HIST1H1D
This is one of several genes that encode linker histone proteins that are recurrently mutated in DLBCL and FL.[@morinMutationalStructuralAnalysis2013; @krysiakRecurrentSomaticMutations2017b] Mutations are often found in the globular domain of the protein, which is critical for its interaction with DNA and other histone proteins.
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timeline
title Publication timing
2013-08-15 : Morin : DLBCL
2017-01-26 : Krysiak : FL
2017-07-27 : Jallades : MZL
2018-05-01 : Chapuy : DLBCL
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
2 | relevance in MZL not firmly established[@jalladesExomeSequencingIdentifies2017] |
 |
1 | high-confidence DLBCL gene [@morinMutationalStructuralAnalysis2013; @chapuyMolecularSubtypesDiffuse2018b] |
 |
1 | high-confidence FL gene [@krysiakRecurrentSomaticMutations2017b] |
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 3.23 |
| BL | Thomas cohort | 4.70 |
| BL | Panea cohort | 4.00 |
| DLBCL | GAMBL genomes | 6.12 |
| DLBCL | Schmitz cohort | 5.74 |
| DLBCL | Reddy cohort | 6.11 |
| DLBCL | Chapuy cohort | 7.69 |
| FL | GAMBL genomes | 3.23 |
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 8.064 | 0 |
| DLBCL | No | No | 2.458 | 0 |
| FL | No | No | 0.857 | 0 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
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