The goal of SimTOST is to estimate the sample size sample size for a
randomized, three-arm, parallel group phase I trial via simulation.
SimTOST is available on CRAN and can be installed by running the
following code.
install.packages("SimTOST")You can also install the development version of SimTOST from GitHub with:
# install.packages("devtools")
devtools::install_github("smartdata-analysis-and-statistics/SimTOST")The main features of this package is sampleSize function which can be
used to calculate sample size for individual and multiple endpoints.
Various worked examples are available as
vignettes
| Vignette | Design | Number of Arms | Number of Endpoints |
|---|---|---|---|
| Bioequivalence Tests for Parallel Trial Designs with Log-Normal Data | Parallel | 2 | Multiple (e.g., 2 or 3) |
| Bioequivalence Tests for 2x2 Cross-Over Trial Designs with Log-Normal Data | Cross-over | 2 | 2 |
| Bioequivalence Tests for Parallel Trial Designs: 2 Arms, 1 Endpoint | Parallel | 2 | 1 |
| Bioequivalence Tests for Parallel Trial Designs: 3 Arms, 1 Endpoint | Parallel | 3 | 1 |
| Bioequivalence Tests for Parallel Trial Designs: 2 Arms, 3 Endpoints | Parallel | 2 | 3 |
| Bioequivalence Tests for Parallel Trial Designs: 3 Arms, 3 Endpoints | Parallel | 3 | 3 |