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CD36

CD36 is a transmembrane glycoprotein involved in fatty acid metabolism, glucose intolerance, and immune responses. It is expressed on various cell types, including platelets, monocytes, and some lymphocytes. One study showed higher rates of CD36 mutations in FL relative to DLBCLs.1

History

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timeline
    title Publication timing
      2011-07-31 : Pasqualucci : DLBCL
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Relevance tier by entity

Entity Tier Description
DLBCL 1 high-confidence DLBCL gene[@pasqualucciAnalysisCodingGenome2011]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 2.29
DLBCL Schmitz cohort 4.89
DLBCL Reddy cohort 2.80
DLBCL Chapuy cohort 2.99

Mutation pattern and selective pressure estimates

Entity aSHM Significant selection dN/dS (missense) dN/dS (nonsense)
BL No No 4.616 0.000
DLBCL No No 0.822 7.247
FL No No 1.559 0.000

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

References

CD36 Expression

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