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shakson-isaac committed Mar 15, 2023
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7 changes: 2 additions & 5 deletions DESCRIPTION
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Expand Up @@ -4,13 +4,10 @@ Title: Single-Cell ENhancer Target (SCENT) gene mapping for single cell multimod
Version: 0.1.0
Author: Saori Sakaue and Shakson Isaac
Maintainer: Shakson Isaac <[email protected]>
Description: SCENT uses single-cell multimodal data (e.g., 10X Multiome RNA/ATAC) and links
Description: R package that contains functions for the SCENT algorithm. SCENT uses
single-cell multimodal data (e.g., 10X Multiome RNA/ATAC) and links
ATAC-seq peaks (putative enhancers) to their target genes by modeling association
between chromatin accessibility and gene expression across individual single cells.
We use Poisson regression to associate gene expression (raw) count and
(binarized) peak accessibility, and estimate errors in coefficients by
bootstrapping framework to control for type I error.
R package.
Imports:
methods,
Hmisc,
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3 changes: 1 addition & 2 deletions README.md
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Expand Up @@ -183,8 +183,7 @@ Arguments in the bash file are user specified as follows:
|2 | num_cores | number of cores (ex. 6) to parallelize to the SCENT algorithm |
|3 | file_SCENT_obj | SCENT object that contains atac_matrix, rna_matrix, metafile, peak_gene_list, etc. To run the SCENT algorithm |
|4 | celltype |User specified celltype (ex. "Tcells") to run the SCENT algorithm |
|5 | output_dir | User specified directory to output the SCENT results to aggregate once parallization is completed.
|
|5 | output_dir | User specified directory to output the SCENT results to aggregate once completed. |


### Contact
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