replica 紙上得來終覺淺,絕知此事要躬行 Title Journal Year Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells Nat. Struct. Mol. Biol. 2013 Resetting transcription factor control circuitry toward ground-state pluripotency in human Cell 2014 Defining the three cell lineages of the human blastocyst by single-cell RNA-seq Development 2015 Single-cell RNA-Seq reveals lineage and X chromosome dynamics in human preimplantation embryos Cell 2016 A developmental coordinate of pluripotency among mice, monkeys and humans Nature 2016 Reconstituting the transcriptome and DNA methylome landscapes of human implantation Nature 2019 Single-cell RNA sequencing reveals regulatory mechanism for trophoblast cell-fate divergence in human peri-implantation conceptuses PLoS Biol. 2019 Dynamics of trophoblast differentiation in peri-implantation–stage human embryos PNAS 2019 A developmental landscape of 3D-cultured human pre-gastrulation embryos Nature 2019 Naïve human pluripotent stem cells respond to Wnt, Nodal and LIF signalling to produce expandable naïve extra-embryonic endoderm Development 2019 Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease Nat. Med. 2020 Derivation of trophoblast stem cells from naïve human pluripotent stem cells eLife 2020 Naïve human embryonic stem cells can give rise to cells with a trophoblast-like transcriptome and methylome Stem Cell Reports 2020 Cells of the adult human heart Nature 2020 Highly sensitive spatial transcriptomics at near-cellular resolution with Slide-seqV2 Nat. Biotechnol. 2020 Naive stem cell blastocyst model captures human embryo lineage segregation Cell Stem Cell 2021 Generation of human blastocyst-like structures from pluripotent stem cells Cell Discov. 2021 Reconstructing aspects of human embryogenesis with pluripotent stem cells Nat. Commun. 2021 Single-cell transcriptomic characterization of a gastrulating human embryo Nature 2021 Human blastoids model blastocyst development and implantation Nature 2021