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Overview

Welcome to the HBV-GLUE wiki!

HBV-GLUE is a sequence-oriented resource for comparative genomic analysis of hepatitis B virus (HBV), developed using the GLUE software framework.

GLUE is an open, integrated software toolkit designed for storing and interpreting sequence data. It supports the creation of bespoke projects, incorporating essential data items for comparative genomic analysis, such as sequences, multiple sequence alignments, genome feature annotations, and other associated data.

Projects are loaded into the GLUE "engine," forming a relational database that represents the semantic relationships between data items. This foundation supports systematic comparative analyses and the development of sequence-based resources.

This HBV-GLUE project contains HBV feature definitions, annotated reference sequences for all HBV genotypes and subtypes, and heirarchically ordered multiple sequence alignments.

Extension Projects

It can be extended with additional layers, also openly available via GitHub, including:

• NCBI-HBV-GLUE: extends HBV-GLUE through the incorporation of all HBV sequence data published in NCBI GenBank.
• HBV-DRUG-RESISTANCE : a drug resistance-focused extension incorporating an analysis tool that provides genotypic assessment of drug resistance/susceptibility.
• HBV-GLUE-WEB: a web interface that can be used to create a HBV-GLUE web-server.

A web instance of HBV-GLUE incorporating both these extension layers is hosted by the University of Glasgow, and can be accessed here.

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