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Fix order of columns on an AE listing #35

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merged 4 commits into from
Mar 14, 2024
Merged

Fix order of columns on an AE listing #35

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e09f51d
Change `reactable` settings to make a listing changeable.
fukuhiro2023 Mar 1, 2024
4b72e70
Fix column order of a listing.
fukuhiro2023 Mar 1, 2024
6334bce
Change column label for listing.
fukuhiro2023 Mar 1, 2024
ad64f5d
Remove a subject ID variable from fixed columns, and add an argument …
fukuhiro2023 Mar 13, 2024
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9 changes: 8 additions & 1 deletion R/ae_forestly.R
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Original file line number Diff line number Diff line change
Expand Up @@ -172,7 +172,14 @@ ae_forestly <- function(outdata, filter = c("prop", "n"), width = 1400) {
reactable::reactable(
t_details,
columns = col_defs,
width = "100%" # Adjust width as needed
width = "100%", # Adjust width as needed
resizable = TRUE,
filterable = TRUE,
searchable = TRUE,
showPageSizeOptions = TRUE,
borderless = TRUE,
striped = TRUE,
highlight = TRUE
)
},
# Default sort variable
Expand Down
59 changes: 33 additions & 26 deletions R/ae_listing.R
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Original file line number Diff line number Diff line change
Expand Up @@ -35,23 +35,22 @@
collect_ae_listing <- function(
outdata,
display = c(
"SEX", "RACE", "AGE", "ASTDY", "AESEV", "AESER",
"USUBJID", "SEX", "RACE", "AGE", "ASTDY", "AESEV", "AESER",
"AEREL", "AEACN", "AEOUT", "SITEID", "ADURN", "ADURU"
)) {
obs_group <- metalite::collect_adam_mapping(outdata$meta, outdata$observation)$group
obs_id <- metalite::collect_adam_mapping(outdata$meta, outdata$observation)$id
par_var <- metalite::collect_adam_mapping(outdata$meta, outdata$parameter)$var

obs <- metalite::collect_observation_record(
outdata$meta,
outdata$population,
outdata$observation,
outdata$parameter,
var = c(par_var, obs_id, obs_group, display)
var = c(par_var, obs_group, display)
)

# Keep variable used to display only
outdata$ae_listing <- obs[, c(par_var, obs_id, obs_group, display)]
outdata$ae_listing <- obs[, c(par_var, obs_group, display)]

# Get all labels from the un-subset data
listing_label <- get_label(obs)
Expand Down Expand Up @@ -80,6 +79,8 @@ propercase <- function(x) paste0(toupper(substr(x, 1, 1)), tolower(substring(x,
#' Format AE listing analysis
#'
#' @param outdata An `outdata` object created by [prepare_ae_specific()].
#' @param display_unique_records A logical value to display only unique records
#' on AE listing table.
#'
#' @return An `outdata` object after adding AE listing information.
#'
Expand All @@ -90,53 +91,66 @@ propercase <- function(x) paste0(toupper(substr(x, 1, 1)), tolower(substring(x,
#' outdata <- metalite.ae::prepare_ae_specific(meta, "apat", "wk12", "rel") |>
#' collect_ae_listing(
#' c(
#' "SEX", "RACE", "AGE", "ASTDY", "AESEV", "AESER",
#' "USUBJID", "SEX", "RACE", "AGE", "ASTDY", "AESEV", "AESER",
#' "AEREL", "AEACN", "AEOUT", "SITEID", "ADURN", "ADURU", "AOCCPFL"
#' )
#' ) |>
#' format_ae_listing()
#'
#' lapply(outdata, head, 20)
format_ae_listing <- function(outdata) {
format_ae_listing <- function(outdata, display_unique_records = FALSE) {
res <- outdata$ae_listing

obs_group <- metalite::collect_adam_mapping(outdata$meta, outdata$observation)$group
obs_id <- metalite::collect_adam_mapping(outdata$meta, outdata$observation)$id
par_var <- metalite::collect_adam_mapping(outdata$meta, outdata$parameter)$var

cols_remove <- c("SEX", "RACE", "AGE", obs_group, par_var, obs_id)
new_name <- c("SITEID", "SITENUM", "USUBJID", "SUBJID", "SEX", "RACE", "AGE", obs_group, "EPOCH",
"ASTDY", par_var, "ADURN", "AESEV", "AESER", "AEREL", "AREL", "AEACN",
"AEOUT", "AEDOSDUR")
name_mapping <- c("Site_Number", "Site_Number", "Participant_ID", "Participant_ID", "Gender", "Race", "Age", "Treatment_Group", "Onset_Epoch",
"Relative_Day_of_Onset", "Adverse_Event", "Duration", "Intensity", "Serious", "Related", "Related", "Action_Taken",
"Outcome", "Total_Dose_on_Day_of_AE_Onset")
names(name_mapping) <- new_name

res_columns <- lapply(toupper(names(res)), function(x) {
if (x %in% names(name_mapping)) {name_mapping[[x]]}
else {x}
}) |> unlist()

# Site ID
if ("SITEID" %in% toupper(names(res))) {
res$Site_Number <- propercase(res$SITEID)
cols_remove <- c(cols_remove, "SITEID")
}

if ("SITENUM" %in% toupper(names(res))) {
res$Site_Number <- res$SITENUM
cols_remove <- c(cols_remove, "SITENUM")
}

# Participant ID
res$Participant_ID <- res[[obs_id]]
if ("USUBJID" %in% toupper(names(res))) {
res$Participant_ID <- res$USUBJID
}
if ("SUBJID" %in% toupper(names(res))) {
res$Participant_ID <- res$SUBJID
}
attr(res$Participant_ID, "label") <- NULL

res$Gender <- tools::toTitleCase(res$SEX)

res$Race <- tools::toTitleCase(tolower(res$RACE))

res$Age <- res$AGE
res$Treatment_Group <- res[[obs_group]]
attr(res$Treatment_Group, "label") <- NULL

# Onset epoch
if ("EPOCH" %in% toupper(names(res))) {
res$Onset_Epoch <- tools::toTitleCase(tolower(res$EPOCH)) # propcase the EPOCH
cols_remove <- c(cols_remove, "EPOCH")
}

# Relative day of onset (ASTDY)
if ("ASTDY" %in% toupper(names(res))) {
res$Relative_Day_of_Onset <- res$ASTDY
cols_remove <- c(cols_remove, "ASTDY")
}

# Adverse event
Expand All @@ -155,37 +169,29 @@ format_ae_listing <- function(outdata) {
}
}
}

cols_remove <- c(cols_remove, "ADURN", "ADURU")
}

# Intensity
if ("AESEV" %in% toupper(names(res))) {
res$Intensity <- propercase(res$AESEV)
cols_remove <- c(cols_remove, "AESEV")
}

# Serious
if ("AESER" %in% toupper(names(res))) {
res$Serious <- propercase(res$AESER)
cols_remove <- c(cols_remove, "AESER")
}

# AE related
if ("AEREL" %in% toupper(names(res))) {
res$Related <- ifelse(res$AEREL == "RELATED", "Y", ifelse(
toupper(res$AEREL) == "NOT RELATED", "N", tools::toTitleCase(tolower(res$AEREL))
))

cols_remove <- c(cols_remove, "AEREL")
}

if ("AREL" %in% toupper(names(res))) {
res$Related <- ifelse(res$AREL == "RELATED", "Y", ifelse(
toupper(res$AREL) == "NOT RELATED", "N", tools::toTitleCase(tolower(res$AREL))
))

cols_remove <- c(cols_remove, "AREL")
}

# Action taken
Expand All @@ -205,8 +211,6 @@ format_ae_listing <- function(outdata) {
} else {
res$Action_Taken <- res$AEACN
}

cols_remove <- c(cols_remove, "AEACN")
}

# Outcome
Expand All @@ -224,7 +228,6 @@ format_ae_listing <- function(outdata) {
} else {
res$Outcome <- res$AEOUT
}
cols_remove <- c(cols_remove, "AEOUT")
}

# Total dose on day of AE onset
Expand Down Expand Up @@ -272,15 +275,19 @@ format_ae_listing <- function(outdata) {
res$Total_Dose_on_Day_of_AE_Onset <- res$AEDOSDUR
}
res <- res[, !(names(res) == "ymd"), drop = FALSE]
cols_remove <- c(cols_remove, "AEDOSDUR")
}

# Customized variable will use label as column header in
# drill down listing on interactive forest plot
outdata$ae_listing <- res[, !(colnames(res) %in% cols_remove), drop = FALSE]
if (!display_unique_records) {
outdata$ae_listing <- res[, res_columns]
} else {
outdata$ae_listing <- res[, res_columns] |> unique()
}

# Get all labels from the un-subset data
listing_label <- get_label(res)
listing_label <- gsub("_", " ", listing_label)
# Assign labels
outdata$ae_listing <- assign_label(
data = outdata$ae_listing,
Expand Down
9 changes: 6 additions & 3 deletions R/prepare_ae_forestly.R
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Original file line number Diff line number Diff line change
Expand Up @@ -21,6 +21,8 @@
#' @inheritParams metalite.ae::prepare_ae_specific
#' @param ae_listing_display A vector of name of variables used to display
#' on AE listing table.
#' @param ae_listing_unique A logical value to display only unique records
#' on AE listing table.
#'
#' @return An `outdata` object.
#'
Expand All @@ -44,9 +46,10 @@ prepare_ae_forestly <- function(
parameter = NULL,
reference_group = NULL,
ae_listing_display = c(
"SEX", "RACE", "AGE", "ASTDY", "AESEV", "AESER",
"USUBJID", "SEX", "RACE", "AGE", "ASTDY", "AESEV", "AESER",
"AEREL", "AEACN", "AEOUT", "SITEID", "ADURN", "ADURU"
)) {
),
ae_listing_unique = FALSE) {


if (is.null(population)) {
Expand Down Expand Up @@ -81,7 +84,7 @@ prepare_ae_forestly <- function(
) |>
metalite.ae::extend_ae_specific_inference() |>
collect_ae_listing(display = ae_listing_display) |>
format_ae_listing()
format_ae_listing(display_unique_records = ae_listing_unique)
})

ae_listing <- data.frame()
Expand Down
8 changes: 6 additions & 2 deletions man/prepare_ae_forestly.Rd
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