Step 1. Compute ASCAT (version 2.4) scores
Step 2. Use ASCAT segmentation profile to estimate segmentation mean
Step 3. Estimate Telomeric Allelic Imbalance (TAI), Loss of Heterozygosity (LOH) and Large scale transition (LST) scores
Step 4. Predict HRD status based on TAI, LOH, LST and composite score (arithmetic mean of the 3 scores) estimated in step 3.