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rdmorin edited this page Jun 25, 2024 · 11 revisions

bibliography: 'morinlab.bib' csl: 'NLM.csl' link-citations: true

FAT4

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
timeline
    title Publication timing
      2013-08-15 : Morin : DLBCL
      2013-12-13 : Parry : MZL
      2014-05-08 : Zhang : MCL
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Relevance tier by entity

Entity Tier Description
PMBL 1 high-confidence PMBL/cHL/GZL gene
MZL 2 relevance in MZL not firmly established[@parryWholeExomeSequencing2013]
DLBCL 2 relevance in DLBCL not firmly established[@morinMutationalStructuralAnalysis2013]
MCL 2 relevance in MCL not firmly established [@zhangGenomicLandscapeMantle2014]

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 12.81
DLBCL Schmitz cohort 20.43
DLBCL Reddy cohort 14.91
DLBCL Chapuy cohort 16.67
MCL GAMBL genomes 3.79

Mutation pattern and selective pressure estimates

Entity aSHM Significant selection dN/dS (missense) dN/dS (nonsense)
BL No No 0.000 0.000
DLBCL No No 1.682 4.189
FL No No 0.000 0.000

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

FAT4 Expression

All Mutations

DLBCL

RG014 RG038 RG043 RG055 RG077 RG081 RG111

References

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