Project for estimating heritability of all diagnoses with sufficient prevalence in the Danish health registers using twins and siblings.
The project is divided into three parts:
- Definition of phenotypes through conversion of ICD8 and ICD10 to phecodes
- Creation of twin and sibling cohorts
- Heritability estimation using the method in Repurposing large health insurance claims data to estimate genetic and environmental contributions in 560 phenotypes