CDC73
<<Warn("The variants reported in this gene in DLBCL failed QC")>>
Mutations in this gene were first described in BL in 2012 by Love et al1 and subsequently in DLBCL by Reddy et al.2 Subsequent exome and genome-wide studies of DLBCL and BL did not reproduce these observations.
%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
timeline
title Publication timing
2012-12-01 : Love : BL
2017-10-10 : Reddy : DLBCL
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in BL not firmly established [@loveGeneticLandscapeMutations2012] |
 |
2 | relevance in DLBCL not firmly established[@reddyGeneticFunctionalDrivers2017] |
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 2.54 |
| BL | Thomas cohort | NA |
| BL | Panea cohort | NA |
| DLBCL | GAMBL genomes | 0.57 |
| DLBCL | Schmitz cohort | 0.64 |
| DLBCL | Reddy cohort | 0.70 |
| DLBCL | Chapuy cohort | 1.28 |
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 3.951 | 0 |
| DLBCL | No | No | 1.702 | 0 |
| FL | No | No | 3.603 | 0 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
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