WP Profiler is an mu-plugin implementation of the PHP Profiler library to make it easier to submit XHProf profiling data to XHGui.
After installing this mu-plugin in your application of choice, you'll need to run composer install to install the PHP Profiler library dependency. Next, you will need to configure the profiler settings in plugin.php to connect to your XHGui application.
To use this as a standalone profiler with WordPress, a sample .wp-env.json configuration is included.
See: WordPress/gutenberg#48147 for the status of having XHProf supported directly in the @wordpress/env (i.e., wp-env) package.