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Testing the effects of CFR, infected, dead and health workers on Ebola transmission

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patcarrasco/ebolaNetworks

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File list--for each parameter tested, there is one:

  • Raw data file containing network information at each timestep
  • Raw data file containing health information for agents at each timestep
  • Full model with graphs

Model Information

The default parameters for this model are as follows:

  • Population = 1000
  • Timesteps = 100
  • CFR = 0.65
  • Initial number of infected = 10
  • Health workers in population = 10

Assumptions for model:

  • Population is ignorant of ebolavirus
  • Deceased individalas are buried the same day of death
  • Deceased are more infectious than infected individuals
  • Healers / Doctors will always seek to help infected

Tested parameters:

  • Transmission from dead --> susceptible (CORPSE)
  • Transmission from infected --> susceptible (INFECTED)
  • Case Fatality Rate effect on transmission (CFR)
  • Amount of health workers effect on transmission (HEALTHWORKER)

Model Description

  • Model is here run to 100 timesteps (It is recommended to run to completion, and this can be done with a while loop. However this may cause model to take > 5 hours to run each tested parameter)
  • 100 iterations are done for each tested parameter

1. Doctor Movements

  • Doctor / Healthcare worker checks for connection to infected
  • If doctor is attached to an infected, no movement occurs
  • If doctor is NOT attached to an infected, doctor will find an infected person in the population to attach to
  • Doctor will attempt to heal infected individaul

2. Latent Individuals Checked

  • Exposed individuals are identified, checked and updated in the exposed registry
  • Individuals exposed for 8 days become symptomatic and enter infected class

3. Infected Individuals Checked

  • Infected individauls are identified, checked and updated in the infected registry
  • At 3 days in, infected indivudals can start to feel better and enter recovered class
  • Past 3 days in, infected individuals can start dying
  • At 8 days in, infected individuals die

4. New Infections

  • If infected person connected to a susceptible person, infection can occur at previously set probability
  • If dead person connected to a susceptibe person, infection can occur at previously set probability

5. Burials

  • Dead individauls are removed from the network

Results

Example of one simulation of a community at time step 1

image

Example of case data obtained from 100 simulations of control parameters

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The blue line is the average number of cases present at each time step

Example of death data obtained from 100 simulations of control parameters

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The blue line is the average number of deaths at each time step.

Testing a range of Case Fatality Rates

image
Normally distributed, W = 0.92105, p-value = 0.4385
AOV: F = 3.904, p = 0.0956, No statistical difference

image
Normally distributed : W = 0.97896, p-value = 0.9576
AOV: F = 0.125, p = 0.736, No statistical difference

This is result is interesting. One could expect a higher case fatality rate resulting in a higher amount of deaths. However, this lack of difference could be due to higher CFR rates being detrimental to viral success. A higher death rate could decrease the chances the virus has to infect another individual.

Changing amount of treatment available in the community

image
Normally Distributed: W = 0.93463, p-value = 0.4949
AOV: F = 0.469, p = 0.513, No statistical difference

image
Normally distributed :W = 0.97536, p-value = 0.9356
AOV: F = 0.358 p = 0.566, No statistical difference

Testing a range of infection rates from corpses

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Shapiro-wilks: W = 0.93404, p-value = 0.4888
AOV: F = 380.9, p < 0.001, means of case numbers statistically different

image
Shapiro-Wilks: W = 0.93291, p-value = 0.4771
AOV: F = 349.1, p < 0.001, means of deaths statistically different

Testing a range of infection rates from live hosts

image
Shapiro-wilks: W = 0.9631, p-value = 0.8206
AOV: F = 102.8, p <.001, means of case numbers statistically different

capture
Shapiro-Wilks: W = 0.95509, p-value = 0.7287
AOV: F = 95.55, p < 0.001, means of deahts statistically different

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