HIV

Group

• Molly
• Joe ([email protected])
• Florencia,
• Katie ([email protected])
• Jim ([email protected])

Notes

Questions:

• Which parts of the immune system are regulating pathogens populations? How many strains are there?
• 2 species HIV 1 and 2
• 4 groups M (major), N, O, and P
• M has at least 11 subtypes (A, B, C, D, E, F, G, H, I, J, K)

Attacks CD4 T cells Glycan shield masks HIV surface protein from immune antibody recognition Founder virus more adapted to HLA type leads to higher viral loads (Carlson 2016)

• What explains patterns of genetic diversity?
• What explains population dynamics?
• What's an outstanding question for your system? How would you conduct a study to address this and how would you analyze data from this study?