LCOR
LCOR (Ligand Dependent Nuclear Receptor Corepressor) is involved in the regulation of gene expression by acting as a corepressor for various nuclear receptors and transcription factors. It influences chromatin structure and gene transcription, which can impact cell growth and differentiation. Although recurrently mutated in DLBCL, owing to different annotations of this gene and C10orf12 in hg19 and hg38, there is some confusion about the mutation rate.
| Entity | Tier | Description |
|---|---|---|
| DLBCL | 1 | high-confidence DLBCL gene |
| BL | 2 | relevance in BL not firmly established |
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 6.31 |
| DLBCL | Schmitz cohort | 0.43 |
| DLBCL | Reddy cohort | 0.50 |
| DLBCL | Chapuy cohort | 0.43 |
| BL | GAMBL genomes+capture | 3.46 |
| BL | Thomas cohort | 0.00 |
| BL | Panea cohort | NA |
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0 | 0 |
| DLBCL | No | No | 0 | 0 |
| FL | No | No | 0 | 0 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
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