diff --git a/.guix/manifest.scm b/.guix/manifest.scm
new file mode 100644
index 0000000..8ce2ab7
--- /dev/null
+++ b/.guix/manifest.scm
@@ -0,0 +1,69 @@
+;; Fibers: cooperative, event-driven user-space threads.
+
+;;;; Copyright (C) 2024 Ludovic Courtès <ludo@gnu.org>
+;;;;
+;;;; This library is free software; you can redistribute it and/or
+;;;; modify it under the terms of the GNU Lesser General Public
+;;;; License as published by the Free Software Foundation; either
+;;;; version 3 of the License, or (at your option) any later version.
+;;;;
+;;;; This library is distributed in the hope that it will be useful,
+;;;; but WITHOUT ANY WARRANTY; without even the implied warranty of
+;;;; MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the GNU
+;;;; Lesser General Public License for more details.
+;;;;
+;;;; You should have received a copy of the GNU Lesser General Public License
+;;;; along with this program.  If not, see <http://www.gnu.org/licenses/>.
+
+(use-modules (guix)
+             (guix profiles)
+             (fibers-package)
+             (srfi srfi-1))
+
+;;; Commentary:
+;;;
+;;; This file defines a manifest containing a configuration matrix for
+;;; different native and cross-compilation targets and different variants.
+;;; To build them, run:
+;;;
+;;;   guix build -L .guix/modules -m manifest.scm
+;;;
+;;; Code:
+
+(define* (package->manifest-entry* package system
+                                   #:key target)
+  "Return a manifest entry for PACKAGE on SYSTEM, optionally cross-compiled to
+TARGET."
+  (manifest-entry
+    (inherit (package->manifest-entry package))
+    (name (string-append (package-name package) "." system
+                         (if target
+                             (string-append "." target)
+                             "")))
+    (item (with-parameters ((%current-system system)
+                            (%current-target-system target))
+            package))))
+
+(define native-builds
+  (manifest
+   (append-map (lambda (system)
+                 (map (lambda (package)
+                        (package->manifest-entry* package system))
+                      (list guile-fibers
+                            guile2.2-fibers
+                            guile-fibers/libevent)))
+               '("x86_64-linux"
+                 "i686-linux"))))
+
+(define cross-builds
+  (manifest
+   (map (lambda (target)
+          (package->manifest-entry* (if (string-contains target "linux")
+                                        guile-fibers
+                                        guile-fibers/libevent)
+                                    "x86_64-linux"
+                                    #:target target))
+        '("i586-pc-gnu"
+          "aarch64-linux-gnu"))))
+
+(concatenate-manifests (list native-builds cross-builds))
diff --git a/Makefile.am b/Makefile.am
index 62af854..e7a352e 100644
--- a/Makefile.am
+++ b/Makefile.am
@@ -137,6 +137,7 @@ EXTRA_DIST += \
 	$(TESTS) \
 	env.in \
         guix.scm \
+        .guix/manifest.scm \
         .guix/modules/fibers-package.scm \
 	HACKING \
         COPYING.LESSER \