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Memory cells can affinity mature

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Antibody feedback may limit adaptation

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- - Childs et al. 2015 - -
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...but diversify the repertoire

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Ab feedback may diversify the repertoire

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Broadly neutralizing antibodies to flu elusive

Will they dominate?

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"Restricted" responses to epitopes

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+ + Dunand and Wilson 2015 + +
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Genotype affects response to H5N1 vaccination

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Avnir et al. 2016