diff --git a/src/VO.owl b/src/VO.owl
index 877e90b..14242dd 100644
--- a/src/VO.owl
+++ b/src/VO.owl
@@ -1600,6 +1600,8 @@ The range of this relation is a organism.</obo:IAO_0000115>
     <!-- http://purl.obolibrary.org/obo/VO_0003355 -->
 
     <owl:ObjectProperty rdf:about="http://purl.obolibrary.org/obo/VO_0003355">
+        <rdfs:domain rdf:resource="http://purl.obolibrary.org/obo/VO_0000001"/>
+        <rdfs:range rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
         <obo:IAO_0000115>a shortcut relation that equals to:
 
 processed material and (is_specified_output_of some vaccine preparation) and (has function some (vaccine function and (is realized by only (vaccine immunization and (realizes some (&apos;immunization target role&apos; and (role_of some &apos;MICROBE&apos;))))))))
@@ -10645,7 +10647,7 @@ MUTATION: An isogenic sodC mutant constructed from B abortus 2308 by gene replac
     <!-- http://purl.obolibrary.org/obo/VO_0000165 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/VO_0000165">
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0000001"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0005504"/>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/VO_0003355"/>
@@ -12032,7 +12034,7 @@ Ref: Hadler TC, et al. Immunization in developing countries. In: Vaccines. Edito
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_4751"/>
             </owl:Restriction>
         </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0000001"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0005504"/>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/VO_0003355"/>
@@ -14497,7 +14499,7 @@ Thiomersal (thimerosal) is added as a preservative. Being manufactured in chicke
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_2759"/>
             </owl:Restriction>
         </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0000001"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0005504"/>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/VO_0003355"/>
@@ -17538,7 +17540,7 @@ The best way to determine if a vaccine is effective is to test it in a randomize
                 <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10239"/>
             </owl:Restriction>
         </owl:equivalentClass>
-        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0000001"/>
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0005504"/>
         <rdfs:subClassOf>
             <owl:Restriction>
                 <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/VO_0003355"/>
@@ -119234,6 +119236,23 @@ https://clinicaltrials.gov/ct2/show/NCT03926728</obo:IAO_0000116>
     
 
 
+    <!-- http://purl.obolibrary.org/obo/VO_0005504 -->
+
+    <owl:Class rdf:about="http://purl.obolibrary.org/obo/VO_0005504">
+        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/VO_0000001"/>
+        <rdfs:subClassOf>
+            <owl:Restriction>
+                <owl:onProperty rdf:resource="http://purl.obolibrary.org/obo/VO_0003355"/>
+                <owl:someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/OBI_0100026"/>
+            </owl:Restriction>
+        </rdfs:subClassOf>
+        <obo:IAO_0000115>a grouping class for vaccines for specific pathogens</obo:IAO_0000115>
+        <dc:contributor rdf:resource="https://orcid.org/0000-0003-4423-4370"/>
+        <rdfs:label xml:lang="en">vaccine for pathogen</rdfs:label>
+    </owl:Class>
+    
+
+
     <!-- http://purl.obolibrary.org/obo/VO_0010000 -->
 
     <owl:Class rdf:about="http://purl.obolibrary.org/obo/VO_0010000">