CD58
CD58, also known as lymphocyte function-associated antigen 3 (LFA-3), is crucial for immune recognition, facilitating interactions between tumor cells and cytotoxic T cells and natural killer (NK) cells.
In DLBCL, mutations prevent the expression of CD58 on the cell surface, impairing the ability of T and NK cells to recognize and attack the tumor cells. This is often accompanied by mutations in the β2-Microglobulin gene, which further aids in immune evasion.[@challa-malladiCombinedGeneticInactivationa]
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timeline
title Publication timing
2011-07-27 : Morin : DLBCL
2012-03-06 : Lohr : DLBCL
2013-08-15 : Morin : DLBCL
2015-10-01 : Schneider : PMBL
2017-05-01 : Albuquerque : DLBCL
2017-10-10 : Reddy : DLBCL
2018-04-12 : Schmitz : DLBCL
2018-05-01 : Chapuy : DLBCL
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene[@schneiderAlterationsCD58Gene2015a] |
 |
1-EE | high-confidence DLBCL gene [@morinFrequentMutationHistonemodifying2011] |
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 7.84 |
| DLBCL | Schmitz cohort | 10.00 |
| DLBCL | Reddy cohort | 2.80 |
| DLBCL | Chapuy cohort | 6.84 |
| BL | GAMBL genomes+capture | 0.92 |
| BL | Thomas cohort | 0.80 |
| BL | Panea cohort | 2.00 |
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 3.10 | 32.536 |
| DLBCL | No | Yes | 8.62 | 292.453 |
| FL | No | Yes | 0.00 | 107.458 |
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