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@@ -4,13 +4,10 @@ Title: Single-Cell ENhancer Target (SCENT) gene mapping for single cell multimod | |
Version: 0.1.0 | ||
Author: Saori Sakaue and Shakson Isaac | ||
Maintainer: Shakson Isaac <[email protected]> | ||
Description: SCENT uses single-cell multimodal data (e.g., 10X Multiome RNA/ATAC) and links | ||
Description: R package that contains functions for the SCENT algorithm. SCENT uses | ||
single-cell multimodal data (e.g., 10X Multiome RNA/ATAC) and links | ||
ATAC-seq peaks (putative enhancers) to their target genes by modeling association | ||
between chromatin accessibility and gene expression across individual single cells. | ||
We use Poisson regression to associate gene expression (raw) count and | ||
(binarized) peak accessibility, and estimate errors in coefficients by | ||
bootstrapping framework to control for type I error. | ||
R package. | ||
Imports: | ||
methods, | ||
Hmisc, | ||
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