Skip to content

Commit

Permalink
Merge pull request #877 from greenelab/RLordan-patch-1
Browse files Browse the repository at this point in the history
  • Loading branch information
rando2 committed Feb 24, 2021
1 parent ea894a0 commit fcae038
Show file tree
Hide file tree
Showing 11 changed files with 264 additions and 71 deletions.
2 changes: 1 addition & 1 deletion citations.tsv
Original file line number Diff line number Diff line change
Expand Up @@ -667,9 +667,9 @@ doi:10.1186/s12937-018-0356-8 doi:10.1186/s12937-018-0356-8 doi:10.1186/s12937-0
doi:10.1016/j.immuni.2014.02.009 doi:10.1016/j.immuni.2014.02.009 doi:10.1016/j.immuni.2014.02.009 BIVORG2X
doi:10.1038/nri.2015.4 doi:10.1038/nri.2015.4 doi:10.1038/nri.2015.4 uPOTvvjR
doi:10.1002/biof.1691 doi:10.1002/biof.1691 doi:10.1002/biof.1691 sxgmhJ68
doi:10.1016/j.cell.2013.02.027 doi:10.1016/j.cell.2013.02.027 doi:10.1016/j.cell.2013.02.027 fIo3ESPM
doi:10.1038/nature13479 doi:10.1038/nature13479 doi:10.1038/nature13479 OSEnHt6H
doi:10.4049/jimmunol.1302795 doi:10.4049/jimmunol.1302795 doi:10.4049/jimmunol.1302795 MK0GQ55y
doi:10.1016/j.cell.2013.02.027 doi:10.1016/j.cell.2013.02.027 doi:10.1016/j.cell.2013.02.027 fIo3ESPM
doi:10.1007/s10555-020-09889-4 doi:10.1007/s10555-020-09889-4 doi:10.1007/s10555-020-09889-4 14LjKv9ZH
doi:10.1016/j.mehy.2020.110340 doi:10.1016/j.mehy.2020.110340 doi:10.1016/j.mehy.2020.110340 PRLlghQS
doi:10.3389/fimmu.2020.01997 doi:10.3389/fimmu.2020.01997 doi:10.3389/fimmu.2020.01997 oLunKkIG
Expand Down
72 changes: 38 additions & 34 deletions manuscript.html

Large diffs are not rendered by default.

52 changes: 28 additions & 24 deletions manuscript.md

Large diffs are not rendered by default.

Binary file modified manuscript.pdf
Binary file not shown.
Binary file added nutraceuticals-manuscript.docx
Binary file not shown.
Binary file removed pathogenesis-manuscript.docx
Binary file not shown.
Binary file modified pharmaceuticals-manuscript.docx
Binary file not shown.
188 changes: 188 additions & 0 deletions references.json
Original file line number Diff line number Diff line change
Expand Up @@ -103,6 +103,194 @@
"abstract": " COVID-19 has revealed limitations of existing mechanisms for rationing medical resources under emergency scenarios. Many argue that these mechanisms abandon various ethical values such as equity by discriminating against disadvantaged communities. Illustrating that these limitations are aggravated by a restrictive choice of mechanism, we formulate pandemic rationing of medical resources as a new application of market design and propose a reserve system as a resolution. We develop a general theory of reserve design, introduce new concepts such as cutoff equilibria and smart reserves, extend analysis of previously-known ones such as sequential reserve matching, relate these concepts to current debates, and present preliminary policy impact. ",
"note": "license: http://arxiv.org/licenses/nonexclusive-distrib/1.0/\nThis CSL JSON Item was automatically generated by Manubot v0.4.1 using citation-by-identifier.\nstandard_id: arxiv:2008.00374\nLoaded from an external bibliography file by Manubot.\nsource_bibliography: manual-references-2021-02-08.json\noriginal_id: FaGAJ7AI"
},
{
"id": "r366f5T3",
"URL": "https://arxiv.org/abs/2102.01521",
"number": "2102.01521",
"title": "Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through analysis of Viral Genomics and Structure",
"issued": {
"date-parts": [
[
2021,
2,
15
]
]
},
"author": [
{
"given": "Halie M.",
"family": "Rando"
},
{
"given": "Adam L.",
"family": "MacLean"
},
{
"given": "Alexandra J.",
"family": "Lee"
},
{
"given": "Sandipan",
"family": "Ray"
},
{
"given": "Vikas",
"family": "Bansal"
},
{
"given": "Ashwin N.",
"family": "Skelly"
},
{
"given": "Elizabeth",
"family": "Sell"
},
{
"given": "John J.",
"family": "Dziak"
},
{
"given": "Lamonica",
"family": "Shinholster"
},
{
"given": "Lucy D'Agostino",
"family": "McGowan"
},
{
"given": "Marouen Ben",
"family": "Guebila"
},
{
"given": "Nils",
"family": "Wellhausen"
},
{
"given": "Sergey",
"family": "Knyazev"
},
{
"given": "Simina M.",
"family": "Boca"
},
{
"given": "Stephen",
"family": "Capone"
},
{
"given": "Yanjun",
"family": "Qi"
},
{
"given": "YoSon",
"family": "Park"
},
{
"given": "Yuchen",
"family": "Sun"
},
{
"given": "David",
"family": "Mai"
},
{
"given": "Christian",
"family": "Brueffer"
},
{
"given": "James Brian",
"family": "Byrd"
},
{
"given": "Jinhui",
"family": "Wang"
},
{
"given": "Ronan",
"family": "Lordan"
},
{
"given": "Ryan",
"family": "Velazquez"
},
{
"given": "Gregory L",
"family": "Szeto"
},
{
"given": "John P.",
"family": "Barton"
},
{
"given": "Rishi Raj",
"family": "Goel"
},
{
"given": "Serghei",
"family": "Mangul"
},
{
"given": "Tiago",
"family": "Lubiana"
},
{
"given": "COVID-19 Review",
"family": "Consortium"
},
{
"given": "Anthony",
"family": "Gitter"
},
{
"given": "Casey S.",
"family": "Greene"
}
],
"container-title": "arXiv",
"publisher": "arXiv",
"type": "report",
"abstract": " The novel coronavirus SARS-CoV-2, which emerged in late 2019, has since spread around the world infecting tens of millions of people with coronavirus disease 2019 (COVID-19). While this viral species was unknown prior to January 2020, its similarity to other coronaviruses that infect humans has allowed for rapid insight into the mechanisms that it uses to infect human hosts, as well as the ways in which the human immune system can respond. Here, we contextualize SARS-CoV-2 among other coronaviruses and identify what is known and what can be inferred about its behavior once inside a human host. Because the genomic content of coronaviruses, which specifies the virus's structure, is highly conserved, early genomic analysis provided a significant head start in predicting viral pathogenesis. The pathogenesis of the virus offers insights into symptomatology, transmission, and individual susceptibility. Additionally, prior research into interactions between the human immune system and coronaviruses has identified how these viruses can evade the immune system's protective mechanisms. We also explore systems-level research into the regulatory and proteomic effects of SARS-CoV-2 infection and the immune response. Understanding the structure and behavior of the virus serves to contextualize the many facets of the COVID-19 pandemic and can influence efforts to control the virus and treat the disease. ",
"note": "license: http://creativecommons.org/licenses/by/4.0/\nThis CSL Item was generated by Manubot v0.5.0 from its persistent identifier (standard_id).\nstandard_id: arxiv:2102.01521"
},
{
"id": "1B22G6dja",
"URL": "https://arxiv.org/abs/2102.02250",
"number": "2102.02250",
"title": "Dietary Supplements and Nutraceuticals Under Investigation for COVID-19 Prevention and Treatment",
"issued": {
"date-parts": [
[
2021,
2,
5
]
]
},
"author": [
{
"given": "Ronan",
"family": "Lordan"
},
{
"given": "Halie M.",
"family": "Rando"
},
{
"given": "COVID-19 Review",
"family": "Consortium"
},
{
"given": "Casey S.",
"family": "Greene"
}
],
"container-title": "arXiv",
"publisher": "arXiv",
"type": "report",
"abstract": " Coronavirus disease 2019 (COVID-19) has caused global disruption and a significant loss of life. Existing treatments that can be repurposed as prophylactic and therapeutic agents could reduce the pandemic's devastation. Emerging evidence of potential applications in other therapeutic contexts has led to the investigation of dietary supplements and nutraceuticals for COVID-19. Such products include vitamin C, vitamin D, omega 3 polyunsaturated fatty acids, probiotics, and zinc, all of which are currently under clinical investigation. In this review, we critically appraise the evidence surrounding dietary supplements and nutraceuticals for the prophylaxis and treatment of COVID-19. Overall, further study is required before evidence-based recommendations can be formulated, but nutritional status plays a significant role in patient outcomes, and these products could help alleviate deficiencies. For example, evidence indicates that vitamin D deficiency may be associated with greater incidence of infection and severity of COVID-19, suggesting that vitamin D supplementation may hold prophylactic or therapeutic value. A growing number of scientific organizations are now considering recommending vitamin D supplementation to those at high risk of COVID-19. Because research in vitamin D and other nutraceuticals and supplements is preliminary, here we evaluate the extent to which these nutraceutical and dietary supplements hold potential in the COVID-19 crisis. ",
"note": "license: http://creativecommons.org/licenses/by/4.0/\nThis CSL Item was generated by Manubot v0.5.0 from its persistent identifier (standard_id).\nstandard_id: arxiv:2102.02250"
},
{
"id": "65ggO2DM",
"type": "webpage",
Expand Down
2 changes: 0 additions & 2 deletions spelling-error-locations.txt
Original file line number Diff line number Diff line change
Expand Up @@ -19,5 +19,3 @@ content/20.pharmaceuticals.md:775:immunocompetent
content/20.pharmaceuticals.md:776:ADG
content/20.pharmaceuticals.md:781:REGN
content/22.vaccines.md:22:niaid
content/22.vaccines.md:247:propiolactone
content/22.vaccines.md:254:poliovirus
3 changes: 1 addition & 2 deletions spelling-errors.txt
Original file line number Diff line number Diff line change
Expand Up @@ -10,6 +10,5 @@ immunocompetent
JS
Junshi
NIAID
poliovirus
propiolactone
Nrf
REGN
16 changes: 8 additions & 8 deletions variables.json

Large diffs are not rendered by default.

0 comments on commit fcae038

Please sign in to comment.