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12 changes: 6 additions & 6 deletions README.md
Original file line number Diff line number Diff line change
Expand Up @@ -18,10 +18,10 @@
- [Integrate computational method](#c-integrate-feature-selection-and-prioritization-method)

## Introduction
Multioviz is a [free, user-friendly, interactive platform](https://multioviz-de57keuawa-uc.a.run.app/) that facilitates *in silico* hypothesis testing by combining computational inference of gene regulatory network (GRN) architectures with interactive visualization and perturbation. To generate a perturbable GRN, users can input either individual or population level multiomics data in addition to corresponding phenotypic data. Users can also directly visualize GRNs by directly inputting prioritized lists of molecular features along with mapping data between and within molecular levels the features belong to. We provide an R package version of Multioviz that allows programmers to integrate any computational method that performs feature selection and prioritization, generalizing our platform to accept and model different genomic datasets at multiple molecular scales.
Multioviz is a free, user-friendly, interactive platform that facilitates *in silico* hypothesis testing by combining computational inference of gene regulatory network (GRN) architectures with interactive visualization and perturbation. To generate a perturbable GRN, users can input either individual or population level multiomics data in addition to corresponding phenotypic data. Users can also directly visualize GRNs by directly inputting prioritized lists of molecular features along with mapping data between and within molecular levels the features belong to. We provide an R package version of Multioviz that allows programmers to integrate any computational method that performs feature selection and prioritization, generalizing our platform to accept and model different genomic datasets at multiple molecular scales. Visit Multioviz at https://multioviz.ccv.brown.edu/.

<img
src="./app/readme/fig1.svg"
src="./app/readme/figure1.png"
alt="Alt text"
style="display: inline-block; margin: 0 auto; max-width: 2500px">

Expand Down Expand Up @@ -54,8 +54,8 @@ Multioviz has three usages: To (1) visualize ranked molecular features as GRNs a
2. Run docker image ```docker run -p 3838:3838 multioviz```
### Clone repo
1. Clone multio-viz repository ```git clone [email protected]:lcrawlab/multio-viz.git```
2. Setup dependencies ```sh setup_multioviz.sh```
3. Within multio-viz directory, run ```Rscript runApp.R```
2. Setup dependencies ```sh setupMultioviz.sh```
3. Within multio-viz directory, run ```Rscript runMultioviz.R```
### Install R package (for method integration)
1. Clone multio-viz repository ```git clone [email protected]:lcrawlab/multio-viz.git```
2. Within multio-viz directory, run ```R CMD INSTALL multioviz_0.0.0.9000.tar.gz```
Expand Down Expand Up @@ -111,7 +111,7 @@ runModel <- function(X_input, y_input, mask_input) {
To faciliate *in silico* hypothesis generation, Multioviz allows users to visualize ranked lists and maps of enriched molecular features for a given phenotypic state as GRNs.

<img
src="./app/readme/fig2.svg"
src="./app/readme/fig2.png"
alt="Alt text"
style="display: inline-block; margin: 0 auto; max-width: 2500px">

Expand Down Expand Up @@ -151,7 +151,7 @@ To faciliate *in silico* hypothesis generation, Multioviz allows users to visual
To faciliate *in silico* hypothesis testing, Multioviz allows users to manually delete nodes and edges, and then rerun the ranking model to generate a new network with different significant molecular features.

<img
src="./app/readme/fig3.svg"
src="./app/readme/fig3.png"
alt="Alt text"
style="display: inline-block; margin: 0 auto; max-width: 2500px">

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