diff --git a/src/cluster/index.js b/src/cluster/index.js
index af0a919a6..a0dea79dc 100644
--- a/src/cluster/index.js
+++ b/src/cluster/index.js
@@ -108,11 +108,29 @@ module.exports = class Cluster {
     })
 
     this[PRIVATE.REFRESH_METADATA] = sharedPromiseTo(async () => {
-      return await this.brokerPool.refreshMetadata(Array.from(this.targetTopics))
+      try {
+        return await this.brokerPool.refreshMetadata(Array.from(this.targetTopics))
+      } catch (e) {
+        if (e.type === 'UNKNOWN_TOPIC_OR_PARTITION' && e.unknownTopics) {
+          await this.removeMultipleTargetTopics(e.unknownTopics)
+          return await this.brokerPool.refreshMetadata(Array.from(this.targetTopics))
+        } else {
+          throw e
+        }
+      }
     })
 
     this[PRIVATE.REFRESH_METADATA_IF_NECESSARY] = sharedPromiseTo(async () => {
-      return await this.brokerPool.refreshMetadataIfNecessary(Array.from(this.targetTopics))
+      try {
+        return await this.brokerPool.refreshMetadataIfNecessary(Array.from(this.targetTopics))
+      } catch (e) {
+        if (e.type === 'UNKNOWN_TOPIC_OR_PARTITION' && e.unknownTopics) {
+          await this.removeMultipleTargetTopics(e.unknownTopics)
+          return await this.brokerPool.refreshMetadataIfNecessary(Array.from(this.targetTopics))
+        } else {
+          throw e
+        }
+      }
     })
 
     this[PRIVATE.FIND_CONTROLLER_BROKER] = sharedPromiseTo(async () => {
@@ -245,6 +263,32 @@ module.exports = class Cluster {
     }
   }
 
+  /**
+   * @public
+   * @param {string[]} topics
+   * @return {Promise}
+   */
+  async removeMultipleTargetTopics(topics) {
+    /* this may be called from addMultipleTargetTopics which already acquired the lock */
+    const isLockNeeded = !this.mutatingTargetTopics.isLocked()
+
+    if (isLockNeeded) {
+      await this.mutatingTargetTopics.acquire()
+    }
+
+    try {
+      for (const topic of topics) {
+        if (this.targetTopics.has(topic)) {
+          this.targetTopics.delete(topic)
+        }
+      }
+    } finally {
+      if (isLockNeeded) {
+        await this.mutatingTargetTopics.release()
+      }
+    }
+  }
+
   /** @type {() => string[]} */
   getNodeIds() {
     return this.brokerPool.getNodeIds()
diff --git a/src/protocol/requests/metadata/v0/response.js b/src/protocol/requests/metadata/v0/response.js
index 3b2fb7650..40027114e 100644
--- a/src/protocol/requests/metadata/v0/response.js
+++ b/src/protocol/requests/metadata/v0/response.js
@@ -1,5 +1,5 @@
 const Decoder = require('../../../decoder')
-const { failure, createErrorFromCode } = require('../../../error')
+const { createErrorFromCode, errorCodes, failure } = require('../../../error')
 
 /**
  * Metadata Response (Version: 0) => [brokers] [topic_metadata]
@@ -18,6 +18,10 @@ const { failure, createErrorFromCode } = require('../../../error')
  *       isr => INT32
  */
 
+const unknownTopicOrPartitionErrorCode = errorCodes.find(
+  v => v.type === 'UNKNOWN_TOPIC_OR_PARTITION'
+).code
+
 const broker = decoder => ({
   nodeId: decoder.readInt32(),
   host: decoder.readString(),
@@ -52,7 +56,21 @@ const parse = async data => {
   const topicsWithErrors = data.topicMetadata.filter(topic => failure(topic.topicErrorCode))
   if (topicsWithErrors.length > 0) {
     const { topicErrorCode } = topicsWithErrors[0]
-    throw createErrorFromCode(topicErrorCode)
+    const error = createErrorFromCode(topicErrorCode)
+    const unknownTopics = topicsWithErrors
+      .filter(topic => topic.topicErrorCode === unknownTopicOrPartitionErrorCode)
+      .map(topic => topic.topic)
+    if (unknownTopics.length > 0) {
+      /**
+       * Add an additional "unknownTopics" property when the Kafka metadata
+       * request finds an unknown topic.  There are multiple versions of the
+       * metadata request but all of them use the v0 parse method.  I didn't
+       * create a new error type for this since this error won't be handled
+       * in the same way for other Kafka requests.
+       */
+      error.unknownTopics = unknownTopics
+    }
+    throw error
   }
 
   const errors = data.topicMetadata.flatMap(topic => {
diff --git a/src/utils/lock.js b/src/utils/lock.js
index 07de4bcc5..a61135774 100644
--- a/src/utils/lock.js
+++ b/src/utils/lock.js
@@ -60,4 +60,8 @@ module.exports = class Lock {
       return waitingLock()
     }
   }
+
+  isLocked() {
+    return this[PRIVATE.LOCKED]
+  }
 }
diff --git a/src/utils/lock.spec.js b/src/utils/lock.spec.js
index 882d11362..ee16948cb 100644
--- a/src/utils/lock.spec.js
+++ b/src/utils/lock.spec.js
@@ -16,12 +16,13 @@ describe('Utils > Lock', () => {
         await lock.release()
       }
     }
+    const graceMilliseconds = 5
 
     await Promise.all([callResource(), callResource(), callResource()])
     const calls = resource.mock.calls.flat()
     expect(calls.length).toEqual(3)
-    expect(calls[1] - calls[0]).toBeGreaterThanOrEqual(50)
-    expect(calls[2] - calls[1]).toBeGreaterThanOrEqual(50)
+    expect(calls[1] - calls[0]).toBeGreaterThanOrEqual(50 - graceMilliseconds)
+    expect(calls[2] - calls[1]).toBeGreaterThanOrEqual(50 - graceMilliseconds)
   })
 
   it('throws an error if the lock cannot be acquired within a period', async () => {