulus )", - "authors": "Yuan Gao, Jingjian Li, Jiayue He, Yaqi Yu, Zexin Qian, Zhiqiang Geng, Liuhui Yang, Yumin Zhang, Yujie Ke, Qiaoshan Lin, Jing Wang, Sumei Chen, Fadi Chen, Yao-Wu Yuan, Baoqing Ding", - "abstract": "Morphological novelties, or key innovations, are instrumental to the diversification of the organisms. In plants, one such innovation is the evolution of zygomorphic flowers, which is thought to promote outcrossing and increase flower morphological diversity. We isolated three allelic mutants from two Mimulus species displaying altered floral symmetry and identified the causal gene as the ortholog of Arabidopsis BLADE-ON-PETIOLE . We found that MlBOP and MlCYC2A physically interact and this BOP-CYC interaction module is highly conserved across the angiosperms. Furthermore, MlBOP self-ubiquitinates and suppresses MlCYC2A self-activation. MlCYC2A, in turn, impedes MlBOP ubiquitination. Thus, this molecular tug-of-war between MlBOP and MlCYC2A fine-tunes the expression of MlCYC2A , contributing to the formation of bilateral symmetry in flowers, a key trait in angiosperm evolution.", - "url": "http://dx.doi.org/10.1126/sciadv.ado4571", - "doi": "10.1126/sciadv.ado4571", + "title": "The iron nitrogenase reduces carbon dioxide to formate and methane under physiological conditions: A route to feedstock chemicals", + "authors": "Niels N. Oehlmann, Frederik V. Schmidt, Marcello Herzog, Annelise L. Goldman, Johannes G. Rebelein", + "abstract": "Nitrogenases are the only known enzymes that reduce molecular nitrogen (N 2 ) to ammonia. Recent findings have demonstrated that nitrogenases also reduce the greenhouse gas carbon dioxide (CO 2 ), suggesting CO 2 to be a competitor of N 2 . However, the impact of omnipresent CO 2 on N 2 fixation has not been investigated to date. Here, we study the competing reduction of CO 2 and N 2 by the two nitrogenases of Rhodobacter capsulatus , the molybdenum and the iron nitrogenase. The iron nitrogenase is almost threefold more efficient in CO 2 reduction and profoundly less selective for N 2 than the molybdenum isoform under mixtures of N 2 and CO 2 . Correspondingly, the growth rate of diazotrophically grown R. capsulatus strains relying on the iron nitrogenase notably decreased after adding CO 2 . The in vivo CO 2 activity of the iron nitrogenase facilitates the light-driven extracellular accumulation of formate and methane, one-carbon substrates for other microbes, and feedstock chemicals for a circular economy.", + "url": "http://dx.doi.org/10.1126/sciadv.ado7729", + "doi": "10.1126/sciadv.ado7729", "filter": 2 }, { - "title": "Single neuron responses to perceptual difficulty in the mouse auditory cortex", - "authors": "Baruch Haimson, Omri David Gilday, Amichai Lavi-Rudel, Hadar Sagi, Eran Lottem, Adi Mizrahi", - "abstract": "Perceptual learning leads to improvement in behavioral performance, yet how the brain supports challenging perceptual demands is unknown. We used two photon imaging in the mouse primary auditory cortex during behavior in a Go-NoGo task designed to test perceptual difficulty. Using general linear model analysis, we found a subset of neurons that increased their responses during high perceptual demands. Single neurons increased their responses to both Go and NoGo sounds when mice were engaged in the more difficult perceptual discrimination. This increased responsiveness contributes to enhanced cortical network discriminability for the learned sounds. Under passive listening conditions, the same neurons responded weaker to the more similar sound pairs of the difficult task, and the training protocol by itself induced specific suppression to the learned sounds. Our findings identify how neuronal activity in auditory cortex is modulated during high perceptual demands, which is a fundamental feature associated with perceptual improvement.", - "url": "http://dx.doi.org/10.1126/sciadv.adp9816", - "doi": "10.1126/sciadv.adp9816", + "title": "Long-read sequencing reveals extensive gut phageome structural variations driven by genetic exchange with bacterial hosts", + "authors": "Senying Lai, Huarui Wang, Peer Bork, Wei-Hua Chen, Xing-Ming Zhao", + "abstract": "Genetic variations are instrumental for unraveling phage evolution and deciphering their functional implications. Here, we explore the underlying fine-scale genetic variations in the gut phageome, especially structural variations (SVs). By using virome-enriched long-read metagenomic sequencing across 91 individuals, we identified a total of 14,438 nonredundant phage SVs and revealed their prevalence within the human gut phageome. These SVs are mainly enriched in genes involved in recombination, DNA methylation, and antibiotic resistance. Notably, a substantial fraction of phage SV sequences share close homology with bacterial fragments, with most SVs enriched for horizontal gene transfer (HGT) mechanism. Further investigations showed that these SV sequences were genetic exchanged between specific phage-bacteria pairs, particularly between phages and their respective bacterial hosts. Temperate phages exhibit a higher frequency of genetic exchange with bacterial chromosomes and then virulent phages. Collectively, our findings provide insights into the genetic landscape of the human gut phageome.", + "url": "http://dx.doi.org/10.1126/sciadv.adn3316", + "doi": "10.1126/sciadv.adn3316", "filter": 2 }, { - "title": "Dual-phase microporous polymer nanofilms by interfacial polymerization for ultrafast molecular separation", - "authors": "Tae Hoon Lee, Marcel Balcik, Wan-Ni Wu, Ingo Pinnau, Zachary P. Smith", - "abstract": "Fine-tuning microporosity in polymers with a scalable method has great potential for energy-efficient molecular separations. Here, we report a dual-phase molecular engineering approach to prepare microporous polymer nanofilms through interfacial polymerization. By integrating two micropore-generating units such as a water-soluble Tröger’s base diamine (TBD) and a contorted spirobifluorene (SBF) motif, the resultant TBD-SBF polyamide shows an unprecedentedly high surface area. An ultrathin TBD-SBF membrane (~20 nm) exhibits up to 220 times improved solvent permeance with a moderate molecular weight cutoff (~640 g mol −1 ) compared to the control membrane prepared by conventional chemistry, which outperforms currently reported polymeric membranes. We also highlight the great potential of the SBF-based microporous polyamides for hydrocarbon separations by exploring the isomeric effects of aqueous phase monomers to manipulate microporosity.", - "url": "http://dx.doi.org/10.1126/sciadv.adp6666", - "doi": "10.1126/sciadv.adp6666", + "title": "Structural basis for the ligand recognition and G protein subtype selectivity of kisspeptin receptor", + "authors": "Zhangsong Wu, Geng Chen, Chen Qiu, Xiaoyi Yan, Lezhi Xu, Shirui Jiang, Jun Xu, Runyuan Han, Tingyi Shi, Yiming Liu, Wei Gao, Qian Wang, Jiancheng Li, Fang Ye, Xin Pan, Zhiyi Zhang, Peiruo Ning, Binghao Zhang, Jing Chen, Yang Du", + "abstract": "Kisspeptin receptor (KISS1R), belonging to the class A peptide-GPCR family, plays a key role in the regulation of reproductive physiology after stimulation by kisspeptin and is regarded as an attractive drug target for reproductive diseases. Here, we demonstrated that KISS1R can couple to the G i/o pathway besides the well-known G q/11 pathway. We further resolved the cryo–electron microscopy (cryo-EM) structure of KISS1R-G q and KISS1R-G i complexes bound to the synthetic agonist TAK448 and structure of KISS1R-G q complex bound to the endogenous agonist KP54. The high-resolution structures provided clear insights into mechanism of KISS1R recognition by its ligand and can facilitate the design of targeted drugs with high affinity to improve treatment effects. Moreover, the structural and functional analyses indicated that conformational differences in the extracellular loops (ECLs), intracellular loops (ICLs) of the receptor, and the “wavy hook” of the Gα subunit may account for the specificity of G protein coupling for KISS1R signaling.", + "url": "http://dx.doi.org/10.1126/sciadv.adn7771", + "doi": "10.1126/sciadv.adn7771", "filter": 2 }, { @@ -1852,14 +1829,6 @@ "doi": "10.1126/sciadv.adp0021", "filter": 2 }, - { - "title": "Structural basis for the ligand recognition and G protein subtype selectivity of kisspeptin receptor", - "authors": "Zhangsong Wu, Geng Chen, Chen Qiu, Xiaoyi Yan, Lezhi Xu, Shirui Jiang, Jun Xu, Runyuan Han, Tingyi Shi, Yiming Liu, Wei Gao, Qian Wang, Jiancheng Li, Fang Ye, Xin Pan, Zhiyi Zhang, Peiruo Ning, Binghao Zhang, Jing Chen, Yang Du", - "abstract": "Kisspeptin receptor (KISS1R), belonging to the class A peptide-GPCR family, plays a key role in the regulation of reproductive physiology after stimulation by kisspeptin and is regarded as an attractive drug target for reproductive diseases. Here, we demonstrated that KISS1R can couple to the G i/o pathway besides the well-known G q/11 pathway. We further resolved the cryo–electron microscopy (cryo-EM) structure of KISS1R-G q and KISS1R-G i complexes bound to the synthetic agonist TAK448 and structure of KISS1R-G q complex bound to the endogenous agonist KP54. The high-resolution structures provided clear insights into mechanism of KISS1R recognition by its ligand and can facilitate the design of targeted drugs with high affinity to improve treatment effects. Moreover, the structural and functional analyses indicated that conformational differences in the extracellular loops (ECLs), intracellular loops (ICLs) of the receptor, and the “wavy hook” of the Gα subunit may account for the specificity of G protein coupling for KISS1R signaling.", - "url": "http://dx.doi.org/10.1126/sciadv.adn7771", - "doi": "10.1126/sciadv.adn7771", - "filter": 2 - }, { "title": "Microwave field mapping for EPR-on-a-chip experiments", "authors": "Silvio Künstner, Joseph E. McPeak, Anh Chu, Michal Kern, Markus Wick, Klaus-Peter Dinse, Jens Anders, Boris Naydenov, Klaus Lips", @@ -1884,6 +1853,14 @@ "doi": "10.1126/sciadv.ado0614", "filter": 2 }, + { + "title": "Epinephrine promotes breast cancer metastasis through a ubiquitin-specific peptidase 22–mediated lipolysis circuit", + "authors": "Yuanzhang Zhou, Peng Chu, Ya Wang, Na Li, Qiong Gao, Shengnan Wang, Juncheng Wei, Guoqing Xue, Yue Zhao, Huijun Jia, Jiankun Song, Yue Zhang, Yujie Pang, Houyu Zhu, Jia Sun, Suxian Ma, Chen Su, Bingjin Hu, Zhuoyue Zhao, Hui Zhang, Janice Lu, Jian Wang, Hongjiang Wang, Zhaolin Sun, Deyu Fang", + "abstract": "Chronic stress–induced epinephrine (EPI) accelerates breast cancer progression and metastasis, but the molecular mechanisms remain unclear. Herein, we found a strong positive correlation between circulating EPI levels and the tumoral expression of ubiquitin-specific peptidase 22 (USP22) in patients with breast cancer. USP22 facilitated EPI-induced breast cancer progression and metastasis by enhancing adipose triglyceride lipase (ATGL)–mediated lipolysis. Targeted USP22 deletion decreased ATGL expression and lipolysis, subsequently inhibiting EPI-mediated breast cancer lung metastasis. USP22 acts as a bona fide deubiquitinase for the Atgl gene transcription factor FOXO1, and EPI architects a lipolysis signaling pathway to stabilize USP22 through AKT-mediated phosphorylation. Notably, USP22 phosphorylation levels are positively associated with EPI and with downstream pathways involving both FOXO1 and ATGL in breast cancers. Pharmacological USP22 inhibition synergized with β-blockers in treating preclinical xenograft breast cancer models. This study reveals a molecular pathway behind EPI’s tumor-promoting effects and provides a strong rationale for combining USP22 inhibition with β-blockers to treat aggressive breast cancer.", + "url": "http://dx.doi.org/10.1126/sciadv.ado1533", + "doi": "10.1126/sciadv.ado1533", + "filter": 2 + }, { "title": "A thalamic nucleus reuniens–lateral septum–lateral hypothalamus circuit for comorbid anxiety–like behaviors in chronic itch", "authors": "Su-Shan Guo, Yu Gong, Ting-Ting Zhang, Xin-Yu Su, Yan-Jiao Wu, Yi-Xiao Yan, Yue Cao, Xing-Lei Song, Jian-Cheng Xie, Dehua Wu, Qin Jiang, Ying Li, Xuan Zhao, Michael X. Zhu, Tian-Le Xu, Ming-Gang Liu", @@ -1893,11 +1870,35 @@ "filter": 2 }, { - "title": "Epinephrine promotes breast cancer metastasis through a ubiquitin-specific peptidase 22–mediated lipolysis circuit", - "authors": "Yuanzhang Zhou, Peng Chu, Ya Wang, Na Li, Qiong Gao, Shengnan Wang, Juncheng Wei, Guoqing Xue, Yue Zhao, Huijun Jia, Jiankun Song, Yue Zhang, Yujie Pang, Houyu Zhu, Jia Sun, Suxian Ma, Chen Su, Bingjin Hu, Zhuoyue Zhao, Hui Zhang, Janice Lu, Jian Wang, Hongjiang Wang, Zhaolin Sun, Deyu Fang", - "abstract": "Chronic stress–induced epinephrine (EPI) accelerates breast cancer progression and metastasis, but the molecular mechanisms remain unclear. Herein, we found a strong positive correlation between circulating EPI levels and the tumoral expression of ubiquitin-specific peptidase 22 (USP22) in patients with breast cancer. USP22 facilitated EPI-induced breast cancer progression and metastasis by enhancing adipose triglyceride lipase (ATGL)–mediated lipolysis. Targeted USP22 deletion decreased ATGL expression and lipolysis, subsequently inhibiting EPI-mediated breast cancer lung metastasis. USP22 acts as a bona fide deubiquitinase for the Atgl gene transcription factor FOXO1, and EPI architects a lipolysis signaling pathway to stabilize USP22 through AKT-mediated phosphorylation. Notably, USP22 phosphorylation levels are positively associated with EPI and with downstream pathways involving both FOXO1 and ATGL in breast cancers. Pharmacological USP22 inhibition synergized with β-blockers in treating preclinical xenograft breast cancer models. This study reveals a molecular pathway behind EPI’s tumor-promoting effects and provides a strong rationale for combining USP22 inhibition with β-blockers to treat aggressive breast cancer.", - "url": "http://dx.doi.org/10.1126/sciadv.ado1533", - "doi": "10.1126/sciadv.ado1533", + "title": "Single neuron responses to perceptual difficulty in the mouse auditory cortex", + "authors": "Baruch Haimson, Omri David Gilday, Amichai Lavi-Rudel, Hadar Sagi, Eran Lottem, Adi Mizrahi", + "abstract": "Perceptual learning leads to improvement in behavioral performance, yet how the brain supports challenging perceptual demands is unknown. We used two photon imaging in the mouse primary auditory cortex during behavior in a Go-NoGo task designed to test perceptual difficulty. Using general linear model analysis, we found a subset of neurons that increased their responses during high perceptual demands. Single neurons increased their responses to both Go and NoGo sounds when mice were engaged in the more difficult perceptual discrimination. This increased responsiveness contributes to enhanced cortical network discriminability for the learned sounds. Under passive listening conditions, the same neurons responded weaker to the more similar sound pairs of the difficult task, and the training protocol by itself induced specific suppression to the learned sounds. Our findings identify how neuronal activity in auditory cortex is modulated during high perceptual demands, which is a fundamental feature associated with perceptual improvement.", + "url": "http://dx.doi.org/10.1126/sciadv.adp9816", + "doi": "10.1126/sciadv.adp9816", + "filter": 2 + }, + { + "title": "BLADE-ON-PETIOLE interacts with CYCLOIDEA to fine-tune CYCLOIDEA -mediated flower symmetry in monkeyflowers ( Mimulus )", + "authors": "Yuan Gao, Jingjian Li, Jiayue He, Yaqi Yu, Zexin Qian, Zhiqiang Geng, Liuhui Yang, Yumin Zhang, Yujie Ke, Qiaoshan Lin, Jing Wang, Sumei Chen, Fadi Chen, Yao-Wu Yuan, Baoqing Ding", + "abstract": "Morphological novelties, or key innovations, are instrumental to the diversification of the organisms. In plants, one such innovation is the evolution of zygomorphic flowers, which is thought to promote outcrossing and increase flower morphological diversity. We isolated three allelic mutants from two Mimulus species displaying altered floral symmetry and identified the causal gene as the ortholog of Arabidopsis BLADE-ON-PETIOLE . We found that MlBOP and MlCYC2A physically interact and this BOP-CYC interaction module is highly conserved across the angiosperms. Furthermore, MlBOP self-ubiquitinates and suppresses MlCYC2A self-activation. MlCYC2A, in turn, impedes MlBOP ubiquitination. Thus, this molecular tug-of-war between MlBOP and MlCYC2A fine-tunes the expression of MlCYC2A , contributing to the formation of bilateral symmetry in flowers, a key trait in angiosperm evolution.", + "url": "http://dx.doi.org/10.1126/sciadv.ado4571", + "doi": "10.1126/sciadv.ado4571", + "filter": 2 + }, + { + "title": "Dual-phase microporous polymer nanofilms by interfacial polymerization for ultrafast molecular separation", + "authors": "Tae Hoon Lee, Marcel Balcik, Wan-Ni Wu, Ingo Pinnau, Zachary P. Smith", + "abstract": "Fine-tuning microporosity in polymers with a scalable method has great potential for energy-efficient molecular separations. Here, we report a dual-phase molecular engineering approach to prepare microporous polymer nanofilms through interfacial polymerization. By integrating two micropore-generating units such as a water-soluble Tröger’s base diamine (TBD) and a contorted spirobifluorene (SBF) motif, the resultant TBD-SBF polyamide shows an unprecedentedly high surface area. An ultrathin TBD-SBF membrane (~20 nm) exhibits up to 220 times improved solvent permeance with a moderate molecular weight cutoff (~640 g mol −1 ) compared to the control membrane prepared by conventional chemistry, which outperforms currently reported polymeric membranes. We also highlight the great potential of the SBF-based microporous polyamides for hydrocarbon separations by exploring the isomeric effects of aqueous phase monomers to manipulate microporosity.", + "url": "http://dx.doi.org/10.1126/sciadv.adp6666", + "doi": "10.1126/sciadv.adp6666", + "filter": 2 + }, + { + "title": "Sprayable biomimetic double mask with rapid autophasing and hierarchical programming for scarless wound healing", + "authors": "Yuhe Yang, Di Suo, Tianpeng Xu, Shuai Zhao, Xiaoxiao Xu, Ho-Pan Bei, Kenneth Kak-yuen Wong, Qibin Li, Zijian Zheng, Bin Li, Xin Zhao", + "abstract": "Current sprayable hydrogel masks lack the stepwise protection, cleansing, and nourishment of extensive wounds, leading to delayed healing with scarring. Here, we develop a sprayable biomimetic double wound mask (BDM) with rapid autophasing and hierarchical programming for scarless wound healing. The BDMs comprise hydrophobic poly (lactide- co –propylene glycol– co -lactide) dimethacrylate (PLD) as top layer and hydrophilic gelatin methacrylate (GelMA) hydrogel as bottom layer, enabling swift autophasing into bilayered structure. After photocrosslinking, BDMs rapidly solidify with strong interfacial bonding, robust tissue adhesion, and excellent joint adaptiveness. Upon implementation, the bottom GelMA layer could immediately release calcium ion for rapid hemostasis, while the top PLD layer could maintain a moist, breathable, and sterile environment. These traits synergistically suppress the inflammatory tumor necrosis factor–α pathway while coordinating the cyclic guanosine monophosphate/protein kinase G–Wnt/calcium ion signaling pathways to nourish angiogenesis. Collectively, our BDMs with self-regulated construction of bilayered structure could hierarchically program the healing progression with transformative potential for scarless wound healing.", + "url": "http://dx.doi.org/10.1126/sciadv.ado9479", + "doi": "10.1126/sciadv.ado9479", "filter": 2 }, {